Affinity Data by PubMed id=17049248

PubMed code 17049248

Found 19 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25052 (3-{6-bromoimidazo[1,2-a]pyridin-3-yl}-1-[(2-methyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25050 (3-{6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl}-1-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25030 (3-{6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl}-1-[...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25057 (imidazo[1,2-a]pyridine derivative, 14b \| {2-[(4-{6...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25055 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25054 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25053 (3-{6-chloroimidazo[1,2-a]pyridin-3-yl}-1-[(2-methy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25049 (3-{6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl}-1-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM12915 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one \|...) Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM12915 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one \|...) Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25029 (1-[(4-fluorobenzene)sulfonyl]-3-{2-methylimidazo[1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25047 (3-{6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl}-1-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM12915 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one \|...) Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM12915 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one \|...) Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM25048 (3-{6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl}-1-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	7.4	22
Astellas Pharma Inc.					Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...				Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
Astellas Pharma Inc.					More data for this Ligand-Target Pair

* indicates data uncertainty>20%