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PubMed code 17428659

Compile data set for download or QSAR
Found 192 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210400
PNG
(1-((2-ethylphenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES CCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C26H29NO/c1-2-21-11-9-10-16-24(21)25(22-12-5-3-6-13-22)27-19-17-26(28,18-20-27)23-14-7-4-8-15-23/h3-16,25,28H,2,17-20H2,1H3
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0.600n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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0.700n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I][14Tyr]nociceptin FQ from human cloned NOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210393
PNG
(1-((2-methoxyphenyl)(phenyl)methyl)-4-phenylpiperi...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c1-28-23-15-9-8-14-22(23)24(20-10-4-2-5-11-20)26-18-16-25(27,17-19-26)21-12-6-3-7-13-21/h2-15,24,27H,16-19H2,1H3
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1n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210375
PNG
(1-(bis(2-chlorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C24H23Cl2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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2n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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2n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I][14Tyr]nociceptin FQ from human cloned NOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210389
PNG
(1-(bis(2-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1OC
Show InChI InChI=1S/C26H29NO3/c1-29-23-14-8-6-12-21(23)25(22-13-7-9-15-24(22)30-2)27-18-16-26(28,17-19-27)20-10-4-3-5-11-20/h3-15,25,28H,16-19H2,1-2H3
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3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210392
PNG
(4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1cccc(c1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-9-8-12-22(19-20)24(21-10-4-2-5-11-21)26-17-15-25(27,16-18-26)23-13-6-3-7-14-23/h2-14,19,24,27H,15-18H2,1H3
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3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210404
PNG
(1-((2-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Cl)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210387
PNG
(1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol | CHEMB...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C26H29NO/c1-20-10-6-8-14-23(20)25(24-15-9-7-11-21(24)2)27-18-16-26(28,17-19-27)22-12-4-3-5-13-22/h3-15,25,28H,16-19H2,1-2H3
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4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210398
PNG
(1-((2-fluorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1F)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24FNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210377
PNG
(4-phenyl-1-(1-phenylpentyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C22H29NO/c1-2-3-14-21(19-10-6-4-7-11-19)23-17-15-22(24,16-18-23)20-12-8-5-9-13-20/h4-13,21,24H,2-3,14-18H2,1H3
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5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210415
PNG
(1-(bis(2-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1F)c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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6n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210394
PNG
(1-((2-(hydroxymethyl)phenyl)(phenyl)methyl)-4-phen...)
Show SMILES OCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c27-19-21-11-7-8-14-23(21)24(20-9-3-1-4-10-20)26-17-15-25(28,16-18-26)22-12-5-2-6-13-22/h1-14,24,27-28H,15-19H2
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9n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210407
PNG
(1-(4-methyl-1-phenylpentyl)-4-phenylpiperidin-4-ol...)
Show SMILES CC(C)CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-19(2)13-14-22(20-9-5-3-6-10-20)24-17-15-23(25,16-18-24)21-11-7-4-8-12-21/h3-12,19,22,25H,13-18H2,1-2H3
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9n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210400
PNG
(1-((2-ethylphenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES CCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C26H29NO/c1-2-21-11-9-10-16-24(21)25(22-12-5-3-6-13-22)27-19-17-26(28,18-20-27)23-14-7-4-8-15-23/h3-16,25,28H,2,17-20H2,1H3
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9n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210391
PNG
(1-((2-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Br)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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11n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210395
PNG
(4-phenyl-1-(phenyl(2-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)29-17-15-24(30,16-18-29)20-11-5-2-6-12-20/h1-14,23,30H,15-18H2
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12n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210223
PNG
(1-benzhydryl-4-phenylpiperidin-4-ol | CHEMBL228690)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO/c26-24(22-14-8-3-9-15-22)16-18-25(19-17-24)23(20-10-4-1-5-11-20)21-12-6-2-7-13-21/h1-15,23,26H,16-19H2
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13n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210418
PNG
(4-phenyl-1-(1-phenylhexyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-2-3-6-15-22(20-11-7-4-8-12-20)24-18-16-23(25,17-19-24)21-13-9-5-10-14-21/h4-5,7-14,22,25H,2-3,6,15-19H2,1H3
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14n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210403
PNG
(1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol | CHE...)
Show SMILES OC1(CCN(CC1)C(Cc1ccccc1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c27-25(23-14-8-3-9-15-23)16-18-26(19-17-25)24(22-12-6-2-7-13-22)20-21-10-4-1-5-11-21/h1-15,24,27H,16-20H2
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16n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210397
PNG
(4-phenyl-1-(1-phenylheptyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:6.5|
Show InChI InChI=1S/C24H33NO/c1-2-3-4-11-16-23(21-12-7-5-8-13-21)25-19-17-24(26,18-20-25)22-14-9-6-10-15-22/h5-10,12-15,23,26H,2-4,11,16-20H2,1H3
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18n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210405
PNG
(4-phenyl-1-(1-phenylbutyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C21H27NO/c1-2-9-20(18-10-5-3-6-11-18)22-16-14-21(23,15-17-22)19-12-7-4-8-13-19/h3-8,10-13,20,23H,2,9,14-17H2,1H3
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19n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210422
PNG
(1-(bis(2-bromophenyl)methyl)-4-phenylpiperidin-4-o...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1Br)c1ccccc1Br)c1ccccc1
Show InChI InChI=1S/C24H23Br2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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21n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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23n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210403
PNG
(1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol | CHE...)
Show SMILES OC1(CCN(CC1)C(Cc1ccccc1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c27-25(23-14-8-3-9-15-23)16-18-26(19-17-25)24(22-12-6-2-7-13-22)20-21-10-4-1-5-11-21/h1-15,24,27H,16-20H2
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24n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210414
PNG
(1-((3-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(Cl)c1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)26-16-14-24(27,15-17-26)21-11-5-2-6-12-21/h1-13,18,23,27H,14-17H2
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26n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210393
PNG
(1-((2-methoxyphenyl)(phenyl)methyl)-4-phenylpiperi...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c1-28-23-15-9-8-14-22(23)24(20-10-4-2-5-11-20)26-18-16-25(27,17-19-26)21-12-6-3-7-13-21/h2-15,24,27H,16-19H2,1H3
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28n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210377
PNG
(4-phenyl-1-(1-phenylpentyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C22H29NO/c1-2-3-14-21(19-10-6-4-7-11-19)23-17-15-22(24,16-18-23)20-12-8-5-9-13-20/h4-13,21,24H,2-3,14-18H2,1H3
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29n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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35n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210399
PNG
(4-phenyl-1-(phenyl(thiophen-2-yl)methyl)piperidin-...)
Show SMILES OC1(CCN(CC1)C(c1cccs1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C22H23NOS/c24-22(19-10-5-2-6-11-19)13-15-23(16-14-22)21(20-12-7-17-25-20)18-8-3-1-4-9-18/h1-12,17,21,24H,13-16H2
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35n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210377
PNG
(4-phenyl-1-(1-phenylpentyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C22H29NO/c1-2-3-14-21(19-10-6-4-7-11-19)23-17-15-22(24,16-18-23)20-12-8-5-9-13-20/h4-13,21,24H,2-3,14-18H2,1H3
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36n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210418
PNG
(4-phenyl-1-(1-phenylhexyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-2-3-6-15-22(20-11-7-4-8-12-20)24-18-16-23(25,17-19-24)21-13-9-5-10-14-21/h4-5,7-14,22,25H,2-3,6,15-19H2,1H3
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37n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210386
PNG
(1-(cyclopentyl(phenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(C1CCCC1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H29NO/c25-23(21-13-5-2-6-14-21)15-17-24(18-16-23)22(20-11-7-8-12-20)19-9-3-1-4-10-19/h1-6,9-10,13-14,20,22,25H,7-8,11-12,15-18H2
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41n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210396
PNG
(1-(bis(4-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-10-6-18(7-11-21)23(19-8-12-22(26)13-9-19)27-16-14-24(28,15-17-27)20-4-2-1-3-5-20/h1-13,23,28H,14-17H2
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42n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210385
PNG
(4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-12-14-22(15-13-20)24(21-8-4-2-5-9-21)26-18-16-25(27,17-19-26)23-10-6-3-7-11-23/h2-15,24,27H,16-19H2,1H3
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53n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210388
PNG
(1-benzhydryl-4-methoxy-4-phenylpiperidine | CHEMBL...)
Show SMILES COC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO/c1-27-25(23-15-9-4-10-16-23)17-19-26(20-18-25)24(21-11-5-2-6-12-21)22-13-7-3-8-14-22/h2-16,24H,17-20H2,1H3
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54n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210378
PNG
(1-benzhydryl-4-ethoxy-4-phenylpiperidine | CHEMBL2...)
Show SMILES CCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H29NO/c1-2-28-26(24-16-10-5-11-17-24)18-20-27(21-19-26)25(22-12-6-3-7-13-22)23-14-8-4-9-15-23/h3-17,25H,2,18-21H2,1H3
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59n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210401
PNG
(1-benzhydryl-4-phenyl-4-propoxypiperidine | CHEMBL...)
Show SMILES CCCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31NO/c1-2-22-29-27(25-16-10-5-11-17-25)18-20-28(21-19-27)26(23-12-6-3-7-13-23)24-14-8-4-9-15-24/h3-17,26H,2,18-22H2,1H3
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72n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210394
PNG
(1-((2-(hydroxymethyl)phenyl)(phenyl)methyl)-4-phen...)
Show SMILES OCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c27-19-21-11-7-8-14-23(21)24(20-9-3-1-4-10-20)26-17-15-25(28,16-18-26)22-12-5-2-6-13-22/h1-14,24,27-28H,15-19H2
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120n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210396
PNG
(1-(bis(4-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-10-6-18(7-11-21)23(19-8-12-22(26)13-9-19)27-16-14-24(28,15-17-27)20-4-2-1-3-5-20/h1-13,23,28H,14-17H2
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123n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210407
PNG
(1-(4-methyl-1-phenylpentyl)-4-phenylpiperidin-4-ol...)
Show SMILES CC(C)CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-19(2)13-14-22(20-9-5-3-6-10-20)24-17-15-23(25,16-18-24)21-11-7-4-8-12-21/h3-12,19,22,25H,13-18H2,1-2H3
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125n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210374
PNG
(1-((4-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Br)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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125n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210395
PNG
(4-phenyl-1-(phenyl(2-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)29-17-15-24(30,16-18-29)20-11-5-2-6-12-20/h1-14,23,30H,15-18H2
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127n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210410
PNG
(1-((4-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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132n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210419
PNG
(1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol ...)
Show SMILES CCOCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C21H27NO2/c1-2-24-17-20(18-9-5-3-6-10-18)22-15-13-21(23,14-16-22)19-11-7-4-8-12-19/h3-12,20,23H,2,13-17H2,1H3
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134n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210384
PNG
(4-phenyl-1-(1-phenylpropyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:2.1|
Show InChI InChI=1S/C20H25NO/c1-2-19(17-9-5-3-6-10-17)21-15-13-20(22,14-16-21)18-11-7-4-8-12-18/h3-12,19,22H,2,13-16H2,1H3
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135n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210397
PNG
(4-phenyl-1-(1-phenylheptyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:6.5|
Show InChI InChI=1S/C24H33NO/c1-2-3-4-11-16-23(21-12-7-5-8-13-21)25-19-17-24(26,18-20-25)22-14-9-6-10-15-22/h5-10,12-15,23,26H,2-4,11,16-20H2,1H3
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144n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210392
PNG
(4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1cccc(c1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-9-8-12-22(19-20)24(21-10-4-2-5-11-21)26-17-15-25(27,16-18-26)23-13-6-3-7-14-23/h2-14,19,24,27H,15-18H2,1H3
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147n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210415
PNG
(1-(bis(2-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1F)c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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148n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210379
PNG
(1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine | CH...)
Show SMILES C(OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H31NO/c1-5-13-26(14-6-1)25-33-31(29-19-11-4-12-20-29)21-23-32(24-22-31)30(27-15-7-2-8-16-27)28-17-9-3-10-18-28/h1-20,30H,21-25H2
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162n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210410
PNG
(1-((4-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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164n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210391
PNG
(1-((2-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Br)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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170n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210398
PNG
(1-((2-fluorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1F)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24FNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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177n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210396
PNG
(1-(bis(4-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-10-6-18(7-11-21)23(19-8-12-22(26)13-9-19)27-16-14-24(28,15-17-27)20-4-2-1-3-5-20/h1-13,23,28H,14-17H2
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183n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210418
PNG
(4-phenyl-1-(1-phenylhexyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-2-3-6-15-22(20-11-7-4-8-12-20)24-18-16-23(25,17-19-24)21-13-9-5-10-14-21/h4-5,7-14,22,25H,2-3,6,15-19H2,1H3
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184n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210407
PNG
(1-(4-methyl-1-phenylpentyl)-4-phenylpiperidin-4-ol...)
Show SMILES CC(C)CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-19(2)13-14-22(20-9-5-3-6-10-20)24-17-15-23(25,16-18-24)21-11-7-4-8-12-21/h3-12,19,22,25H,13-18H2,1-2H3
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185n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210403
PNG
(1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol | CHE...)
Show SMILES OC1(CCN(CC1)C(Cc1ccccc1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c27-25(23-14-8-3-9-15-23)16-18-26(19-17-25)24(22-12-6-2-7-13-22)20-21-10-4-1-5-11-21/h1-15,24,27H,16-20H2
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187n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210414
PNG
(1-((3-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(Cl)c1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)26-16-14-24(27,15-17-26)21-11-5-2-6-12-21/h1-13,18,23,27H,14-17H2
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201n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210411
PNG
(4-phenyl-1-(phenyl(pyridin-2-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccn1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(20-11-5-2-6-12-20)14-17-25(18-15-23)22(19-9-3-1-4-10-19)21-13-7-8-16-24-21/h1-13,16,22,26H,14-15,17-18H2
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214n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210418
PNG
(4-phenyl-1-(1-phenylhexyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-2-3-6-15-22(20-11-7-4-8-12-20)24-18-16-23(25,17-19-24)21-13-9-5-10-14-21/h4-5,7-14,22,25H,2-3,6,15-19H2,1H3
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220n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210413
PNG
(4-phenyl-1-(phenyl(4-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)29-17-15-24(30,16-18-29)21-9-5-2-6-10-21/h1-14,23,30H,15-18H2
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225n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210223
PNG
(1-benzhydryl-4-phenylpiperidin-4-ol | CHEMBL228690)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO/c26-24(22-14-8-3-9-15-22)16-18-25(19-17-24)23(20-10-4-1-5-11-20)21-12-6-2-7-13-21/h1-15,23,26H,16-19H2
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233n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210400
PNG
(1-((2-ethylphenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES CCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C26H29NO/c1-2-21-11-9-10-16-24(21)25(22-12-5-3-6-13-22)27-19-17-26(28,18-20-27)23-14-7-4-8-15-23/h3-16,25,28H,2,17-20H2,1H3
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237n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210405
PNG
(4-phenyl-1-(1-phenylbutyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C21H27NO/c1-2-9-20(18-10-5-3-6-11-18)22-16-14-21(23,15-17-22)19-12-7-4-8-13-19/h3-8,10-13,20,23H,2,9,14-17H2,1H3
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245n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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246n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210375
PNG
(1-(bis(2-chlorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C24H23Cl2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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256n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210403
PNG
(1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol | CHE...)
Show SMILES OC1(CCN(CC1)C(Cc1ccccc1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c27-25(23-14-8-3-9-15-23)16-18-26(19-17-25)24(22-12-6-2-7-13-22)20-21-10-4-1-5-11-21/h1-15,24,27H,16-20H2
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288n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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295n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210408
PNG
(1-(2-methoxy-1-phenylethyl)-4-phenylpiperidin-4-ol...)
Show SMILES COCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C20H25NO2/c1-23-16-19(17-8-4-2-5-9-17)21-14-12-20(22,13-15-21)18-10-6-3-7-11-18/h2-11,19,22H,12-16H2,1H3
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295n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210389
PNG
(1-(bis(2-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1OC
Show InChI InChI=1S/C26H29NO3/c1-29-23-14-8-6-12-21(23)25(22-13-7-9-15-24(22)30-2)27-18-16-26(28,17-19-27)20-10-4-3-5-11-20/h3-15,25,28H,16-19H2,1-2H3
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306n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210386
PNG
(1-(cyclopentyl(phenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(C1CCCC1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H29NO/c25-23(21-13-5-2-6-14-21)15-17-24(18-16-23)22(20-11-7-8-12-20)19-9-3-1-4-10-19/h1-6,9-10,13-14,20,22,25H,7-8,11-12,15-18H2
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312n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210380
PNG
(4-phenyl-1-(1-phenylethyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C19H23NO/c1-16(17-8-4-2-5-9-17)20-14-12-19(21,13-15-20)18-10-6-3-7-11-18/h2-11,16,21H,12-15H2,1H3
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323n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210417
PNG
(4-phenyl-1-(phenyl(pyridin-3-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccnc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-5-2-6-12-21)13-16-25(17-14-23)22(19-8-3-1-4-9-19)20-10-7-15-24-18-20/h1-12,15,18,22,26H,13-14,16-17H2
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323n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210397
PNG
(4-phenyl-1-(1-phenylheptyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:6.5|
Show InChI InChI=1S/C24H33NO/c1-2-3-4-11-16-23(21-12-7-5-8-13-21)25-19-17-24(26,18-20-25)22-14-9-6-10-15-22/h5-10,12-15,23,26H,2-4,11,16-20H2,1H3
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335n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210405
PNG
(4-phenyl-1-(1-phenylbutyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C21H27NO/c1-2-9-20(18-10-5-3-6-11-18)22-16-14-21(23,15-17-22)19-12-7-4-8-13-19/h3-8,10-13,20,23H,2,9,14-17H2,1H3
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341n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210388
PNG
(1-benzhydryl-4-methoxy-4-phenylpiperidine | CHEMBL...)
Show SMILES COC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO/c1-27-25(23-15-9-4-10-16-23)17-19-26(20-18-25)24(21-11-5-2-6-12-21)22-13-7-3-8-14-22/h2-16,24H,17-20H2,1H3
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343n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210407
PNG
(1-(4-methyl-1-phenylpentyl)-4-phenylpiperidin-4-ol...)
Show SMILES CC(C)CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:5.4|
Show InChI InChI=1S/C23H31NO/c1-19(2)13-14-22(20-9-5-3-6-10-20)24-17-15-23(25,16-18-24)21-11-7-4-8-12-21/h3-12,19,22,25H,13-18H2,1-2H3
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348n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210376
PNG
(4-phenyl-1-(phenyl(3-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(c1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)29-16-14-24(30,15-17-29)21-11-5-2-6-12-21/h1-13,18,23,30H,14-17H2
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357n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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361n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210223
PNG
(1-benzhydryl-4-phenylpiperidin-4-ol | CHEMBL228690)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO/c26-24(22-14-8-3-9-15-22)16-18-25(19-17-24)23(20-10-4-1-5-11-20)21-12-6-2-7-13-21/h1-15,23,26H,16-19H2
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364n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210378
PNG
(1-benzhydryl-4-ethoxy-4-phenylpiperidine | CHEMBL2...)
Show SMILES CCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H29NO/c1-2-28-26(24-16-10-5-11-17-24)18-20-27(21-19-26)25(22-12-6-3-7-13-22)23-14-8-4-9-15-23/h3-17,25H,2,18-21H2,1H3
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377n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210399
PNG
(4-phenyl-1-(phenyl(thiophen-2-yl)methyl)piperidin-...)
Show SMILES OC1(CCN(CC1)C(c1cccs1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C22H23NOS/c24-22(19-10-5-2-6-11-19)13-15-23(16-14-22)21(20-12-7-17-25-20)18-8-3-1-4-9-18/h1-12,17,21,24H,13-16H2
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405n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210388
PNG
(1-benzhydryl-4-methoxy-4-phenylpiperidine | CHEMBL...)
Show SMILES COC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO/c1-27-25(23-15-9-4-10-16-23)17-19-26(20-18-25)24(21-11-5-2-6-12-21)22-13-7-3-8-14-22/h2-16,24H,17-20H2,1H3
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412n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210412
PNG
(1-(bis(4-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H29NO3/c1-29-23-12-8-20(9-13-23)25(21-10-14-24(30-2)15-11-21)27-18-16-26(28,17-19-27)22-6-4-3-5-7-22/h3-15,25,28H,16-19H2,1-2H3
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439n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210377
PNG
(4-phenyl-1-(1-phenylpentyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C22H29NO/c1-2-3-14-21(19-10-6-4-7-11-19)23-17-15-22(24,16-18-23)20-12-8-5-9-13-20/h4-13,21,24H,2-3,14-18H2,1H3
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441n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210419
PNG
(1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol ...)
Show SMILES CCOCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C21H27NO2/c1-2-24-17-20(18-9-5-3-6-10-18)22-15-13-21(23,14-16-22)19-11-7-4-8-12-19/h3-12,20,23H,2,13-17H2,1H3
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451n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210378
PNG
(1-benzhydryl-4-ethoxy-4-phenylpiperidine | CHEMBL2...)
Show SMILES CCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H29NO/c1-2-28-26(24-16-10-5-11-17-24)18-20-27(21-19-26)25(22-12-6-3-7-13-22)23-14-8-4-9-15-23/h3-17,25H,2,18-21H2,1H3
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488n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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503n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210393
PNG
(1-((2-methoxyphenyl)(phenyl)methyl)-4-phenylpiperi...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c1-28-23-15-9-8-14-22(23)24(20-10-4-2-5-11-20)26-18-16-25(27,17-19-26)21-12-6-3-7-13-21/h2-15,24,27H,16-19H2,1H3
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519n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210400
PNG
(1-((2-ethylphenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES CCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C26H29NO/c1-2-21-11-9-10-16-24(21)25(22-12-5-3-6-13-22)27-19-17-26(28,18-20-27)23-14-7-4-8-15-23/h3-16,25,28H,2,17-20H2,1H3
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535n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210397
PNG
(4-phenyl-1-(1-phenylheptyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCCCCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:6.5|
Show InChI InChI=1S/C24H33NO/c1-2-3-4-11-16-23(21-12-7-5-8-13-21)25-19-17-24(26,18-20-25)22-14-9-6-10-15-22/h5-10,12-15,23,26H,2-4,11,16-20H2,1H3
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550n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210396
PNG
(1-(bis(4-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-10-6-18(7-11-21)23(19-8-12-22(26)13-9-19)27-16-14-24(28,15-17-27)20-4-2-1-3-5-20/h1-13,23,28H,14-17H2
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584n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210404
PNG
(1-((2-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Cl)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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609n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210402
PNG
(1-(3,3-diphenylpropyl)-4-phenylpiperidin-4-ol | CH...)
Show SMILES OC1(CCN(CCC(c2ccccc2)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C26H29NO/c28-26(24-14-8-3-9-15-24)17-20-27(21-18-26)19-16-25(22-10-4-1-5-11-22)23-12-6-2-7-13-23/h1-15,25,28H,16-21H2
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613n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210375
PNG
(1-(bis(2-chlorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C24H23Cl2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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635n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210376
PNG
(4-phenyl-1-(phenyl(3-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(c1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)29-16-14-24(30,15-17-29)21-11-5-2-6-12-21/h1-13,18,23,30H,14-17H2
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714n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210408
PNG
(1-(2-methoxy-1-phenylethyl)-4-phenylpiperidin-4-ol...)
Show SMILES COCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C20H25NO2/c1-23-16-19(17-8-4-2-5-9-17)21-14-12-20(22,13-15-21)18-10-6-3-7-11-18/h2-11,19,22H,12-16H2,1H3
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780n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210386
PNG
(1-(cyclopentyl(phenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(C1CCCC1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H29NO/c25-23(21-13-5-2-6-14-21)15-17-24(18-16-23)22(20-11-7-8-12-20)19-9-3-1-4-10-19/h1-6,9-10,13-14,20,22,25H,7-8,11-12,15-18H2
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787n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210410
PNG
(1-((4-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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793n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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802n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210417
PNG
(4-phenyl-1-(phenyl(pyridin-3-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccnc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-5-2-6-12-21)13-16-25(17-14-23)22(19-8-3-1-4-9-19)20-10-7-15-24-18-20/h1-12,15,18,22,26H,13-14,16-17H2
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819n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210412
PNG
(1-(bis(4-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H29NO3/c1-29-23-12-8-20(9-13-23)25(21-10-14-24(30-2)15-11-21)27-18-16-26(28,17-19-27)22-6-4-3-5-7-22/h3-15,25,28H,16-19H2,1-2H3
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843n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210389
PNG
(1-(bis(2-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1OC
Show InChI InChI=1S/C26H29NO3/c1-29-23-14-8-6-12-21(23)25(22-13-7-9-15-24(22)30-2)27-18-16-26(28,17-19-27)20-10-4-3-5-11-20/h3-15,25,28H,16-19H2,1-2H3
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843n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210378
PNG
(1-benzhydryl-4-ethoxy-4-phenylpiperidine | CHEMBL2...)
Show SMILES CCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H29NO/c1-2-28-26(24-16-10-5-11-17-24)18-20-27(21-19-26)25(22-12-6-3-7-13-22)23-14-8-4-9-15-23/h3-17,25H,2,18-21H2,1H3
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898n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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969n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210399
PNG
(4-phenyl-1-(phenyl(thiophen-2-yl)methyl)piperidin-...)
Show SMILES OC1(CCN(CC1)C(c1cccs1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C22H23NOS/c24-22(19-10-5-2-6-11-19)13-15-23(16-14-22)21(20-12-7-17-25-20)18-8-3-1-4-9-18/h1-12,17,21,24H,13-16H2
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971n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210393
PNG
(1-((2-methoxyphenyl)(phenyl)methyl)-4-phenylpiperi...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c1-28-23-15-9-8-14-22(23)24(20-10-4-2-5-11-20)26-18-16-25(27,17-19-26)21-12-6-3-7-13-21/h2-15,24,27H,16-19H2,1H3
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975n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210419
PNG
(1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol ...)
Show SMILES CCOCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C21H27NO2/c1-2-24-17-20(18-9-5-3-6-10-18)22-15-13-21(23,14-16-22)19-11-7-4-8-12-19/h3-12,20,23H,2,13-17H2,1H3
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1.03E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210392
PNG
(4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1cccc(c1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-9-8-12-22(19-20)24(21-10-4-2-5-11-21)26-17-15-25(27,16-18-26)23-13-6-3-7-14-23/h2-14,19,24,27H,15-18H2,1H3
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1.10E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210404
PNG
(1-((2-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Cl)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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1.14E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210391
PNG
(1-((2-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Br)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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1.14E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210415
PNG
(1-(bis(2-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1F)c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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1.17E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210394
PNG
(1-((2-(hydroxymethyl)phenyl)(phenyl)methyl)-4-phen...)
Show SMILES OCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c27-19-21-11-7-8-14-23(21)24(20-9-3-1-4-10-20)26-17-15-25(28,16-18-26)22-12-5-2-6-13-22/h1-14,24,27-28H,15-19H2
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1.17E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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1.21E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210413
PNG
(4-phenyl-1-(phenyl(4-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)29-17-15-24(30,16-18-29)21-9-5-2-6-10-21/h1-14,23,30H,15-18H2
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1.21E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210395
PNG
(4-phenyl-1-(phenyl(2-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)29-17-15-24(30,16-18-29)20-11-5-2-6-12-20/h1-14,23,30H,15-18H2
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1.27E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210395
PNG
(4-phenyl-1-(phenyl(2-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)29-17-15-24(30,16-18-29)20-11-5-2-6-12-20/h1-14,23,30H,15-18H2
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1.36E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210384
PNG
(4-phenyl-1-(1-phenylpropyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:2.1|
Show InChI InChI=1S/C20H25NO/c1-2-19(17-9-5-3-6-10-17)21-15-13-20(22,14-16-21)18-11-7-4-8-12-18/h3-12,19,22H,2,13-16H2,1H3
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1.43E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210410
PNG
(1-((4-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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1.43E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210398
PNG
(1-((2-fluorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1F)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24FNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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1.48E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210401
PNG
(1-benzhydryl-4-phenyl-4-propoxypiperidine | CHEMBL...)
Show SMILES CCCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31NO/c1-2-22-29-27(25-16-10-5-11-17-25)18-20-28(21-19-27)26(23-12-6-3-7-13-23)24-14-8-4-9-15-24/h3-17,26H,2,18-22H2,1H3
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1.48E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210401
PNG
(1-benzhydryl-4-phenyl-4-propoxypiperidine | CHEMBL...)
Show SMILES CCCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31NO/c1-2-22-29-27(25-16-10-5-11-17-25)18-20-28(21-19-27)26(23-12-6-3-7-13-23)24-14-8-4-9-15-24/h3-17,26H,2,18-22H2,1H3
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1.65E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210375
PNG
(1-(bis(2-chlorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C24H23Cl2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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1.67E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210223
PNG
(1-benzhydryl-4-phenylpiperidin-4-ol | CHEMBL228690)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO/c26-24(22-14-8-3-9-15-22)16-18-25(19-17-24)23(20-10-4-1-5-11-20)21-12-6-2-7-13-21/h1-15,23,26H,16-19H2
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1.67E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210404
PNG
(1-((2-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Cl)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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1.67E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210387
PNG
(1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol | CHEMB...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C26H29NO/c1-20-10-6-8-14-23(20)25(24-15-9-7-11-21(24)2)27-18-16-26(28,17-19-27)22-12-4-3-5-13-22/h3-15,25,28H,16-19H2,1-2H3
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1.71E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210408
PNG
(1-(2-methoxy-1-phenylethyl)-4-phenylpiperidin-4-ol...)
Show SMILES COCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C20H25NO2/c1-23-16-19(17-8-4-2-5-9-17)21-14-12-20(22,13-15-21)18-10-6-3-7-11-18/h2-11,19,22H,12-16H2,1H3
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1.77E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210415
PNG
(1-(bis(2-fluorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1F)c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C24H23F2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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1.78E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210381
PNG
(CHEMBL228736 | methyl 2-(4-hydroxy-4-phenylpiperid...)
Show SMILES COC(=O)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.4|
Show InChI InChI=1S/C20H23NO3/c1-24-19(22)18(16-8-4-2-5-9-16)21-14-12-20(23,13-15-21)17-10-6-3-7-11-17/h2-11,18,23H,12-15H2,1H3
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1.89E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210414
PNG
(1-((3-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(Cl)c1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)26-16-14-24(27,15-17-26)21-11-5-2-6-12-21/h1-13,18,23,27H,14-17H2
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1.97E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210394
PNG
(1-((2-(hydroxymethyl)phenyl)(phenyl)methyl)-4-phen...)
Show SMILES OCc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c27-19-21-11-7-8-14-23(21)24(20-9-3-1-4-10-20)26-17-15-25(28,16-18-26)22-12-5-2-6-13-22/h1-14,24,27-28H,15-19H2
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1.98E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210409
PNG
(1-benzyl-4-phenylpiperidin-4-ol | CHEMBL230141)
Show SMILES OC1(CCN(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C18H21NO/c20-18(17-9-5-2-6-10-17)11-13-19(14-12-18)15-16-7-3-1-4-8-16/h1-10,20H,11-15H2
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1.98E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210391
PNG
(1-((2-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1Br)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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2.11E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210387
PNG
(1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol | CHEMB...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C26H29NO/c1-20-10-6-8-14-23(20)25(24-15-9-7-11-21(24)2)27-18-16-26(28,17-19-27)22-12-4-3-5-13-22/h3-15,25,28H,16-19H2,1-2H3
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2.15E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210384
PNG
(4-phenyl-1-(1-phenylpropyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:2.1|
Show InChI InChI=1S/C20H25NO/c1-2-19(17-9-5-3-6-10-17)21-15-13-20(22,14-16-21)18-11-7-4-8-12-18/h3-12,19,22H,2,13-16H2,1H3
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2.30E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210392
PNG
(4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1cccc(c1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-9-8-12-22(19-20)24(21-10-4-2-5-11-21)26-17-15-25(27,16-18-26)23-13-6-3-7-14-23/h2-14,19,24,27H,15-18H2,1H3
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2.44E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210374
PNG
(1-((4-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Br)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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2.44E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210374
PNG
(1-((4-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Br)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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2.45E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210388
PNG
(1-benzhydryl-4-methoxy-4-phenylpiperidine | CHEMBL...)
Show SMILES COC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO/c1-27-25(23-15-9-4-10-16-23)17-19-26(20-18-25)24(21-11-5-2-6-12-21)22-13-7-3-8-14-22/h2-16,24H,17-20H2,1H3
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2.65E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210385
PNG
(4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-12-14-22(15-13-20)24(21-8-4-2-5-9-21)26-18-16-25(27,17-19-26)23-10-6-3-7-11-23/h2-15,24,27H,16-19H2,1H3
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2.69E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210401
PNG
(1-benzhydryl-4-phenyl-4-propoxypiperidine | CHEMBL...)
Show SMILES CCCOC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31NO/c1-2-22-29-27(25-16-10-5-11-17-25)18-20-28(21-19-27)26(23-12-6-3-7-13-23)24-14-8-4-9-15-24/h3-17,26H,2,18-22H2,1H3
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2.77E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210382
PNG
(2-((4-hydroxy-4-phenylpiperidin-1-yl)(phenyl)methy...)
Show SMILES OC(=O)c1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:9.10|
Show InChI InChI=1S/C25H25NO3/c27-24(28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-25(29,16-18-26)20-11-5-2-6-12-20/h1-14,23,29H,15-18H2,(H,27,28)
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2.86E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210412
PNG
(1-(bis(4-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H29NO3/c1-29-23-12-8-20(9-13-23)25(21-10-14-24(30-2)15-11-21)27-18-16-26(28,17-19-27)22-6-4-3-5-7-22/h3-15,25,28H,16-19H2,1-2H3
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2.88E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210398
PNG
(1-((2-fluorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccc1F)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24FNO/c25-22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-24(27,16-18-26)20-11-5-2-6-12-20/h1-14,23,27H,15-18H2
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2.95E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210417
PNG
(4-phenyl-1-(phenyl(pyridin-3-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccnc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-5-2-6-12-21)13-16-25(17-14-23)22(19-8-3-1-4-9-19)20-10-7-15-24-18-20/h1-12,15,18,22,26H,13-14,16-17H2
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2.99E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210414
PNG
(1-((3-chlorophenyl)(phenyl)methyl)-4-phenylpiperid...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(Cl)c1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24ClNO/c25-22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)26-16-14-24(27,15-17-26)21-11-5-2-6-12-21/h1-13,18,23,27H,14-17H2
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3.03E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210385
PNG
(4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-12-14-22(15-13-20)24(21-8-4-2-5-9-21)26-18-16-25(27,17-19-26)23-10-6-3-7-11-23/h2-15,24,27H,16-19H2,1H3
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3.73E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210416
PNG
(CHEMBL228738 | N-(2,6-difluorophenyl)-2-(4-hydroxy...)
Show SMILES OC1(CCN(CC1)C(C(=O)Nc1c(F)cccc1F)c1ccccc1)c1ccccc1 |w:7.20|
Show InChI InChI=1S/C25H24F2N2O2/c26-20-12-7-13-21(27)22(20)28-24(30)23(18-8-3-1-4-9-18)29-16-14-25(31,15-17-29)19-10-5-2-6-11-19/h1-13,23,31H,14-17H2,(H,28,30)
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3.74E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210379
PNG
(1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine | CH...)
Show SMILES C(OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H31NO/c1-5-13-26(14-6-1)25-33-31(29-19-11-4-12-20-29)21-23-32(24-22-31)30(27-15-7-2-8-16-27)28-17-9-3-10-18-28/h1-20,30H,21-25H2
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3.74E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210420
PNG
(1-(2-hydroxy-1-phenylethyl)-4-phenylpiperidin-4-ol...)
Show SMILES OCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:2.1|
Show InChI InChI=1S/C19H23NO2/c21-15-18(16-7-3-1-4-8-16)20-13-11-19(22,12-14-20)17-9-5-2-6-10-17/h1-10,18,21-22H,11-15H2
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4.04E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210405
PNG
(4-phenyl-1-(1-phenylbutyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CCCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C21H27NO/c1-2-9-20(18-10-5-3-6-11-18)22-16-14-21(23,15-17-22)19-12-7-4-8-13-19/h3-8,10-13,20,23H,2,9,14-17H2,1H3
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4.13E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210380
PNG
(4-phenyl-1-(1-phenylethyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C19H23NO/c1-16(17-8-4-2-5-9-17)20-14-12-19(21,13-15-20)18-10-6-3-7-11-18/h2-11,16,21H,12-15H2,1H3
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4.15E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210413
PNG
(4-phenyl-1-(phenyl(4-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)29-17-15-24(30,16-18-29)21-9-5-2-6-10-21/h1-14,23,30H,15-18H2
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4.29E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210416
PNG
(CHEMBL228738 | N-(2,6-difluorophenyl)-2-(4-hydroxy...)
Show SMILES OC1(CCN(CC1)C(C(=O)Nc1c(F)cccc1F)c1ccccc1)c1ccccc1 |w:7.20|
Show InChI InChI=1S/C25H24F2N2O2/c26-20-12-7-13-21(27)22(20)28-24(30)23(18-8-3-1-4-9-18)29-16-14-25(31,15-17-29)19-10-5-2-6-11-19/h1-13,23,31H,14-17H2,(H,28,30)
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4.38E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210374
PNG
(1-((4-bromophenyl)(phenyl)methyl)-4-phenylpiperidi...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(Br)cc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C24H24BrNO/c25-22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)26-17-15-24(27,16-18-26)21-9-5-2-6-10-21/h1-14,23,27H,15-18H2
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4.46E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210386
PNG
(1-(cyclopentyl(phenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(C1CCCC1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H29NO/c25-23(21-13-5-2-6-14-21)15-17-24(18-16-23)22(20-11-7-8-12-20)19-9-3-1-4-10-19/h1-6,9-10,13-14,20,22,25H,7-8,11-12,15-18H2
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5.32E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210387
PNG
(1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol | CHEMB...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C26H29NO/c1-20-10-6-8-14-23(20)25(24-15-9-7-11-21(24)2)27-18-16-26(28,17-19-27)22-12-4-3-5-13-22/h3-15,25,28H,16-19H2,1-2H3
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5.79E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210411
PNG
(4-phenyl-1-(phenyl(pyridin-2-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccn1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(20-11-5-2-6-12-20)14-17-25(18-15-23)22(19-9-3-1-4-10-19)21-13-7-8-16-24-21/h1-13,16,22,26H,14-15,17-18H2
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5.94E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210380
PNG
(4-phenyl-1-(1-phenylethyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C19H23NO/c1-16(17-8-4-2-5-9-17)20-14-12-19(21,13-15-20)18-10-6-3-7-11-18/h2-11,16,21H,12-15H2,1H3
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6.27E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210376
PNG
(4-phenyl-1-(phenyl(3-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(c1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)29-16-14-24(30,15-17-29)21-11-5-2-6-12-21/h1-13,18,23,30H,14-17H2
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6.62E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210381
PNG
(CHEMBL228736 | methyl 2-(4-hydroxy-4-phenylpiperid...)
Show SMILES COC(=O)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.4|
Show InChI InChI=1S/C20H23NO3/c1-24-19(22)18(16-8-4-2-5-9-16)21-14-12-20(23,13-15-21)17-10-6-3-7-11-17/h2-11,18,23H,12-15H2,1H3
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6.75E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210382
PNG
(2-((4-hydroxy-4-phenylpiperidin-1-yl)(phenyl)methy...)
Show SMILES OC(=O)c1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:9.10|
Show InChI InChI=1S/C25H25NO3/c27-24(28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-25(29,16-18-26)20-11-5-2-6-12-20/h1-14,23,29H,15-18H2,(H,27,28)
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6.75E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210376
PNG
(4-phenyl-1-(phenyl(3-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccc(c1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-7-10-20(18-22)23(19-8-3-1-4-9-19)29-16-14-24(30,15-17-29)21-11-5-2-6-12-21/h1-13,18,23,30H,14-17H2
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7.36E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210399
PNG
(4-phenyl-1-(phenyl(thiophen-2-yl)methyl)piperidin-...)
Show SMILES OC1(CCN(CC1)C(c1cccs1)c1ccccc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C22H23NOS/c24-22(19-10-5-2-6-11-19)13-15-23(16-14-22)21(20-12-7-17-25-20)18-8-3-1-4-9-18/h1-12,17,21,24H,13-16H2
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7.85E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210382
PNG
(2-((4-hydroxy-4-phenylpiperidin-1-yl)(phenyl)methy...)
Show SMILES OC(=O)c1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:9.10|
Show InChI InChI=1S/C25H25NO3/c27-24(28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-25(29,16-18-26)20-11-5-2-6-12-20/h1-14,23,29H,15-18H2,(H,27,28)
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8.06E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210416
PNG
(CHEMBL228738 | N-(2,6-difluorophenyl)-2-(4-hydroxy...)
Show SMILES OC1(CCN(CC1)C(C(=O)Nc1c(F)cccc1F)c1ccccc1)c1ccccc1 |w:7.20|
Show InChI InChI=1S/C25H24F2N2O2/c26-20-12-7-13-21(27)22(20)28-24(30)23(18-8-3-1-4-9-18)29-16-14-25(31,15-17-29)19-10-5-2-6-11-19/h1-13,23,31H,14-17H2,(H,28,30)
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8.18E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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8.77E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210411
PNG
(4-phenyl-1-(phenyl(pyridin-2-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccn1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(20-11-5-2-6-12-20)14-17-25(18-15-23)22(19-9-3-1-4-10-19)21-13-7-8-16-24-21/h1-13,16,22,26H,14-15,17-18H2
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9.32E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210385
PNG
(4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-12-14-22(15-13-20)24(21-8-4-2-5-9-21)26-18-16-25(27,17-19-26)23-10-6-3-7-11-23/h2-15,24,27H,16-19H2,1H3
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9.37E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210421
PNG
(2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylaceto...)
Show SMILES OC1(CCN(CC1)C(C#N)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C19H20N2O/c20-15-18(16-7-3-1-4-8-16)21-13-11-19(22,12-14-21)17-9-5-2-6-10-17/h1-10,18,22H,11-14H2
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1.00E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210413
PNG
(4-phenyl-1-(phenyl(4-(trifluoromethyl)phenyl)methy...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(F)(F)F)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H24F3NO/c26-25(27,28)22-13-11-20(12-14-22)23(19-7-3-1-4-8-19)29-17-15-24(30,16-18-29)21-9-5-2-6-10-21/h1-14,23,30H,15-18H2
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1.01E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210417
PNG
(4-phenyl-1-(phenyl(pyridin-3-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1cccnc1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-5-2-6-12-21)13-16-25(17-14-23)22(19-8-3-1-4-9-19)20-10-7-15-24-18-20/h1-12,15,18,22,26H,13-14,16-17H2
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1.09E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50210379
PNG
(1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine | CH...)
Show SMILES C(OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H31NO/c1-5-13-26(14-6-1)25-33-31(29-19-11-4-12-20-29)21-23-32(24-22-31)30(27-15-7-2-8-16-27)28-17-9-3-10-18-28/h1-20,30H,21-25H2
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1.34E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210412
PNG
(1-(bis(4-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccc(cc1)C(N1CCC(O)(CC1)c1ccccc1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H29NO3/c1-29-23-12-8-20(9-13-23)25(21-10-14-24(30-2)15-11-21)27-18-16-26(28,17-19-27)22-6-4-3-5-7-22/h3-15,25,28H,16-19H2,1-2H3
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1.37E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210419
PNG
(1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol ...)
Show SMILES CCOCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.3|
Show InChI InChI=1S/C21H27NO2/c1-2-24-17-20(18-9-5-3-6-10-18)22-15-13-21(23,14-16-22)19-11-7-4-8-12-19/h3-12,20,23H,2,13-17H2,1H3
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1.53E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210389
PNG
(1-(bis(2-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1OC
Show InChI InChI=1S/C26H29NO3/c1-29-23-14-8-6-12-21(23)25(22-13-7-9-15-24(22)30-2)27-18-16-26(28,17-19-27)20-10-4-3-5-11-20/h3-15,25,28H,16-19H2,1-2H3
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1.82E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210384
PNG
(4-phenyl-1-(1-phenylpropyl)piperidin-4-ol | CHEMBL...)
Show SMILES CCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:2.1|
Show InChI InChI=1S/C20H25NO/c1-2-19(17-9-5-3-6-10-17)21-15-13-20(22,14-16-21)18-11-7-4-8-12-18/h3-12,19,22H,2,13-16H2,1H3
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2.09E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210379
PNG
(1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine | CH...)
Show SMILES C(OC1(CCN(CC1)C(c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H31NO/c1-5-13-26(14-6-1)25-33-31(29-19-11-4-12-20-29)21-23-32(24-22-31)30(27-15-7-2-8-16-27)28-17-9-3-10-18-28/h1-20,30H,21-25H2
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2.15E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210411
PNG
(4-phenyl-1-(phenyl(pyridin-2-yl)methyl)piperidin-4...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1)c1ccccn1)c1ccccc1 |w:7.7|
Show InChI InChI=1S/C23H24N2O/c26-23(20-11-5-2-6-12-20)14-17-25(18-15-23)22(19-9-3-1-4-10-19)21-13-7-8-16-24-21/h1-13,16,22,26H,14-15,17-18H2
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2.19E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210416
PNG
(CHEMBL228738 | N-(2,6-difluorophenyl)-2-(4-hydroxy...)
Show SMILES OC1(CCN(CC1)C(C(=O)Nc1c(F)cccc1F)c1ccccc1)c1ccccc1 |w:7.20|
Show InChI InChI=1S/C25H24F2N2O2/c26-20-12-7-13-21(27)22(20)28-24(30)23(18-8-3-1-4-9-18)29-16-14-25(31,15-17-29)19-10-5-2-6-11-19/h1-13,23,31H,14-17H2,(H,28,30)
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2.23E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210408
PNG
(1-(2-methoxy-1-phenylethyl)-4-phenylpiperidin-4-ol...)
Show SMILES COCC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:3.2|
Show InChI InChI=1S/C20H25NO2/c1-23-16-19(17-8-4-2-5-9-17)21-14-12-20(22,13-15-21)18-10-6-3-7-11-18/h2-11,19,22H,12-16H2,1H3
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3.30E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210380
PNG
(4-phenyl-1-(1-phenylethyl)piperidin-4-ol | CHEMBL2...)
Show SMILES CC(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C19H23NO/c1-16(17-8-4-2-5-9-17)20-14-12-19(21,13-15-20)18-10-6-3-7-11-18/h2-11,16,21H,12-15H2,1H3
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3.31E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50210381
PNG
(CHEMBL228736 | methyl 2-(4-hydroxy-4-phenylpiperid...)
Show SMILES COC(=O)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.4|
Show InChI InChI=1S/C20H23NO3/c1-24-19(22)18(16-8-4-2-5-9-16)21-14-12-20(23,13-15-21)17-10-6-3-7-11-17/h2-11,18,23H,12-15H2,1H3
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5.98E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human MOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210382
PNG
(2-((4-hydroxy-4-phenylpiperidin-1-yl)(phenyl)methy...)
Show SMILES OC(=O)c1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:9.10|
Show InChI InChI=1S/C25H25NO3/c27-24(28)22-14-8-7-13-21(22)23(19-9-3-1-4-10-19)26-17-15-25(29,16-18-26)20-11-5-2-6-12-20/h1-14,23,29H,15-18H2,(H,27,28)
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>1.00E+5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50210381
PNG
(CHEMBL228736 | methyl 2-(4-hydroxy-4-phenylpiperid...)
Show SMILES COC(=O)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:4.4|
Show InChI InChI=1S/C20H23NO3/c1-24-19(22)18(16-8-4-2-5-9-16)21-14-12-20(23,13-15-21)17-10-6-3-7-11-17/h2-11,18,23H,12-15H2,1H3
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1.22E+5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human DOP receptor expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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n/an/an/an/a 23n/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210393
PNG
(1-((2-methoxyphenyl)(phenyl)methyl)-4-phenylpiperi...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:8.9|
Show InChI InChI=1S/C25H27NO2/c1-28-23-15-9-8-14-22(23)24(20-10-4-2-5-11-20)26-18-16-25(27,17-19-26)21-12-6-3-7-13-21/h2-15,24,27H,16-19H2,1H3
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n/an/an/an/a 26n/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210387
PNG
(1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol | CHEMB...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1C
Show InChI InChI=1S/C26H29NO/c1-20-10-6-8-14-23(20)25(24-15-9-7-11-21(24)2)27-18-16-26(28,17-19-27)22-12-4-3-5-13-22/h3-15,25,28H,16-19H2,1-2H3
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n/an/an/an/a 114n/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210375
PNG
(1-(bis(2-chlorophenyl)methyl)-4-phenylpiperidin-4-...)
Show SMILES OC1(CCN(CC1)C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C24H23Cl2NO/c25-21-12-6-4-10-19(21)23(20-11-5-7-13-22(20)26)27-16-14-24(28,15-17-27)18-8-2-1-3-9-18/h1-13,23,28H,14-17H2
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n/an/an/an/a 222n/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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n/an/an/an/a 331n/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210389
PNG
(1-(bis(2-methoxyphenyl)methyl)-4-phenylpiperidin-4...)
Show SMILES COc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1OC
Show InChI InChI=1S/C26H29NO3/c1-29-23-14-8-6-12-21(23)25(22-13-7-9-15-24(22)30-2)27-18-16-26(28,17-19-27)20-10-4-3-5-11-20/h3-15,25,28H,16-19H2,1-2H3
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n/an/an/an/a 117n/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50210383
PNG
(4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol |...)
Show SMILES Cc1ccccc1C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C25H27NO/c1-20-10-8-9-15-23(20)24(21-11-4-2-5-12-21)26-18-16-25(27,17-19-26)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
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n/an/an/an/a 29n/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding


Bioorg Med Chem Lett 17: 3023-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.061
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%