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PubMed code 17276684

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 1


(RAT)		BDBM50204428
PNG
((S)-4-(3,3-dimethylbutan-2-yl) 2-propyl 3,5-dimeth...)
Show SMILES CCCOC(=O)c1[nH]c(C)c(C(=O)O[C@@H](C)C(C)(C)C)c1C
Show InChI InChI=1S/C17H27NO4/c1-8-9-21-16(20)14-10(2)13(11(3)18-14)15(19)22-12(4)17(5,6)7/h12,18H,8-9H2,1-7H3/t12-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204429
PNG
(CHEMBL388669 | adamantane-1-carboxylic acid (1-oxo...)
Show SMILES O=C(Nc1ccc2[nH]c3c(CCNC3=O)c2c1)C12CC3CC(CC(C3)C1)C2 |TLB:20:21:25:19.24.18,THB:18:19:22:25.26.17,18:17:20.19.24:22,20:19:25:21.22.26|
Show InChI InChI=1S/C22H25N3O2/c26-20-19-16(3-4-23-20)17-8-15(1-2-18(17)25-19)24-21(27)22-9-12-5-13(10-22)7-14(6-12)11-22/h1-2,8,12-14,25H,3-7,9-11H2,(H,23,26)(H,24,27)
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n/an/a 71n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204434
PNG
(1-oxo-2,3,4,9-tetrahydro-1H-beta-carboline-6-carbo...)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1ccc2[nH]c3c(CCNC3=O)c2c1 |THB:2:3:6:10.8.9,8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C22H25N3O2/c26-20(25-22-9-12-5-13(10-22)7-14(6-12)11-22)15-1-2-18-17(8-15)16-3-4-23-21(27)19(16)24-18/h1-2,8,12-14,24H,3-7,9-11H2,(H,23,27)(H,25,26)
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n/an/a 71n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204446
PNG
(1-oxo-2,3,4,9-tetrahydro-1H-beta-carboline-6-carbo...)
Show SMILES O=C(NC1C2CC3CC(C2)CC1C3)c1ccc2[nH]c3c(CCNC3=O)c2c1 |TLB:9:8:12:5.4.3,9:4:7.8.10:12,THB:3:4:7:10.11.12,3:11:7:5.9.4,2:3:7.8.10:12,(-2.07,-19.86,;-2.06,-21.41,;-3.4,-22.18,;-4.74,-21.42,;-6.1,-22.09,;-7.03,-21,;-7.2,-19.6,;-8.87,-19.1,;-7.82,-20.25,;-7.69,-21.76,;-6.41,-19.53,;-4.85,-19.91,;-5.88,-18.92,;-.72,-22.17,;-.72,-23.71,;.62,-24.48,;1.95,-23.69,;3.42,-24.16,;4.28,-22.89,;3.41,-21.67,;4.03,-20.27,;5.56,-20.09,;6.46,-21.34,;5.85,-22.75,;6.76,-23.99,;1.94,-22.16,;.6,-21.39,)|
Show InChI InChI=1S/C22H25N3O2/c26-21(25-19-14-6-11-5-12(8-14)9-15(19)7-11)13-1-2-18-17(10-13)16-3-4-23-22(27)20(16)24-18/h1-2,10-12,14-15,19,24H,3-9H2,(H,23,27)(H,25,26)
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n/an/a 93n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204435
PNG
(6-(benzyloxy)-3,4-dihydro-2H-pyrido[3,4-b]indol-1(...)
Show SMILES O=C1NCCc2c1[nH]c1ccc(OCc3ccccc3)cc21
Show InChI InChI=1S/C18H16N2O2/c21-18-17-14(8-9-19-18)15-10-13(6-7-16(15)20-17)22-11-12-4-2-1-3-5-12/h1-7,10,20H,8-9,11H2,(H,19,21)
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n/an/a 104n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204445
PNG
(CHEMBL234960 | N-(3,3-dimethylbutan-2-yl)-N-methyl...)
Show SMILES CC(N(C)C(=O)c1ccc2[nH]c3c(CCNC3=O)c2c1)C(C)(C)C |w:1.0|
Show InChI InChI=1S/C19H25N3O2/c1-11(19(2,3)4)22(5)18(24)12-6-7-15-14(10-12)13-8-9-20-17(23)16(13)21-15/h6-7,10-11,21H,8-9H2,1-5H3,(H,20,23)
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n/an/a 120n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204433
PNG
(6-(benzyloxy)-7-methyl-3,4-dihydro-2H-pyrido[3,4-b...)
Show SMILES Cc1cc2[nH]c3c(CCNC3=O)c2cc1OCc1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-12-9-16-15(14-7-8-20-19(22)18(14)21-16)10-17(12)23-11-13-5-3-2-4-6-13/h2-6,9-10,21H,7-8,11H2,1H3,(H,20,22)
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n/an/a 167n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204427
PNG
(CHEMBL243020 | N-(bicyclo[2.2.1]heptan-2-yl)-1-oxo...)
Show SMILES O=C(NC1CC2CCC1C2)c1ccc2[nH]c3c(CCNC3=O)c2c1 |w:8.7,5.5,3.2,TEB:2:3:6.7:9|
Show InChI InChI=1S/C19H21N3O2/c23-18(22-16-8-10-1-2-11(16)7-10)12-3-4-15-14(9-12)13-5-6-20-19(24)17(13)21-15/h3-4,9-11,16,21H,1-2,5-8H2,(H,20,24)(H,22,23)
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n/an/a 226n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204439
PNG
(6-(3,3-dimethylbutan-2-yloxy)-3,4-dihydro-2H-pyrid...)
Show SMILES CC(Oc1ccc2[nH]c3c(CCNC3=O)c2c1)C(C)(C)C |w:1.0|
Show InChI InChI=1S/C17H22N2O2/c1-10(17(2,3)4)21-11-5-6-14-13(9-11)12-7-8-18-16(20)15(12)19-14/h5-6,9-10,19H,7-8H2,1-4H3,(H,18,20)
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n/an/a 239n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204444
PNG
(1-oxo-2,3,4,9-tetrahydro-1H-beta-carboline-6-carbo...)
Show SMILES O=C(NCC12CC3CC(CC(C3)C1)C2)c1ccc2[nH]c3c(CCNC3=O)c2c1 |TLB:3:4:7:11.9.10,THB:9:8:5:11.10.12,9:10:7.8.13:5,12:10:7:13.4.5,12:4:7:11.9.10|
Show InChI InChI=1S/C23H27N3O2/c27-21(25-12-23-9-13-5-14(10-23)7-15(6-13)11-23)16-1-2-19-18(8-16)17-3-4-24-22(28)20(17)26-19/h1-2,8,13-15,26H,3-7,9-12H2,(H,24,28)(H,25,27)
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n/an/a 312n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204443
PNG
(6-(1-phenylethoxy)-3,4-dihydro-2H-pyrido[3,4-b]ind...)
Show SMILES CC(Oc1ccc2[nH]c3c(CCNC3=O)c2c1)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C19H18N2O2/c1-12(13-5-3-2-4-6-13)23-14-7-8-17-16(11-14)15-9-10-20-19(22)18(15)21-17/h2-8,11-12,21H,9-10H2,1H3,(H,20,22)
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n/an/a 380n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204442
PNG
(7-(benzyloxy)-1,2-dihydropyrrolo[3,4-b]indol-3(4H)...)
Show SMILES O=C1NCc2c1[nH]c1ccc(OCc3ccccc3)cc21
Show InChI InChI=1S/C17H14N2O2/c20-17-16-14(9-18-17)13-8-12(6-7-15(13)19-16)21-10-11-4-2-1-3-5-11/h1-8,19H,9-10H2,(H,18,20)
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n/an/a 683n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204431
PNG
(8-benzyloxy-3,4a,5,9b-tetrahydro-pyridazino[4,5-b]...)
Show SMILES O=C1NNCc2c1[nH]c1ccc(OCc3ccccc3)cc21
Show InChI InChI=1S/C17H15N3O2/c21-17-16-14(9-18-20-17)13-8-12(6-7-15(13)19-16)22-10-11-4-2-1-3-5-11/h1-8,18-19H,9-10H2,(H,20,21)
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n/an/a 1.02E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204430
PNG
(1-oxo-N-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]...)
Show SMILES O=C(Nc1ccccc1)c1ccc2[nH]c3c(CCNC3=O)c2c1
Show InChI InChI=1S/C18H15N3O2/c22-17(20-12-4-2-1-3-5-12)11-6-7-15-14(10-11)13-8-9-19-18(23)16(13)21-15/h1-7,10,21H,8-9H2,(H,19,23)(H,20,22)
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n/an/a 1.04E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204432
PNG
(6-benzyloxy-2,3,4,4a,9,9a-hexahydro-beta-carbolin-...)
Show SMILES O=C1NCCC2C1Nc1ccc(OCc3ccccc3)cc21 |w:5.4,6.7|
Show InChI InChI=1S/C18H18N2O2/c21-18-17-14(8-9-19-18)15-10-13(6-7-16(15)20-17)22-11-12-4-2-1-3-5-12/h1-7,10,14,17,20H,8-9,11H2,(H,19,21)
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n/an/a 1.67E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204437
PNG
(7-(benzyloxy)-3,4-dihydro-2H-pyrido[3,4-b]indol-1(...)
Show SMILES O=C1NCCc2c1[nH]c1cc(OCc3ccccc3)ccc21
Show InChI InChI=1S/C18H16N2O2/c21-18-17-15(8-9-19-18)14-7-6-13(10-16(14)20-17)22-11-12-4-2-1-3-5-12/h1-7,10,20H,8-9,11H2,(H,19,21)
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n/an/a 2.85E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204441
PNG
(5-(benzyloxy)-3,4-dihydro-2H-pyrido[3,4-b]indol-1(...)
Show SMILES O=C1NCCc2c1[nH]c1cccc(OCc3ccccc3)c21
Show InChI InChI=1S/C18H16N2O2/c21-18-17-13(9-10-19-18)16-14(20-17)7-4-8-15(16)22-11-12-5-2-1-3-6-12/h1-8,20H,9-11H2,(H,19,21)
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n/an/a 3.98E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204447
PNG
(6-phenoxy-3,4-dihydro-2H-pyrido[3,4-b]indol-1(9H)-...)
Show SMILES O=C1NCCc2c1[nH]c1ccc(Oc3ccccc3)cc21
Show InChI InChI=1S/C17H14N2O2/c20-17-16-13(8-9-18-17)14-10-12(6-7-15(14)19-16)21-11-4-2-1-3-5-11/h1-7,10,19H,8-9H2,(H,18,20)
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n/an/a 4.07E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204436
PNG
(1-adamantan-1-yl-3-(1-oxo-2,3,4,9-tetrahydro-1H-be...)
Show SMILES O=C(Nc1ccc2[nH]c3c(CCNC3=O)c2c1)NC12CC3CC(CC(C3)C1)C2 |TLB:21:22:26:20.25.19,THB:21:20:26:22.23.27,23:22:26.25.24:19,23:24:21.22.27:19|
Show InChI InChI=1S/C22H26N4O2/c27-20-19-16(3-4-23-20)17-8-15(1-2-18(17)25-19)24-21(28)26-22-9-12-5-13(10-22)7-14(6-12)11-22/h1-2,8,12-14,25H,3-7,9-11H2,(H,23,27)(H2,24,26,28)
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n/an/a 4.66E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204426
PNG
(6-(cyclohexylmethoxy)-3,4-dihydro-2H-pyrido[3,4-b]...)
Show SMILES O=C1NCCc2c1[nH]c1ccc(OCC3CCCCC3)cc21
Show InChI InChI=1S/C18H22N2O2/c21-18-17-14(8-9-19-18)15-10-13(6-7-16(15)20-17)22-11-12-4-2-1-3-5-12/h6-7,10,12,20H,1-5,8-9,11H2,(H,19,21)
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n/an/a 5.56E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204424
PNG
(6-benzyloxy-2,3,4,4a,9,9a-hexahydro-1H-beta-carbol...)
Show SMILES C(Oc1ccc2NC3CNCCC3c2c1)c1ccccc1 |w:12.11,7.7|
Show InChI InChI=1S/C18H20N2O/c1-2-4-13(5-3-1)12-21-14-6-7-17-16(10-14)15-8-9-19-11-18(15)20-17/h1-7,10,15,18-20H,8-9,11-12H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204448
PNG
(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]i...)
Show SMILES C(Oc1ccc2[nH]c3CNCCc3c2c1)c1ccccc1
Show InChI InChI=1S/C18H18N2O/c1-2-4-13(5-3-1)12-21-14-6-7-17-16(10-14)15-8-9-19-11-18(15)20-17/h1-7,10,19-20H,8-9,11-12H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204425
PNG
(CHEMBL234959 | N-(3,3-dimethylbutan-2-yl)-1-oxo-2,...)
Show SMILES CC(NC(=O)c1ccc2[nH]c3c(CCNC3=O)c2c1)C(C)(C)C |w:1.0|
Show InChI InChI=1S/C18H23N3O2/c1-10(18(2,3)4)20-16(22)11-5-6-14-13(9-11)12-7-8-19-17(23)15(12)21-14/h5-6,9-10,21H,7-8H2,1-4H3,(H,19,23)(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204440
PNG
(6-(benzyloxy)-3,4-dihydro-2H-carbazol-1(9H)-one | ...)
Show SMILES O=C1CCCc2c1[nH]c1ccc(OCc3ccccc3)cc21
Show InChI InChI=1S/C19H17NO2/c21-18-8-4-7-15-16-11-14(9-10-17(16)20-19(15)18)22-12-13-5-2-1-3-6-13/h1-3,5-6,9-11,20H,4,7-8,12H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50058672
PNG
(6-Methoxy-2,3,4,9-tetrahydro-beta-carbolin-1-one |...)
Show SMILES COc1ccc2[nH]c3c(CCNC3=O)c2c1
Show InChI InChI=1S/C12H12N2O2/c1-16-7-2-3-10-9(6-7)8-4-5-13-12(15)11(8)14-10/h2-3,6,14H,4-5H2,1H3,(H,13,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50204438
PNG
(6-hydroxy-3,4-dihydro-1-oxo-beta-carboline | 6-hyd...)
Show SMILES Oc1ccc2[nH]c3c(CCNC3=O)c2c1
Show InChI InChI=1S/C11H10N2O2/c14-6-1-2-9-8(5-6)7-3-4-12-11(15)10(7)13-9/h1-2,5,13-14H,3-4H2,(H,12,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Medicine Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay

Bioorg Med Chem Lett 17: 2254-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.055
BindingDB Entry DOI: 10.7270/Q2FT8KPZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%