Affinity Data by PubMed id=17395460

PubMed code 17395460

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM24089 ((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209228 ((S)-2-(3-aminopropyl)-4-(2,5-difluorophenyl)-N,N-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209230 ((S)-2-((S)-3-amino-4,4-difluorobutyl)-4-(2,5-diflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209232 ((S)-4-(2,5-difluorophenyl)-2-(3-(2-fluoroethylamin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209227 ((S)-4-(2,5-difluorophenyl)-2-(3-(ethylamino)propyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209229 ((S)-2-(3-(2,2-difluoroethylamino)propyl)-4-(2,5-di...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209228 ((S)-2-(3-aminopropyl)-4-(2,5-difluorophenyl)-N,N-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP in KBV1 cells overexpressing Pgp				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209230 ((S)-2-((S)-3-amino-4,4-difluorobutyl)-4-(2,5-diflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP in KB31 cells				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209231 ((S)-4-(2,5-difluorophenyl)-N,N-dimethyl-2-phenyl-2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50209230 ((S)-2-((S)-3-amino-4,4-difluorobutyl)-4-(2,5-diflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KSP in KBV1 cells overexpressing Pgp				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50209228 ((S)-2-(3-aminopropyl)-4-(2,5-difluorophenyl)-N,N-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of hERG expressed in CHO cells by cell voltage clamp assay				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50209230 ((S)-2-((S)-3-amino-4,4-difluorobutyl)-4-(2,5-diflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of hERG expressed in CHO cells by cell voltage clamp assay				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24089 ((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of hERG expressed in CHO cells by cell voltage clamp assay				Bioorg Med Chem Lett 17: 2697-702 (2007) Article DOI: 10.1016/j.bmcl.2007.03.006 BindingDB Entry DOI: 10.7270/Q26Q1WXZ
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%