BindingDB logo
myBDB logout

PubMed code 16945533

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16530
PNG
(2-arylpyridazin-3-one, 36 | N-{3-[(2-chlorophenyl)...)
Show SMILES FC(F)(F)C1CCC(CC1)C(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl |(13.52,-3.17,;12.75,-4.5,;14.08,-5.27,;11.98,-5.84,;11.41,-3.73,;11.41,-2.19,;10.08,-1.42,;8.74,-2.19,;8.74,-3.73,;10.08,-4.5,;7.41,-1.42,;7.41,.12,;6.08,-2.19,;4.74,-1.42,;3.41,-2.19,;2.08,-1.42,;.74,-2.19,;-.59,-1.42,;-1.92,-2.19,;-3.26,-1.42,;-3.26,.12,;-4.59,.89,;-1.92,.89,;-.59,.12,;-1.92,2.43,;-.59,3.2,;-.59,4.74,;-1.92,5.51,;-3.26,4.74,;-3.26,3.2,;-4.59,2.43,;.74,-3.73,;-.59,-4.5,;-.59,-6.04,;.74,-6.81,;2.08,-6.04,;2.08,-4.5,;3.41,-3.73,)|
Show InChI InChI=1S/C27H27Cl2F3N4O2/c28-20-6-1-3-8-22(20)35(24-14-15-25(37)36(34-24)23-9-4-2-7-21(23)29)17-5-16-33-26(38)18-10-12-19(13-11-18)27(30,31)32/h1-4,6-9,14-15,18-19H,5,10-13,16-17H2,(H,33,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16524
PNG
(2-arylpyridazin-3-one, 30 | 2-{3-[(2-chlorophenyl)...)
Show SMILES Clc1ccccc1N(CCCN1C(=O)c2ccccc2C1=O)c1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C27H20Cl2N4O3/c28-20-10-3-5-12-22(20)31(16-7-17-32-26(35)18-8-1-2-9-19(18)27(32)36)24-14-15-25(34)33(30-24)23-13-6-4-11-21(23)29/h1-6,8-15H,7,16-17H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16529
PNG
(2-arylpyridazin-3-one, 35 | N-{3-[(2-chlorophenyl)...)
Show SMILES Clc1ccccc1N(CCCNC(=O)C1CCNCC1)c1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C25H27Cl2N5O2/c26-19-6-1-3-8-21(19)31(17-5-14-29-25(34)18-12-15-28-16-13-18)23-10-11-24(33)32(30-23)22-9-4-2-7-20(22)27/h1-4,6-11,18,28H,5,12-17H2,(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16525
PNG
(2-arylpyridazin-3-one, 31 | 2-{3-[(2-chloro-4-fluo...)
Show SMILES Fc1ccc(N(CCCN2C(=O)c3ccccc3C2=O)c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1
Show InChI InChI=1S/C27H19Cl2FN4O3/c28-20-8-3-4-9-23(20)34-25(35)13-12-24(31-34)32(22-11-10-17(30)16-21(22)29)14-5-15-33-26(36)18-6-1-2-7-19(18)27(33)37/h1-4,6-13,16H,5,14-15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Similars
MMDB
PDB
Article
PubMed
n/an/a 9n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16528
PNG
(2-arylpyridazin-3-one, 34 | N-{3-[(2-chlorophenyl)...)
Show SMILES Clc1ccccc1N(CCCNC(=O)C1CCCN1)c1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C24H25Cl2N5O2/c25-17-7-1-3-10-20(17)30(16-6-15-28-24(33)19-9-5-14-27-19)22-12-13-23(32)31(29-22)21-11-4-2-8-18(21)26/h1-4,7-8,10-13,19,27H,5-6,9,14-16H2,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16524
PNG
(2-arylpyridazin-3-one, 30 | 2-{3-[(2-chlorophenyl)...)
Show SMILES Clc1ccccc1N(CCCN1C(=O)c2ccccc2C1=O)c1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C27H20Cl2N4O3/c28-20-10-3-5-12-22(20)31(16-7-17-32-26(35)18-8-1-2-9-19(18)27(32)36)24-14-15-25(34)33(30-24)23-13-6-4-11-21(23)29/h1-6,8-15H,7,16-17H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16525
PNG
(2-arylpyridazin-3-one, 31 | 2-{3-[(2-chloro-4-fluo...)
Show SMILES Fc1ccc(N(CCCN2C(=O)c3ccccc3C2=O)c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1
Show InChI InChI=1S/C27H19Cl2FN4O3/c28-20-8-3-4-9-23(20)34-25(35)13-12-24(31-34)32(22-11-10-17(30)16-21(22)29)14-5-15-33-26(36)18-6-1-2-7-19(18)27(33)37/h1-4,6-13,16H,5,14-15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16530
PNG
(2-arylpyridazin-3-one, 36 | N-{3-[(2-chlorophenyl)...)
Show SMILES FC(F)(F)C1CCC(CC1)C(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl |(13.52,-3.17,;12.75,-4.5,;14.08,-5.27,;11.98,-5.84,;11.41,-3.73,;11.41,-2.19,;10.08,-1.42,;8.74,-2.19,;8.74,-3.73,;10.08,-4.5,;7.41,-1.42,;7.41,.12,;6.08,-2.19,;4.74,-1.42,;3.41,-2.19,;2.08,-1.42,;.74,-2.19,;-.59,-1.42,;-1.92,-2.19,;-3.26,-1.42,;-3.26,.12,;-4.59,.89,;-1.92,.89,;-.59,.12,;-1.92,2.43,;-.59,3.2,;-.59,4.74,;-1.92,5.51,;-3.26,4.74,;-3.26,3.2,;-4.59,2.43,;.74,-3.73,;-.59,-4.5,;-.59,-6.04,;.74,-6.81,;2.08,-6.04,;2.08,-4.5,;3.41,-3.73,)|
Show InChI InChI=1S/C27H27Cl2F3N4O2/c28-20-6-1-3-8-22(20)35(24-14-15-25(37)36(34-24)23-9-4-2-7-21(23)29)17-5-16-33-26(38)18-10-12-19(13-11-18)27(30,31)32/h1-4,6-9,14-15,18-19H,5,10-13,16-17H2,(H,33,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16526
PNG
(2-amino-N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-...)
Show SMILES NCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C21H21Cl2N5O2/c22-15-6-1-3-8-17(15)27(13-5-12-25-20(29)14-24)19-10-11-21(30)28(26-19)18-9-4-2-7-16(18)23/h1-4,6-11H,5,12-14,24H2,(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16529
PNG
(2-arylpyridazin-3-one, 35 | N-{3-[(2-chlorophenyl)...)
Show SMILES Clc1ccccc1N(CCCNC(=O)C1CCNCC1)c1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C25H27Cl2N5O2/c26-19-6-1-3-8-21(19)31(17-5-14-29-25(34)18-12-15-28-16-13-18)23-10-11-24(33)32(30-23)22-9-4-2-7-20(22)27/h1-4,6-11,18,28H,5,12-17H2,(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16527
PNG
(2-arylpyridazin-3-one, 33 | N-{3-[(2-chlorophenyl)...)
Show SMILES CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C22H23Cl2N5O2/c1-25-15-21(30)26-13-6-14-28(18-9-4-2-7-16(18)23)20-11-12-22(31)29(27-20)19-10-5-3-8-17(19)24/h2-5,7-12,25H,6,13-15H2,1H3,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16528
PNG
(2-arylpyridazin-3-one, 34 | N-{3-[(2-chlorophenyl)...)
Show SMILES Clc1ccccc1N(CCCNC(=O)C1CCCN1)c1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C24H25Cl2N5O2/c25-17-7-1-3-10-20(17)30(16-6-15-28-24(33)19-9-5-14-27-19)22-12-13-23(32)31(29-22)21-11-4-2-8-18(21)26/h1-4,7-8,10-13,19,27H,5-6,9,14-16H2,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16527
PNG
(2-arylpyridazin-3-one, 33 | N-{3-[(2-chlorophenyl)...)
Show SMILES CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C22H23Cl2N5O2/c1-25-15-21(30)26-13-6-14-28(18-9-4-2-7-16(18)23)20-11-12-22(31)29(27-20)19-10-5-3-8-17(19)24/h2-5,7-12,25H,6,13-15H2,1H3,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 35n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16526
PNG
(2-amino-N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-...)
Show SMILES NCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C21H21Cl2N5O2/c22-15-6-1-3-8-17(15)27(13-5-12-25-20(29)14-24)19-10-11-21(30)28(26-19)18-9-4-2-7-16(18)23/h1-4,6-11H,5,12-14,24H2,(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16521
PNG
(2-arylpyridazin-3-one, 27 | 6-[(2-chloro-4-fluorop...)
Show SMILES OCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccc(F)cc1Cl
Show InChI InChI=1S/C18H14Cl2FN3O2/c19-13-3-1-2-4-16(13)24-18(26)8-7-17(22-24)23(9-10-25)15-6-5-12(21)11-14(15)20/h1-8,11,25H,9-10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 135n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16517
PNG
(2-(2-chlorophenyl)-6-[(2-fluorophenyl)sulfanyl]-2,...)
Show SMILES Fc1ccccc1Sc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C16H10ClFN2OS/c17-11-5-1-3-7-13(11)20-16(21)10-9-15(19-20)22-14-8-4-2-6-12(14)18/h1-10H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 140n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16521
PNG
(2-arylpyridazin-3-one, 27 | 6-[(2-chloro-4-fluorop...)
Show SMILES OCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccc(F)cc1Cl
Show InChI InChI=1S/C18H14Cl2FN3O2/c19-13-3-1-2-4-16(13)24-18(26)8-7-17(22-24)23(9-10-25)15-6-5-12(21)11-14(15)20/h1-8,11,25H,9-10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 168n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16522
PNG
(2-arylpyridazin-3-one, 28 | 6-[(3-aminopropyl)(2-c...)
Show SMILES NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C19H18Cl2N4O/c20-14-6-1-3-8-16(14)24(13-5-12-22)18-10-11-19(26)25(23-18)17-9-4-2-7-15(17)21/h1-4,6-11H,5,12-13,22H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 197n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16522
PNG
(2-arylpyridazin-3-one, 28 | 6-[(3-aminopropyl)(2-c...)
Show SMILES NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C19H18Cl2N4O/c20-14-6-1-3-8-16(14)24(13-5-12-22)18-10-11-19(26)25(23-18)17-9-4-2-7-15(17)21/h1-4,6-11H,5,12-13,22H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 211n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16518
PNG
(2-(4-chloro-2-methylphenyl)-6-[(2,4-difluorophenyl...)
Show SMILES Cc1cc(Cl)ccc1-n1nc(Sc2ccc(F)cc2F)ccc1=O
Show InChI InChI=1S/C17H11ClF2N2OS/c1-10-8-11(18)2-4-14(10)22-17(23)7-6-16(21-22)24-15-5-3-12(19)9-13(15)20/h2-9H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 310n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16515
PNG
(2-(2-chlorophenyl)-6-[(2-methylphenyl)amino]-2,3-d...)
Show SMILES Cc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C17H14ClN3O/c1-12-6-2-4-8-14(12)19-16-10-11-17(22)21(20-16)15-9-5-3-7-13(15)18/h2-11H,1H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16517
PNG
(2-(2-chlorophenyl)-6-[(2-fluorophenyl)sulfanyl]-2,...)
Show SMILES Fc1ccccc1Sc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C16H10ClFN2OS/c17-11-5-1-3-7-13(11)20-16(21)10-9-15(19-20)22-14-8-4-2-6-12(14)18/h1-10H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16523
PNG
(2-(2-chlorophenyl)-6-[(2-chlorophenyl)(3-{[(2,3,4-...)
Show SMILES COc1ccc(CNCCCN(c2ccc(=O)n(n2)-c2ccccc2Cl)c2ccccc2Cl)c(OC)c1OC
Show InChI InChI=1S/C29H30Cl2N4O4/c1-37-25-14-13-20(28(38-2)29(25)39-3)19-32-17-8-18-34(23-11-6-4-9-21(23)30)26-15-16-27(36)35(33-26)24-12-7-5-10-22(24)31/h4-7,9-16,32H,8,17-19H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 490n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16514
PNG
(2-(2-chlorophenyl)-6-[(2-ethylphenyl)amino]-2,3-di...)
Show SMILES CCc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C18H16ClN3O/c1-2-13-7-3-5-9-15(13)20-17-11-12-18(23)22(21-17)16-10-6-4-8-14(16)19/h3-12H,2H2,1H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 560n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16523
PNG
(2-(2-chlorophenyl)-6-[(2-chlorophenyl)(3-{[(2,3,4-...)
Show SMILES COc1ccc(CNCCCN(c2ccc(=O)n(n2)-c2ccccc2Cl)c2ccccc2Cl)c(OC)c1OC
Show InChI InChI=1S/C29H30Cl2N4O4/c1-37-25-14-13-20(28(38-2)29(25)39-3)19-32-17-8-18-34(23-11-6-4-9-21(23)30)26-15-16-27(36)35(33-26)24-12-7-5-10-22(24)31/h4-7,9-16,32H,8,17-19H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16515
PNG
(2-(2-chlorophenyl)-6-[(2-methylphenyl)amino]-2,3-d...)
Show SMILES Cc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C17H14ClN3O/c1-12-6-2-4-8-14(12)19-16-10-11-17(22)21(20-16)15-9-5-3-7-13(15)18/h2-11H,1H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 760n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16513
PNG
(2-(2-chlorophenyl)-6-[(2-chlorophenyl)amino]-2,3-d...)
Show SMILES Clc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C16H11Cl2N3O/c17-11-5-1-3-7-13(11)19-15-9-10-16(22)21(20-15)14-8-4-2-6-12(14)18/h1-10H,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 790n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16518
PNG
(2-(4-chloro-2-methylphenyl)-6-[(2,4-difluorophenyl...)
Show SMILES Cc1cc(Cl)ccc1-n1nc(Sc2ccc(F)cc2F)ccc1=O
Show InChI InChI=1S/C17H11ClF2N2OS/c1-10-8-11(18)2-4-14(10)22-17(23)7-6-16(21-22)24-15-5-3-12(19)9-13(15)20/h2-9H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16516
PNG
(2-(2-chlorophenyl)-6-[(2-methoxyphenyl)amino]-2,3-...)
Show SMILES COc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C17H14ClN3O2/c1-23-15-9-5-3-7-13(15)19-16-10-11-17(22)21(20-16)14-8-4-2-6-12(14)18/h2-11H,1H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 920n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Mus musculus (mouse))		BDBM16513
PNG
(2-(2-chlorophenyl)-6-[(2-chlorophenyl)amino]-2,3-d...)
Show SMILES Clc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C16H11Cl2N3O/c17-11-5-1-3-7-13(11)19-15-9-10-16(22)21(20-15)14-8-4-2-6-12(14)18/h1-10H,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 990n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16519
PNG
(2-(4-chloro-2-methylphenyl)-6-[(4-chlorophenyl)sul...)
Show SMILES Cc1cc(Cl)ccc1-n1nc(Sc2ccc(Cl)cc2)ccc1=O
Show InChI InChI=1S/C17H12Cl2N2OS/c1-11-10-13(19)4-7-15(11)21-17(22)9-8-16(20-21)23-14-5-2-12(18)3-6-14/h2-10H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16516
PNG
(2-(2-chlorophenyl)-6-[(2-methoxyphenyl)amino]-2,3-...)
Show SMILES COc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C17H14ClN3O2/c1-23-15-9-5-3-7-13(15)19-16-10-11-17(22)21(20-16)14-8-4-2-6-12(14)18/h2-11H,1H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40E+3n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Mus musculus (mouse))		BDBM16520
PNG
(2-(2-chlorophenyl)-6-{[(2-methylphenyl)methyl]amin...)
Show SMILES Cc1ccccc1CNc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C18H16ClN3O/c1-13-6-2-3-7-14(13)12-20-17-10-11-18(23)22(21-17)16-9-5-4-8-15(16)19/h2-11H,12H2,1H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.50E+3n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...

Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%