Affinity Data by PubMed id=17174554

PubMed code 17174554

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200766 (4-(3-phenoxylphenyl)-5-cyano-2H-1,2,3-triazole \| C...) Show SMILES N#Cc1[nH]nnc1-c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200765 (4-(4-bromophenyl)-5-cyano-2H-1,2,3-triazole \| CHEM...) Show SMILES Brc1ccc(cc1)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200758 (4-(4-chlorophenyl)-5-cyano-2H-1,2,3-triazole \| CHE...) Show SMILES Clc1ccc(cc1)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200764 (4-(4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole \| ...) Show SMILES CC(C)c1ccc(cc1)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200757 (4-(4-fluoro-3-phenoxylphenyl)-5-cyano-2H-1,2,3-tri...) Show SMILES Fc1cc(ccc1Oc1ccccc1)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200755 (4-(4-fluorophenyl)-5-cyano-2H-1,2,3-triazole \| CHE...) Show SMILES Fc1ccc(cc1)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200759 (4-(4-methylphenyl)-5-cyano-2H-1,2,3-triazole \| CHE...) Show SMILES Cc1ccc(cc1)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200756 (4-(3,4,5-trimethoxyphenyl)-5-cyano-2H-1,2,3-triazo...) Show SMILES COc1cc(cc(OC)c1OC)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200761 (4-(4-methoxyphenyl)-5-cyano-2H-1,2,3-triazole \| CH...) Show SMILES COc1ccc(cc1)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200760 (4-(3,4-dimethoxyphenyl)-5-cyano-2H-1,2,3-triazole ...) Show SMILES COc1ccc(cc1OC)-c1nn[nH]c1C#N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200762 (4-(2,3-dimethoxyphenyl)-5-cyano-2H-1,2,3-triazole ...) Show SMILES COc1cccc(-c2nn[nH]c2C#N)c1OC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50200763 (4-phenyl-5-cyano-1,2,3-triazole \| CHEMBL269528) Show SMILES N#Cc1[nH]nnc1-c1ccccc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HER2 tyrosine kinase phosphorylation in human MDA-MB-453 cells by Western blot assay				Bioorg Med Chem 15: 1533-8 (2007) Article DOI: 10.1016/j.bmc.2006.09.041 BindingDB Entry DOI: 10.7270/Q2M0452P
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%