Found 53 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30202
(Pyrrolopyridine, 33)Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C24H24N4O2/c29-23(27-18-3-1-2-4-18)16-7-5-15(6-8-16)21-13-17(9-11-25-21)22-14-19-20(28-22)10-12-26-24(19)30/h5-9,11,13-14,18,28H,1-4,10,12H2,(H,26,30)(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30204
(Pyrrolopyridine, 35)Show SMILES O=C(NCc1ccccc1)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C26H22N4O2/c31-25(29-16-17-4-2-1-3-5-17)19-8-6-18(7-9-19)23-14-20(10-12-27-23)24-15-21-22(30-24)11-13-28-26(21)32/h1-10,12,14-15,30H,11,13,16H2,(H,28,32)(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30185
(CHEMBL226403 | Pyrrolopyridine, 16)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1 Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30201
(Pyrrolopyridine, 32)Show SMILES O=C(NC1CC1)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C22H20N4O2/c27-21(25-16-5-6-16)14-3-1-13(2-4-14)19-11-15(7-9-23-19)20-12-17-18(26-20)8-10-24-22(17)28/h1-4,7,9,11-12,16,26H,5-6,8,10H2,(H,24,28)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30203
(Pyrrolopyridine, 34)Show SMILES O=C(NC1CCCCC1)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C25H26N4O2/c30-24(28-19-4-2-1-3-5-19)17-8-6-16(7-9-17)22-14-18(10-12-26-22)23-15-20-21(29-23)11-13-27-25(20)31/h6-10,12,14-15,19,29H,1-5,11,13H2,(H,27,31)(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30188
(Pyrrolopyridine, 19)Show SMILES Oc1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C18H15N3O2/c22-13-3-1-11(2-4-13)16-9-12(5-7-19-16)17-10-14-15(21-17)6-8-20-18(14)23/h1-5,7,9-10,21-22H,6,8H2,(H,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30200
(Pyrrolopyridine, 31)Show SMILES OC(=O)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C19H15N3O3/c23-18-14-10-17(22-15(14)6-8-21-18)13-5-7-20-16(9-13)11-1-3-12(4-2-11)19(24)25/h1-5,7,9-10,22H,6,8H2,(H,21,23)(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30187
(Pyrrolopyridine, 18)Show SMILES Oc1cccc(c1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C18H15N3O2/c22-13-3-1-2-11(8-13)16-9-12(4-6-19-16)17-10-14-15(21-17)5-7-20-18(14)23/h1-4,6,8-10,21-22H,5,7H2,(H,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30184
(Pyrrolopyridine, 15)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cc2ccccc2s1 Show InChI InChI=1S/C20H15N3OS/c24-20-14-11-16(23-15(14)6-8-22-20)12-5-7-21-17(9-12)19-10-13-3-1-2-4-18(13)25-19/h1-5,7,9-11,23H,6,8H2,(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30193
(Pyrrolopyridine, 24)Show SMILES Fc1cccc(c1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C18H14FN3O/c19-13-3-1-2-11(8-13)16-9-12(4-6-20-16)17-10-14-15(22-17)5-7-21-18(14)23/h1-4,6,8-10,22H,5,7H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30191
(Pyrrolopyridine, 22)Show SMILES Clc1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C18H14ClN3O/c19-13-3-1-11(2-4-13)16-9-12(5-7-20-16)17-10-14-15(22-17)6-8-21-18(14)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30190
(Pyrrolopyridine, 21)Show SMILES Clc1cccc(c1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C18H14ClN3O/c19-13-3-1-2-11(8-13)16-9-12(4-6-20-16)17-10-14-15(22-17)5-7-21-18(14)23/h1-4,6,8-10,22H,5,7H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30199
(Pyrrolopyridine, 30)Show SMILES Nc1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C18H16N4O/c19-13-3-1-11(2-4-13)16-9-12(5-7-20-16)17-10-14-15(22-17)6-8-21-18(14)23/h1-5,7,9-10,22H,6,8,19H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30205
(Pyrrolopyridine, 36)Show SMILES O=C(NCCc1ccccc1)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C27H24N4O2/c32-26(29-13-10-18-4-2-1-3-5-18)20-8-6-19(7-9-20)24-16-21(11-14-28-24)25-17-22-23(31-25)12-15-30-27(22)33/h1-9,11,14,16-17,31H,10,12-13,15H2,(H,29,32)(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30180
(Pyrrolopyridine, 11)Show InChI InChI=1S/C17H14N4O/c22-17-13-9-16(21-14(13)4-7-20-17)11-3-6-19-15(8-11)12-2-1-5-18-10-12/h1-3,5-6,8-10,21H,4,7H2,(H,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30194
(Pyrrolopyridine, 25)Show SMILES Fc1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C18H14FN3O/c19-13-3-1-11(2-4-13)16-9-12(5-7-20-16)17-10-14-15(22-17)6-8-21-18(14)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30197
(Pyrrolopyridine, 28)Show SMILES CC(=O)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C20H17N3O2/c1-12(24)13-2-4-14(5-3-13)18-10-15(6-8-21-18)19-11-16-17(23-19)7-9-22-20(16)25/h2-6,8,10-11,23H,7,9H2,1H3,(H,22,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30183
(Pyrrolopyridine, 14)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C22H17N3O/c26-22-18-13-21(25-19(18)8-10-24-22)17-7-9-23-20(12-17)16-6-5-14-3-1-2-4-15(14)11-16/h1-7,9,11-13,25H,8,10H2,(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30198
(Pyrrolopyridine, 29)Show SMILES COc1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C19H17N3O2/c1-24-14-4-2-12(3-5-14)17-10-13(6-8-20-17)18-11-15-16(22-18)7-9-21-19(15)23/h2-6,8,10-11,22H,7,9H2,1H3,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30206
(Pyrrolopyridine, 37)Show SMILES CN(Cc1ccccc1)C(=O)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C27H24N4O2/c1-31(17-18-5-3-2-4-6-18)27(33)20-9-7-19(8-10-20)24-15-21(11-13-28-24)25-16-22-23(30-25)12-14-29-26(22)32/h2-11,13,15-16,30H,12,14,17H2,1H3,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30179
(Pyrrolopyridine, 10)Show InChI InChI=1S/C17H14N4O/c22-17-13-10-16(21-14(13)4-8-20-17)12-3-7-19-15(9-12)11-1-5-18-6-2-11/h1-3,5-7,9-10,21H,4,8H2,(H,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30196
(Pyrrolopyridine, 27)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1ccc(cc1)C#N Show InChI InChI=1S/C19H14N4O/c20-11-12-1-3-13(4-2-12)17-9-14(5-7-21-17)18-10-15-16(23-18)6-8-22-19(15)24/h1-5,7,9-10,23H,6,8H2,(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30178
(Pyrrolopyridine, 9)Show InChI InChI=1S/C18H15N3O/c22-18-14-11-17(21-15(14)7-9-20-18)13-6-8-19-16(10-13)12-4-2-1-3-5-12/h1-6,8,10-11,21H,7,9H2,(H,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30195
(Pyrrolopyridine, 26)Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI InChI=1S/C19H14F3N3O/c20-19(21,22)13-3-1-11(2-4-13)16-9-12(5-7-23-16)17-10-14-15(25-17)6-8-24-18(14)26/h1-5,7,9-10,25H,6,8H2,(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30182
(Pyrrolopyridine, 13)Show InChI InChI=1S/C16H13N3OS/c20-16-12-8-15(19-13(12)2-5-18-16)10-1-4-17-14(7-10)11-3-6-21-9-11/h1,3-4,6-9,19H,2,5H2,(H,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 5
(Homo sapiens (Human)) | BDBM30185
(CHEMBL226403 | Pyrrolopyridine, 16)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1 Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL
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MCE
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PC cid
PC sid
PDB
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30181
(Pyrrolopyridine, 12)Show InChI InChI=1S/C16H13N5O/c22-16-12-6-15(21-13(12)2-4-20-16)10-1-3-19-14(5-10)11-7-17-9-18-8-11/h1,3,5-9,21H,2,4H2,(H,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30192
(Pyrrolopyridine, 23)Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
MAP kinase-activated protein kinase 5
(Homo sapiens (Human)) | BDBM30178
(Pyrrolopyridine, 9)Show InChI InChI=1S/C18H15N3O/c22-18-14-11-17(21-15(14)7-9-20-18)13-6-8-19-16(10-13)12-4-2-1-3-5-12/h1-6,8,10-11,21H,7,9H2,(H,20,22) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
MCE
PC cid
PC sid
PDB
UniChem
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| Article
PubMed
| n/a | n/a | 171 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 5
(Homo sapiens (Human)) | BDBM30192
(Pyrrolopyridine, 23)Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 3
(Homo sapiens (Human)) | BDBM30185
(CHEMBL226403 | Pyrrolopyridine, 16)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1 Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30186
(Pyrrolopyridine, 17)Show InChI InChI=1S/C18H15N3O2/c22-17-4-2-1-3-12(17)16-9-11(5-7-19-16)15-10-13-14(21-15)6-8-20-18(13)23/h1-5,7,9-10,21-22H,6,8H2,(H,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 5
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM30189
(Pyrrolopyridine, 20)Show InChI InChI=1S/C18H14ClN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 606 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM27388
(2-(2-chloropyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)Show InChI InChI=1S/C12H10ClN3O/c13-11-5-7(1-3-14-11)10-6-8-9(16-10)2-4-15-12(8)17/h1,3,5-6,16H,2,4H2,(H,15,17) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 608 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 3
(Homo sapiens (Human)) | BDBM30178
(Pyrrolopyridine, 9)Show InChI InChI=1S/C18H15N3O/c22-18-14-11-17(21-15(14)7-9-20-18)13-6-8-19-16(10-13)12-4-2-1-3-5-12/h1-6,8,10-11,21H,7,9H2,(H,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
MAP kinase-activated protein kinase 3
(Homo sapiens (Human)) | BDBM30192
(Pyrrolopyridine, 23)Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-4
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM30185
(CHEMBL226403 | Pyrrolopyridine, 16)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1 Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.44E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM30192
(Pyrrolopyridine, 23)Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM30185
(CHEMBL226403 | Pyrrolopyridine, 16)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1 Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM30192
(Pyrrolopyridine, 23)Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM30178
(Pyrrolopyridine, 9)Show InChI InChI=1S/C18H15N3O/c22-18-14-11-17(21-15(14)7-9-20-18)13-6-8-19-16(10-13)12-4-2-1-3-5-12/h1-6,8,10-11,21H,7,9H2,(H,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 3
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.77E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Ribosomal protein S6 kinase alpha-4
(Homo sapiens (Human)) | BDBM30192
(Pyrrolopyridine, 23)Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM30178
(Pyrrolopyridine, 9)Show InChI InChI=1S/C18H15N3O/c22-18-14-11-17(21-15(14)7-9-20-18)13-6-8-19-16(10-13)12-4-2-1-3-5-12/h1-6,8,10-11,21H,7,9H2,(H,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.46E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-4
(Homo sapiens (Human)) | BDBM30178
(Pyrrolopyridine, 9)Show InChI InChI=1S/C18H15N3O/c22-18-14-11-17(21-15(14)7-9-20-18)13-6-8-19-16(10-13)12-4-2-1-3-5-12/h1-6,8,10-11,21H,7,9H2,(H,20,22) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.48E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM30185
(CHEMBL226403 | Pyrrolopyridine, 16)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1 Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM30192
(Pyrrolopyridine, 23)Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-4
(Homo sapiens (Human)) | BDBM30185
(CHEMBL226403 | Pyrrolopyridine, 16)Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1 Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ... |
J Med Chem 50: 2647-54 (2007)
Article DOI: 10.1021/jm0611004
BindingDB Entry DOI: 10.7270/Q2794313 |
More data for this
Ligand-Target Pair | |
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