Found 8 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM21896
(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4cnc[nH]4)cc23)C#N)cc1Cl Show InChI InChI=1S/C20H14ClFN6/c21-17-6-14(1-3-18(17)22)28-20-12(7-23)8-26-19-4-2-13(5-16(19)20)25-10-15-9-24-11-27-15/h1-6,8-9,11,25H,10H2,(H,24,27)(H,26,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase autophosphorylation in A431 cells |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50218849
(4-cycloheptylamino-6-[(pyridin-3-ylmethyl)-amino]-...)Show InChI InChI=1S/C22H24N6/c23-11-17-14-25-20-15-27-21(26-13-16-6-5-9-24-12-16)10-19(20)22(17)28-18-7-3-1-2-4-8-18/h5-6,9-10,12,14-15,18H,1-4,7-8,13H2,(H,25,28)(H,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase autophosphorylation in A431 cells |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50218849
(4-cycloheptylamino-6-[(pyridin-3-ylmethyl)-amino]-...)Show InChI InChI=1S/C22H24N6/c23-11-17-14-25-20-15-27-21(26-13-16-6-5-9-24-12-16)10-19(20)22(17)28-18-7-3-1-2-4-8-18/h5-6,9-10,12,14-15,18H,1-4,7-8,13H2,(H,25,28)(H,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src kinase |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50218861
(4-tert-butylamino-6-[(pyridin-3-ylmethyl)-amino]-[...)Show InChI InChI=1S/C19H20N6/c1-19(2,3)25-18-14(8-20)11-22-16-12-24-17(7-15(16)18)23-10-13-5-4-6-21-9-13/h4-7,9,11-12H,10H2,1-3H3,(H,22,25)(H,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase autophosphorylation in A431 cells |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50218859
(4-(1,1-dimethylpropylamino)-6-[(pyridin-3-ylmethyl...)Show InChI InChI=1S/C20H22N6/c1-4-20(2,3)26-19-15(9-21)12-23-17-13-25-18(8-16(17)19)24-11-14-6-5-7-22-10-14/h5-8,10,12-13H,4,11H2,1-3H3,(H,23,26)(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase autophosphorylation in A431 cells |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50218847
(4-cyclopropylamino-6-[(pyridin-3-ylmethyl)-amino]-...)Show InChI InChI=1S/C18H16N6/c19-7-13-10-21-16-11-23-17(22-9-12-2-1-5-20-8-12)6-15(16)18(13)24-14-3-4-14/h1-2,5-6,8,10-11,14H,3-4,9H2,(H,21,24)(H,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase autophosphorylation in A431 cells |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50218843
(4-cyclohexylamino-6-[(pyridin-3-ylmethyl)-amino]-[...)Show InChI InChI=1S/C21H22N6/c22-10-16-13-24-19-14-26-20(25-12-15-5-4-8-23-11-15)9-18(19)21(16)27-17-6-2-1-3-7-17/h4-5,8-9,11,13-14,17H,1-3,6-7,12H2,(H,24,27)(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase autophosphorylation in A431 cells |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50218848
(4-cyclopentylamino-6-[(pyridin-3-ylmethyl)-amino]-...)Show InChI InChI=1S/C20H20N6/c21-9-15-12-23-18-13-25-19(24-11-14-4-3-7-22-10-14)8-17(18)20(15)26-16-5-1-2-6-16/h3-4,7-8,10,12-13,16H,1-2,5-6,11H2,(H,23,26)(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase autophosphorylation in A431 cells |
Bioorg Med Chem 15: 6425-42 (2007)
Article DOI: 10.1016/j.bmc.2007.06.054
BindingDB Entry DOI: 10.7270/Q2T43STV |
More data for this
Ligand-Target Pair | |
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