Found 41 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195878
(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)Show SMILES Nc1ncc(-c2ccccc2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H18F4N4O2/c28-21-11-8-17(27(29,30)31)12-22(21)35-26(36)34-18-9-6-16(7-10-18)20-14-37-24-19(13-33-25(32)23(20)24)15-4-2-1-3-5-15/h1-14H,(H2,32,33)(H2,34,35,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-Tie2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50195878
(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)Show SMILES Nc1ncc(-c2ccccc2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H18F4N4O2/c28-21-11-8-17(27(29,30)31)12-22(21)35-26(36)34-18-9-6-16(7-10-18)20-14-37-24-19(13-33-25(32)23(20)24)15-4-2-1-3-5-15/h1-14H,(H2,32,33)(H2,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195888
(2-(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,...)Show SMILES NC(=O)Cc1cccc(c1)-c1cnc(N)c2c(csc12)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C21H15ClFN3OS/c22-16-8-13(4-5-17(16)23)15-10-28-20-14(9-26-21(25)19(15)20)12-3-1-2-11(6-12)7-18(24)27/h1-6,8-10H,7H2,(H2,24,27)(H2,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50195878
(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)Show SMILES Nc1ncc(-c2ccccc2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H18F4N4O2/c28-21-11-8-17(27(29,30)31)12-22(21)35-26(36)34-18-9-6-16(7-10-18)20-14-37-24-19(13-33-25(32)23(20)24)15-4-2-1-3-5-15/h1-14H,(H2,32,33)(H2,34,35,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-Tie2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195877
(3-(3-chloro-4-fluorophenyl)-7-(pyridin-3-yl)thieno...)Show SMILES Nc1ncc(-c2cccnc2)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C18H11ClFN3S/c19-14-6-10(3-4-15(14)20)13-9-24-17-12(8-23-18(21)16(13)17)11-2-1-5-22-7-11/h1-9H,(H2,21,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195892
(3-(3-chloro-4-fluorophenyl)-7-(3-(methylsulfonyl)p...)Show SMILES CS(=O)(=O)c1cccc(c1)-c1cnc(N)c2c(csc12)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C20H14ClFN2O2S2/c1-28(25,26)13-4-2-3-11(7-13)14-9-24-20(23)18-15(10-27-19(14)18)12-5-6-17(22)16(21)8-12/h2-10H,1H3,(H2,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195884
(3-(3-chloro-4-fluorophenyl)-7-(3,4,5-trimethoxyphe...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C22H18ClFN2O3S/c1-27-17-7-12(8-18(28-2)20(17)29-3)13-9-26-22(25)19-14(10-30-21(13)19)11-4-5-16(24)15(23)6-11/h4-10H,1-3H3,(H2,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195890
(3-(4-chlorophenyl)-7-(3,4,5-trimethoxyphenyl)thien...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H19ClN2O3S/c1-26-17-8-13(9-18(27-2)20(17)28-3)15-10-25-22(24)19-16(11-29-21(15)19)12-4-6-14(23)7-5-12/h4-11H,1-3H3,(H2,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195893
(3-(2,3-dichlorophenyl)-7-(3,4,5-trimethoxyphenyl)t...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C22H18Cl2N2O3S/c1-27-16-7-11(8-17(28-2)20(16)29-3)13-9-26-22(25)18-14(10-30-21(13)18)12-5-4-6-15(23)19(12)24/h4-10H,1-3H3,(H2,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195885
(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)Show SMILES Nc1ncc(-c2cccc(Cl)c2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H17ClF4N4O2/c28-17-3-1-2-15(10-17)19-12-34-25(33)23-20(13-38-24(19)23)14-4-7-18(8-5-14)35-26(37)36-22-11-16(27(30,31)32)6-9-21(22)29/h1-13H,(H2,33,34)(H2,35,36,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 389 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195883
(7-bromo-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]py...)Show InChI InChI=1S/C13H7BrClFN2S/c14-8-4-18-13(17)11-7(5-19-12(8)11)6-1-2-10(16)9(15)3-6/h1-5H,(H2,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 575 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50195885
(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)Show SMILES Nc1ncc(-c2cccc(Cl)c2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H17ClF4N4O2/c28-17-3-1-2-15(10-17)19-12-34-25(33)23-20(13-38-24(19)23)14-4-7-18(8-5-14)35-26(37)36-22-11-16(27(30,31)32)6-9-21(22)29/h1-13H,(H2,33,34)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 933 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195880
(3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-4-...)Show InChI InChI=1S/C13H8ClFN2S/c14-9-5-7(1-2-10(9)15)8-6-18-11-3-4-17-13(16)12(8)11/h1-6H,(H2,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50195885
(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)Show SMILES Nc1ncc(-c2cccc(Cl)c2)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H17ClF4N4O2/c28-17-3-1-2-15(10-17)19-12-34-25(33)23-20(13-38-24(19)23)14-4-7-18(8-5-14)35-26(37)36-22-11-16(27(30,31)32)6-9-21(22)29/h1-13H,(H2,33,34)(H2,35,36,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-Tie2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195891
(3-(naphthalen-2-yl)-7-(3,4,5-trimethoxyphenyl)thie...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1ccc2ccccc2c1 Show InChI InChI=1S/C26H22N2O3S/c1-29-21-11-18(12-22(30-2)24(21)31-3)19-13-28-26(27)23-20(14-32-25(19)23)17-9-8-15-6-4-5-7-16(15)10-17/h4-14H,1-3H3,(H2,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195889
(3-(pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)thieno[...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1cccnc1 Show InChI InChI=1S/C21H19N3O3S/c1-25-16-7-13(8-17(26-2)19(16)27-3)14-10-24-21(22)18-15(11-28-20(14)18)12-5-4-6-23-9-12/h4-11H,1-3H3,(H2,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195881
(3-(4-methoxyphenyl)-7-(3,4,5-trimethoxyphenyl)thie...)Show SMILES COc1ccc(cc1)-c1csc2c(cnc(N)c12)-c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C23H22N2O4S/c1-26-15-7-5-13(6-8-15)17-12-30-22-16(11-25-23(24)20(17)22)14-9-18(27-2)21(29-4)19(10-14)28-3/h5-12H,1-4H3,(H2,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of Akt3 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of IKK2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of ErbB2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of GSK3b |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of GSK3b |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of IKK2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of ErbB2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of MAPKAPK2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of MAPKAPK2 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of Akt3 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50195876
(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of PLK1 |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50195879
(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)Show SMILES Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 Show InChI InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-Tie2 by HTRF method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195886
(3-(4-(methylsulfonyl)phenyl)-7-(3,4,5-trimethoxyph...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C23H22N2O5S2/c1-28-18-9-14(10-19(29-2)21(18)30-3)16-11-25-23(24)20-17(12-31-22(16)20)13-5-7-15(8-6-13)32(4,26)27/h5-12H,1-4H3,(H2,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195894
(1-(4-(4-amino-7-(3,4,5-trimethoxyphenyl)thieno[3,2...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1ccc(cc1)C(C)=O Show InChI InChI=1S/C24H22N2O4S/c1-13(27)14-5-7-15(8-6-14)18-12-31-23-17(11-26-24(25)21(18)23)16-9-19(28-2)22(30-4)20(10-16)29-3/h5-12H,1-4H3,(H2,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195882
(2-(3-(4-amino-7-(3,4,5-trimethoxyphenyl)thieno[3,2...)Show SMILES COc1cc(cc(OC)c1OC)-c1cnc(N)c2c(csc12)-c1cccc(CC(N)=O)c1 Show InChI InChI=1S/C24H23N3O4S/c1-29-18-9-15(10-19(30-2)22(18)31-3)16-11-27-24(26)21-17(12-32-23(16)21)14-6-4-5-13(7-14)8-20(25)28/h4-7,9-12H,8H2,1-3H3,(H2,25,28)(H2,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50195887
(3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyr...)Show InChI InChI=1S/C16H15BrN2O3S/c1-20-11-4-8(5-12(21-2)14(11)22-3)9-6-19-16(18)13-10(17)7-23-15(9)13/h4-7H,1-3H3,(H2,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline K.K.
Curated by ChEMBL
| Assay Description Inhibition of human EphB4 by scintillation proximity method |
Bioorg Med Chem Lett 17: 250-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.050 BindingDB Entry DOI: 10.7270/Q2SB45D5 |
More data for this Ligand-Target Pair | |