Affinity Data by PubMed id=17376430

PubMed code 17376430

Found 19 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50326005 (4,4'-(1H-indazol-6-ylazanediyl)bis(methylene)diben...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50326005 (4,4'-(1H-indazol-6-ylazanediyl)bis(methylene)diben...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human GST-fused Src-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50326008 (4-((7,7a-dihydrobenzo[d][1,3]dioxol-5-ylamino)meth...) Show SMILES CC(=O)Oc1ccc(CNc2ccc3OCOc3c2)cc1OC(C)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50326004 (4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol \|...) Show SMILES Oc1ccc(CNc2ccc3cn[nH]c3c2)cc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50326007 (4,4'-(naphthalen-2-ylazanediyl)bis(methylene)diben...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50326003 (4-((benzo[d][1,3]dioxol-5-ylamino)methyl)benzene-1...) Show SMILES Oc1ccc(CNc2ccc3OCOc3c2)cc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50326003 (4-((benzo[d][1,3]dioxol-5-ylamino)methyl)benzene-1...) Show SMILES Oc1ccc(CNc2ccc3OCOc3c2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human GST-fused Src-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50326003 (4-((benzo[d][1,3]dioxol-5-ylamino)methyl)benzene-1...) Show SMILES Oc1ccc(CNc2ccc3OCOc3c2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50326004 (4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol \|...) Show SMILES Oc1ccc(CNc2ccc3cn[nH]c3c2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50326007 (4,4'-(naphthalen-2-ylazanediyl)bis(methylene)diben...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of IGF1R-mediated colony formation in human LNCaP cells after 12 days by MTT assay				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50326006 (4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol \|...) Show SMILES Oc1ccc(CNc2ccc3ccccc3c2)cc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50326006 (4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol \|...) Show SMILES Oc1ccc(CNc2ccc3ccccc3c2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of IGF1R-mediated colony formation in human MCF7 cells after 12 days by MTT assay				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of IGF1R-mediated colony formation in human PC3 cells after 12 days by MTT assay				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50326008 (4-((7,7a-dihydrobenzo[d][1,3]dioxol-5-ylamino)meth...) Show SMILES CC(=O)Oc1ccc(CNc2ccc3OCOc3c2)cc1OC(C)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%