BindingDB logo
myBDB logout

PubMed code 17585750

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20557
PNG
(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20554
PNG
(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2[nH]c1=O
Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-17(23)18(28)26-12/h1-9H,(H2,23,27)(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.570n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20557
PNG
(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.620n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20554
PNG
(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2[nH]c1=O
Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-17(23)18(28)26-12/h1-9H,(H2,23,27)(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.640n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20557
PNG
(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.760n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20554
PNG
(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2[nH]c1=O
Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-17(23)18(28)26-12/h1-9H,(H2,23,27)(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.800n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20554
PNG
(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2[nH]c1=O
Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-17(23)18(28)26-12/h1-9H,(H2,23,27)(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20557
PNG
(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20556
PNG
(4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C18H11F3N4OS/c19-18(20,21)11-6-4-10(5-7-11)12-8-15(24-9-23-12)26-13-2-1-3-14-16(13)25-17(22)27-14/h1-9H,(H2,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.20n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20532
PNG
(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.70n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20532
PNG
(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 7.40n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20532
PNG
(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20548
PNG
(4-Oxopyrimidine, 20 | 8-({6-[4-(trifluoromethyl)ph...)
Show SMILES Nc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C20H13F3N4O/c21-20(22,23)14-7-4-12(5-8-14)15-10-18(26-11-25-15)28-16-3-1-2-13-6-9-17(24)27-19(13)16/h1-11H,(H2,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 11n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20552
PNG
(4-Oxopyrimidine, 30 | 8-({6-[4-(trifluoromethyl)ph...)
Show SMILES Nc1ncc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C19H12F3N5O/c20-19(21,22)13-6-4-11(5-7-13)14-8-16(26-10-25-14)28-15-3-1-2-12-9-24-18(23)27-17(12)15/h1-10H,(H2,23,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 14n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20539
PNG
(4-Oxopyrimidine, 28a | 8-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3cccnc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-8-6-13(7-9-15)16-11-18(26-12-25-16)27-17-5-1-3-14-4-2-10-24-19(14)17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 15n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20551
PNG
(4-Oxopyrimidine, 22 | N-[8-({6-[4-(trifluoromethyl...)
Show SMILES CC(=O)Nc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C22H15F3N4O2/c1-13(30)28-19-10-7-15-3-2-4-18(21(15)29-19)31-20-11-17(26-12-27-20)14-5-8-16(9-6-14)22(23,24)25/h2-12H,1H3,(H,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20553
PNG
(4-Oxopyrimidine, 31 | 8-({6-[4-(trifluoromethyl)ph...)
Show SMILES Nc1cnc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C19H12F3N5O/c20-19(21,22)12-6-4-11(5-7-12)14-8-17(26-10-25-14)28-15-3-1-2-13-18(15)27-16(23)9-24-13/h1-10H,(H2,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20549
PNG
(4-Oxopyrimidine, 29c | N-methyl-8-({6-[4-(trifluor...)
Show SMILES CNc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C21H15F3N4O/c1-25-18-10-7-14-3-2-4-17(20(14)28-18)29-19-11-16(26-12-27-19)13-5-8-15(9-6-13)21(22,23)24/h2-12H,1H3,(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 35n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20549
PNG
(4-Oxopyrimidine, 29c | N-methyl-8-({6-[4-(trifluor...)
Show SMILES CNc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C21H15F3N4O/c1-25-18-10-7-14-3-2-4-17(20(14)28-18)29-19-11-16(26-12-27-19)13-5-8-15(9-6-13)21(22,23)24/h2-12H,1H3,(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20548
PNG
(4-Oxopyrimidine, 20 | 8-({6-[4-(trifluoromethyl)ph...)
Show SMILES Nc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C20H13F3N4O/c21-20(22,23)14-7-4-12(5-8-14)15-10-18(26-11-25-15)28-16-3-1-2-13-6-9-17(24)27-19(13)16/h1-11H,(H2,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 62n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20553
PNG
(4-Oxopyrimidine, 31 | 8-({6-[4-(trifluoromethyl)ph...)
Show SMILES Nc1cnc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C19H12F3N5O/c20-19(21,22)12-6-4-11(5-7-12)14-8-17(26-10-25-14)28-15-3-1-2-13-18(15)27-16(23)9-24-13/h1-10H,(H2,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 63n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20551
PNG
(4-Oxopyrimidine, 22 | N-[8-({6-[4-(trifluoromethyl...)
Show SMILES CC(=O)Nc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C22H15F3N4O2/c1-13(30)28-19-10-7-15-3-2-4-18(21(15)29-19)31-20-11-17(26-12-27-20)14-5-8-16(9-6-14)22(23,24)25/h2-12H,1H3,(H,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 77n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20541
PNG
(4-Oxopyrimidine, 28c | 5-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3cnccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-4-13(5-7-15)17-10-19(26-12-25-17)27-18-3-1-2-14-11-24-9-8-16(14)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 120n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20540
PNG
(4-Oxopyrimidine, 28b | 8-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3ccncc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-4-14(5-7-15)17-10-19(26-12-25-17)27-18-3-1-2-13-8-9-24-11-16(13)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20540
PNG
(4-Oxopyrimidine, 28b | 8-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3ccncc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-4-14(5-7-15)17-10-19(26-12-25-17)27-18-3-1-2-13-8-9-24-11-16(13)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 150n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20533
PNG
(4-Oxopyrimidine, 27a | 7-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3ccncc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)16-4-1-14(2-5-16)18-10-19(26-12-25-18)27-17-6-3-13-7-8-24-11-15(13)9-17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 460n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20537
PNG
(3-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cc3ccccc3cn2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)16-7-5-13(6-8-16)17-10-19(26-12-25-17)27-18-9-14-3-1-2-4-15(14)11-24-18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 630n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20542
PNG
(4-Oxopyrimidine, 28d | 5-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3ncccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)14-8-6-13(7-9-14)17-11-19(26-12-25-17)27-18-5-1-4-16-15(18)3-2-10-24-16/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 660n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20538
PNG
(2-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3ccccc3n2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-8-5-14(6-9-15)17-11-19(25-12-24-17)27-18-10-7-13-3-1-2-4-16(13)26-18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 730n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20558
PNG
(4-Oxopyrimidine, 26 | N-methyl-N-[4-({6-[4-(triflu...)
Show SMILES CN(C(C)=O)c1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C21H15F3N4O2S/c1-12(29)28(2)20-27-19-16(4-3-5-17(19)31-20)30-18-10-15(25-11-26-18)13-6-8-14(9-7-13)21(22,23)24/h3-11H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 860n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20559
PNG
(4-Oxopyrimidine, 24 | N-[4-({6-[4-(trifluoromethyl...)
Show SMILES CCC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C21H15F3N4O2S/c1-2-17(29)27-20-28-19-15(4-3-5-16(19)31-20)30-18-10-14(25-11-26-18)12-6-8-13(9-7-12)21(22,23)24/h3-11H,2H2,1H3,(H,27,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20534
PNG
(4-Oxopyrimidine, 27b | 6-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cnccc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)16-4-1-13(2-5-16)18-10-19(26-12-25-18)27-17-6-3-15-11-24-8-7-14(15)9-17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.40E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20559
PNG
(4-Oxopyrimidine, 24 | N-[4-({6-[4-(trifluoromethyl...)
Show SMILES CCC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C21H15F3N4O2S/c1-2-17(29)27-20-28-19-15(4-3-5-16(19)31-20)30-18-10-14(25-11-26-18)12-6-8-13(9-7-12)21(22,23)24/h3-11H,2H2,1H3,(H,27,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20544
PNG
(4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cncc3ccccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-7-5-13(6-8-15)17-9-19(26-12-25-17)27-18-11-24-10-14-3-1-2-4-16(14)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.90E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20541
PNG
(4-Oxopyrimidine, 28c | 5-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3cnccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-4-13(5-7-15)17-10-19(26-12-25-17)27-18-3-1-2-14-11-24-9-8-16(14)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20542
PNG
(4-Oxopyrimidine, 28d | 5-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3ncccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)14-8-6-13(7-9-14)17-11-19(26-12-25-17)27-18-5-1-4-16-15(18)3-2-10-24-16/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20555
PNG
(3-amino-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Show SMILES Nc1nc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2[nH]c1=O
Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-18(28)17(23)26-12/h1-9H,(H2,23,26)(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20544
PNG
(4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cncc3ccccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-7-5-13(6-8-15)17-9-19(26-12-25-17)27-18-11-24-10-14-3-1-2-4-16(14)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20550
PNG
(4-Oxopyrimidine, 29d | N,N-dimethyl-8-({6-[4-(trif...)
Show SMILES CN(C)c1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C22H17F3N4O/c1-29(2)19-11-8-15-4-3-5-18(21(15)28-19)30-20-12-17(26-13-27-20)14-6-9-16(10-7-14)22(23,24)25/h3-13H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20535
PNG
(4-Oxopyrimidine, 27c | 6-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3ncccc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-5-3-13(4-6-15)18-11-19(26-12-25-18)27-16-7-8-17-14(10-16)2-1-9-24-17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20545
PNG
(1-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2nccc3ccccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-7-5-14(6-8-15)17-11-18(26-12-25-17)27-19-16-4-2-1-3-13(16)9-10-24-19/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20558
PNG
(4-Oxopyrimidine, 26 | N-methyl-N-[4-({6-[4-(triflu...)
Show SMILES CN(C(C)=O)c1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C21H15F3N4O2S/c1-12(29)28(2)20-27-19-16(4-3-5-17(19)31-20)30-18-10-15(25-11-26-18)13-6-8-14(9-7-13)21(22,23)24/h3-11H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20538
PNG
(2-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3ccccc3n2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-8-5-14(6-9-15)17-11-19(25-12-24-17)27-18-10-7-13-3-1-2-4-16(13)26-18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20550
PNG
(4-Oxopyrimidine, 29d | N,N-dimethyl-8-({6-[4-(trif...)
Show SMILES CN(C)c1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C22H17F3N4O/c1-29(2)19-11-8-15-4-3-5-18(21(15)28-19)30-20-12-17(26-13-27-20)14-6-9-16(10-7-14)22(23,24)25/h3-13H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20539
PNG
(4-Oxopyrimidine, 28a | 8-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3cccnc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-8-6-13(7-9-15)16-11-18(26-12-25-16)27-17-5-1-3-14-4-2-10-24-19(14)17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20560
PNG
(2-methyl-N-[4-({6-[4-(trifluoromethyl)phenyl]pyrim...)
Show SMILES CC(C)C(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C22H17F3N4O2S/c1-12(2)20(30)29-21-28-19-16(4-3-5-17(19)32-21)31-18-10-15(26-11-27-18)13-6-8-14(9-7-13)22(23,24)25/h3-12H,1-2H3,(H,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20552
PNG
(4-Oxopyrimidine, 30 | 8-({6-[4-(trifluoromethyl)ph...)
Show SMILES Nc1ncc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C19H12F3N5O/c20-19(21,22)13-6-4-11(5-7-13)14-8-16(26-10-25-14)28-15-3-1-2-12-9-24-18(23)27-17(12)15/h1-10H,(H2,23,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20547
PNG
(2-methoxy-8-({6-[4-(trifluoromethyl)phenyl]pyrimid...)
Show SMILES COc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C21H14F3N3O2/c1-28-18-10-7-14-3-2-4-17(20(14)27-18)29-19-11-16(25-12-26-19)13-5-8-15(9-6-13)21(22,23)24/h2-12H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20547
PNG
(2-methoxy-8-({6-[4-(trifluoromethyl)phenyl]pyrimid...)
Show SMILES COc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C21H14F3N3O2/c1-28-18-10-7-14-3-2-4-17(20(14)27-18)29-19-11-16(25-12-26-19)13-5-8-15(9-6-13)21(22,23)24/h2-12H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20560
PNG
(2-methyl-N-[4-({6-[4-(trifluoromethyl)phenyl]pyrim...)
Show SMILES CC(C)C(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C22H17F3N4O2S/c1-12(2)20(30)29-21-28-19-16(4-3-5-17(19)32-21)31-18-10-15(26-11-27-18)13-6-8-14(9-7-13)22(23,24)25/h3-12H,1-2H3,(H,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20546
PNG
(4-Oxopyrimidine, 29a | 8-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3ccc(=O)[nH]c23)ncn1
Show InChI InChI=1S/C20H12F3N3O2/c21-20(22,23)14-7-4-12(5-8-14)15-10-18(25-11-24-15)28-16-3-1-2-13-6-9-17(27)26-19(13)16/h1-11H,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20555
PNG
(3-amino-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Show SMILES Nc1nc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2[nH]c1=O
Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)11-6-4-10(5-7-11)13-8-15(25-9-24-13)29-14-3-1-2-12-16(14)27-18(28)17(23)26-12/h1-9H,(H2,23,26)(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20545
PNG
(1-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2nccc3ccccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-7-5-14(6-8-15)17-11-18(26-12-25-17)27-19-16-4-2-1-3-13(16)9-10-24-19/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20543
PNG
(4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccnc3ccccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)14-7-5-13(6-8-14)17-11-19(26-12-25-17)27-18-9-10-24-16-4-2-1-3-15(16)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20535
PNG
(4-Oxopyrimidine, 27c | 6-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3ncccc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-5-3-13(4-6-15)18-11-19(26-12-25-18)27-16-7-8-17-14(10-16)2-1-9-24-17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20534
PNG
(4-Oxopyrimidine, 27b | 6-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cnccc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)16-4-1-13(2-5-16)18-10-19(26-12-25-18)27-17-6-3-15-11-24-8-7-14(15)9-17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20543
PNG
(4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccnc3ccccc23)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)14-7-5-13(6-8-14)17-11-19(26-12-25-17)27-18-9-10-24-16-4-2-1-3-15(16)18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20556
PNG
(4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Show InChI InChI=1S/C18H11F3N4OS/c19-18(20,21)11-6-4-10(5-7-11)12-8-15(24-9-23-12)26-13-2-1-3-14-16(13)25-17(22)27-14/h1-9H,(H2,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20546
PNG
(4-Oxopyrimidine, 29a | 8-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cccc3ccc(=O)[nH]c23)ncn1
Show InChI InChI=1S/C20H12F3N3O2/c21-20(22,23)14-7-4-12(5-8-14)15-10-18(25-11-24-15)28-16-3-1-2-13-6-9-17(27)26-19(13)16/h1-11H,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20537
PNG
(3-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cc3ccccc3cn2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)16-7-5-13(6-8-16)17-10-19(26-12-25-17)27-18-9-14-3-1-2-4-15(14)11-24-18/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20536
PNG
(3-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cnc3ccccc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-7-5-13(6-8-15)18-10-19(26-12-25-18)27-16-9-14-3-1-2-4-17(14)24-11-16/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20536
PNG
(3-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2cnc3ccccc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-7-5-13(6-8-15)18-10-19(26-12-25-18)27-16-9-14-3-1-2-4-17(14)24-11-16/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20533
PNG
(4-Oxopyrimidine, 27a | 7-({6-[4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3ccncc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)16-4-1-14(2-5-16)18-10-19(26-12-25-18)27-17-6-3-13-7-8-24-11-15(13)9-17/h1-12H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3515-27 (2007)


Article DOI: 10.1021/jm070190p
BindingDB Entry DOI: 10.7270/Q2RN364D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%