Affinity Data by PubMed id=16913701

PubMed code 16913701

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50193410 (CHEMBL536975 \| N-[(1S,2S)-2-((R)-1-naphthalen-1-yl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50193411 (3,4-dichloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50161093 ((R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthale...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50193408 (CHEMBL556781 \| N-((1R,2R)-2-((R)-1-(naphthalen-1-y...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50193408 (CHEMBL556781 \| N-((1R,2R)-2-((R)-1-(naphthalen-1-y...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50193412 (CHEMBL537427 \| N-[(1S,2S)-2-((R)-1-naphthalen-1-yl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50193407 (CHEMBL537426 \| N1-[4-(trifluoromethoxy)benzenesulf...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Rattus norvegicus)	BDBM50193413 (4-methoxy-N-((1R,2R)-2-(1-(naphthalen-1-yl)ethylam...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation				J Med Chem 49: 5119-28 (2006) Article DOI: 10.1021/jm051233+ BindingDB Entry DOI: 10.7270/Q2DJ5GFC
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%