Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16219 (4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]pi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16218 (2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]et...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16220 ((2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16217 (4-phenyl-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16221 ((2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16216 (2-phenyl-2-[4-(1H-pyrazol-4-yl)phenyl]ethan-1-amin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16214 (3-[4-(1H-pyrazol-4-yl)phenyl]propan-1-amine | pyra...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16213 (2-[4-(5-methyl-1H-pyrazol-4-yl)phenyl]ethan-1-amin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16212 (1-[4-(5-methyl-1H-pyrazol-4-yl)phenyl]methanamine ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16311 (2-(4-CHLORO-PHENYL)-2-PHENYL-ETHYLAMINE | 2-(4-chl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 7.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16211 (5-methyl-4-phenyl-1H-pyrazole | CHEMBL228114 | pyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM16215 (4-phenyl-1H-pyrazole | CHEMBL390066 | JMC514968 Co...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.35E+5 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | J Med Chem 50: 2293-2296 (2007) Article DOI: 10.1021/jm070091b BindingDB Entry DOI: 10.7270/Q2QV3JST | |||||||||||
More data for this Ligand-Target Pair |