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PubMed code 16750366

Compile data set for download or QSAR
Found 104 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188149
PNG
(4-[(2S)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188168
PNG
(4-[(2S)-3-{[(2S)-1-(benzylamino)-3-(4-hydroxypheny...)
Show SMILES CN[C@H](CN(C)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H35N3O2/c1-28-24(16-21-8-12-26(31)13-9-21)20-30(2)25(17-22-10-14-27(32)15-11-22)19-29-18-23-6-4-3-5-7-23/h3-15,24-25,28-29,31-32H,16-20H2,1-2H3/t24-,25-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50188156
PNG
(4-[(2S)-3-{[(2S)-1-(4-hydroxyphenyl)-3-{methyl[(2S...)
Show SMILES CNC[C@@H]1CCCN1C[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)NC
Show InChI InChI=1S/C36H53N5O2/c1-37-24-32-11-8-20-41(32)27-34(22-28-9-6-5-7-10-28)40(4)26-33(23-30-14-18-36(43)19-15-30)39(3)25-31(38-2)21-29-12-16-35(42)17-13-29/h5-7,9-10,12-19,31-34,37-38,42-43H,8,11,20-27H2,1-4H3/t31-,32-,33-,34-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Antagonist activity against mu opioid receptor in guinea-pig ileum assay


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50188167
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-{[(2S)-1-[(2S)-2-(amino...)
Show SMILES NC[C@@H]1CCCN1C[C@H](Cc1ccccc1)NC[C@H](Cc1ccc(O)cc1)NC[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C32H45N5O2/c33-20-30-7-4-16-37(30)23-29(19-24-5-2-1-3-6-24)36-22-28(18-26-10-14-32(39)15-11-26)35-21-27(34)17-25-8-12-31(38)13-9-25/h1-3,5-6,8-15,27-30,35-36,38-39H,4,7,16-23,33-34H2/t27-,28-,29-,30-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Antagonist activity against mu opioid receptor in guinea-pig ileum assay


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50188203
PNG
(4-[(2S)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H]1CCCN1C[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C37H55N5O2/c1-38-25-32-12-9-21-42(32)28-35(23-29-10-7-6-8-11-29)41(5)27-34(24-31-15-19-37(44)20-16-31)40(4)26-33(39(2)3)22-30-13-17-36(43)18-14-30/h6-8,10-11,13-20,32-35,38,43-44H,9,12,21-28H2,1-5H3/t32-,33-,34-,35-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Antagonist activity against mu opioid receptor in guinea-pig ileum assay


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188209
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(benzylamino)-3-(4-hydr...)
Show SMILES CN(C[C@@H](N)Cc1ccc(O)cc1)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C26H33N3O2/c1-29(19-23(27)15-20-7-11-25(30)12-8-20)24(16-21-9-13-26(31)14-10-21)18-28-17-22-5-3-2-4-6-22/h2-14,23-24,28,30-31H,15-19,27H2,1H3/t23-,24-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50188210
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(4-hydroxyphenyl)-3-{me...)
Show SMILES CNC[C@@H]1CCCN1C[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C35H51N5O2/c1-37-23-31-10-7-19-40(31)26-33(21-27-8-5-4-6-9-27)39(3)25-32(22-29-13-17-35(42)18-14-29)38(2)24-30(36)20-28-11-15-34(41)16-12-28/h4-6,8-9,11-18,30-33,37,41-42H,7,10,19-26,36H2,1-3H3/t30-,31-,32-,33-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Antagonist activity against mu opioid receptor in guinea-pig ileum assay


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188217
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-(aminomethyl)p...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C34H49N5O3/c1-2-36-28(18-25-5-11-32(40)12-6-25)22-37-29(19-26-7-13-33(41)14-8-26)23-38-30(20-27-9-15-34(42)16-10-27)24-39-17-3-4-31(39)21-35/h5-16,28-31,36-38,40-42H,2-4,17-24,35H2,1H3/t28-,29-,30-,31-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188195
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@H](CN)CCSC)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C43H69N7O3S/c1-4-45-37(23-34-12-16-41(52)17-13-34)27-46-38(24-35-14-18-42(53)19-15-35)28-47-39(25-33-9-6-5-7-10-33)31-50-21-8-11-40(50)29-49-43(32(2)51)30-48-36(26-44)20-22-54-3/h5-7,9-10,12-19,32,36-40,43,45-49,51-53H,4,8,11,20-31,44H2,1-3H3/t32-,36+,37+,38+,39+,40+,43+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188202
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-[...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN1CCC[C@H]1CN)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C43H67N7O3/c1-3-45-36(23-34-13-17-41(52)18-14-34)27-46-37(24-35-15-19-42(53)20-16-35)28-47-38(25-33-9-5-4-6-10-33)30-49-21-8-12-40(49)29-48-43(32(2)51)31-50-22-7-11-39(50)26-44/h4-6,9-10,13-20,32,36-40,43,45-48,51-53H,3,7-8,11-12,21-31,44H2,1-2H3/t32-,36+,37+,38+,39+,40+,43+/m1/s1
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Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188211
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-[(2S...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN1CCC[C@H]1CN)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C48H69N7O3/c1-2-50-40(26-37-12-18-46(56)19-13-37)31-51-41(27-38-14-20-47(57)21-15-38)32-52-42(28-36-8-4-3-5-9-36)35-55-25-7-11-45(55)33-53-43(29-39-16-22-48(58)23-17-39)34-54-24-6-10-44(54)30-49/h3-5,8-9,12-23,40-45,50-53,56-58H,2,6-7,10-11,24-35,49H2,1H3/t40-,41-,42-,43-,44-,45-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188194
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@@H](CN)CO)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C41H65N7O4/c1-3-43-34(20-32-11-15-39(51)16-12-32)24-44-35(21-33-13-17-40(52)18-14-33)25-45-36(22-31-8-5-4-6-9-31)28-48-19-7-10-38(48)26-47-41(30(2)50)27-46-37(23-42)29-49/h4-6,8-9,11-18,30,34-38,41,43-47,49-52H,3,7,10,19-29,42H2,1-2H3/t30-,34+,35+,36+,37+,38+,41+/m1/s1
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Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188186
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@H](CN)Cc1ccccc1)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H69N7O3/c1-3-49-41(26-38-16-20-45(56)21-17-38)30-50-42(27-39-18-22-46(57)23-19-39)31-51-43(28-37-13-8-5-9-14-37)34-54-24-10-15-44(54)32-53-47(35(2)55)33-52-40(29-48)25-36-11-6-4-7-12-36/h4-9,11-14,16-23,35,40-44,47,49-53,55-57H,3,10,15,24-34,48H2,1-2H3/t35-,40+,41+,42+,43+,44+,47+/m1/s1
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Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188215
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@H](CN)Cc1ccc(O)cc1)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H69N7O4/c1-3-49-40(25-37-13-19-45(57)20-14-37)29-50-41(26-38-15-21-46(58)22-16-38)30-51-42(27-35-8-5-4-6-9-35)33-54-23-7-10-43(54)31-53-47(34(2)55)32-52-39(28-48)24-36-11-17-44(56)18-12-36/h4-6,8-9,11-22,34,39-43,47,49-53,55-58H,3,7,10,23-33,48H2,1-2H3/t34-,39+,40+,41+,42+,43+,47+/m1/s1
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Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188212
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-amin...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C43H60N6O3/c1-2-45-37(24-34-12-18-42(51)19-13-34)28-46-38(25-35-14-20-43(52)21-15-35)29-47-39(26-32-7-4-3-5-8-32)31-49-22-6-9-40(49)30-48-36(27-44)23-33-10-16-41(50)17-11-33/h3-5,7-8,10-21,36-40,45-48,50-52H,2,6,9,22-31,44H2,1H3/t36-,37-,38-,39-,40-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188184
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H71N7O4/c1-2-54-44(28-40-12-20-50(61)21-13-40)33-56-45(29-41-14-22-51(62)23-15-41)35-57-47(31-38-7-4-3-5-8-38)37-59-26-6-9-48(59)36-58-46(30-42-16-24-52(63)25-17-42)34-55-43(32-53)27-39-10-18-49(60)19-11-39/h3-5,7-8,10-25,43-48,54-58,60-63H,2,6,9,26-37,53H2,1H3/t43-,44-,45-,46-,47-,48-/m0/s1
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Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188200
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H71N7O3/c1-2-54-45(29-41-15-21-50(60)22-16-41)34-56-46(30-42-17-23-51(61)24-18-42)36-57-48(32-40-12-7-4-8-13-40)38-59-27-9-14-49(59)37-58-47(31-43-19-25-52(62)26-20-43)35-55-44(33-53)28-39-10-5-3-6-11-39/h3-8,10-13,15-26,44-49,54-58,60-62H,2,9,14,27-38,53H2,1H3/t44-,45-,46-,47-,48-,49-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188173
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@@H](CN)CO)[C@@H](C)O)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C41H65N7O5/c1-3-43-33(19-30-6-12-38(51)13-7-30)23-44-34(20-31-8-14-39(52)15-9-31)24-45-35(21-32-10-16-40(53)17-11-32)27-48-18-4-5-37(48)25-47-41(29(2)50)26-46-36(22-42)28-49/h6-17,29,33-37,41,43-47,49-53H,3-5,18-28,42H2,1-2H3/t29-,33+,34+,35+,36+,37+,41+/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188214
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)CCSC)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C48H71N7O3S/c1-3-50-41(26-37-11-17-46(56)18-12-37)31-52-42(27-38-13-19-47(57)20-14-38)33-53-44(29-36-8-5-4-6-9-36)35-55-24-7-10-45(55)34-54-43(28-39-15-21-48(58)22-16-39)32-51-40(30-49)23-25-59-2/h4-6,8-9,11-22,40-45,50-54,56-58H,3,7,10,23-35,49H2,1-2H3/t40-,41-,42-,43-,44-,45-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188157
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(4-hydroxyphenyl)-3-{me...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C30H42N4O2/c1-32-20-27(18-23-7-5-4-6-8-23)34(3)22-28(19-25-11-15-30(36)16-12-25)33(2)21-26(31)17-24-9-13-29(35)14-10-24/h4-16,26-28,32,35-36H,17-22,31H2,1-3H3/t26-,27+,28-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188178
PNG
(4-[(2S)-3-{[(2S)-1-(benzylamino)-3-(4-hydroxypheny...)
Show SMILES CN(C)[C@H](CN(C)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C28H37N3O2/c1-30(2)26(18-23-11-15-28(33)16-12-23)21-31(3)25(17-22-9-13-27(32)14-10-22)20-29-19-24-7-5-4-6-8-24/h4-16,25-26,29,32-33H,17-21H2,1-3H3/t25-,26-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188198
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-[...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN1CCC[C@H]1CN)[C@@H](C)O)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C43H67N7O4/c1-3-45-35(22-32-8-14-40(52)15-9-32)26-46-36(23-33-10-16-41(53)17-11-33)27-47-37(24-34-12-18-42(54)19-13-34)29-49-20-5-7-39(49)28-48-43(31(2)51)30-50-21-4-6-38(50)25-44/h8-19,31,35-39,43,45-48,51-54H,3-7,20-30,44H2,1-2H3/t31-,35+,36+,37+,38+,39+,43+/m1/s1
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n/an/a 41n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50188193
PNG
(4-[(2S)-2-amino-3-{ethyl[(2S)-1-{ethyl[(2S)-1-[(2S...)
Show SMILES CCNC[C@@H]1CCCN1C[C@H](Cc1ccccc1)N(CC)C[C@H](Cc1ccc(O)cc1)N(CC)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C38H57N5O2/c1-4-40-26-34-13-10-22-43(34)29-36(24-30-11-8-7-9-12-30)42(6-3)28-35(25-32-16-20-38(45)21-17-32)41(5-2)27-33(39)23-31-14-18-37(44)19-15-31/h7-9,11-12,14-21,33-36,40,44-45H,4-6,10,13,22-29,39H2,1-3H3/t33-,34-,35-,36-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Antagonist activity against mu opioid receptor in guinea-pig ileum assay


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188192
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-amino-3-phenylpropan-2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C29H40N4O2/c1-2-31-26(17-23-8-12-28(34)13-9-23)20-33-27(18-24-10-14-29(35)15-11-24)21-32-25(19-30)16-22-6-4-3-5-7-22/h3-15,25-27,31-35H,2,16-21,30H2,1H3/t25-,26-,27-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188206
PNG
(4-[(2S,5S,8S,11S,14S)-2-{[(2S)-2-(aminomethyl)pyrr...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H71N7O3/c1-2-54-44(30-41-15-21-50(60)22-16-41)34-55-47(31-42-17-23-51(61)24-18-42)36-56-45(28-39-10-5-3-6-11-39)35-57-46(29-40-12-7-4-8-13-40)37-58-48(32-43-19-25-52(62)26-20-43)38-59-27-9-14-49(59)33-53/h3-8,10-13,15-26,44-49,54-58,60-62H,2,9,14,27-38,53H2,1H3/t44-,45-,46-,47-,48-,49-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188196
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@H](CN)Cc1ccc(O)cc1)[C@@H](C)O)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H69N7O5/c1-3-49-39(24-35-8-16-44(57)17-9-35)28-50-40(25-36-10-18-45(58)19-11-36)29-51-41(26-37-12-20-46(59)21-13-37)32-54-22-4-5-42(54)30-53-47(33(2)55)31-52-38(27-48)23-34-6-14-43(56)15-7-34/h6-21,33,38-42,47,49-53,55-59H,3-5,22-32,48H2,1-2H3/t33-,38+,39+,40+,41+,42+,47+/m1/s1
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n/an/a 61n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188201
PNG
((2S,5S,8S,11S,14S,17S)-2-(aminomethyl)-8,11-dibenz...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN)CO)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C50H69N7O4/c1-2-52-42(27-39-13-19-48(59)20-14-39)31-53-45(28-40-15-21-49(60)22-16-40)34-55-43(25-37-9-5-3-6-10-37)32-54-44(26-38-11-7-4-8-12-38)33-56-46(35-57-47(30-51)36-58)29-41-17-23-50(61)24-18-41/h3-24,42-47,52-61H,2,25-36,51H2,1H3/t42-,43-,44-,45-,46-,47-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188162
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)CO)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C46H67N7O4/c1-2-48-38(23-35-10-16-44(55)17-11-35)28-49-39(24-36-12-18-45(56)19-13-36)29-50-41(26-34-7-4-3-5-8-34)32-53-22-6-9-43(53)31-52-40(30-51-42(27-47)33-54)25-37-14-20-46(57)21-15-37/h3-5,7-8,10-21,38-43,48-52,54-57H,2,6,9,22-33,47H2,1H3/t38-,39-,40-,41-,42+,43-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188162
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)CO)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C46H67N7O4/c1-2-48-38(23-35-10-16-44(55)17-11-35)28-49-39(24-36-12-18-45(56)19-13-36)29-50-41(26-34-7-4-3-5-8-34)32-53-22-6-9-43(53)31-52-40(30-51-42(27-47)33-54)25-37-14-20-46(57)21-15-37/h3-5,7-8,10-21,38-43,48-52,54-57H,2,6,9,22-33,47H2,1H3/t38-,39-,40-,41-,42+,43-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188158
PNG
((4S,7S,10S,13S,16S,17R)-16-({[(2S)-1-amino-3-(4-hy...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN[C@H](CN)Cc1ccc(O)cc1)[C@@H](C)O)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C51H71N7O4/c1-3-53-44(29-41-16-22-49(61)23-17-41)32-54-46(30-42-18-24-50(62)25-19-42)34-55-45(27-38-10-6-4-7-11-38)33-56-47(28-39-12-8-5-9-13-39)35-58-51(37(2)59)36-57-43(31-52)26-40-14-20-48(60)21-15-40/h4-25,37,43-47,51,53-62H,3,26-36,52H2,1-2H3/t37-,43+,44+,45+,46+,47+,51+/m1/s1
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n/an/a 78n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188160
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-[(2S...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN1CCC[C@H]1CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C48H69N7O4/c1-2-50-39(25-35-7-15-45(56)16-8-35)30-51-40(26-36-9-17-46(57)18-10-36)31-52-41(27-37-11-19-47(58)20-12-37)34-55-24-4-6-44(55)32-53-42(28-38-13-21-48(59)22-14-38)33-54-23-3-5-43(54)29-49/h7-22,39-44,50-53,56-59H,2-6,23-34,49H2,1H3/t39-,40-,41-,42-,43-,44-/m0/s1
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n/an/a 79n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188148
PNG
((4S,7S,10S,13S,16S,17R)-16-{[(2S)-2-(aminomethyl)p...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN1CCC[C@H]1CN)[C@@H](C)O)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H69N7O3/c1-3-49-40(27-38-16-20-45(56)21-17-38)30-50-42(28-39-18-22-46(57)23-19-39)32-51-41(25-36-11-6-4-7-12-36)31-52-43(26-37-13-8-5-9-14-37)33-53-47(35(2)55)34-54-24-10-15-44(54)29-48/h4-9,11-14,16-23,35,40-44,47,49-53,55-57H,3,10,15,24-34,48H2,1-2H3/t35-,40+,41+,42+,43+,44+,47+/m1/s1
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n/an/a 82n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188207
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H71N7O4/c1-2-54-44(28-39-10-18-49(60)19-11-39)33-56-45(29-40-12-20-50(61)21-13-40)35-57-47(31-42-16-24-52(63)25-17-42)37-59-26-6-9-48(59)36-58-46(30-41-14-22-51(62)23-15-41)34-55-43(32-53)27-38-7-4-3-5-8-38/h3-5,7-8,10-25,43-48,54-58,60-63H,2,6,9,26-37,53H2,1H3/t43-,44-,45-,46-,47-,48-/m0/s1
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n/an/a 83n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188189
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H71N7O5/c1-2-54-43(27-38-7-17-49(61)18-8-38)32-56-44(28-39-9-19-50(62)20-10-39)34-57-46(30-41-13-23-52(64)24-14-41)36-59-25-3-4-47(59)35-58-45(29-40-11-21-51(63)22-12-40)33-55-42(31-53)26-37-5-15-48(60)16-6-37/h5-24,42-47,54-58,60-64H,2-4,25-36,53H2,1H3/t42-,43-,44-,45-,46-,47-/m0/s1
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n/an/a 87n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188188
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)CO)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C46H67N7O5/c1-2-48-37(22-33-5-13-43(55)14-6-33)27-49-38(23-34-7-15-44(56)16-8-34)28-50-40(25-36-11-19-46(58)20-12-36)31-53-21-3-4-42(53)30-52-39(29-51-41(26-47)32-54)24-35-9-17-45(57)18-10-35/h5-20,37-42,48-52,54-58H,2-4,21-32,47H2,1H3/t37-,38-,39-,40-,41+,42-/m0/s1
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n/an/a 89n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188170
PNG
((2S,5S,8S,11S,14S,17S)-2-(aminomethyl)-8,11-dibenz...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN[C@@H](CN)CO)[C@@H](C)O)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C45H67N7O4/c1-3-47-38(24-36-14-18-43(55)19-15-36)27-48-40(25-37-16-20-44(56)21-17-37)29-49-39(22-34-10-6-4-7-11-34)28-50-41(23-35-12-8-5-9-13-35)30-52-45(33(2)54)31-51-42(26-46)32-53/h4-21,33,38-42,45,47-56H,3,22-32,46H2,1-2H3/t33-,38+,39+,40+,41+,42+,45+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188190
PNG
(4-[(2S,5S,8S,11S,14S,17S)-1-amino-8,11-dibenzyl-17...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C56H73N7O4/c1-2-58-48(32-44-15-23-54(65)24-16-44)36-60-52(34-46-19-27-56(67)28-20-46)40-62-49(30-41-9-5-3-6-10-41)38-61-50(31-42-11-7-4-8-12-42)39-63-51(33-45-17-25-55(66)26-18-45)37-59-47(35-57)29-43-13-21-53(64)22-14-43/h3-28,47-52,58-67H,2,29-40,57H2,1H3/t47-,48-,49-,50-,51-,52-/m0/s1
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n/an/a 95n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188161
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-{[(2S)-1-amino-3-(4-hy...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C38H51N5O4/c1-2-40-32(20-28-5-13-36(45)14-6-28)24-42-34(22-30-9-17-38(47)18-10-30)26-43-33(21-29-7-15-37(46)16-8-29)25-41-31(23-39)19-27-3-11-35(44)12-4-27/h3-18,31-34,40-47H,2,19-26,39H2,1H3/t31-,32-,33-,34-/m0/s1
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n/an/a 96n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188199
PNG
((4S,7S,10S,13S,16S,17R)-16-({[(2S)-1-amino-3-pheny...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN[C@H](CN)Cc1ccccc1)[C@@H](C)O)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C51H71N7O3/c1-3-53-45(30-42-19-23-49(60)24-20-42)33-54-47(31-43-21-25-50(61)26-22-43)35-55-46(28-40-15-9-5-10-16-40)34-56-48(29-41-17-11-6-12-18-41)36-58-51(38(2)59)37-57-44(32-52)27-39-13-7-4-8-14-39/h4-26,38,44-48,51,53-61H,3,27-37,52H2,1-2H3/t38-,44+,45+,46+,47+,48+,51+/m1/s1
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n/an/a 108n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188177
PNG
(4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan...)
Show SMILES CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C19H27N3O2/c1-21-17(11-15-4-8-19(24)9-5-15)13-22-16(12-20)10-14-2-6-18(23)7-3-14/h2-9,16-17,21-24H,10-13,20H2,1H3/t16-,17-/m0/s1
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n/an/a 111n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188182
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@H](CN)CCSC)[C@@H](C)O)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C43H69N7O4S/c1-4-45-36(22-32-7-13-40(52)14-8-32)26-46-37(23-33-9-15-41(53)16-10-33)27-47-38(24-34-11-17-42(54)18-12-34)30-50-20-5-6-39(50)28-49-43(31(2)51)29-48-35(25-44)19-21-55-3/h7-18,31,35-39,43,45-49,51-54H,4-6,19-30,44H2,1-3H3/t31-,35+,36+,37+,38+,39+,43+/m1/s1
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n/an/a 112n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188187
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S)-1-{[(2...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@H](CN[C@H](CN)CCSC)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C48H71N7O4S/c1-3-50-40(25-35-6-14-45(56)15-7-35)30-52-41(26-36-8-16-46(57)17-9-36)32-53-43(28-38-12-20-48(59)21-13-38)34-55-23-4-5-44(55)33-54-42(27-37-10-18-47(58)19-11-37)31-51-39(29-49)22-24-60-2/h6-21,39-44,50-54,56-59H,3-5,22-34,49H2,1-2H3/t39-,40-,41-,42-,43-,44-/m0/s1
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n/an/a 113n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188181
PNG
((4S,7S,10S,13S,16S,17R)-16-({[(2S)-1-amino-4-(meth...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN[C@H](CN)CCSC)[C@@H](C)O)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H71N7O3S/c1-4-49-41(27-38-15-19-45(56)20-16-38)30-50-43(28-39-17-21-46(57)22-18-39)32-51-42(25-36-11-7-5-8-12-36)31-52-44(26-37-13-9-6-10-14-37)33-54-47(35(2)55)34-53-40(29-48)23-24-58-3/h5-22,35,40-44,47,49-57H,4,23-34,48H2,1-3H3/t35-,40+,41+,42+,43+,44+,47+/m1/s1
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n/an/a 115n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188179
PNG
(4-[(5S,8S,11S,14S,17S,20S)-5-(aminomethyl)-11,14-d...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)CCSC)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H73N7O3S/c1-3-54-45(30-41-14-20-50(60)21-15-41)34-56-49(32-43-18-24-52(62)25-19-43)38-58-46(28-39-10-6-4-7-11-39)36-57-47(29-40-12-8-5-9-13-40)37-59-48(31-42-16-22-51(61)23-17-42)35-55-44(33-53)26-27-63-2/h4-25,44-49,54-62H,3,26-38,53H2,1-2H3/t44-,45-,46-,47-,48-,49-/m0/s1
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n/an/a 126n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188175
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-({[(2S,3R)-1-{...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN[C@@H](CN[C@H](CN)Cc1ccccc1)[C@@H](C)O)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H69N7O4/c1-3-49-40(25-36-11-17-44(56)18-12-36)29-50-41(26-37-13-19-45(57)20-14-37)30-51-42(27-38-15-21-46(58)22-16-38)33-54-23-7-10-43(54)31-53-47(34(2)55)32-52-39(28-48)24-35-8-5-4-6-9-35/h4-6,8-9,11-22,34,39-43,47,49-53,55-58H,3,7,10,23-33,48H2,1-2H3/t34-,39+,40+,41+,42+,43+,47+/m1/s1
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n/an/a 128n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188159
PNG
(4-[(2S)-3-{[(2S)-1-{[(2S)-1-amino-3-(4-hydroxyphen...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C29H40N4O3/c1-2-31-25(16-22-5-11-28(35)12-6-22)19-33-26(17-23-7-13-29(36)14-8-23)20-32-24(18-30)15-21-3-9-27(34)10-4-21/h3-14,24-26,31-36H,2,15-20,30H2,1H3/t24-,25-,26-/m0/s1
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n/an/a 138n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188180
PNG
(4-[(2S,5S,8S,11S,14S)-1-amino-14-(ethylamino)-2,5,...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H62N6O5/c1-2-49-39(24-34-5-15-44(55)16-6-34)29-51-41(26-36-9-19-46(57)20-10-36)31-53-42(27-37-11-21-47(58)22-12-37)32-52-40(25-35-7-17-45(56)18-8-35)30-50-38(28-48)23-33-3-13-43(54)14-4-33/h3-22,38-42,49-58H,2,23-32,48H2,1H3/t38-,39-,40-,41-,42-/m0/s1
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n/an/a 146n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188152
PNG
(4-[(2S,5S,8S,11S,14S)-2-{[(2S)-2-(aminomethyl)pyrr...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H71N7O4/c1-2-54-43(28-39-10-18-49(60)19-11-39)33-55-45(29-40-12-20-50(61)21-13-40)34-57-46(30-41-14-22-51(62)23-15-41)35-56-44(27-38-7-4-3-5-8-38)36-58-47(31-42-16-24-52(63)25-17-42)37-59-26-6-9-48(59)32-53/h3-5,7-8,10-25,43-48,54-58,60-63H,2,6,9,26-37,53H2,1H3/t43-,44-,45-,46-,47-,48-/m0/s1
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n/an/a 148n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188185
PNG
((4S,7S,10S,13S,16S,17R)-16-{[(2S)-2-(aminomethyl)p...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN1CCC[C@H]1CN)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H69N7O4/c1-3-49-39(25-36-11-17-44(56)18-12-36)29-50-40(26-37-13-19-45(57)20-14-37)30-51-41(27-38-15-21-46(58)22-16-38)31-52-42(24-35-8-5-4-6-9-35)32-53-47(34(2)55)33-54-23-7-10-43(54)28-48/h4-6,8-9,11-22,34,39-43,47,49-53,55-58H,3,7,10,23-33,48H2,1-2H3/t34-,39+,40+,41+,42+,43+,47+/m1/s1
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n/an/a 155n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188174
PNG
((2S,5S,8S,11S,14S,17S)-2-(aminomethyl)-8-benzyl-5-...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN[C@@H](CN)CO)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C45H67N7O5/c1-3-47-37(22-34-9-15-42(55)16-10-34)26-48-38(23-35-11-17-43(56)18-12-35)27-49-39(24-36-13-19-44(57)20-14-36)28-50-40(21-33-7-5-4-6-8-33)29-52-45(32(2)54)30-51-41(25-46)31-53/h4-20,32,37-41,45,47-57H,3,21-31,46H2,1-2H3/t32-,37+,38+,39+,40+,41+,45+/m1/s1
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n/an/a 163n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188216
PNG
(4-[(2S,5S,8S,11S,14S,17S)-1-amino-2,8,11-tribenzyl...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C56H73N7O3/c1-2-58-49(33-45-18-24-54(64)25-19-45)37-60-53(35-47-22-28-56(66)29-23-47)41-62-50(31-43-14-8-4-9-15-43)39-61-51(32-44-16-10-5-11-17-44)40-63-52(34-46-20-26-55(65)27-21-46)38-59-48(36-57)30-42-12-6-3-7-13-42/h3-29,48-53,58-66H,2,30-41,57H2,1H3/t48-,49-,50-,51-,52-,53-/m0/s1
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n/an/a 176n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188165
PNG
((4S,7S,10S,13S,16S,17R)-16-({[(2S)-1-amino-4-(meth...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN[C@H](CN)CCSC)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C47H71N7O4S/c1-4-49-40(25-36-10-16-44(56)17-11-36)29-50-41(26-37-12-18-45(57)19-13-37)30-51-42(27-38-14-20-46(58)21-15-38)31-52-43(24-35-8-6-5-7-9-35)32-54-47(34(2)55)33-53-39(28-48)22-23-59-3/h5-21,34,39-43,47,49-58H,4,22-33,48H2,1-3H3/t34-,39+,40+,41+,42+,43+,47+/m1/s1
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n/an/a 181n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188213
PNG
((4S,7S,10S,13S,16S,17R)-16-({[(2S)-1-amino-3-(4-hy...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN[C@H](CN)Cc1ccc(O)cc1)[C@@H](C)O)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C51H71N7O5/c1-3-53-43(27-39-11-19-48(61)20-12-39)31-54-44(28-40-13-21-49(62)22-14-40)32-55-45(29-41-15-23-50(63)24-16-41)33-56-46(26-37-7-5-4-6-8-37)34-58-51(36(2)59)35-57-42(30-52)25-38-9-17-47(60)18-10-38/h4-24,36,42-46,51,53-63H,3,25-35,52H2,1-2H3/t36-,42+,43+,44+,45+,46+,51+/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188176
PNG
(4-[(2S,5S,8S,11S,14S,17S)-1-amino-2,8-dibenzyl-17-...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C56H73N7O4/c1-2-58-48(31-43-13-21-53(64)22-14-43)36-60-51(33-45-17-25-55(66)26-18-45)39-63-52(34-46-19-27-56(67)28-20-46)40-61-49(30-42-11-7-4-8-12-42)38-62-50(32-44-15-23-54(65)24-16-44)37-59-47(35-57)29-41-9-5-3-6-10-41/h3-28,47-52,58-67H,2,29-40,57H2,1H3/t47-,48-,49-,50-,51-,52-/m0/s1
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n/an/a 258n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188191
PNG
(4-[(5S,8S,11S,14S,17S,20S)-5-(aminomethyl)-11-benz...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)CCSC)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C52H73N7O4S/c1-3-54-44(28-39-9-17-49(60)18-10-39)33-56-47(30-41-13-21-51(62)22-14-41)36-59-48(31-42-15-23-52(63)24-16-42)37-57-45(27-38-7-5-4-6-8-38)35-58-46(29-40-11-19-50(61)20-12-40)34-55-43(32-53)25-26-64-2/h4-24,43-48,54-63H,3,25-37,53H2,1-2H3/t43-,44-,45-,46-,47-,48-/m0/s1
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n/an/a 260n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188204
PNG
(4-[(2S,5S,8S,11S,14S,17S)-1-amino-8-benzyl-17-(eth...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C56H73N7O5/c1-2-58-47(30-42-10-20-53(65)21-11-42)35-60-50(32-44-14-24-55(67)25-15-44)38-63-51(33-45-16-26-56(68)27-17-45)39-61-48(29-40-6-4-3-5-7-40)37-62-49(31-43-12-22-54(66)23-13-43)36-59-46(34-57)28-41-8-18-52(64)19-9-41/h3-27,46-51,58-68H,2,28-39,57H2,1H3/t46-,47-,48-,49-,50-,51-/m0/s1
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n/an/a 261n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188163
PNG
(4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan...)
Show SMILES CN(C)[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C20H29N3O2/c1-23(2)18(12-16-5-9-20(25)10-6-16)14-22-17(13-21)11-15-3-7-19(24)8-4-15/h3-10,17-18,22,24-25H,11-14,21H2,1-2H3/t17-,18-/m0/s1
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n/an/a 262n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188155
PNG
(4-[(2S)-2-amino-3-{[(2R)-1-(4-hydroxyphenyl)-3-{me...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C30H42N4O2/c1-32-20-27(18-23-7-5-4-6-8-23)34(3)22-28(19-25-11-15-30(36)16-12-25)33(2)21-26(31)17-24-9-13-29(35)14-10-24/h4-16,26-28,32,35-36H,17-22,31H2,1-3H3/t26-,27-,28+/m0/s1
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n/an/a 339n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188169
PNG
(4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan...)
Show SMILES CCN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C20H29N3O2/c1-2-22-18(12-16-5-9-20(25)10-6-16)14-23-17(13-21)11-15-3-7-19(24)8-4-15/h3-10,17-18,22-25H,2,11-14,21H2,1H3/t17-,18-/m0/s1
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n/an/a 344n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188171
PNG
((2S,5S,8S,11S,14S,17S)-2-(aminomethyl)-8-benzyl-5,...)
Show SMILES CCN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@H](CN[C@@H](CN)CO)Cc1ccc(O)cc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C50H69N7O5/c1-2-52-41(25-37-8-16-47(59)17-9-37)30-53-43(26-38-10-18-48(60)19-11-38)32-55-44(27-39-12-20-49(61)21-13-39)33-54-42(24-36-6-4-3-5-7-36)31-56-45(34-57-46(29-51)35-58)28-40-14-22-50(62)23-15-40/h3-23,41-46,52-62H,2,24-35,51H2,1H3/t41-,42-,43-,44-,45-,46-/m0/s1
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n/an/a 345n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188150
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30-/m0/s1
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n/an/a 662n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188166
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30-/m1/s1
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n/an/a 835n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188172
PNG
(4-[(2S)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30-/m1/s1
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n/an/a 876n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188154
PNG
(4-[(2S)-2-amino-3-{benzyl[(2S)-1-(4-hydroxyphenyl)...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@@H](N)Cc1ccc(O)cc1)Cc1ccccc1
Show InChI InChI=1S/C26H33N3O2/c1-28-17-24(16-21-9-13-26(31)14-10-21)29(18-22-5-3-2-4-6-22)19-23(27)15-20-7-11-25(30)12-8-20/h2-14,23-24,28,30-31H,15-19,27H2,1H3/t23-,24-/m0/s1
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n/an/a 882n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188151
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30+/m1/s1
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n/an/a 958n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188149
PNG
(4-[(2S)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30-/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188153
PNG
(4-[(2S)-3-{benzyl[(2S)-1-(4-hydroxyphenyl)-3-(meth...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@H](Cc1ccc(O)cc1)NC)Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c1-28-18-25(17-22-10-14-27(32)15-11-22)30(19-23-6-4-3-5-7-23)20-24(29-2)16-21-8-12-26(31)13-9-21/h3-15,24-25,28-29,31-32H,16-20H2,1-2H3/t24-,25-/m0/s1
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n/an/a 1.21E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188183
PNG
(4-[(2S)-3-{benzyl[(2S)-1-(4-hydroxyphenyl)-3-(meth...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@H](Cc1ccc(O)cc1)N(C)C)Cc1ccccc1
Show InChI InChI=1S/C28H37N3O2/c1-29-19-25(17-22-9-13-27(32)14-10-22)31(20-24-7-5-4-6-8-24)21-26(30(2)3)18-23-11-15-28(33)16-12-23/h4-16,25-26,29,32-33H,17-21H2,1-3H3/t25-,26-/m0/s1
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n/an/a 1.28E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188157
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(4-hydroxyphenyl)-3-{me...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C30H42N4O2/c1-32-20-27(18-23-7-5-4-6-8-23)34(3)22-28(19-25-11-15-30(36)16-12-25)33(2)21-26(31)17-24-9-13-29(35)14-10-24/h4-16,26-28,32,35-36H,17-22,31H2,1-3H3/t26-,27+,28-/m0/s1
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n/an/a 1.45E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188197
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30+/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188178
PNG
(4-[(2S)-3-{[(2S)-1-(benzylamino)-3-(4-hydroxypheny...)
Show SMILES CN(C)[C@H](CN(C)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C28H37N3O2/c1-30(2)26(18-23-11-15-28(33)16-12-23)21-31(3)25(17-22-9-13-27(32)14-10-22)20-29-19-24-7-5-4-6-8-24/h4-16,25-26,29,32-33H,17-21H2,1-3H3/t25-,26-/m0/s1
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n/an/a 2.36E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188168
PNG
(4-[(2S)-3-{[(2S)-1-(benzylamino)-3-(4-hydroxypheny...)
Show SMILES CN[C@H](CN(C)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H35N3O2/c1-28-24(16-21-8-12-26(31)13-9-21)20-30(2)25(17-22-10-14-27(32)15-11-22)19-29-18-23-6-4-3-5-7-23/h3-15,24-25,28-29,31-32H,16-20H2,1-2H3/t24-,25-/m0/s1
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n/an/a 3.86E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188168
PNG
(4-[(2S)-3-{[(2S)-1-(benzylamino)-3-(4-hydroxypheny...)
Show SMILES CN[C@H](CN(C)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H35N3O2/c1-28-24(16-21-8-12-26(31)13-9-21)20-30(2)25(17-22-10-14-27(32)15-11-22)19-29-18-23-6-4-3-5-7-23/h3-15,24-25,28-29,31-32H,16-20H2,1-2H3/t24-,25-/m0/s1
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n/an/a 3.97E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188209
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(benzylamino)-3-(4-hydr...)
Show SMILES CN(C[C@@H](N)Cc1ccc(O)cc1)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C26H33N3O2/c1-29(19-23(27)15-20-7-11-25(30)12-8-20)24(16-21-9-13-26(31)14-10-21)18-28-17-22-5-3-2-4-6-22/h2-14,23-24,28,30-31H,15-19,27H2,1H3/t23-,24-/m0/s1
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n/an/a 4.14E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50188205
PNG
(4-[(2S)-2-amino-3-{benzyl[(2S)-1-{benzyl[(2S)-1-[(...)
Show SMILES N[C@H](CN(Cc1ccccc1)[C@H](CN(Cc1ccccc1)[C@H](CN1CCC[C@H]1CNCc1ccccc1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C53H63N5O2/c54-48(32-43-23-27-52(59)28-24-43)39-57(37-46-18-9-3-10-19-46)51(34-44-25-29-53(60)30-26-44)41-58(38-47-20-11-4-12-21-47)50(33-42-14-5-1-6-15-42)40-56-31-13-22-49(56)36-55-35-45-16-7-2-8-17-45/h1-12,14-21,23-30,48-51,55,59-60H,13,22,31-41,54H2/t48-,49-,50-,51-/m0/s1
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n/an/a 4.46E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Antagonist activity against mu opioid receptor in guinea-pig ileum assay


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188149
PNG
(4-[(2S)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30-/m0/s1
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n/an/a 4.90E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188166
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30-/m1/s1
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n/an/a 4.97E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50188164
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-amino-3-(4-hydroxypheny...)
Show SMILES NC[C@H](Cc1ccc(O)cc1)NC[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C18H25N3O2/c19-11-16(10-14-3-7-18(23)8-4-14)21-12-15(20)9-13-1-5-17(22)6-2-13/h1-8,15-16,21-23H,9-12,19-20H2/t15-,16-/m0/s1
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n/an/a 6.04E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188197
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30+/m0/s1
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n/an/a 6.06E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188178
PNG
(4-[(2S)-3-{[(2S)-1-(benzylamino)-3-(4-hydroxypheny...)
Show SMILES CN(C)[C@H](CN(C)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C28H37N3O2/c1-30(2)26(18-23-11-15-28(33)16-12-23)21-31(3)25(17-22-9-13-27(32)14-10-22)20-29-19-24-7-5-4-6-8-24/h4-16,25-26,29,32-33H,17-21H2,1-3H3/t25-,26-/m0/s1
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n/an/a 8.26E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188157
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(4-hydroxyphenyl)-3-{me...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C30H42N4O2/c1-32-20-27(18-23-7-5-4-6-8-23)34(3)22-28(19-25-11-15-30(36)16-12-25)33(2)21-26(31)17-24-9-13-29(35)14-10-24/h4-16,26-28,32,35-36H,17-22,31H2,1-3H3/t26-,27+,28-/m0/s1
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n/an/a 8.53E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188166
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30-/m1/s1
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n/an/a 8.76E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188150
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30-/m0/s1
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n/an/a 9.05E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188177
PNG
(4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan...)
Show SMILES CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C19H27N3O2/c1-21-17(11-15-4-8-19(24)9-5-15)13-22-16(12-20)10-14-2-6-18(23)7-3-14/h2-9,16-17,21-24H,10-13,20H2,1H3/t16-,17-/m0/s1
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n/an/a 9.67E+3n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188209
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(benzylamino)-3-(4-hydr...)
Show SMILES CN(C[C@@H](N)Cc1ccc(O)cc1)[C@H](CNCc1ccccc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C26H33N3O2/c1-29(19-23(27)15-20-7-11-25(30)12-8-20)24(16-21-9-13-26(31)14-10-21)18-28-17-22-5-3-2-4-6-22/h2-14,23-24,28,30-31H,15-19,27H2,1H3/t23-,24-/m0/s1
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n/an/a 1.02E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188153
PNG
(4-[(2S)-3-{benzyl[(2S)-1-(4-hydroxyphenyl)-3-(meth...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@H](Cc1ccc(O)cc1)NC)Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c1-28-18-25(17-22-10-14-27(32)15-11-22)30(19-23-6-4-3-5-7-23)20-24(29-2)16-21-8-12-26(31)13-9-21/h3-15,24-25,28-29,31-32H,16-20H2,1-2H3/t24-,25-/m0/s1
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n/an/a 1.02E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188150
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30-/m0/s1
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n/an/a 1.05E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188183
PNG
(4-[(2S)-3-{benzyl[(2S)-1-(4-hydroxyphenyl)-3-(meth...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@H](Cc1ccc(O)cc1)N(C)C)Cc1ccccc1
Show InChI InChI=1S/C28H37N3O2/c1-29-19-25(17-22-9-13-27(32)14-10-22)31(20-24-7-5-4-6-8-24)21-26(30(2)3)18-23-11-15-28(33)16-12-23/h4-16,25-26,29,32-33H,17-21H2,1-3H3/t25-,26-/m0/s1
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n/an/a 1.06E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188177
PNG
(4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan...)
Show SMILES CN[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C19H27N3O2/c1-21-17(11-15-4-8-19(24)9-5-15)13-22-16(12-20)10-14-2-6-18(23)7-3-14/h2-9,16-17,21-24H,10-13,20H2,1H3/t16-,17-/m0/s1
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n/an/a 1.09E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188153
PNG
(4-[(2S)-3-{benzyl[(2S)-1-(4-hydroxyphenyl)-3-(meth...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@H](Cc1ccc(O)cc1)NC)Cc1ccccc1
Show InChI InChI=1S/C27H35N3O2/c1-28-18-25(17-22-10-14-27(32)15-11-22)30(19-23-6-4-3-5-7-23)20-24(29-2)16-21-8-12-26(31)13-9-21/h3-15,24-25,28-29,31-32H,16-20H2,1-2H3/t24-,25-/m0/s1
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n/an/a 1.11E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188151
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30+/m1/s1
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n/an/a 1.13E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188154
PNG
(4-[(2S)-2-amino-3-{benzyl[(2S)-1-(4-hydroxyphenyl)...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@@H](N)Cc1ccc(O)cc1)Cc1ccccc1
Show InChI InChI=1S/C26H33N3O2/c1-28-17-24(16-21-9-13-26(31)14-10-21)29(18-22-5-3-2-4-6-22)19-23(27)15-20-7-11-25(30)12-8-20/h2-14,23-24,28,30-31H,15-19,27H2,1H3/t23-,24-/m0/s1
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n/an/a 1.44E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188151
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2S)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29-,30+/m1/s1
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n/an/a 1.56E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188172
PNG
(4-[(2S)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30-/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188197
PNG
(4-[(2R)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30+/m0/s1
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n/an/a 1.78E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188163
PNG
(4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan...)
Show SMILES CN(C)[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C20H29N3O2/c1-23(2)18(12-16-5-9-20(25)10-6-16)14-22-17(13-21)11-15-3-7-19(24)8-4-15/h3-10,17-18,22,24-25H,11-14,21H2,1-2H3/t17-,18-/m0/s1
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n/an/a 1.79E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50188208
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-(4-hydroxyphenyl)-3-[(n...)
Show SMILES N[C@H](CN(Cc1ccc2ccccc2c1)[C@H](CN(Cc1ccc2ccccc2c1)[C@H](CN1CCC[C@H]1CNCc1ccc2ccccc2c1)Cc1ccccc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C65H69N5O2/c66-60(38-49-23-30-64(71)31-24-49)45-69(43-52-21-28-55-14-5-8-17-58(55)36-52)63(40-50-25-32-65(72)33-26-50)47-70(44-53-22-29-56-15-6-9-18-59(56)37-53)62(39-48-11-2-1-3-12-48)46-68-34-10-19-61(68)42-67-41-51-20-27-54-13-4-7-16-57(54)35-51/h1-9,11-18,20-33,35-37,60-63,67,71-72H,10,19,34,38-47,66H2/t60-,61-,62-,63-/m0/s1
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n/an/a 1.86E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Antagonist activity against mu opioid receptor in guinea-pig ileum assay


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188172
PNG
(4-[(2S)-2-(dimethylamino)-3-{[(2R)-1-(4-hydroxyphe...)
Show SMILES CNC[C@@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C
Show InChI InChI=1S/C32H46N4O2/c1-33-22-28(19-25-9-7-6-8-10-25)35(4)24-30(21-27-13-17-32(38)18-14-27)36(5)23-29(34(2)3)20-26-11-15-31(37)16-12-26/h6-18,28-30,33,37-38H,19-24H2,1-5H3/t28-,29+,30-/m1/s1
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n/an/a 2.24E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188155
PNG
(4-[(2S)-2-amino-3-{[(2R)-1-(4-hydroxyphenyl)-3-{me...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C30H42N4O2/c1-32-20-27(18-23-7-5-4-6-8-23)34(3)22-28(19-25-11-15-30(36)16-12-25)33(2)21-26(31)17-24-9-13-29(35)14-10-24/h4-16,26-28,32,35-36H,17-22,31H2,1-3H3/t26-,27-,28+/m0/s1
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n/an/a 2.25E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188163
PNG
(4-[(2S)-3-{[(2S)-1-amino-3-(4-hydroxyphenyl)propan...)
Show SMILES CN(C)[C@H](CN[C@H](CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Show InChI InChI=1S/C20H29N3O2/c1-23(2)18(12-16-5-9-20(25)10-6-16)14-22-17(13-21)11-15-3-7-19(24)8-4-15/h3-10,17-18,22,24-25H,11-14,21H2,1-2H3/t17-,18-/m0/s1
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n/an/a 2.26E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50188164
PNG
(4-[(2S)-2-amino-3-{[(2S)-1-amino-3-(4-hydroxypheny...)
Show SMILES NC[C@H](Cc1ccc(O)cc1)NC[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C18H25N3O2/c19-11-16(10-14-3-7-18(23)8-4-14)21-12-15(20)9-13-1-5-17(22)6-2-13/h1-8,15-16,21-23H,9-12,19-20H2/t15-,16-/m0/s1
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n/an/a 3.22E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188154
PNG
(4-[(2S)-2-amino-3-{benzyl[(2S)-1-(4-hydroxyphenyl)...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@@H](N)Cc1ccc(O)cc1)Cc1ccccc1
Show InChI InChI=1S/C26H33N3O2/c1-28-17-24(16-21-9-13-26(31)14-10-21)29(18-22-5-3-2-4-6-22)19-23(27)15-20-7-11-25(30)12-8-20/h2-14,23-24,28,30-31H,15-19,27H2,1H3/t23-,24-/m0/s1
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n/an/a 3.56E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188155
PNG
(4-[(2S)-2-amino-3-{[(2R)-1-(4-hydroxyphenyl)-3-{me...)
Show SMILES CNC[C@H](Cc1ccccc1)N(C)C[C@@H](Cc1ccc(O)cc1)N(C)C[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C30H42N4O2/c1-32-20-27(18-23-7-5-4-6-8-23)34(3)22-28(19-25-11-15-30(36)16-12-25)33(2)21-26(31)17-24-9-13-29(35)14-10-24/h4-16,26-28,32,35-36H,17-22,31H2,1-3H3/t26-,27-,28+/m0/s1
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n/an/a 4.82E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50188183
PNG
(4-[(2S)-3-{benzyl[(2S)-1-(4-hydroxyphenyl)-3-(meth...)
Show SMILES CNC[C@H](Cc1ccc(O)cc1)N(C[C@H](Cc1ccc(O)cc1)N(C)C)Cc1ccccc1
Show InChI InChI=1S/C28H37N3O2/c1-29-19-25(17-22-9-13-27(32)14-10-22)31(20-24-7-5-4-6-8-24)21-26(30(2)3)18-23-11-15-28(33)16-12-23/h4-16,25-26,29,32-33H,17-21H2,1-3H3/t25-,26-/m0/s1
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n/an/a 5.67E+4n/an/an/an/an/an/a



Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDE from delta opioid receptor


Bioorg Med Chem Lett 16: 4331-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.053
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%