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PubMed code 17289383

Compile data set for download or QSAR
Found 157 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204794
PNG
(8-(8-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26FN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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0.300n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204769
PNG
(8-(5-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26FN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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0.800n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204768
PNG
(8-(7-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26FN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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0.900n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204783
PNG
(1-phenyl-8-(1-phenyl-pentyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-2-3-14-22(20-10-6-4-7-11-20)26-17-15-24(16-18-26)23(28)25-19-27(24)21-12-8-5-9-13-21/h4-13,22H,2-3,14-19H2,1H3,(H,25,28)
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1.10n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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1.20n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM26947
PNG
(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H31N3O/c1-24(2)13-12-22(20-10-6-7-11-21(20)24)27-16-14-25(15-17-27)23(29)26-18-28(25)19-8-4-3-5-9-19/h3-11,22H,12-18H2,1-2H3,(H,26,29)
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1.30n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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1.40n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204764
PNG
(8-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H30ClN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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1.40n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204785
PNG
(8-(4-methyl-1-phenyl-pentyl)-1-phenyl-1,3,8-triaza...)
Show SMILES CC(C)CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-20(2)13-14-23(21-9-5-3-6-10-21)27-17-15-25(16-18-27)24(29)26-19-28(25)22-11-7-4-8-12-22/h3-12,20,23H,13-19H2,1-2H3,(H,26,29)
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1.5n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204778
PNG
(8-(5-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26ClN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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2n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM26919
PNG
(8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-tria...)
Show SMILES Clc1cccc(Cl)c1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H21Cl2N3O/c21-17-7-4-8-18(22)16(17)13-24-11-9-20(10-12-24)19(26)23-14-25(20)15-5-2-1-3-6-15/h1-8H,9-14H2,(H,23,26)
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2.30n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204784
PNG
(1-phenyl-8-(1-phenyl-butyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O/c1-2-9-21(19-10-5-3-6-11-19)25-16-14-23(15-17-25)22(27)24-18-26(23)20-12-7-4-8-13-20/h3-8,10-13,21H,2,9,14-18H2,1H3,(H,24,27)
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2.40n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204779
PNG
(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26ClN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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2.60n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204767
PNG
(8-(2-chloro-benzyl)-1-phenyl-1,3,8-triaza-spiro[4....)
Show SMILES Clc1ccccc1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H22ClN3O/c21-18-9-5-4-6-16(18)14-23-12-10-20(11-13-23)19(25)22-15-24(20)17-7-2-1-3-8-17/h1-9H,10-15H2,(H,22,25)
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3.20n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204765
PNG
(1-phenyl-8-(1-phenyl-ethyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-17(18-8-4-2-5-9-18)23-14-12-21(13-15-23)20(25)22-16-24(21)19-10-6-3-7-11-19/h2-11,17H,12-16H2,1H3,(H,22,25)
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3.5n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204775
PNG
(8-(cyclopentyl-phenyl-methyl)-1-phenyl-1,3,8-triaz...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(C1CCCC1)c1ccccc1 |w:17.19|
Show InChI InChI=1S/C25H31N3O/c29-24-25(28(19-26-24)22-13-5-2-6-14-22)15-17-27(18-16-25)23(21-11-7-8-12-21)20-9-3-1-4-10-20/h1-6,9-10,13-14,21,23H,7-8,11-12,15-19H2,(H,26,29)
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4.60n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204794
PNG
(8-(8-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26FN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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5.10n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204773
PNG
(8-[bis-(2-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1F
Show InChI InChI=1S/C26H25F2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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6.30n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM26949
PNG
(8-[bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triaz...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C26H25Cl2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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6.80n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204776
PNG
(8-(6-fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(F)cc12 |w:5.5|
Show InChI InChI=1S/C25H30FN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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8.40n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204791
PNG
(8-di-o-tolylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C28H31N3O/c1-21-10-6-8-14-24(21)26(25-15-9-7-11-22(25)2)30-18-16-28(17-19-30)27(32)29-20-31(28)23-12-4-3-5-13-23/h3-15,26H,16-20H2,1-2H3,(H,29,32)
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9n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204782
PNG
(8-[(2-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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9n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204790
PNG
(8-(7-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26ClN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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11n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50175929
PNG
(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h1-10H,11-16H2,(H,21,24)
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11n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204779
PNG
(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26ClN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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11n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204781
PNG
(8-[(2-fluoro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26FN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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11n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204771
PNG
(1-phenyl-8-(phenyl-o-tolyl-methyl)-1,3,8-triaza-sp...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C27H29N3O/c1-21-10-8-9-15-24(21)25(22-11-4-2-5-12-22)29-18-16-27(17-19-29)26(31)28-20-30(27)23-13-6-3-7-14-23/h2-15,25H,16-20H2,1H3,(H,28,31)
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12n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204783
PNG
(1-phenyl-8-(1-phenyl-pentyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-2-3-14-22(20-10-6-4-7-11-20)26-17-15-24(16-18-26)23(28)25-19-27(24)21-12-8-5-9-13-21/h4-13,22H,2-3,14-19H2,1H3,(H,25,28)
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13n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204769
PNG
(8-(5-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26FN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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14n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204786
PNG
(1-phenyl-8-thiophen-3-ylmethyl-1,3,8-triaza-spiro[...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccsc2)CC1
Show InChI InChI=1S/C18H21N3OS/c22-17-18(21(14-19-17)16-4-2-1-3-5-16)7-9-20(10-8-18)12-15-6-11-23-13-15/h1-6,11,13H,7-10,12,14H2,(H,19,22)
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14n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204772
PNG
(8-(6,7-dichloro-4,4-dimethyl-1,2,3,4-tetrahydro-na...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2cc(Cl)c(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H29Cl2N3O/c1-24(2)9-8-22(18-14-20(26)21(27)15-19(18)24)29-12-10-25(11-13-29)23(31)28-16-30(25)17-6-4-3-5-7-17/h3-7,14-15,22H,8-13,16H2,1-2H3,(H,28,31)
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15n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204762
PNG
(1-phenyl-8-(6,7,8,9-tetrahydro-5H-benzocyclohepten...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCCc2ccccc12 |w:17.19|
Show InChI InChI=1S/C24H29N3O/c28-23-24(27(18-25-23)20-10-2-1-3-11-20)14-16-26(17-15-24)22-13-7-5-9-19-8-4-6-12-21(19)22/h1-4,6,8,10-12,22H,5,7,9,13-18H2,(H,25,28)
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15n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204767
PNG
(8-(2-chloro-benzyl)-1-phenyl-1,3,8-triaza-spiro[4....)
Show SMILES Clc1ccccc1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H22ClN3O/c21-18-9-5-4-6-16(18)14-23-12-10-20(11-13-23)19(25)22-15-24(20)17-7-2-1-3-8-17/h1-9H,10-15H2,(H,22,25)
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16n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204787
PNG
(1-phenyl-8-(1-phenyl-propyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c1-2-20(18-9-5-3-6-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)19-11-7-4-8-12-19/h3-12,20H,2,13-17H2,1H3,(H,23,26)
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17n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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19n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204783
PNG
(1-phenyl-8-(1-phenyl-pentyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-2-3-14-22(20-10-6-4-7-11-20)26-17-15-24(16-18-26)23(28)25-19-27(24)21-12-8-5-9-13-21/h4-13,22H,2-3,14-19H2,1H3,(H,25,28)
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22n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM26888
PNG
(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H27N3O/c30-25-26(29(20-27-25)23-14-8-3-9-15-23)16-18-28(19-17-26)24(21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-15,24H,16-20H2,(H,27,30)
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23n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204784
PNG
(1-phenyl-8-(1-phenyl-butyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O/c1-2-9-21(19-10-5-3-6-11-19)25-16-14-23(15-17-25)22(27)24-18-26(23)20-12-7-4-8-13-20/h3-8,10-13,21H,2,9,14-18H2,1H3,(H,24,27)
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23n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204775
PNG
(8-(cyclopentyl-phenyl-methyl)-1-phenyl-1,3,8-triaz...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(C1CCCC1)c1ccccc1 |w:17.19|
Show InChI InChI=1S/C25H31N3O/c29-24-25(28(19-26-24)22-13-5-2-6-14-22)15-17-27(18-16-25)23(21-11-7-8-12-21)20-9-3-1-4-10-20/h1-6,9-10,13-14,21,23H,7-8,11-12,15-19H2,(H,26,29)
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26n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204786
PNG
(1-phenyl-8-thiophen-3-ylmethyl-1,3,8-triaza-spiro[...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccsc2)CC1
Show InChI InChI=1S/C18H21N3OS/c22-17-18(21(14-19-17)16-4-2-1-3-5-16)7-9-20(10-8-18)12-15-6-11-23-13-15/h1-6,11,13H,7-10,12,14H2,(H,19,22)
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26n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204785
PNG
(8-(4-methyl-1-phenyl-pentyl)-1-phenyl-1,3,8-triaza...)
Show SMILES CC(C)CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-20(2)13-14-23(21-9-5-3-6-10-21)27-17-15-25(16-18-27)24(29)26-19-28(25)22-11-7-4-8-12-22/h3-12,20,23H,13-19H2,1-2H3,(H,26,29)
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26n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM26919
PNG
(8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-tria...)
Show SMILES Clc1cccc(Cl)c1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H21Cl2N3O/c21-17-7-4-8-18(22)16(17)13-24-11-9-20(10-12-24)19(26)23-14-25(20)15-5-2-1-3-6-15/h1-8H,9-14H2,(H,23,26)
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30n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204785
PNG
(8-(4-methyl-1-phenyl-pentyl)-1-phenyl-1,3,8-triaza...)
Show SMILES CC(C)CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-20(2)13-14-23(21-9-5-3-6-10-21)27-17-15-25(16-18-27)24(29)26-19-28(25)22-11-7-4-8-12-22/h3-12,20,23H,13-19H2,1-2H3,(H,26,29)
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30n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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32n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204768
PNG
(8-(7-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26FN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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34n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204793
PNG
(8-(5H-dibenzo[a,d]cyclohepten-5-yl)-1-phenyl-1,3,8...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2C=Cc2ccccc12 |c:28|
Show InChI InChI=1S/C28H27N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-15,26H,16-20H2,(H,29,32)
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37n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204767
PNG
(8-(2-chloro-benzyl)-1-phenyl-1,3,8-triaza-spiro[4....)
Show SMILES Clc1ccccc1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H22ClN3O/c21-18-9-5-4-6-16(18)14-23-12-10-20(11-13-23)19(25)22-15-24(20)17-7-2-1-3-8-17/h1-9H,10-15H2,(H,22,25)
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37n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM26947
PNG
(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H31N3O/c1-24(2)13-12-22(20-10-6-7-11-21(20)24)27-16-14-25(15-17-27)23(29)26-18-28(25)19-8-4-3-5-9-19/h3-11,22H,12-18H2,1-2H3,(H,26,29)
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48n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204764
PNG
(8-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H30ClN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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49n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204770
PNG
(8-[bis-(4-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F2N3O/c27-21-10-6-19(7-11-21)24(20-8-12-22(28)13-9-20)30-16-14-26(15-17-30)25(32)29-18-31(26)23-4-2-1-3-5-23/h1-13,24H,14-18H2,(H,29,32)
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49n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204765
PNG
(1-phenyl-8-(1-phenyl-ethyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-17(18-8-4-2-5-9-18)23-14-12-21(13-15-23)20(25)22-16-24(21)19-10-6-3-7-11-19/h2-11,17H,12-16H2,1H3,(H,22,25)
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50n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM26919
PNG
(8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-tria...)
Show SMILES Clc1cccc(Cl)c1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H21Cl2N3O/c21-17-7-4-8-18(22)16(17)13-24-11-9-20(10-12-24)19(26)23-14-25(20)15-5-2-1-3-6-15/h1-8H,9-14H2,(H,23,26)
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52n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204776
PNG
(8-(6-fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(F)cc12 |w:5.5|
Show InChI InChI=1S/C25H30FN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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59n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204787
PNG
(1-phenyl-8-(1-phenyl-propyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c1-2-20(18-9-5-3-6-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)19-11-7-4-8-12-19/h3-12,20H,2,13-17H2,1H3,(H,23,26)
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61n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204780
PNG
(8-cyclohexylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C20H29N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h2,5-6,9-10,17H,1,3-4,7-8,11-16H2,(H,21,24)
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61n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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65n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204790
PNG
(8-(7-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26ClN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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67n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204769
PNG
(8-(5-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26FN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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72n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204765
PNG
(1-phenyl-8-(1-phenyl-ethyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-17(18-8-4-2-5-9-18)23-14-12-21(13-15-23)20(25)22-16-24(21)19-10-6-3-7-11-19/h2-11,17H,12-16H2,1H3,(H,22,25)
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74n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204778
PNG
(8-(5-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26ClN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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95n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204777
PNG
(1-phenyl-8-pyridin-2-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-7-2-1-3-8-17)9-12-22(13-10-19)14-16-6-4-5-11-20-16/h1-8,11H,9-10,12-15H2,(H,21,24)
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119n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204778
PNG
(8-(5-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26ClN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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131n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204768
PNG
(8-(7-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26FN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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133n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204763
PNG
(1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)
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133n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204786
PNG
(1-phenyl-8-thiophen-3-ylmethyl-1,3,8-triaza-spiro[...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccsc2)CC1
Show InChI InChI=1S/C18H21N3OS/c22-17-18(21(14-19-17)16-4-2-1-3-5-16)7-9-20(10-8-18)12-15-6-11-23-13-15/h1-6,11,13H,7-10,12,14H2,(H,19,22)
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133n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM26888
PNG
(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H27N3O/c30-25-26(29(20-27-25)23-14-8-3-9-15-23)16-18-28(19-17-26)24(21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-15,24H,16-20H2,(H,27,30)
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137n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204766
PNG
(8-[(4-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-22-13-11-21(12-14-22)24(20-7-3-1-4-8-20)29-17-15-26(16-18-29)25(31)28-19-30(26)23-9-5-2-6-10-23/h1-14,24H,15-19H2,(H,28,31)
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140n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204779
PNG
(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26ClN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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143n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204794
PNG
(8-(8-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26FN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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145n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204790
PNG
(8-(7-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26ClN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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162n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204776
PNG
(8-(6-fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(F)cc12 |w:5.5|
Show InChI InChI=1S/C25H30FN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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169n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50175929
PNG
(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h1-10H,11-16H2,(H,21,24)
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196n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204762
PNG
(1-phenyl-8-(6,7,8,9-tetrahydro-5H-benzocyclohepten...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCCc2ccccc12 |w:17.19|
Show InChI InChI=1S/C24H29N3O/c28-23-24(27(18-25-23)20-10-2-1-3-11-20)14-16-26(17-15-24)22-13-7-5-9-19-8-4-6-12-21(19)22/h1-4,6,8,10-12,22H,5,7,9,13-18H2,(H,25,28)
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203n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204774
PNG
(8-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C28H29N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-13,26H,14-20H2,(H,29,32)
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225n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204763
PNG
(1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)
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233n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204784
PNG
(1-phenyl-8-(1-phenyl-butyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O/c1-2-9-21(19-10-5-3-6-11-19)25-16-14-23(15-17-25)22(27)24-18-26(23)20-12-7-4-8-13-20/h3-8,10-13,21H,2,9,14-18H2,1H3,(H,24,27)
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244n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204788
PNG
(8-[bis-(3-chloro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Clc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H25Cl2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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249n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204789
PNG
(8-[bis-(3-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C26H25F2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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250n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204763
PNG
(1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)
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252n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204764
PNG
(8-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H30ClN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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282n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204777
PNG
(1-phenyl-8-pyridin-2-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-7-2-1-3-8-17)9-12-22(13-10-19)14-16-6-4-5-11-20-16/h1-8,11H,9-10,12-15H2,(H,21,24)
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321n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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346n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204791
PNG
(8-di-o-tolylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C28H31N3O/c1-21-10-6-8-14-24(21)26(25-15-9-7-11-22(25)2)30-18-16-28(17-19-30)27(32)29-20-31(28)23-12-4-3-5-13-23/h3-15,26H,16-20H2,1-2H3,(H,29,32)
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346n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204787
PNG
(1-phenyl-8-(1-phenyl-propyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c1-2-20(18-9-5-3-6-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)19-11-7-4-8-12-19/h3-12,20H,2,13-17H2,1H3,(H,23,26)
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355n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204775
PNG
(8-(cyclopentyl-phenyl-methyl)-1-phenyl-1,3,8-triaz...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(C1CCCC1)c1ccccc1 |w:17.19|
Show InChI InChI=1S/C25H31N3O/c29-24-25(28(19-26-24)22-13-5-2-6-14-22)15-17-27(18-16-25)23(21-11-7-8-12-21)20-9-3-1-4-10-20/h1-6,9-10,13-14,21,23H,7-8,11-12,15-19H2,(H,26,29)
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398n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204793
PNG
(8-(5H-dibenzo[a,d]cyclohepten-5-yl)-1-phenyl-1,3,8...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2C=Cc2ccccc12 |c:28|
Show InChI InChI=1S/C28H27N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-15,26H,16-20H2,(H,29,32)
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475n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM26888
PNG
(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H27N3O/c30-25-26(29(20-27-25)23-14-8-3-9-15-23)16-18-28(19-17-26)24(21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-15,24H,16-20H2,(H,27,30)
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486n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50175929
PNG
(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h1-10H,11-16H2,(H,21,24)
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500n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204780
PNG
(8-cyclohexylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C20H29N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h2,5-6,9-10,17H,1,3-4,7-8,11-16H2,(H,21,24)
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517n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM26947
PNG
(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H31N3O/c1-24(2)13-12-22(20-10-6-7-11-21(20)24)27-16-14-25(15-17-27)23(29)26-18-28(25)19-8-4-3-5-9-19/h3-11,22H,12-18H2,1-2H3,(H,26,29)
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540n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204773
PNG
(8-[bis-(2-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1F
Show InChI InChI=1S/C26H25F2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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567n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204771
PNG
(1-phenyl-8-(phenyl-o-tolyl-methyl)-1,3,8-triaza-sp...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C27H29N3O/c1-21-10-8-9-15-24(21)25(22-11-4-2-5-12-22)29-18-16-27(17-19-29)26(31)28-20-30(27)23-13-6-3-7-14-23/h2-15,25H,16-20H2,1H3,(H,28,31)
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579n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM26949
PNG
(8-[bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triaz...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C26H25Cl2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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595n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204762
PNG
(1-phenyl-8-(6,7,8,9-tetrahydro-5H-benzocyclohepten...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCCc2ccccc12 |w:17.19|
Show InChI InChI=1S/C24H29N3O/c28-23-24(27(18-25-23)20-10-2-1-3-11-20)14-16-26(17-15-24)22-13-7-5-9-19-8-4-6-12-21(19)22/h1-4,6,8,10-12,22H,5,7,9,13-18H2,(H,25,28)
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673n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204767
PNG
(8-(2-chloro-benzyl)-1-phenyl-1,3,8-triaza-spiro[4....)
Show SMILES Clc1ccccc1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H22ClN3O/c21-18-9-5-4-6-16(18)14-23-12-10-20(11-13-23)19(25)22-15-24(20)17-7-2-1-3-8-17/h1-9H,10-15H2,(H,22,25)
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725n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204785
PNG
(8-(4-methyl-1-phenyl-pentyl)-1-phenyl-1,3,8-triaza...)
Show SMILES CC(C)CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-20(2)13-14-23(21-9-5-3-6-10-21)27-17-15-25(16-18-27)24(29)26-19-28(25)22-11-7-4-8-12-22/h3-12,20,23H,13-19H2,1-2H3,(H,26,29)
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736n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204793
PNG
(8-(5H-dibenzo[a,d]cyclohepten-5-yl)-1-phenyl-1,3,8...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2C=Cc2ccccc12 |c:28|
Show InChI InChI=1S/C28H27N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-15,26H,16-20H2,(H,29,32)
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776n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204782
PNG
(8-[(2-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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778n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204770
PNG
(8-[bis-(4-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F2N3O/c27-21-10-6-19(7-11-21)24(20-8-12-22(28)13-9-20)30-16-14-26(15-17-30)25(32)29-18-31(26)23-4-2-1-3-5-23/h1-13,24H,14-18H2,(H,29,32)
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787n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204781
PNG
(8-[(2-fluoro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26FN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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818n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50204792
PNG
(1-phenyl-8-pyridin-4-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccncc2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-4-2-1-3-5-17)8-12-22(13-9-19)14-16-6-10-20-11-7-16/h1-7,10-11H,8-9,12-15H2,(H,21,24)
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824n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204773
PNG
(8-[bis-(2-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1F
Show InChI InChI=1S/C26H25F2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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858n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204780
PNG
(8-cyclohexylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C20H29N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h2,5-6,9-10,17H,1,3-4,7-8,11-16H2,(H,21,24)
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887n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204772
PNG
(8-(6,7-dichloro-4,4-dimethyl-1,2,3,4-tetrahydro-na...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2cc(Cl)c(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H29Cl2N3O/c1-24(2)9-8-22(18-14-20(26)21(27)15-19(18)24)29-12-10-25(11-13-29)23(31)28-16-30(25)17-6-4-3-5-7-17/h3-7,14-15,22H,8-13,16H2,1-2H3,(H,28,31)
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938n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204772
PNG
(8-(6,7-dichloro-4,4-dimethyl-1,2,3,4-tetrahydro-na...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2cc(Cl)c(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H29Cl2N3O/c1-24(2)9-8-22(18-14-20(26)21(27)15-19(18)24)29-12-10-25(11-13-29)23(31)28-16-30(25)17-6-4-3-5-7-17/h3-7,14-15,22H,8-13,16H2,1-2H3,(H,28,31)
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977n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204765
PNG
(1-phenyl-8-(1-phenyl-ethyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-17(18-8-4-2-5-9-18)23-14-12-21(13-15-23)20(25)22-16-24(21)19-10-6-3-7-11-19/h2-11,17H,12-16H2,1H3,(H,22,25)
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1.04E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204782
PNG
(8-[(2-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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1.09E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204771
PNG
(1-phenyl-8-(phenyl-o-tolyl-methyl)-1,3,8-triaza-sp...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C27H29N3O/c1-21-10-8-9-15-24(21)25(22-11-4-2-5-12-22)29-18-16-27(17-19-29)26(31)28-20-30(27)23-13-6-3-7-14-23/h2-15,25H,16-20H2,1H3,(H,28,31)
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1.11E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204781
PNG
(8-[(2-fluoro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26FN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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1.18E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204794
PNG
(8-(8-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26FN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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1.23E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204764
PNG
(8-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H30ClN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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1.29E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204779
PNG
(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12 |w:9.9|
Show InChI InChI=1S/C23H26ClN3O/c24-19-10-4-6-17-7-5-11-20(21(17)19)26-14-12-23(13-15-26)22(28)25-16-27(23)18-8-2-1-3-9-18/h1-4,6,8-10,20H,5,7,11-16H2,(H,25,28)
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1.38E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204783
PNG
(1-phenyl-8-(1-phenyl-pentyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H31N3O/c1-2-3-14-22(20-10-6-4-7-11-20)26-17-15-24(16-18-26)23(28)25-19-27(24)21-12-8-5-9-13-21/h4-13,22H,2-3,14-19H2,1H3,(H,25,28)
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1.42E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204789
PNG
(8-[bis-(3-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C26H25F2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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1.45E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204791
PNG
(8-di-o-tolylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C28H31N3O/c1-21-10-6-8-14-24(21)26(25-15-9-7-11-22(25)2)30-18-16-28(17-19-30)27(32)29-20-31(28)23-12-4-3-5-13-23/h3-15,26H,16-20H2,1-2H3,(H,29,32)
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1.60E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204788
PNG
(8-[bis-(3-chloro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Clc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H25Cl2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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1.62E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM26919
PNG
(8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-tria...)
Show SMILES Clc1cccc(Cl)c1CN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C20H21Cl2N3O/c21-17-7-4-8-18(22)16(17)13-24-11-9-20(10-12-24)19(26)23-14-25(20)15-5-2-1-3-6-15/h1-8H,9-14H2,(H,23,26)
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1.63E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204774
PNG
(8-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C28H29N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-13,26H,14-20H2,(H,29,32)
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1.67E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204777
PNG
(1-phenyl-8-pyridin-2-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-7-2-1-3-8-17)9-12-22(13-10-19)14-16-6-4-5-11-20-16/h1-8,11H,9-10,12-15H2,(H,21,24)
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1.76E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM26947
PNG
(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H31N3O/c1-24(2)13-12-22(20-10-6-7-11-21(20)24)27-16-14-25(15-17-27)23(29)26-18-28(25)19-8-4-3-5-9-19/h3-11,22H,12-18H2,1-2H3,(H,26,29)
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1.79E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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1.85E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204762
PNG
(1-phenyl-8-(6,7,8,9-tetrahydro-5H-benzocyclohepten...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCCc2ccccc12 |w:17.19|
Show InChI InChI=1S/C24H29N3O/c28-23-24(27(18-25-23)20-10-2-1-3-11-20)14-16-26(17-15-24)22-13-7-5-9-19-8-4-6-12-21(19)22/h1-4,6,8,10-12,22H,5,7,9,13-18H2,(H,25,28)
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1.91E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204770
PNG
(8-[bis-(4-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F2N3O/c27-21-10-6-19(7-11-21)24(20-8-12-22(28)13-9-20)30-16-14-26(15-17-30)25(32)29-18-31(26)23-4-2-1-3-5-23/h1-13,24H,14-18H2,(H,29,32)
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2.01E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204778
PNG
(8-(5-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26ClN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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2.27E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204769
PNG
(8-(5-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1 |w:6.12|
Show InChI InChI=1S/C23H26FN3O/c24-20-10-4-9-19-18(20)8-5-11-21(19)26-14-12-23(13-15-26)22(28)25-16-27(23)17-6-2-1-3-7-17/h1-4,6-7,9-10,21H,5,8,11-16H2,(H,25,28)
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2.40E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204774
PNG
(8-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C28H29N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-13,26H,14-20H2,(H,29,32)
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2.45E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204776
PNG
(8-(6-fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccc(F)cc12 |w:5.5|
Show InChI InChI=1S/C25H30FN3O/c1-24(2)11-10-22(20-9-8-18(26)16-21(20)24)28-14-12-25(13-15-28)23(30)27-17-29(25)19-6-4-3-5-7-19/h3-9,16,22H,10-15,17H2,1-2H3,(H,27,30)
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2.46E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204790
PNG
(8-(7-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Clc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26ClN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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2.51E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204768
PNG
(8-(7-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Fc1ccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c2c1 |w:8.8|
Show InChI InChI=1S/C23H26FN3O/c24-18-10-9-17-5-4-8-21(20(17)15-18)26-13-11-23(12-14-26)22(28)25-16-27(23)19-6-2-1-3-7-19/h1-3,6-7,9-10,15,21H,4-5,8,11-14,16H2,(H,25,28)
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2.65E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50175929
PNG
(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h1-10H,11-16H2,(H,21,24)
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2.95E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204789
PNG
(8-[bis-(3-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C26H25F2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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3.19E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204784
PNG
(1-phenyl-8-(1-phenyl-butyl)-1,3,8-triaza-spiro[4.5...)
Show SMILES CCCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H29N3O/c1-2-9-21(19-10-5-3-6-11-19)25-16-14-23(15-17-25)22(27)24-18-26(23)20-12-7-4-8-13-20/h3-8,10-13,21H,2,9,14-18H2,1H3,(H,24,27)
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3.37E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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3.51E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204766
PNG
(8-[(4-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-22-13-11-21(12-14-22)24(20-7-3-1-4-8-20)29-17-15-26(16-18-29)25(31)28-19-30(26)23-9-5-2-6-10-23/h1-14,24H,15-19H2,(H,28,31)
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3.53E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204763
PNG
(1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-6-2-1-3-7-17)8-11-22(12-9-19)14-16-5-4-10-20-13-16/h1-7,10,13H,8-9,11-12,14-15H2,(H,21,24)
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3.79E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204788
PNG
(8-[bis-(3-chloro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Clc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H25Cl2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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4.63E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204775
PNG
(8-(cyclopentyl-phenyl-methyl)-1-phenyl-1,3,8-triaz...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(C1CCCC1)c1ccccc1 |w:17.19|
Show InChI InChI=1S/C25H31N3O/c29-24-25(28(19-26-24)22-13-5-2-6-14-22)15-17-27(18-16-25)23(21-11-7-8-12-21)20-9-3-1-4-10-20/h1-6,9-10,13-14,21,23H,7-8,11-12,15-19H2,(H,26,29)
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4.68E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204766
PNG
(8-[(4-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-22-13-11-21(12-14-22)24(20-7-3-1-4-8-20)29-17-15-26(16-18-29)25(31)28-19-30(26)23-9-5-2-6-10-23/h1-14,24H,15-19H2,(H,28,31)
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5.08E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204770
PNG
(8-[bis-(4-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F2N3O/c27-21-10-6-19(7-11-21)24(20-8-12-22(28)13-9-20)30-16-14-26(15-17-30)25(32)29-18-31(26)23-4-2-1-3-5-23/h1-13,24H,14-18H2,(H,29,32)
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5.60E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM26949
PNG
(8-[bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triaz...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C26H25Cl2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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5.89E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204771
PNG
(1-phenyl-8-(phenyl-o-tolyl-methyl)-1,3,8-triaza-sp...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C27H29N3O/c1-21-10-8-9-15-24(21)25(22-11-4-2-5-12-22)29-18-16-27(17-19-29)26(31)28-20-30(27)23-13-6-3-7-14-23/h2-15,25H,16-20H2,1H3,(H,28,31)
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6.04E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204787
PNG
(1-phenyl-8-(1-phenyl-propyl)-1,3,8-triaza-spiro[4....)
Show SMILES CCC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c1-2-20(18-9-5-3-6-10-18)24-15-13-22(14-16-24)21(26)23-17-25(22)19-11-7-4-8-12-19/h3-12,20H,2,13-17H2,1H3,(H,23,26)
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6.85E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204791
PNG
(8-di-o-tolylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES Cc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C28H31N3O/c1-21-10-6-8-14-24(21)26(25-15-9-7-11-22(25)2)30-18-16-28(17-19-30)27(32)29-20-31(28)23-12-4-3-5-13-23/h3-15,26H,16-20H2,1-2H3,(H,29,32)
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8.60E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204786
PNG
(1-phenyl-8-thiophen-3-ylmethyl-1,3,8-triaza-spiro[...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccsc2)CC1
Show InChI InChI=1S/C18H21N3OS/c22-17-18(21(14-19-17)16-4-2-1-3-5-16)7-9-20(10-8-18)12-15-6-11-23-13-15/h1-6,11,13H,7-10,12,14H2,(H,19,22)
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9.00E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204774
PNG
(8-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C28H29N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-13,26H,14-20H2,(H,29,32)
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9.78E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204789
PNG
(8-[bis-(3-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C26H25F2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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1.04E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204793
PNG
(8-(5H-dibenzo[a,d]cyclohepten-5-yl)-1-phenyl-1,3,8...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1c2ccccc2C=Cc2ccccc12 |c:28|
Show InChI InChI=1S/C28H27N3O/c32-27-28(31(20-29-27)23-10-2-1-3-11-23)16-18-30(19-17-28)26-24-12-6-4-8-21(24)14-15-22-9-5-7-13-25(22)26/h1-15,26H,16-20H2,(H,29,32)
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1.15E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204772
PNG
(8-(6,7-dichloro-4,4-dimethyl-1,2,3,4-tetrahydro-na...)
Show SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2cc(Cl)c(Cl)cc12 |w:5.5|
Show InChI InChI=1S/C25H29Cl2N3O/c1-24(2)9-8-22(18-14-20(26)21(27)15-19(18)24)29-12-10-25(11-13-29)23(31)28-16-30(25)17-6-4-3-5-7-17/h3-7,14-15,22H,8-13,16H2,1-2H3,(H,28,31)
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1.17E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204782
PNG
(8-[(2-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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1.48E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204781
PNG
(8-[(2-fluoro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26FN3O/c27-23-14-8-7-13-22(23)24(20-9-3-1-4-10-20)29-17-15-26(16-18-29)25(31)28-19-30(26)21-11-5-2-6-12-21/h1-14,24H,15-19H2,(H,28,31)
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1.57E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204773
PNG
(8-[bis-(2-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Fc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1F
Show InChI InChI=1S/C26H25F2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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1.60E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204766
PNG
(8-[(4-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8...)
Show SMILES Clc1ccc(cc1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C26H26ClN3O/c27-22-13-11-21(12-14-22)24(20-7-3-1-4-8-20)29-17-15-26(16-18-29)25(31)28-19-30(26)23-9-5-2-6-10-23/h1-14,24H,15-19H2,(H,28,31)
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2.48E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204788
PNG
(8-[bis-(3-chloro-phenyl)-methyl]-1-phenyl-1,3,8-tr...)
Show SMILES Clc1cccc(c1)C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H25Cl2N3O/c27-21-8-4-6-19(16-21)24(20-7-5-9-22(28)17-20)30-14-12-26(13-15-30)25(32)29-18-31(26)23-10-2-1-3-11-23/h1-11,16-17,24H,12-15,18H2,(H,29,32)
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2.65E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204777
PNG
(1-phenyl-8-pyridin-2-ylmethyl-1,3,8-triaza-spiro[4...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C19H22N4O/c24-18-19(23(15-21-18)17-7-2-1-3-8-17)9-12-22(13-10-19)14-16-6-4-5-11-20-16/h1-8,11H,9-10,12-15H2,(H,21,24)
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3.19E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM26888
PNG
(8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H27N3O/c30-25-26(29(20-27-25)23-14-8-3-9-15-23)16-18-28(19-17-26)24(21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-15,24H,16-20H2,(H,27,30)
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3.79E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204780
PNG
(8-cyclohexylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C20H29N3O/c24-19-20(23(16-21-19)18-9-5-2-6-10-18)11-13-22(14-12-20)15-17-7-3-1-4-8-17/h2,5-6,9-10,17H,1,3-4,7-8,11-16H2,(H,21,24)
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7.37E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM26949
PNG
(8-[bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triaz...)
Show SMILES Clc1ccccc1C(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C26H25Cl2N3O/c27-22-12-6-4-10-20(22)24(21-11-5-7-13-23(21)28)30-16-14-26(15-17-30)25(32)29-18-31(26)19-8-2-1-3-9-19/h1-13,24H,14-18H2,(H,29,32)
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1.50E+5n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 2281-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.069
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%