Found 35 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human)) | BDBM50292292
((E)-2-hydroxy-5-(5-(3-((1-hydroxy-2,2,6,6-tetramet...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C23H27N2O6/c1-22(2)12-15(13-23(3,4)25(22)30)24-20(27)10-7-16-6-9-19(31-16)14-5-8-18(26)17(11-14)21(28)29/h5-11,15,26H,12-13H2,1-4H3,(H,24,27)(H,28,29)/b10-7+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of HePTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Dual specificity protein phosphatase 3
(Homo sapiens (Human)) | BDBM50292292
((E)-2-hydroxy-5-(5-(3-((1-hydroxy-2,2,6,6-tetramet...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C23H27N2O6/c1-22(2)12-15(13-23(3,4)25(22)30)24-20(27)10-7-16-6-9-19(31-16)14-5-8-18(26)17(11-14)21(28)29/h5-11,15,26H,12-13H2,1-4H3,(H,24,27)(H,28,29)/b10-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of VHR |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50292292
((E)-2-hydroxy-5-(5-(3-((1-hydroxy-2,2,6,6-tetramet...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C23H27N2O6/c1-22(2)12-15(13-23(3,4)25(22)30)24-20(27)10-7-16-6-9-19(31-16)14-5-8-18(26)17(11-14)21(28)29/h5-11,15,26H,12-13H2,1-4H3,(H,24,27)(H,28,29)/b10-7+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50292292
((E)-2-hydroxy-5-(5-(3-((1-hydroxy-2,2,6,6-tetramet...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C23H27N2O6/c1-22(2)12-15(13-23(3,4)25(22)30)24-20(27)10-7-16-6-9-19(31-16)14-5-8-18(26)17(11-14)21(28)29/h5-11,15,26H,12-13H2,1-4H3,(H,24,27)(H,28,29)/b10-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of CD45 |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50292292
((E)-2-hydroxy-5-(5-(3-((1-hydroxy-2,2,6,6-tetramet...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C23H27N2O6/c1-22(2)12-15(13-23(3,4)25(22)30)24-20(27)10-7-16-6-9-19(31-16)14-5-8-18(26)17(11-14)21(28)29/h5-11,15,26H,12-13H2,1-4H3,(H,24,27)(H,28,29)/b10-7+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of PTP1B |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Dual specificity protein phosphatase 3
(Homo sapiens (Human)) | BDBM50292298
((E)-2,2,6,6-tetramethyl-4-(3-(5-(3-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1cccc(c1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)11-9-18-8-10-19(30-18)15-6-5-7-17(12-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b11-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of VHR |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human)) | BDBM50292298
((E)-2,2,6,6-tetramethyl-4-(3-(5-(3-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1cccc(c1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)11-9-18-8-10-19(30-18)15-6-5-7-17(12-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b11-9+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.11E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of HePTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Dual specificity protein phosphatase 3
(Homo sapiens (Human)) | BDBM50292295
(2-hydroxy-5-(5-(((1-hydroxy-2,2,6,6-tetramethylpip...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NCc1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H27N2O5/c1-20(2)10-14(11-21(3,4)23(20)27)22-12-15-6-8-18(28-15)13-5-7-17(24)16(9-13)19(25)26/h5-9,14,22,24H,10-12H2,1-4H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.41E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of VHR |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50292298
((E)-2,2,6,6-tetramethyl-4-(3-(5-(3-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1cccc(c1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)11-9-18-8-10-19(30-18)15-6-5-7-17(12-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b11-9+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50292295
(2-hydroxy-5-(5-(((1-hydroxy-2,2,6,6-tetramethylpip...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NCc1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H27N2O5/c1-20(2)10-14(11-21(3,4)23(20)27)22-12-15-6-8-18(28-15)13-5-7-17(24)16(9-13)19(25)26/h5-9,14,22,24H,10-12H2,1-4H3,(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Dual specificity protein phosphatase 3
(Homo sapiens (Human)) | BDBM50292297
(CHEMBL227608 | Methyl 2-hydroxy-5-(5-(((1-hydroxy-...)Show SMILES COC(=O)c1cc(ccc1O)-c1ccc(CNC2CC(C)(C)N([O])C(C)(C)C2)o1 |^1:23| Show InChI InChI=1S/C22H29N2O5/c1-21(2)11-15(12-22(3,4)24(21)27)23-13-16-7-9-19(29-16)14-6-8-18(25)17(10-14)20(26)28-5/h6-10,15,23,25H,11-13H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of VHR |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50292293
(4-(5-((4-hydroxy-3-(methoxycarbonyl)phenyl)amino)-...)Show SMILES COC(=O)c1cc(NC(=O)CCCC(=O)NC2CC(C)(C)N([O])C(C)(C)C2)ccc1O |^1:22| Show InChI InChI=1S/C22H32N3O6/c1-21(2)12-15(13-22(3,4)25(21)30)24-19(28)8-6-7-18(27)23-14-9-10-17(26)16(11-14)20(29)31-5/h9-11,15,26H,6-8,12-13H2,1-5H3,(H,23,27)(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of CD45 |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Dual specificity protein phosphatase 3
(Homo sapiens (Human)) | BDBM50292293
(4-(5-((4-hydroxy-3-(methoxycarbonyl)phenyl)amino)-...)Show SMILES COC(=O)c1cc(NC(=O)CCCC(=O)NC2CC(C)(C)N([O])C(C)(C)C2)ccc1O |^1:22| Show InChI InChI=1S/C22H32N3O6/c1-21(2)12-15(13-22(3,4)25(21)30)24-19(28)8-6-7-18(27)23-14-9-10-17(26)16(11-14)20(29)31-5/h9-11,15,26H,6-8,12-13H2,1-5H3,(H,23,27)(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of VHR |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50292296
((E)-2,2,6,6-tetramethyl-4-(3-(5-(4-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)12-10-18-9-11-19(30-18)15-5-7-17(8-6-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b12-10+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of PTP1B |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50292293
(4-(5-((4-hydroxy-3-(methoxycarbonyl)phenyl)amino)-...)Show SMILES COC(=O)c1cc(NC(=O)CCCC(=O)NC2CC(C)(C)N([O])C(C)(C)C2)ccc1O |^1:22| Show InChI InChI=1S/C22H32N3O6/c1-21(2)12-15(13-22(3,4)25(21)30)24-19(28)8-6-7-18(27)23-14-9-10-17(26)16(11-14)20(29)31-5/h9-11,15,26H,6-8,12-13H2,1-5H3,(H,23,27)(H,24,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50292296
((E)-2,2,6,6-tetramethyl-4-(3-(5-(4-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)12-10-18-9-11-19(30-18)15-5-7-17(8-6-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b12-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of CD45 |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50292298
((E)-2,2,6,6-tetramethyl-4-(3-(5-(3-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1cccc(c1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)11-9-18-8-10-19(30-18)15-6-5-7-17(12-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b11-9+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of PTP1B |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50292294
(4-(5-((3-carboxy-4-hydroxyphenyl)amino)-5-oxopenta...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)CCCC(=O)Nc1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H30N3O6/c1-20(2)11-14(12-21(3,4)24(20)30)23-18(27)7-5-6-17(26)22-13-8-9-16(25)15(10-13)19(28)29/h8-10,14,25H,5-7,11-12H2,1-4H3,(H,22,26)(H,23,27)(H,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50292293
(4-(5-((4-hydroxy-3-(methoxycarbonyl)phenyl)amino)-...)Show SMILES COC(=O)c1cc(NC(=O)CCCC(=O)NC2CC(C)(C)N([O])C(C)(C)C2)ccc1O |^1:22| Show InChI InChI=1S/C22H32N3O6/c1-21(2)12-15(13-22(3,4)25(21)30)24-19(28)8-6-7-18(27)23-14-9-10-17(26)16(11-14)20(29)31-5/h9-11,15,26H,6-8,12-13H2,1-5H3,(H,23,27)(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of PTP1B |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Dual specificity protein phosphatase 3
(Homo sapiens (Human)) | BDBM50292294
(4-(5-((3-carboxy-4-hydroxyphenyl)amino)-5-oxopenta...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)CCCC(=O)Nc1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H30N3O6/c1-20(2)11-14(12-21(3,4)24(20)30)23-18(27)7-5-6-17(26)22-13-8-9-16(25)15(10-13)19(28)29/h8-10,14,25H,5-7,11-12H2,1-4H3,(H,22,26)(H,23,27)(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of VHR |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50292297
(CHEMBL227608 | Methyl 2-hydroxy-5-(5-(((1-hydroxy-...)Show SMILES COC(=O)c1cc(ccc1O)-c1ccc(CNC2CC(C)(C)N([O])C(C)(C)C2)o1 |^1:23| Show InChI InChI=1S/C22H29N2O5/c1-21(2)11-15(12-22(3,4)24(21)27)23-13-16-7-9-19(29-16)14-6-8-18(25)17(10-14)20(26)28-5/h6-10,15,23,25H,11-13H2,1-5H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of PTP1B |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human)) | BDBM50292294
(4-(5-((3-carboxy-4-hydroxyphenyl)amino)-5-oxopenta...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)CCCC(=O)Nc1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H30N3O6/c1-20(2)11-14(12-21(3,4)24(20)30)23-18(27)7-5-6-17(26)22-13-8-9-16(25)15(10-13)19(28)29/h8-10,14,25H,5-7,11-12H2,1-4H3,(H,22,26)(H,23,27)(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of HePTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50292295
(2-hydroxy-5-(5-(((1-hydroxy-2,2,6,6-tetramethylpip...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NCc1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H27N2O5/c1-20(2)10-14(11-21(3,4)23(20)27)22-12-15-6-8-18(28-15)13-5-7-17(24)16(9-13)19(25)26/h5-9,14,22,24H,10-12H2,1-4H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of CD45 |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50292297
(CHEMBL227608 | Methyl 2-hydroxy-5-(5-(((1-hydroxy-...)Show SMILES COC(=O)c1cc(ccc1O)-c1ccc(CNC2CC(C)(C)N([O])C(C)(C)C2)o1 |^1:23| Show InChI InChI=1S/C22H29N2O5/c1-21(2)11-15(12-22(3,4)24(21)27)23-13-16-7-9-19(29-16)14-6-8-18(25)17(10-14)20(26)28-5/h6-10,15,23,25H,11-13H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of CD45 |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50292294
(4-(5-((3-carboxy-4-hydroxyphenyl)amino)-5-oxopenta...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)CCCC(=O)Nc1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H30N3O6/c1-20(2)11-14(12-21(3,4)24(20)30)23-18(27)7-5-6-17(26)22-13-8-9-16(25)15(10-13)19(28)29/h8-10,14,25H,5-7,11-12H2,1-4H3,(H,22,26)(H,23,27)(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of CD45 |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50292295
(2-hydroxy-5-(5-(((1-hydroxy-2,2,6,6-tetramethylpip...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NCc1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H27N2O5/c1-20(2)10-14(11-21(3,4)23(20)27)22-12-15-6-8-18(28-15)13-5-7-17(24)16(9-13)19(25)26/h5-9,14,22,24H,10-12H2,1-4H3,(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of PTP1B |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50292297
(CHEMBL227608 | Methyl 2-hydroxy-5-(5-(((1-hydroxy-...)Show SMILES COC(=O)c1cc(ccc1O)-c1ccc(CNC2CC(C)(C)N([O])C(C)(C)C2)o1 |^1:23| Show InChI InChI=1S/C22H29N2O5/c1-21(2)11-15(12-22(3,4)24(21)27)23-13-16-7-9-19(29-16)14-6-8-18(25)17(10-14)20(26)28-5/h6-10,15,23,25H,11-13H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human)) | BDBM50292293
(4-(5-((4-hydroxy-3-(methoxycarbonyl)phenyl)amino)-...)Show SMILES COC(=O)c1cc(NC(=O)CCCC(=O)NC2CC(C)(C)N([O])C(C)(C)C2)ccc1O |^1:22| Show InChI InChI=1S/C22H32N3O6/c1-21(2)12-15(13-22(3,4)25(21)30)24-19(28)8-6-7-18(27)23-14-9-10-17(26)16(11-14)20(29)31-5/h9-11,15,26H,6-8,12-13H2,1-5H3,(H,23,27)(H,24,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of HePTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human)) | BDBM50292295
(2-hydroxy-5-(5-(((1-hydroxy-2,2,6,6-tetramethylpip...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NCc1ccc(o1)-c1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H27N2O5/c1-20(2)10-14(11-21(3,4)23(20)27)22-12-15-6-8-18(28-15)13-5-7-17(24)16(9-13)19(25)26/h5-9,14,22,24H,10-12H2,1-4H3,(H,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of HePTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Dual specificity protein phosphatase 3
(Homo sapiens (Human)) | BDBM50292296
((E)-2,2,6,6-tetramethyl-4-(3-(5-(4-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)12-10-18-9-11-19(30-18)15-5-7-17(8-6-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b12-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of VHR |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50292294
(4-(5-((3-carboxy-4-hydroxyphenyl)amino)-5-oxopenta...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)CCCC(=O)Nc1ccc(O)c(c1)C(O)=O |^1:10| Show InChI InChI=1S/C21H30N3O6/c1-20(2)11-14(12-21(3,4)24(20)30)23-18(27)7-5-6-17(26)22-13-8-9-16(25)15(10-13)19(28)29/h8-10,14,25H,5-7,11-12H2,1-4H3,(H,22,26)(H,23,27)(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of PTP1B |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase C
(Homo sapiens (Human)) | BDBM50292298
((E)-2,2,6,6-tetramethyl-4-(3-(5-(3-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1cccc(c1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)11-9-18-8-10-19(30-18)15-6-5-7-17(12-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b11-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of CD45 |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human)) | BDBM50292297
(CHEMBL227608 | Methyl 2-hydroxy-5-(5-(((1-hydroxy-...)Show SMILES COC(=O)c1cc(ccc1O)-c1ccc(CNC2CC(C)(C)N([O])C(C)(C)C2)o1 |^1:23| Show InChI InChI=1S/C22H29N2O5/c1-21(2)11-15(12-22(3,4)24(21)27)23-13-16-7-9-19(29-16)14-6-8-18(25)17(10-14)20(26)28-5/h6-10,15,23,25H,11-13H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of HePTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50292296
((E)-2,2,6,6-tetramethyl-4-(3-(5-(4-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)12-10-18-9-11-19(30-18)15-5-7-17(8-6-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b12-10+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 7
(Homo sapiens (Human)) | BDBM50292296
((E)-2,2,6,6-tetramethyl-4-(3-(5-(4-nitrophenyl)fur...)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)\C=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O |^1:10| Show InChI InChI=1S/C22H26N3O5/c1-21(2)13-16(14-22(3,4)25(21)29)23-20(26)12-10-18-9-11-19(30-18)15-5-7-17(8-6-15)24(27)28/h5-12,16H,13-14H2,1-4H3,(H,23,26)/b12-10+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description
Inhibition of HePTP |
J Med Chem 50: 2137-43 (2007)
Article DOI: 10.1021/jm061481l
BindingDB Entry DOI: 10.7270/Q2BG2NP4 |
More data for this
Ligand-Target Pair | |
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