Affinity Data by PubMed id=17114291

PubMed code 17114291

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17847 (CHEMBL327579 \| pyridine-2-carboxylic acid inhibito...) Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17849 (3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...) Show SMILES CC(C)(C)C(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17850 (3-(3-phenylpropanamido)-N-(1,3-thiazol-2-yl)pyridi...) Show SMILES O=C(CCc1ccccc1)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17851 (3-[(E)-(2-methylpropylidene)amino]-N-(1,3-thiazol-...) Show SMILES CC(C)C=Nc1cccnc1C(=O)Nc1nccs1 \|w:4.4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17847 (CHEMBL327579 \| pyridine-2-carboxylic acid inhibito...) Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17852 (3-octanamido-N-(1,3-thiazol-2-yl)pyridine-2-carbox...) Show SMILES CCCCCCCC(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17852 (3-octanamido-N-(1,3-thiazol-2-yl)pyridine-2-carbox...) Show SMILES CCCCCCCC(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17849 (3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...) Show SMILES CC(C)(C)C(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17850 (3-(3-phenylpropanamido)-N-(1,3-thiazol-2-yl)pyridi...) Show SMILES O=C(CCc1ccccc1)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17851 (3-[(E)-(2-methylpropylidene)amino]-N-(1,3-thiazol-...) Show SMILES CC(C)C=Nc1cccnc1C(=O)Nc1nccs1 \|w:4.4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair

* indicates data uncertainty>20%