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PubMed code 17276681

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17720
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 16 | 2-(4-{...)
Show SMILES CC(C)N(CCOc1ccc(cc1)-c1oc2nccc(NCCN3CCNCC3)c2c1-c1ccccc1)C(C)C
Show InChI InChI=1S/C33H43N5O2/c1-24(2)38(25(3)4)22-23-39-28-12-10-27(11-13-28)32-30(26-8-6-5-7-9-26)31-29(14-15-36-33(31)40-32)35-18-21-37-19-16-34-17-20-37/h5-15,24-25,34H,16-23H2,1-4H3,(H,35,36)
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n/an/a 19n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17723
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 19 | 3-phen...)
Show SMILES C(Cc1cccnc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-9-26(10-4-1)30-31-29(35-18-15-25-8-7-17-34-24-25)16-19-36-33(31)39-32(30)27-11-13-28(14-12-27)38-23-22-37-20-5-2-6-21-37/h1,3-4,7-14,16-17,19,24H,2,5-6,15,18,20-23H2,(H,35,36)
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n/an/a 20n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17717
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 13 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C31H37N5O3/c1-2-4-24(5-3-1)28-29-27(33-14-17-35-15-12-32-13-16-35)10-11-34-31(29)39-30(28)25-6-8-26(9-7-25)38-23-20-36-18-21-37-22-19-36/h1-11,32H,12-23H2,(H,33,34)
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n/an/a 22n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17719
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 15 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C30H32N6O2/c1-2-4-23(5-3-1)27-28-26(33-15-19-35-16-12-31-13-17-35)10-11-34-30(28)38-29(27)24-6-8-25(9-7-24)37-21-20-36-18-14-32-22-36/h1-11,14,18,22,31H,12-13,15-17,19-21H2,(H,33,34)
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n/an/a 25n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17715
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 6 | N-[(2S)...)
Show SMILES C(Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1)[C@@H]1CCCO1 |r|
Show InChI InChI=1S/C24H22N2O2/c1-3-8-17(9-4-1)21-22-20(26-16-19-12-7-15-27-19)13-14-25-24(22)28-23(21)18-10-5-2-6-11-18/h1-6,8-11,13-14,19H,7,12,15-16H2,(H,25,26)/t19-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17721
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 17 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H39N5O2/c1-3-7-25(8-4-1)29-30-28(34-17-22-37-20-15-33-16-21-37)13-14-35-32(30)39-31(29)26-9-11-27(12-10-26)38-24-23-36-18-5-2-6-19-36/h1,3-4,7-14,33H,2,5-6,15-24H2,(H,34,35)
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n/an/a 29n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17719
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 15 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C30H32N6O2/c1-2-4-23(5-3-1)27-28-26(33-15-19-35-16-12-31-13-17-35)10-11-34-30(28)38-29(27)24-6-8-25(9-7-24)37-21-20-36-18-14-32-22-36/h1-11,14,18,22,31H,12-13,15-17,19-21H2,(H,33,34)
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n/an/a 30n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17717
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 13 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C31H37N5O3/c1-2-4-24(5-3-1)28-29-27(33-14-17-35-15-12-32-13-16-35)10-11-34-31(29)39-30(28)25-6-8-26(9-7-25)38-23-20-36-18-21-37-22-19-36/h1-11,32H,12-23H2,(H,33,34)
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n/an/a 32n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17723
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 19 | 3-phen...)
Show SMILES C(Cc1cccnc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-9-26(10-4-1)30-31-29(35-18-15-25-8-7-17-34-24-25)16-19-36-33(31)39-32(30)27-11-13-28(14-12-27)38-23-22-37-20-5-2-6-21-37/h1,3-4,7-14,16-17,19,24H,2,5-6,15,18,20-23H2,(H,35,36)
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n/an/a 37n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17720
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 16 | 2-(4-{...)
Show SMILES CC(C)N(CCOc1ccc(cc1)-c1oc2nccc(NCCN3CCNCC3)c2c1-c1ccccc1)C(C)C
Show InChI InChI=1S/C33H43N5O2/c1-24(2)38(25(3)4)22-23-39-28-12-10-27(11-13-28)32-30(26-8-6-5-7-9-26)31-29(14-15-36-33(31)40-32)35-18-21-37-19-16-34-17-20-37/h5-15,24-25,34H,16-23H2,1-4H3,(H,35,36)
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n/an/a 44n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17718
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C31H37N5O2/c1-2-6-24(7-3-1)28-29-27(33-16-21-36-19-14-32-15-20-36)12-13-34-31(29)38-30(28)25-8-10-26(11-9-25)37-23-22-35-17-4-5-18-35/h1-3,6-13,32H,4-5,14-23H2,(H,33,34)
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n/an/a 54n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17717
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 13 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C31H37N5O3/c1-2-4-24(5-3-1)28-29-27(33-14-17-35-15-12-32-13-16-35)10-11-34-31(29)39-30(28)25-6-8-26(9-7-25)38-23-20-36-18-21-37-22-19-36/h1-11,32H,12-23H2,(H,33,34)
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n/an/a 57n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17720
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 16 | 2-(4-{...)
Show SMILES CC(C)N(CCOc1ccc(cc1)-c1oc2nccc(NCCN3CCNCC3)c2c1-c1ccccc1)C(C)C
Show InChI InChI=1S/C33H43N5O2/c1-24(2)38(25(3)4)22-23-39-28-12-10-27(11-13-28)32-30(26-8-6-5-7-9-26)31-29(14-15-36-33(31)40-32)35-18-21-37-19-16-34-17-20-37/h5-15,24-25,34H,16-23H2,1-4H3,(H,35,36)
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n/an/a 67n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17721
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 17 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H39N5O2/c1-3-7-25(8-4-1)29-30-28(34-17-22-37-20-15-33-16-21-37)13-14-35-32(30)39-31(29)26-9-11-27(12-10-26)38-24-23-36-18-5-2-6-19-36/h1,3-4,7-14,33H,2,5-6,15-24H2,(H,34,35)
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n/an/a 71n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17722
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)
Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36)
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n/an/a 80n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17714
PNG
(5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...)
Show SMILES C(CN1CCNCC1)Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C24H25N5O/c1-3-7-18(8-4-1)20-21-23(26-13-16-29-14-11-25-12-15-29)27-17-28-24(21)30-22(20)19-9-5-2-6-10-19/h1-10,17,25H,11-16H2,(H,26,27,28)
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n/an/a 81n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17719
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 15 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C30H32N6O2/c1-2-4-23(5-3-1)27-28-26(33-15-19-35-16-12-31-13-17-35)10-11-34-30(28)38-29(27)24-6-8-25(9-7-24)37-21-20-36-18-14-32-22-36/h1-11,14,18,22,31H,12-13,15-17,19-21H2,(H,33,34)
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n/an/a 84n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17721
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 17 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H39N5O2/c1-3-7-25(8-4-1)29-30-28(34-17-22-37-20-15-33-16-21-37)13-14-35-32(30)39-31(29)26-9-11-27(12-10-26)38-24-23-36-18-5-2-6-19-36/h1,3-4,7-14,33H,2,5-6,15-24H2,(H,34,35)
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n/an/a 100n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17715
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 6 | N-[(2S)...)
Show SMILES C(Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1)[C@@H]1CCCO1 |r|
Show InChI InChI=1S/C24H22N2O2/c1-3-8-17(9-4-1)21-22-20(26-16-19-12-7-15-27-19)13-14-25-24(22)28-23(21)18-10-5-2-6-11-18/h1-6,8-11,13-14,19H,7,12,15-16H2,(H,25,26)/t19-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17718
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C31H37N5O2/c1-2-6-24(7-3-1)28-29-27(33-16-21-36-19-14-32-15-20-36)12-13-34-31(29)38-30(28)25-8-10-26(11-9-25)37-23-22-35-17-4-5-18-35/h1-3,6-13,32H,4-5,14-23H2,(H,33,34)
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n/an/a 110n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17721
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 17 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H39N5O2/c1-3-7-25(8-4-1)29-30-28(34-17-22-37-20-15-33-16-21-37)13-14-35-32(30)39-31(29)26-9-11-27(12-10-26)38-24-23-36-18-5-2-6-19-36/h1,3-4,7-14,33H,2,5-6,15-24H2,(H,34,35)
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n/an/a 120n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
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n/an/a 140n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17717
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 13 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C31H37N5O3/c1-2-4-24(5-3-1)28-29-27(33-14-17-35-15-12-32-13-16-35)10-11-34-31(29)39-30(28)25-6-8-26(9-7-25)38-23-20-36-18-21-37-22-19-36/h1-11,32H,12-23H2,(H,33,34)
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n/an/a 150n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17719
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 15 | 2-{4-[...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C30H32N6O2/c1-2-4-23(5-3-1)27-28-26(33-15-19-35-16-12-31-13-17-35)10-11-34-30(28)38-29(27)24-6-8-25(9-7-24)37-21-20-36-18-14-32-22-36/h1-11,14,18,22,31H,12-13,15-17,19-21H2,(H,33,34)
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n/an/a 160n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17723
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 19 | 3-phen...)
Show SMILES C(Cc1cccnc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-9-26(10-4-1)30-31-29(35-18-15-25-8-7-17-34-24-25)16-19-36-33(31)39-32(30)27-11-13-28(14-12-27)38-23-22-37-20-5-2-6-21-37/h1,3-4,7-14,16-17,19,24H,2,5-6,15,18,20-23H2,(H,35,36)
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n/an/a 170n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17718
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C31H37N5O2/c1-2-6-24(7-3-1)28-29-27(33-16-21-36-19-14-32-15-20-36)12-13-34-31(29)38-30(28)25-8-10-26(11-9-25)37-23-22-35-17-4-5-18-35/h1-3,6-13,32H,4-5,14-23H2,(H,33,34)
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n/an/a 170n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17722
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)
Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36)
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n/an/a 180n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17720
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 16 | 2-(4-{...)
Show SMILES CC(C)N(CCOc1ccc(cc1)-c1oc2nccc(NCCN3CCNCC3)c2c1-c1ccccc1)C(C)C
Show InChI InChI=1S/C33H43N5O2/c1-24(2)38(25(3)4)22-23-39-28-12-10-27(11-13-28)32-30(26-8-6-5-7-9-26)31-29(14-15-36-33(31)40-32)35-18-21-37-19-16-34-17-20-37/h5-15,24-25,34H,16-23H2,1-4H3,(H,35,36)
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n/an/a 180n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
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n/an/a 210n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17718
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C31H37N5O2/c1-2-6-24(7-3-1)28-29-27(33-16-21-36-19-14-32-15-20-36)12-13-34-31(29)38-30(28)25-8-10-26(11-9-25)37-23-22-35-17-4-5-18-35/h1-3,6-13,32H,4-5,14-23H2,(H,33,34)
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n/an/a 210n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
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n/an/a 360n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17723
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 19 | 3-phen...)
Show SMILES C(Cc1cccnc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-9-26(10-4-1)30-31-29(35-18-15-25-8-7-17-34-24-25)16-19-36-33(31)39-32(30)27-11-13-28(14-12-27)38-23-22-37-20-5-2-6-21-37/h1,3-4,7-14,16-17,19,24H,2,5-6,15,18,20-23H2,(H,35,36)
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n/an/a 370n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17724
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 20 | N-[3-(...)
Show SMILES C(CNc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1)Cn1ccnc1
Show InChI InChI=1S/C32H35N5O2/c1-3-8-25(9-4-1)29-30-28(34-15-7-20-37-21-17-33-24-37)14-16-35-32(30)39-31(29)26-10-12-27(13-11-26)38-23-22-36-18-5-2-6-19-36/h1,3-4,8-14,16-17,21,24H,2,5-7,15,18-20,22-23H2,(H,34,35)
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n/an/a 380n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
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n/an/a 420n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1


(Homo sapiens (Human))		BDBM17724
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 20 | N-[3-(...)
Show SMILES C(CNc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1)Cn1ccnc1
Show InChI InChI=1S/C32H35N5O2/c1-3-8-25(9-4-1)29-30-28(34-15-7-20-37-21-17-33-24-37)14-16-35-32(30)39-31(29)26-10-12-27(13-11-26)38-23-22-36-18-5-2-6-19-36/h1,3-4,8-14,16-17,21,24H,2,5-7,15,18-20,22-23H2,(H,34,35)
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n/an/a 930n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM17724
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 20 | N-[3-(...)
Show SMILES C(CNc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1)Cn1ccnc1
Show InChI InChI=1S/C32H35N5O2/c1-3-8-25(9-4-1)29-30-28(34-15-7-20-37-21-17-33-24-37)14-16-35-32(30)39-31(29)26-10-12-27(13-11-26)38-23-22-36-18-5-2-6-19-36/h1,3-4,8-14,16-17,21,24H,2,5-7,15,18-20,22-23H2,(H,34,35)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17722
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)
Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36)
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n/an/a 1.60E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17724
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 20 | N-[3-(...)
Show SMILES C(CNc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1)Cn1ccnc1
Show InChI InChI=1S/C32H35N5O2/c1-3-8-25(9-4-1)29-30-28(34-15-7-20-37-21-17-33-24-37)14-16-35-32(30)39-31(29)26-10-12-27(13-11-26)38-23-22-36-18-5-2-6-19-36/h1,3-4,8-14,16-17,21,24H,2,5-7,15,18-20,22-23H2,(H,34,35)
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n/an/a 1.70E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM17715
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 6 | N-[(2S)...)
Show SMILES C(Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1)[C@@H]1CCCO1 |r|
Show InChI InChI=1S/C24H22N2O2/c1-3-8-17(9-4-1)21-22-20(26-16-19-12-7-15-27-19)13-14-25-24(22)28-23(21)18-10-5-2-6-11-18/h1-6,8-11,13-14,19H,7,12,15-16H2,(H,25,26)/t19-/m0/s1
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n/an/a 2.10E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17714
PNG
(5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...)
Show SMILES C(CN1CCNCC1)Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C24H25N5O/c1-3-7-18(8-4-1)20-21-23(26-13-16-29-14-11-25-12-15-29)27-17-28-24(21)30-22(20)19-9-5-2-6-10-19/h1-10,17,25H,11-16H2,(H,26,27,28)
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n/an/a 2.60E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17715
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 6 | N-[(2S)...)
Show SMILES C(Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1)[C@@H]1CCCO1 |r|
Show InChI InChI=1S/C24H22N2O2/c1-3-8-17(9-4-1)21-22-20(26-16-19-12-7-15-27-19)13-14-25-24(22)28-23(21)18-10-5-2-6-11-18/h1-6,8-11,13-14,19H,7,12,15-16H2,(H,25,26)/t19-/m0/s1
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n/an/a 4.20E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17722
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)
Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36)
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n/an/a 4.70E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...

Bioorg Med Chem Lett 17: 2299-304 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%