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PubMed code 16913701

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193410
PNG
(CHEMBL536975 | N-[(1S,2S)-2-((R)-1-naphthalen-1-yl...)
Show SMILES C[C@@H](N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27F3N2O2/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)30-23-11-4-5-12-24(23)31-25(32)19-13-15-20(16-14-19)33-26(27,28)29/h2-3,6-10,13-17,23-24,30H,4-5,11-12H2,1H3,(H,31,32)/t17-,23+,24+/m1/s1
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n/an/a 250n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193411
PNG
(3,4-dichloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)...)
Show SMILES C[C@@H](N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(Cl)c(Cl)c1)c1cccc2ccccc12
Show InChI InChI=1S/C25H26Cl2N2O/c1-16(19-10-6-8-17-7-2-3-9-20(17)19)28-23-11-4-5-12-24(23)29-25(30)18-13-14-21(26)22(27)15-18/h2-3,6-10,13-16,23-24,28H,4-5,11-12H2,1H3,(H,29,30)/t16-,23+,24+/m1/s1
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n/an/a 330n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50161093
PNG
((R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthale...)
Show SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N |r|
Show InChI InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193408
PNG
(CHEMBL556781 | N-((1R,2R)-2-((R)-1-(naphthalen-1-y...)
Show SMILES C[C@@H](N[C@@H]1CCCC[C@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27F3N2O2/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)30-23-11-4-5-12-24(23)31-25(32)19-13-15-20(16-14-19)33-26(27,28)29/h2-3,6-10,13-17,23-24,30H,4-5,11-12H2,1H3,(H,31,32)/t17-,23-,24-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193408
PNG
(CHEMBL556781 | N-((1R,2R)-2-((R)-1-(naphthalen-1-y...)
Show SMILES C[C@@H](N[C@@H]1CCCC[C@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27F3N2O2/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)30-23-11-4-5-12-24(23)31-25(32)19-13-15-20(16-14-19)33-26(27,28)29/h2-3,6-10,13-17,23-24,30H,4-5,11-12H2,1H3,(H,31,32)/t17-,23-,24-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193412
PNG
(CHEMBL537427 | N-[(1S,2S)-2-((R)-1-naphthalen-1-yl...)
Show SMILES C[C@@H](N[C@H]1CCCC[C@@H]1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H27F3N2O3S/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)29-23-11-4-5-12-24(23)30-34(31,32)20-15-13-19(14-16-20)33-25(26,27)28/h2-3,6-10,13-17,23-24,29-30H,4-5,11-12H2,1H3/t17-,23+,24+/m1/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193407
PNG
(CHEMBL537426 | N1-[4-(trifluoromethoxy)benzenesulf...)
Show SMILES CC(N[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H27F3N2O3S/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)29-23-11-4-5-12-24(23)30-34(31,32)20-15-13-19(14-16-20)33-25(26,27)28/h2-3,6-10,13-17,23-24,29-30H,4-5,11-12H2,1H3/t17?,23-,24-/m1/s1
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n/an/a 5.40E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193413
PNG
(4-methoxy-N-((1R,2R)-2-(1-(naphthalen-1-yl)ethylam...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@@H]1CCCC[C@H]1NC(C)c1cccc2ccccc12
Show InChI InChI=1S/C25H30N2O3S/c1-18(22-11-7-9-19-8-3-4-10-23(19)22)26-24-12-5-6-13-25(24)27-31(28,29)21-16-14-20(30-2)15-17-21/h3-4,7-11,14-18,24-27H,5-6,12-13H2,1-2H3/t18?,24-,25-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%