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PubMed code 17210255

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202219
PNG
(5-hydroxybenzo[b]furan-2-yl-(5-hydroxy-1Hindol-2-y...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2o1
Show InChI InChI=1S/C17H11NO4/c19-11-1-3-13-9(5-11)7-14(18-13)17(21)16-8-10-6-12(20)2-4-15(10)22-16/h1-8,18-20H
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n/an/a 200n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202219
PNG
(5-hydroxybenzo[b]furan-2-yl-(5-hydroxy-1Hindol-2-y...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2o1
Show InChI InChI=1S/C17H11NO4/c19-11-1-3-13-9(5-11)7-14(18-13)17(21)16-8-10-6-12(20)2-4-15(10)22-16/h1-8,18-20H
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n/an/a 270n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202215
PNG
((benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone | CH...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2ccccc2o1
Show InChI InChI=1S/C17H11NO2/c19-17(14-9-11-5-1-3-7-13(11)18-14)16-10-12-6-2-4-8-15(12)20-16/h1-10,18H
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n/an/a 400n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202210
PNG
(CHEMBL225826 | bis(5-hydroxybenzo[b]furan-2-yl)met...)
Show SMILES Oc1ccc2oc(cc2c1)C(=O)c1cc2cc(O)ccc2o1
Show InChI InChI=1S/C17H10O5/c18-11-1-3-13-9(5-11)7-15(21-13)17(20)16-8-10-6-12(19)2-4-14(10)22-16/h1-8,18-19H
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n/an/a 600n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202220
PNG
(CHEMBL376787 | bis(5-aminobenzo[b]furan-2-yl)metha...)
Show SMILES Nc1ccc2oc(cc2c1)C(=O)c1cc2cc(N)ccc2o1
Show InChI InChI=1S/C17H12N2O3/c18-11-1-3-13-9(5-11)7-15(21-13)17(20)16-8-10-6-12(19)2-4-14(10)22-16/h1-8H,18-19H2
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n/an/a 600n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202216
PNG
(CHEMBL226182 | bis(5-acetoxybenzo[b]furan-2-yl)met...)
Show SMILES CC(=O)Oc1ccc2oc(cc2c1)C(=O)c1cc2cc(OC(C)=O)ccc2o1
Show InChI InChI=1S/C21H14O7/c1-11(22)25-15-3-5-17-13(7-15)9-19(27-17)21(24)20-10-14-8-16(26-12(2)23)4-6-18(14)28-20/h3-10H,1-2H3
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n/an/a 700n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202214
PNG
(CHEMBL225772 | bis(5-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1ccc2oc(cc2c1)C(=O)c1cc2cc(OC)ccc2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-3-5-15-11(7-13)9-17(23-15)19(20)18-10-12-8-14(22-2)4-6-16(12)24-18/h3-10H,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202215
PNG
((benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone | CH...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2ccccc2o1
Show InChI InChI=1S/C17H11NO2/c19-17(14-9-11-5-1-3-7-13(11)18-14)16-10-12-6-2-4-8-15(12)20-16/h1-10,18H
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n/an/a 1.07E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM33408
PNG
(AG1295 | CHEMBL7724 | cid_2048)
Show SMILES Cc1cc2ncc(nc2cc1C)-c1ccccc1
Show InChI InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202220
PNG
(CHEMBL376787 | bis(5-aminobenzo[b]furan-2-yl)metha...)
Show SMILES Nc1ccc2oc(cc2c1)C(=O)c1cc2cc(N)ccc2o1
Show InChI InChI=1S/C17H12N2O3/c18-11-1-3-13-9(5-11)7-15(21-13)17(20)16-8-10-6-12(19)2-4-14(10)22-16/h1-8H,18-19H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202218
PNG
(CHEMBL226417 | bis(benzo[b]furan-2-yl)methanone)
Show SMILES O=C(c1cc2ccccc2o1)c1cc2ccccc2o1
Show InChI InChI=1S/C17H10O3/c18-17(15-9-11-5-1-3-7-13(11)19-15)16-10-12-6-2-4-8-14(12)20-16/h1-10H
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202216
PNG
(CHEMBL226182 | bis(5-acetoxybenzo[b]furan-2-yl)met...)
Show SMILES CC(=O)Oc1ccc2oc(cc2c1)C(=O)c1cc2cc(OC(C)=O)ccc2o1
Show InChI InChI=1S/C21H14O7/c1-11(22)25-15-3-5-17-13(7-15)9-19(27-17)21(24)20-10-14-8-16(26-12(2)23)4-6-18(14)28-20/h3-10H,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202211
PNG
(CHEMBL225827 | bis(6-hydroxybenzo[b]furan-2-yl)met...)
Show SMILES Oc1ccc2cc(oc2c1)C(=O)c1cc2ccc(O)cc2o1
Show InChI InChI=1S/C17H10O5/c18-11-3-1-9-5-15(21-13(9)7-11)17(20)16-6-10-2-4-12(19)8-14(10)22-16/h1-8,18-19H
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202218
PNG
(CHEMBL226417 | bis(benzo[b]furan-2-yl)methanone)
Show SMILES O=C(c1cc2ccccc2o1)c1cc2ccccc2o1
Show InChI InChI=1S/C17H10O3/c18-17(15-9-11-5-1-3-7-13(11)19-15)16-10-12-6-2-4-8-14(12)20-16/h1-10H
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202210
PNG
(CHEMBL225826 | bis(5-hydroxybenzo[b]furan-2-yl)met...)
Show SMILES Oc1ccc2oc(cc2c1)C(=O)c1cc2cc(O)ccc2o1
Show InChI InChI=1S/C17H10O5/c18-11-1-3-13-9(5-11)7-15(21-13)17(20)16-8-10-6-12(19)2-4-14(10)22-16/h1-8,18-19H
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM33408
PNG
(AG1295 | CHEMBL7724 | cid_2048)
Show SMILES Cc1cc2ncc(nc2cc1C)-c1ccccc1
Show InChI InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202211
PNG
(CHEMBL225827 | bis(6-hydroxybenzo[b]furan-2-yl)met...)
Show SMILES Oc1ccc2cc(oc2c1)C(=O)c1cc2ccc(O)cc2o1
Show InChI InChI=1S/C17H10O5/c18-11-3-1-9-5-15(21-13(9)7-11)17(20)16-6-10-2-4-12(19)8-14(10)22-16/h1-8,18-19H
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202217
PNG
(CHEMBL226131 | bis(7-hydroxybenzo[b]furan-2-yl)met...)
Show SMILES Oc1cccc2cc(oc12)C(=O)c1cc2cccc(O)c2o1
Show InChI InChI=1S/C17H10O5/c18-11-5-1-3-9-7-13(21-16(9)11)15(20)14-8-10-4-2-6-12(19)17(10)22-14/h1-8,18-19H
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202217
PNG
(CHEMBL226131 | bis(7-hydroxybenzo[b]furan-2-yl)met...)
Show SMILES Oc1cccc2cc(oc12)C(=O)c1cc2cccc(O)c2o1
Show InChI InChI=1S/C17H10O5/c18-11-5-1-3-9-7-13(21-16(9)11)15(20)14-8-10-4-2-6-12(19)17(10)22-14/h1-8,18-19H
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202212
PNG
(CHEMBL389233 | bis(4-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1cccc2oc(cc12)C(=O)c1cc2c(OC)cccc2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-5-3-7-15-11(13)9-17(23-15)19(20)18-10-12-14(22-2)6-4-8-16(12)24-18/h3-10H,1-2H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202214
PNG
(CHEMBL225772 | bis(5-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1ccc2oc(cc2c1)C(=O)c1cc2cc(OC)ccc2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-3-5-15-11(7-13)9-17(23-15)19(20)18-10-12-8-14(22-2)4-6-16(12)24-18/h3-10H,1-2H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202209
PNG
(CHEMBL389234 | bis(7-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1cccc2cc(oc12)C(=O)c1cc2cccc(OC)c2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-7-3-5-11-9-15(23-18(11)13)17(20)16-10-12-6-4-8-14(22-2)19(12)24-16/h3-10H,1-2H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202213
PNG
(CHEMBL225825 | bis(6-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1ccc2cc(oc2c1)C(=O)c1cc2ccc(OC)cc2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-5-3-11-7-17(23-15(11)9-13)19(20)18-8-12-4-6-14(22-2)10-16(12)24-18/h3-10H,1-2H3
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University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))
BDBM50202212
PNG
(CHEMBL389233 | bis(4-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1cccc2oc(cc12)C(=O)c1cc2c(OC)cccc2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-5-3-7-15-11(13)9-17(23-15)19(20)18-10-12-14(22-2)6-4-8-16(12)24-18/h3-10H,1-2H3
KEGG

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202213
PNG
(CHEMBL225825 | bis(6-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1ccc2cc(oc2c1)C(=O)c1cc2ccc(OC)cc2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-5-3-11-7-17(23-15(11)9-13)19(20)18-8-12-4-6-14(22-2)10-16(12)24-18/h3-10H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50202209
PNG
(CHEMBL389234 | bis(7-methoxybenzo[b]furan-2-yl)met...)
Show SMILES COc1cccc2cc(oc12)C(=O)c1cc2cccc(OC)c2o1
Show InChI InChI=1S/C19H14O5/c1-21-13-7-3-5-11-9-15(23-18(11)13)17(20)16-10-12-6-4-8-14(22-2)19(12)24-16/h3-10H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells


Bioorg Med Chem 15: 2187-97 (2007)


Article DOI: 10.1016/j.bmc.2006.12.011
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%