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PubMed code 16973359

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194988
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((1,5-dimethyl-...)
Show SMILES Cc1c(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)ncn1C
Show InChI InChI=1S/C22H18ClFN6/c1-13-21(28-12-30(13)2)11-26-15-4-6-20-17(7-15)22(14(9-25)10-27-20)29-16-3-5-19(24)18(23)8-16/h3-8,10,12,26H,11H2,1-2H3,(H,27,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194998
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((5-methyl-1H-i...)
Show SMILES Cc1nc[nH]c1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C21H16ClFN6/c1-12-20(28-11-27-12)10-25-14-3-5-19-16(6-14)21(13(8-24)9-26-19)29-15-2-4-18(23)17(22)7-15/h2-7,9,11,25H,10H2,1H3,(H,26,29)(H,27,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195006
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((5-methyl-1-(2...)
Show SMILES Cc1c(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)ncn1CCN1CCOCC1
Show InChI InChI=1S/C27H27ClFN7O/c1-18-26(33-17-36(18)7-6-35-8-10-37-11-9-35)16-31-20-3-5-25-22(12-20)27(19(14-30)15-32-25)34-21-2-4-24(29)23(28)13-21/h2-5,12-13,15,17,31H,6-11,16H2,1H3,(H,32,34)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM21896
PNG
(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4cnc[nH]4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C20H14ClFN6/c21-17-6-14(1-3-18(17)22)28-20-12(7-23)8-26-19-4-2-13(5-16(19)20)25-10-15-9-24-11-27-15/h1-6,8-9,11,25H,10H2,(H,24,27)(H,26,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194987
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(thiazol-2-ylme...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4nccs4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C20H13ClFN5S/c21-16-8-14(1-3-17(16)22)27-20-12(9-23)10-26-18-4-2-13(7-15(18)20)25-11-19-24-5-6-28-19/h1-8,10,25H,11H2,(H,26,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195007
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(1-(pyridin-2-y...)
Show SMILES CC(Nc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccn1
Show InChI InChI=1S/C23H17ClFN5/c1-14(21-4-2-3-9-27-21)29-16-6-8-22-18(10-16)23(15(12-26)13-28-22)30-17-5-7-20(25)19(24)11-17/h2-11,13-14,29H,1H3,(H,28,30)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195000
PNG
(6-((1H-pyrazol-3-yl)methylamino)-4-(3-chloro-4-flu...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4ccn[nH]4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C20H14ClFN6/c21-17-8-14(1-3-18(17)22)27-20-12(9-23)10-25-19-4-2-13(7-16(19)20)24-11-15-5-6-26-28-15/h1-8,10,24H,11H2,(H,25,27)(H,26,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195008
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-2-ylme...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4ccccn4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H15ClFN5/c23-19-10-16(4-6-20(19)24)29-22-14(11-25)12-28-21-7-5-15(9-18(21)22)27-13-17-3-1-2-8-26-17/h1-10,12,27H,13H2,(H,28,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195005
PNG
(6-(3-cyanobenzylamino)-4-(3-chloro-4-fluorophenyla...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4cccc(c4)C#N)cc23)C#N)cc1Cl
Show InChI InChI=1S/C24H15ClFN5/c25-21-10-19(4-6-22(21)26)31-24-17(12-28)14-30-23-7-5-18(9-20(23)24)29-13-16-3-1-2-15(8-16)11-27/h1-10,14,29H,13H2,(H,30,31)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194999
PNG
(4-((4-(3-chloro-4-fluorophenylamino)-3-cyanoquinol...)
Show SMILES NS(=O)(=O)c1ccc(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)cc1
Show InChI InChI=1S/C23H17ClFN5O2S/c24-20-10-17(3-7-21(20)25)30-23-15(11-26)13-29-22-8-4-16(9-19(22)23)28-12-14-1-5-18(6-2-14)33(27,31)32/h1-10,13,28H,12H2,(H,29,30)(H2,27,31,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194984
PNG
(4-(3-chloro-4-fluoro-phenylamino)-6-[(1-oxy-pyridi...)
Show SMILES [O-][n+]1ccccc1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C22H15ClFN5O/c23-19-10-16(4-6-20(19)24)28-22-14(11-25)12-27-21-7-5-15(9-18(21)22)26-13-17-3-1-2-8-29(17)30/h1-10,12,26H,13H2,(H,27,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195003
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-2-ylme...)
Show SMILES Fc1ccc(Nc2c(cnc3cnc(NCc4ccccn4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H14ClFN6/c22-17-7-14(4-5-18(17)23)29-21-13(9-24)10-26-19-12-28-20(8-16(19)21)27-11-15-3-1-2-6-25-15/h1-8,10,12H,11H2,(H,26,29)(H,27,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50173850
PNG
(6-(benzylamino)-4-(3-chloro-4-fluorophenylamino)-1...)
Show SMILES Fc1ccc(Nc2c(cnc3cnc(NCc4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H15ClFN5/c23-18-8-16(6-7-19(18)24)29-22-15(10-25)12-26-20-13-28-21(9-17(20)22)27-11-14-4-2-1-3-5-14/h1-9,12-13H,11H2,(H,26,29)(H,27,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195014
PNG
(6-(3-aminobenzylamino)-4-(3-chloro-4-fluorophenyla...)
Show SMILES Nc1cccc(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)c1
Show InChI InChI=1S/C23H17ClFN5/c24-20-10-18(4-6-21(20)25)30-23-15(11-26)13-29-22-7-5-17(9-19(22)23)28-12-14-2-1-3-16(27)8-14/h1-10,13,28H,12,27H2,(H,29,30)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195004
PNG
((S)-4-(3-chloro-4-fluorophenylamino)-6-((1-ethylpy...)
Show SMILES CCN1CCC[C@H]1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C23H23ClFN5/c1-2-30-9-3-4-18(30)14-27-16-6-8-22-19(10-16)23(15(12-26)13-28-22)29-17-5-7-21(25)20(24)11-17/h5-8,10-11,13,18,27H,2-4,9,14H2,1H3,(H,28,29)/t18-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194980
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((1,4-dimethyl-...)
Show SMILES Cc1ncn(C)c1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C22H18ClFN6/c1-13-21(30(2)12-28-13)11-26-15-4-6-20-17(7-15)22(14(9-25)10-27-20)29-16-3-5-19(24)18(23)8-16/h3-8,10,12,26H,11H2,1-2H3,(H,27,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194981
PNG
(6-(benzylamino)-4-(3-chloro-4-fluorophenylamino)qu...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C23H16ClFN4/c24-20-11-18(6-8-21(20)25)29-23-16(12-26)14-28-22-9-7-17(10-19(22)23)27-13-15-4-2-1-3-5-15/h1-11,14,27H,13H2,(H,28,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195001
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(furan-2-ylmeth...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4ccco4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H14ClFN4O/c22-18-9-15(3-5-19(18)23)27-21-13(10-24)11-26-20-6-4-14(8-17(20)21)25-12-16-2-1-7-28-16/h1-9,11,25H,12H2,(H,26,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195009
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((4-methyl-1-(2...)
Show SMILES Cc1ncn(CCN2CCOCC2)c1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C27H27ClFN7O/c1-18-26(36(17-33-18)7-6-35-8-10-37-11-9-35)16-31-20-3-5-25-22(12-20)27(19(14-30)15-32-25)34-21-2-4-24(29)23(28)13-21/h2-5,12-13,15,17,31H,6-11,16H2,1H3,(H,32,34)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194982
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((2-ethyl-1H-im...)
Show SMILES CCc1ncc(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)[nH]1
Show InChI InChI=1S/C22H18ClFN6/c1-2-21-28-12-16(29-21)11-26-14-4-6-20-17(7-14)22(13(9-25)10-27-20)30-15-3-5-19(24)18(23)8-15/h3-8,10,12,26H,2,11H2,1H3,(H,27,30)(H,28,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194990
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(2-morpholinoet...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCCN4CCOCC4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H21ClFN5O/c23-19-12-17(1-3-20(19)24)28-22-15(13-25)14-27-21-4-2-16(11-18(21)22)26-5-6-29-7-9-30-10-8-29/h1-4,11-12,14,26H,5-10H2,(H,27,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM29896
PNG
(1,7-naphthyridine-3-carbonitrile, 1 | CHEMBL197538)
Show SMILES Fc1ccc(Nc2c(cnc3cnc(NCCN4CCOCC4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H20ClFN6O/c22-17-9-15(1-2-18(17)23)28-21-14(11-24)12-26-19-13-27-20(10-16(19)21)25-3-4-29-5-7-30-8-6-29/h1-2,9-10,12-13H,3-8H2,(H,25,27)(H,26,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194993
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((tetrahydrofur...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCC4CCCO4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H18ClFN4O/c22-18-9-15(3-5-19(18)23)27-21-13(10-24)11-26-20-6-4-14(8-17(20)21)25-12-16-2-1-7-28-16/h3-6,8-9,11,16,25H,1-2,7,12H2,(H,26,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195011
PNG
((R)-4-(3-chloro-4-fluorophenylamino)-6-((1-ethylpy...)
Show SMILES CCN1CCC[C@@H]1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C23H23ClFN5/c1-2-30-9-3-4-18(30)14-27-16-6-8-22-19(10-16)23(15(12-26)13-28-22)29-17-5-7-21(25)20(24)11-17/h5-8,10-11,13,18,27H,2-4,9,14H2,1H3,(H,28,29)/t18-/m1/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194995
PNG
(6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...)
Show SMILES Fc1ccc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(NCc4cnc[nH]4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C27H27ClFN7O2/c28-22-10-19(2-3-23(22)29)35-27-18(13-30)14-32-24-12-26(38-7-1-4-36-5-8-37-9-6-36)25(11-21(24)27)33-16-20-15-31-17-34-20/h2-3,10-12,14-15,17,33H,1,4-9,16H2,(H,31,34)(H,32,35)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194996
PNG
(4-(3-chloro-4-fluorophenylthio)-6-(2-morpholinoeth...)
Show SMILES Fc1ccc(Sc2c(cnc3ccc(NCCN4CCOCC4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H20ClFN4OS/c23-19-12-17(2-3-20(19)24)30-22-15(13-25)14-27-21-4-1-16(11-18(21)22)26-5-6-28-7-9-29-10-8-28/h1-4,11-12,14,26H,5-10H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195010
PNG
(4-(3-chloro-4-fluorophenylamino)-6-phenethylquinol...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(CCc4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C24H17ClFN3/c25-21-13-19(9-10-22(21)26)29-24-18(14-27)15-28-23-11-8-17(12-20(23)24)7-6-16-4-2-1-3-5-16/h1-5,8-13,15H,6-7H2,(H,28,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194986
PNG
(CHEMBL376288 | N-(4-(3-chloro-4-fluorophenylamino)...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NC(=O)c4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C23H14ClFN4O/c24-19-11-17(6-8-20(19)25)28-22-15(12-26)13-27-21-9-7-16(10-18(21)22)29-23(30)14-4-2-1-3-5-14/h1-11,13H,(H,27,28)(H,29,30)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194985
PNG
(CHEMBL374852 | N-(4-(3-chloro-4-fluorophenylamino)...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NS(=O)(=O)c4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H14ClFN4O2S/c23-19-11-15(6-8-20(19)24)27-22-14(12-25)13-26-21-9-7-16(10-18(21)22)28-31(29,30)17-4-2-1-3-5-17/h1-11,13,28H,(H,26,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195012
PNG
(6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...)
Show SMILES Cc1nc2ccc(NCc3cnc[nH]3)cc2c(Nc2ccc(F)c(Cl)c2)c1C#N
Show InChI InChI=1S/C21H16ClFN6/c1-12-17(8-24)21(29-14-2-4-19(23)18(22)7-14)16-6-13(3-5-20(16)28-12)26-10-15-9-25-11-27-15/h2-7,9,11,26H,10H2,1H3,(H,25,27)(H,28,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194991
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(pyrrolidin-2-y...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCC4CCCN4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H19ClFN5/c22-18-9-15(3-5-19(18)23)28-21-13(10-24)11-27-20-6-4-14(8-17(20)21)26-12-16-2-1-7-25-16/h3-6,8-9,11,16,25-26H,1-2,7,12H2,(H,27,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194983
PNG
(6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...)
Show SMILES CC(C)Oc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCc1cnc[nH]1
Show InChI InChI=1S/C23H20ClFN6O/c1-13(2)32-22-7-20-17(6-21(22)29-11-16-10-27-12-30-16)23(14(8-26)9-28-20)31-15-3-4-19(25)18(24)5-15/h3-7,9-10,12-13,29H,11H2,1-2H3,(H,27,30)(H,28,31)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194992
PNG
(4-((3-chloro-4-fluorophenyl)(methyl)amino)-6-(2-mo...)
Show SMILES CN(c1ccc(F)c(Cl)c1)c1c(cnc2ccc(NCCN3CCOCC3)cc12)C#N
Show InChI InChI=1S/C23H23ClFN5O/c1-29(18-3-4-21(25)20(24)13-18)23-16(14-26)15-28-22-5-2-17(12-19(22)23)27-6-7-30-8-10-31-11-9-30/h2-5,12-13,15,27H,6-11H2,1H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194989
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(phenylamino)qu...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(Nc4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H14ClFN4/c23-19-11-17(6-8-20(19)24)28-22-14(12-25)13-26-21-9-7-16(10-18(21)22)27-15-4-2-1-3-5-15/h1-11,13,27H,(H,26,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194997
PNG
(6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...)
Show SMILES Fc1ccc(Nc2c(C#N)c(=O)[nH]c3ccc(NCc4cnc[nH]4)cc23)cc1Cl
Show InChI InChI=1S/C20H14ClFN6O/c21-16-6-12(1-3-17(16)22)27-19-14-5-11(25-9-13-8-24-10-26-13)2-4-18(14)28-20(29)15(19)7-23/h1-6,8,10,25H,9H2,(H,24,26)(H2,27,28,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195013
PNG
(6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...)
Show SMILES Fc1ccc(Nc2c(cnc3cc(OC(F)(F)F)c(NCc4cnc[nH]4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H13ClF4N6O/c22-15-3-12(1-2-16(15)23)32-20-11(6-27)7-29-17-5-19(33-21(24,25)26)18(4-14(17)20)30-9-13-8-28-10-31-13/h1-5,7-8,10,30H,9H2,(H,28,31)(H,29,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194994
PNG
(6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...)
Show SMILES Cc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCc1cnc[nH]1
Show InChI InChI=1S/C21H16ClFN6/c1-12-4-20-16(6-19(12)27-10-15-9-25-11-28-15)21(13(7-24)8-26-20)29-14-2-3-18(23)17(22)5-14/h2-6,8-9,11,27H,10H2,1H3,(H,25,28)(H,26,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195002
PNG
(4-(3-chloro-4-fluorophenoxy)-6-(2-morpholinoethyla...)
Show SMILES Fc1ccc(Oc2c(cnc3ccc(NCCN4CCOCC4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H20ClFN4O2/c23-19-12-17(2-3-20(19)24)30-22-15(13-25)14-27-21-4-1-16(11-18(21)22)26-5-6-28-7-9-29-10-8-28/h1-4,11-12,14,26H,5-10H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%