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PubMed code 1732541

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM25400
PNG
((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)ncnc12
Show InChI InChI=1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1
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 1.20n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50119168
PNG
((2R,3R,4S,5R)-2-(6-Amino-2-hex-1-ynyl-purin-9-yl)-...)
Show SMILES CCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C16H21N5O4/c1-2-3-4-5-6-10-19-14(17)11-15(20-10)21(8-18-11)16-13(24)12(23)9(7-22)25-16/h8-9,12-13,16,22-24H,2-4,7H2,1H3,(H2,17,19,20)/t9-,12-,13-,16-/m1/s1
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 2.80n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50453223
PNG
(CHEMBL2113507)
Show SMILES CCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O4/c1-2-3-4-5-6-7-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,2-5,8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17-/m1/s1
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 5.40n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50452520
PNG
(CHEMBL2094089 | N6-[2-(3,5-dimethoxyphenyl)-2-(2-m...)
Show SMILES COc1cc(OC)cc(c1)C(CNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccccc1C |r|
Show InChI InChI=1S/C27H31N5O6/c1-15-6-4-5-7-19(15)20(16-8-17(36-2)10-18(9-16)37-3)11-28-25-22-26(30-13-29-25)32(14-31-22)27-24(35)23(34)21(12-33)38-27/h4-10,13-14,20-21,23-24,27,33-35H,11-12H2,1-3H3,(H,28,29,30)/t20?,21-,23-,24-,27-/m1/s1
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 6.90n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50453221
PNG
(CHEMBL2113510)
Show SMILES CCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C15H19N5O4/c1-2-3-4-5-9-18-13(16)10-14(19-9)20(7-17-10)15-12(23)11(22)8(6-21)24-15/h7-8,11-12,15,21-23H,2-3,6H2,1H3,(H2,16,18,19)/t8-,11-,12-,15-/m1/s1
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 7.5n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM35804
PNG
((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NCCc3ccc(CCC(O)=O)cc3)nc12
Show InChI InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1
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 8.80n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50453210
PNG
(CHEMBL2113503)
Show SMILES Nc1nc(nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C#CCO |r|
Show InChI InChI=1S/C13H15N5O5/c14-11-8-12(17-7(16-11)2-1-3-19)18(5-15-8)13-10(22)9(21)6(4-20)23-13/h5-6,9-10,13,19-22H,3-4H2,(H2,14,16,17)/t6-,9-,10-,13-/m1/s1
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 10n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368400
PNG
(CHEMBL608309)
Show SMILES CCCOCCC#Cc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O5/c1-2-6-26-7-4-3-5-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)27-17/h9-10,13-14,17,23-25H,2,4,6-8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17?/m1/s1
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 10n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455636
PNG
(CHEMBL2113512)
Show SMILES CCCCOCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O5/c1-2-3-6-26-7-4-5-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)27-17/h9-10,13-14,17,23-25H,2-3,6-8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17-/m1/s1
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 11n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM21220
PNG
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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 12n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50453216
PNG
(2-(l-hexyn-l-yl)adenosine (8, YT-146) | CHEMBL2113...)
Show SMILES CCCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C18H25N5O4/c1-2-3-4-5-6-7-8-12-21-16(19)13-17(22-12)23(10-20-13)18-15(26)14(25)11(9-24)27-18/h10-11,14-15,18,24-26H,2-6,9H2,1H3,(H2,19,21,22)/t11-,14-,15-,18-/m1/s1
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 12n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM21220
PNG
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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 13n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455639
PNG
(CHEMBL2113513)
Show SMILES CCOCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O5/c1-2-26-7-5-3-4-6-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)27-17/h9-10,13-14,17,23-25H,2-3,5,7-8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17-/m1/s1
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 13n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455636
PNG
(CHEMBL2113512)
Show SMILES CCCCOCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O5/c1-2-3-6-26-7-4-5-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)27-17/h9-10,13-14,17,23-25H,2-3,6-8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17-/m1/s1
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 19n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455634
PNG
(CHEMBL2113522)
Show SMILES CCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C14H17N5O4/c1-2-3-4-8-17-12(15)9-13(18-8)19(6-16-9)14-11(22)10(21)7(5-20)23-14/h6-7,10-11,14,20-22H,2,5H2,1H3,(H2,15,17,18)/t7-,10-,11-,14-/m1/s1
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 21n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50453210
PNG
(CHEMBL2113503)
Show SMILES Nc1nc(nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C#CCO |r|
Show InChI InChI=1S/C13H15N5O5/c14-11-8-12(17-7(16-11)2-1-3-19)18(5-15-8)13-10(22)9(21)6(4-20)23-13/h5-6,9-10,13,19-22H,3-4H2,(H2,14,16,17)/t6-,9-,10-,13-/m1/s1
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 21n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455640
PNG
(CHEMBL2113515)
Show SMILES CCCCCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C20H29N5O4/c1-2-3-4-5-6-7-8-9-10-14-23-18(21)15-19(24-14)25(12-22-15)20-17(28)16(27)13(11-26)29-20/h12-13,16-17,20,26-28H,2-8,11H2,1H3,(H2,21,23,24)/t13-,16-,17-,20-/m1/s1
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 33n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455637
PNG
(CHEMBL2113511)
Show SMILES CCCCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C19H27N5O4/c1-2-3-4-5-6-7-8-9-13-22-17(20)14-18(23-13)24(11-21-14)19-16(27)15(26)12(10-25)28-19/h11-12,15-16,19,25-27H,2-7,10H2,1H3,(H2,20,22,23)/t12-,15-,16-,19-/m1/s1
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 34n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455638
PNG
(CHEMBL2113514)
Show SMILES COCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C14H17N5O5/c1-23-4-2-3-8-17-12(15)9-13(18-8)19(6-16-9)14-11(22)10(21)7(5-20)24-14/h6-7,10-11,14,20-22H,4-5H2,1H3,(H2,15,17,18)/t7-,10-,11-,14-/m1/s1
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 38n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368387
PNG
(CHEMBL607728)
Show SMILES Nc1nc(nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O)C#C |r|
Show InChI InChI=1S/C12H13N5O4/c1-2-6-15-10(13)7-11(16-6)17(4-14-7)12-9(20)8(19)5(3-18)21-12/h1,4-5,8-9,12,18-20H,3H2,(H2,13,15,16)/t5-,8-,9-,12?/m1/s1
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 38n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455641
PNG
(CHEMBL2113476)
Show SMILES Nc1nc(nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C#CCCO |r|
Show InChI InChI=1S/C14H17N5O5/c15-12-9-13(18-8(17-12)3-1-2-4-20)19(6-16-9)14-11(23)10(22)7(5-21)24-14/h6-7,10-11,14,20-23H,2,4-5H2,(H2,15,17,18)/t7-,10-,11-,14-/m1/s1
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 40n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368402
PNG
(CHEMBL608905)
Show SMILES CCCCCCCCCCC#Cc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C22H33N5O4/c1-2-3-4-5-6-7-8-9-10-11-12-16-25-20(23)17-21(26-16)27(14-24-17)22-19(30)18(29)15(13-28)31-22/h14-15,18-19,22,28-30H,2-10,13H2,1H3,(H2,23,25,26)/t15-,18-,19-,22?/m1/s1
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 45n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455635
PNG
(CHEMBL2113508)
Show SMILES C[Si](C)(C)C#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C15H21N5O4Si/c1-25(2,3)5-4-9-18-13(16)10-14(19-9)20(7-17-10)15-12(23)11(22)8(6-21)24-15/h7-8,11-12,15,21-23H,6H2,1-3H3,(H2,16,18,19)/t8-,11-,12-,15-/m1/s1
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 70n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455641
PNG
(CHEMBL2113476)
Show SMILES Nc1nc(nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C#CCCO |r|
Show InChI InChI=1S/C14H17N5O5/c15-12-9-13(18-8(17-12)3-1-2-4-20)19(6-16-9)14-11(23)10(22)7(5-21)24-14/h6-7,10-11,14,20-23H,2,4-5H2,(H2,15,17,18)/t7-,10-,11-,14-/m1/s1
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 81n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455638
PNG
(CHEMBL2113514)
Show SMILES COCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C14H17N5O5/c1-23-4-2-3-8-17-12(15)9-13(18-8)19(6-16-9)14-11(22)10(21)7(5-20)24-14/h6-7,10-11,14,20-22H,4-5H2,1H3,(H2,15,17,18)/t7-,10-,11-,14-/m1/s1
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 88n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50452520
PNG
(CHEMBL2094089 | N6-[2-(3,5-dimethoxyphenyl)-2-(2-m...)
Show SMILES COc1cc(OC)cc(c1)C(CNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccccc1C |r|
Show InChI InChI=1S/C27H31N5O6/c1-15-6-4-5-7-19(15)20(16-8-17(36-2)10-18(9-16)37-3)11-28-25-22-26(30-13-29-25)32(14-31-22)27-24(35)23(34)21(12-33)38-27/h4-10,13-14,20-21,23-24,27,33-35H,11-12H2,1-3H3,(H,28,29,30)/t20?,21-,23-,24-,27-/m1/s1
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 103n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM82022
PNG
(2-(Phenylamino)ado (CV-1808) | 2-[6-Amino-2-(3-cyc...)
Show SMILES Nc1nc(Nc2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1
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 107n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50119168
PNG
((2R,3R,4S,5R)-2-(6-Amino-2-hex-1-ynyl-purin-9-yl)-...)
Show SMILES CCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C16H21N5O4/c1-2-3-4-5-6-10-19-14(17)11-15(20-10)21(8-18-11)16-13(24)12(23)9(7-22)25-16/h8-9,12-13,16,22-24H,2-4,7H2,1H3,(H2,17,19,20)/t9-,12-,13-,16-/m1/s1
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 126n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368400
PNG
(CHEMBL608309)
Show SMILES CCCOCCC#Cc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O5/c1-2-6-26-7-4-3-5-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)27-17/h9-10,13-14,17,23-25H,2,4,6-8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17?/m1/s1
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 128n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368386
PNG
(CHEMBL609784)
Show SMILES CCCCCC\C=C/c1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C18H27N5O4/c1-2-3-4-5-6-7-8-12-21-16(19)13-17(22-12)23(10-20-13)18-15(26)14(25)11(9-24)27-18/h7-8,10-11,14-15,18,24-26H,2-6,9H2,1H3,(H2,19,21,22)/b8-7-/t11-,14-,15-,18?/m1/s1
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 150n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50453221
PNG
(CHEMBL2113510)
Show SMILES CCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C15H19N5O4/c1-2-3-4-5-9-18-13(16)10-14(19-9)20(7-17-10)15-12(23)11(22)8(6-21)24-15/h7-8,11-12,15,21-23H,2-3,6H2,1H3,(H2,16,18,19)/t8-,11-,12-,15-/m1/s1
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 154n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50453223
PNG
(CHEMBL2113507)
Show SMILES CCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O4/c1-2-3-4-5-6-7-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,2-5,8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17-/m1/s1
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 170n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455634
PNG
(CHEMBL2113522)
Show SMILES CCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C14H17N5O4/c1-2-3-4-8-17-12(15)9-13(18-8)19(6-16-9)14-11(22)10(21)7(5-20)23-14/h6-7,10-11,14,20-22H,2,5H2,1H3,(H2,15,17,18)/t7-,10-,11-,14-/m1/s1
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 186n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50453216
PNG
(2-(l-hexyn-l-yl)adenosine (8, YT-146) | CHEMBL2113...)
Show SMILES CCCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C18H25N5O4/c1-2-3-4-5-6-7-8-12-21-16(19)13-17(22-12)23(10-20-13)18-15(26)14(25)11(9-24)27-18/h10-11,14-15,18,24-26H,2-6,9H2,1H3,(H2,19,21,22)/t11-,14-,15-,18-/m1/s1
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 202n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455640
PNG
(CHEMBL2113515)
Show SMILES CCCCCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C20H29N5O4/c1-2-3-4-5-6-7-8-9-10-14-23-18(21)15-19(24-14)25(12-22-15)20-17(28)16(27)13(11-26)29-20/h12-13,16-17,20,26-28H,2-8,11H2,1H3,(H2,21,23,24)/t13-,16-,17-,20-/m1/s1
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 232n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455639
PNG
(CHEMBL2113513)
Show SMILES CCOCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C17H23N5O5/c1-2-26-7-5-3-4-6-11-20-15(18)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)27-17/h9-10,13-14,17,23-25H,2-3,5,7-8H2,1H3,(H2,18,20,21)/t10-,13-,14-,17-/m1/s1
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 244n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455637
PNG
(CHEMBL2113511)
Show SMILES CCCCCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C19H27N5O4/c1-2-3-4-5-6-7-8-9-13-22-17(20)14-18(23-13)24(11-21-14)19-16(27)15(26)12(10-25)28-19/h11-12,15-16,19,25-27H,2-7,10H2,1H3,(H2,20,22,23)/t12-,15-,16-,19-/m1/s1
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 257n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368402
PNG
(CHEMBL608905)
Show SMILES CCCCCCCCCCC#Cc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C22H33N5O4/c1-2-3-4-5-6-7-8-9-10-11-12-16-25-20(23)17-21(26-16)27(14-24-17)22-19(30)18(29)15(13-28)31-22/h14-15,18-19,22,28-30H,2-10,13H2,1H3,(H2,23,25,26)/t15-,18-,19-,22?/m1/s1
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 267n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]-CHA

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368387
PNG
(CHEMBL607728)
Show SMILES Nc1nc(nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O)C#C |r|
Show InChI InChI=1S/C12H13N5O4/c1-2-6-15-10(13)7-11(16-6)17(4-14-7)12-9(20)8(19)5(3-18)21-12/h1,4-5,8-9,12,18-20H,3H2,(H2,13,15,16)/t5-,8-,9-,12?/m1/s1
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 272n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455633
PNG
(CHEMBL2113523)
Show SMILES CCCCCCCCOCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C22H33N5O5/c1-2-3-4-5-6-8-11-31-12-9-7-10-16-25-20(23)17-21(26-16)27(14-24-17)22-19(30)18(29)15(13-28)32-22/h14-15,18-19,22,28-30H,2-6,8-9,11-13H2,1H3,(H2,23,25,26)/t15-,18-,19-,22-/m1/s1
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 307n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM25400
PNG
((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)ncnc12
Show InChI InChI=1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1
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 421n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368388
PNG
(CHEMBL609199)
Show SMILES CCCCCCC#Cc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H24N4O5/c1-2-3-4-5-6-7-8-12-20-16-13(17(26)21-12)19-10-22(16)18-15(25)14(24)11(9-23)27-18/h10-11,14-15,18,23-25H,2-6,9H2,1H3,(H,20,21,26)/t11-,14-,15-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368403
PNG
(CHEMBL606229)
Show SMILES CCCCCCCCc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C18H29N5O4/c1-2-3-4-5-6-7-8-12-21-16(19)13-17(22-12)23(10-20-13)18-15(26)14(25)11(9-24)27-18/h10-11,14-15,18,24-26H,2-9H2,1H3,(H2,19,21,22)/t11-,14-,15-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368391
PNG
(CHEMBL606230)
Show SMILES CCc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C12H17N5O4/c1-2-6-15-10(13)7-11(16-6)17(4-14-7)12-9(20)8(19)5(3-18)21-12/h4-5,8-9,12,18-20H,2-3H2,1H3,(H2,13,15,16)/t5-,8-,9-,12?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368393
PNG
(CHEMBL612164)
Show SMILES CCCCCCC#Cc1ncnc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H24N4O4/c1-2-3-4-5-6-7-8-12-14-17(20-10-19-12)22(11-21-14)18-16(25)15(24)13(9-23)26-18/h10-11,13,15-16,18,23-25H,2-6,9H2,1H3/t13-,15-,16-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368390
PNG
(CHEMBL612163)
Show SMILES CCCCCCC#Cc1nc2c(N)ncnc2n1C1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H25N5O4/c1-2-3-4-5-6-7-8-12-22-13-16(19)20-10-21-17(13)23(12)18-15(26)14(25)11(9-24)27-18/h10-11,14-15,18,24-26H,2-6,9H2,1H3,(H2,19,20,21)/t11-,14-,15-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368388
PNG
(CHEMBL609199)
Show SMILES CCCCCCC#Cc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H24N4O5/c1-2-3-4-5-6-7-8-12-20-16-13(17(26)21-12)19-10-22(16)18-15(25)14(24)11(9-23)27-18/h10-11,14-15,18,23-25H,2-6,9H2,1H3,(H,20,21,26)/t11-,14-,15-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50008245
PNG
(2-Oct-1-ynyl-9H-purin-6-ylamine | CHEMBL315101)
Show SMILES CCCCCCC#Cc1nc(N)c2[nH]cnc2n1
Show InChI InChI=1S/C13H17N5/c1-2-3-4-5-6-7-8-10-17-12(14)11-13(18-10)16-9-15-11/h9H,2-6H2,1H3,(H3,14,15,16,17,18)
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368401
PNG
(CHEMBL609783)
Show SMILES CC(=O)c1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C12H15N5O5/c1-4(19)10-15-9(13)6-11(16-10)17(3-14-6)12-8(21)7(20)5(2-18)22-12/h3,5,7-8,12,18,20-21H,2H2,1H3,(H2,13,15,16)/t5-,7-,8-,12?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368386
PNG
(CHEMBL609784)
Show SMILES CCCCCC\C=C/c1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C18H27N5O4/c1-2-3-4-5-6-7-8-12-21-16(19)13-17(22-12)23(10-20-13)18-15(26)14(25)11(9-24)27-18/h7-8,10-11,14-15,18,24-26H,2-6,9H2,1H3,(H2,19,21,22)/b8-7-/t11-,14-,15-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368390
PNG
(CHEMBL612163)
Show SMILES CCCCCCC#Cc1nc2c(N)ncnc2n1C1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H25N5O4/c1-2-3-4-5-6-7-8-12-22-13-16(19)20-10-21-17(13)23(12)18-15(26)14(25)11(9-24)27-18/h10-11,14-15,18,24-26H,2-6,9H2,1H3,(H2,19,20,21)/t11-,14-,15-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50368393
PNG
(CHEMBL612164)
Show SMILES CCCCCCC#Cc1ncnc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H24N4O4/c1-2-3-4-5-6-7-8-12-14-17(20-10-19-12)22(11-21-14)18-16(25)15(24)13(9-23)26-18/h10-11,13,15-16,18,23-25H,2-6,9H2,1H3/t13-,15-,16-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50008245
PNG
(2-Oct-1-ynyl-9H-purin-6-ylamine | CHEMBL315101)
Show SMILES CCCCCCC#Cc1nc(N)c2[nH]cnc2n1
Show InChI InChI=1S/C13H17N5/c1-2-3-4-5-6-7-8-10-17-12(14)11-13(18-10)16-9-15-11/h9H,2-6H2,1H3,(H3,14,15,16,17,18)
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368403
PNG
(CHEMBL606229)
Show SMILES CCCCCCCCc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C18H29N5O4/c1-2-3-4-5-6-7-8-12-21-16(19)13-17(22-12)23(10-20-13)18-15(26)14(25)11(9-24)27-18/h10-11,14-15,18,24-26H,2-9H2,1H3,(H2,19,21,22)/t11-,14-,15-,18?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368401
PNG
(CHEMBL609783)
Show SMILES CC(=O)c1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C12H15N5O5/c1-4(19)10-15-9(13)6-11(16-10)17(3-14-6)12-8(21)7(20)5(2-18)22-12/h3,5,7-8,12,18,20-21H,2H2,1H3,(H2,13,15,16)/t5-,7-,8-,12?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50368391
PNG
(CHEMBL606230)
Show SMILES CCc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C12H17N5O4/c1-2-6-15-10(13)7-11(16-6)17(4-14-7)12-9(20)8(19)5(3-18)21-12/h4-5,8-9,12,18-20H,2-3H2,1H3,(H2,13,15,16)/t5-,8-,9-,12?/m1/s1
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>567n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50455635
PNG
(CHEMBL2113508)
Show SMILES C[Si](C)(C)C#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C15H21N5O4Si/c1-25(2,3)5-4-9-18-13(16)10-14(19-9)20(7-17-10)15-12(23)11(22)8(6-21)24-15/h7-8,11-12,15,21-23H,6H2,1-3H3,(H2,16,18,19)/t8-,11-,12-,15-/m1/s1
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 630n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM82022
PNG
(2-(Phenylamino)ado (CV-1808) | 2-[6-Amino-2-(3-cyc...)
Show SMILES Nc1nc(Nc2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1
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 780n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM35804
PNG
((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(NCCc3ccc(CCC(O)=O)cc3)nc12
Show InChI InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1
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 1.23E+3n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50455633
PNG
(CHEMBL2113523)
Show SMILES CCCCCCCCOCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C22H33N5O5/c1-2-3-4-5-6-8-11-31-12-9-7-10-16-25-20(23)17-21(26-16)27(14-24-17)22-19(30)18(29)15(13-28)32-22/h14-15,18-19,22,28-30H,2-6,8-9,11-13H2,1H3,(H2,23,25,26)/t15-,18-,19-,22-/m1/s1
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PubMed
 1.50E+3n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand

J Med Chem 35: 241-52 (1992)


BindingDB Entry DOI: 10.7270/Q20C4WD2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%