BindingDB logo
myBDB logout

PubMed code 17676829

Compile data set for download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17792
PNG
(benzimidazole-urea, 20 | methyl N-[6-(4-{[(3-bromo...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C22H18BrN5O4/c1-31-22(30)28-20-26-18-10-9-17(12-19(18)27-20)32-16-7-5-14(6-8-16)24-21(29)25-15-4-2-3-13(23)11-15/h2-12H,1H3,(H2,24,25,29)(H2,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17795
PNG
(benzimidazole-urea, 23 | methyl N-(6-{4-[({3-[(tri...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(SC(F)(F)F)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C23H18F3N5O4S/c1-34-22(33)31-20-29-18-10-9-16(12-19(18)30-20)35-15-7-5-13(6-8-15)27-21(32)28-14-3-2-4-17(11-14)36-23(24,25)26/h2-12H,1H3,(H2,27,28,32)(H2,29,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17824
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES CN1CCN(CC(=O)Nc2nc3ccc(Oc4ccc(NC(=O)Nc5cc(ccc5F)C(F)(F)F)cc4)cc3[nH]2)CC1
Show InChI InChI=1S/C28H27F4N7O3/c1-38-10-12-39(13-11-38)16-25(40)37-26-34-22-9-7-20(15-24(22)35-26)42-19-5-3-18(4-6-19)33-27(41)36-23-14-17(28(30,31)32)2-8-21(23)29/h2-9,14-15H,10-13,16H2,1H3,(H2,33,36,41)(H2,34,35,37,40)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17813
PNG
(benzthiazole-urea, 40 | methyl N-{6-[4-({[2-fluoro...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2s1
Show InChI InChI=1S/C23H16F4N4O4S/c1-34-22(33)31-21-30-17-9-7-15(11-19(17)36-21)35-14-5-3-13(4-6-14)28-20(32)29-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,29,32)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17816
PNG
(imidazopyridine-urea, 43 | methyl N-{5-[4-({[2-flu...)
Show SMILES COC(=O)Nc1nc2nc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2[nH]1
Show InChI InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-28-15-8-9-17(30-18(15)31-19)36-13-5-3-12(4-6-13)27-20(33)29-16-10-11(22(24,25)26)2-7-14(16)23/h2-10H,1H3,(H2,27,29,33)(H2,28,30,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17806
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES CC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O3/c1-12(33)28-21-30-18-9-7-16(11-20(18)31-21)35-15-5-3-14(4-6-15)29-22(34)32-19-10-13(23(25,26)27)2-8-17(19)24/h2-11H,1H3,(H2,29,32,34)(H2,28,30,31,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.60n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17806
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES CC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O3/c1-12(33)28-21-30-18-9-7-16(11-20(18)31-21)35-15-5-3-14(4-6-15)29-22(34)32-19-10-13(23(25,26)27)2-8-17(19)24/h2-11H,1H3,(H2,29,32,34)(H2,28,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.60n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17791
PNG
(benzimidazole-urea, 19 | methyl N-[6-(4-{[(3-ethyl...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(Oc3ccc4nc(NC(=O)OC)[nH]c4c3)cc2)c1
Show InChI InChI=1S/C24H23N5O4/c1-3-15-5-4-6-17(13-15)26-23(30)25-16-7-9-18(10-8-16)33-19-11-12-20-21(14-19)28-22(27-20)29-24(31)32-2/h4-14H,3H2,1-2H3,(H2,25,26,30)(H2,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.90n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17805
PNG
(N-(6-{[6-({[2-fluoro-5-(trifluoromethyl)phenyl]car...)
Show SMILES CC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)nc3)cc2[nH]1
Show InChI InChI=1S/C22H16F4N6O3/c1-11(33)28-20-29-16-6-3-13(9-18(16)30-20)35-14-4-7-19(27-10-14)32-21(34)31-17-8-12(22(24,25)26)2-5-15(17)23/h2-10H,1H3,(H2,27,31,32,34)(H2,28,29,30,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.90n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17823
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES COCCOCC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C26H23F4N5O5/c1-38-10-11-39-14-23(36)35-24-32-20-9-7-18(13-22(20)33-24)40-17-5-3-16(4-6-17)31-25(37)34-21-12-15(26(28,29)30)2-8-19(21)27/h2-9,12-13H,10-11,14H2,1H3,(H2,31,34,37)(H2,32,33,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17790
PNG
(benzimidazole-urea, 18 | methyl N-{6-[4-({[2-chlor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4Cl)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17ClF3N5O4/c1-35-22(34)32-20-29-17-9-7-15(11-19(17)30-20)36-14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.30n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17815
PNG
(imidazopyridine-urea,42 | methyl N-{6-[4-({[2-fluo...)
Show SMILES COC(=O)Nc1cn2cc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H17F4N5O4/c1-35-22(34)31-19-12-32-11-16(7-9-20(32)30-19)36-15-5-3-14(4-6-15)28-21(33)29-18-10-13(23(25,26)27)2-8-17(18)24/h2-12H,1H3,(H,31,34)(H2,28,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17815
PNG
(imidazopyridine-urea,42 | methyl N-{6-[4-({[2-fluo...)
Show SMILES COC(=O)Nc1cn2cc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H17F4N5O4/c1-35-22(34)31-19-12-32-11-16(7-9-20(32)30-19)36-15-5-3-14(4-6-15)28-21(33)29-18-10-13(23(25,26)27)2-8-17(18)24/h2-12H,1H3,(H,31,34)(H2,28,29,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17789
PNG
(benzimidazole-urea, 17 | methyl N-{6-[4-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O4/c1-35-22(34)32-20-29-17-9-7-15(11-19(17)30-20)36-14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
MMDB
PDB
Article
PubMed
n/an/a 3.5n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17814
PNG
(benzoxazole-urea, 41 | methyl N-{6-[4-({[2-fluoro-...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2o1
Show InChI InChI=1S/C23H16F4N4O5/c1-34-22(33)31-21-30-17-9-7-15(11-19(17)36-21)35-14-5-3-13(4-6-14)28-20(32)29-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,29,32)(H,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17824
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES CN1CCN(CC(=O)Nc2nc3ccc(Oc4ccc(NC(=O)Nc5cc(ccc5F)C(F)(F)F)cc4)cc3[nH]2)CC1
Show InChI InChI=1S/C28H27F4N7O3/c1-38-10-12-39(13-11-38)16-25(40)37-26-34-22-9-7-20(15-24(22)35-26)42-19-5-3-18(4-6-19)33-27(41)36-23-14-17(28(30,31)32)2-8-21(23)29/h2-9,14-15H,10-13,16H2,1H3,(H2,33,36,41)(H2,34,35,37,40)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4.90n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17788
PNG
(benzimidazole-urea, 16 | methyl N-{6-[4-({[3-(trif...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H18F3N5O4/c1-34-22(33)31-20-29-18-10-9-17(12-19(18)30-20)35-16-7-5-14(6-8-16)27-21(32)28-15-4-2-3-13(11-15)23(24,25)26/h2-12H,1H3,(H2,27,28,32)(H2,29,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17821
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4ccco4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C26H17F4N5O4/c27-18-9-3-14(26(28,29)30)12-20(18)34-25(37)31-15-4-6-16(7-5-15)39-17-8-10-19-21(13-17)33-24(32-19)35-23(36)22-2-1-11-38-22/h1-13H,(H2,31,34,37)(H2,32,33,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.10n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17788
PNG
(benzimidazole-urea, 16 | methyl N-{6-[4-({[3-(trif...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H18F3N5O4/c1-34-22(33)31-20-29-18-10-9-17(12-19(18)30-20)35-16-7-5-14(6-8-16)27-21(32)28-15-4-2-3-13(11-15)23(24,25)26/h2-12H,1H3,(H2,27,28,32)(H2,29,30,31,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.20n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17821
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4ccco4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C26H17F4N5O4/c27-18-9-3-14(26(28,29)30)12-20(18)34-25(37)31-15-4-6-16(7-5-15)39-17-8-10-19-21(13-17)33-24(32-19)35-23(36)22-2-1-11-38-22/h1-13H,(H2,31,34,37)(H2,32,33,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.20n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17817
PNG
(imidazopyridine-urea, 44 | methyl N-{6-[4-({[2-flu...)
Show SMILES COC(=O)Nc1nc2ncc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-29-17-9-14(10-27-18(17)31-19)36-13-5-3-12(4-6-13)28-20(33)30-16-8-11(22(24,25)26)2-7-15(16)23/h2-10H,1H3,(H2,28,30,33)(H2,27,29,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.40n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17796
PNG
(benzimidazole-urea, 24 | methyl N-{6-[4-({[3-(meth...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(SC)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C23H21N5O4S/c1-31-23(30)28-21-26-19-11-10-17(13-20(19)27-21)32-16-8-6-14(7-9-16)24-22(29)25-15-4-3-5-18(12-15)33-2/h3-13H,1-2H3,(H2,24,25,29)(H2,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.40n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17823
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES COCCOCC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C26H23F4N5O5/c1-38-10-11-39-14-23(36)35-24-32-20-9-7-18(13-22(20)33-24)40-17-5-3-16(4-6-17)31-25(37)34-21-12-15(26(28,29)30)2-8-19(21)27/h2-9,12-13H,10-11,14H2,1H3,(H2,31,34,37)(H2,32,33,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.40n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17816
PNG
(imidazopyridine-urea, 43 | methyl N-{5-[4-({[2-flu...)
Show SMILES COC(=O)Nc1nc2nc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2[nH]1
Show InChI InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-28-15-8-9-17(30-18(15)31-19)36-13-5-3-12(4-6-13)27-20(33)29-16-10-11(22(24,25)26)2-7-14(16)23/h2-10H,1H3,(H2,27,29,33)(H2,28,30,31,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.60n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17790
PNG
(benzimidazole-urea, 18 | methyl N-{6-[4-({[2-chlor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4Cl)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17ClF3N5O4/c1-35-22(34)32-20-29-17-9-7-15(11-19(17)30-20)36-14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.30n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17793
PNG
(benzimidazole-urea, 21 | methyl N-[6-(4-{[(3-chlor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C22H18ClN5O4/c1-31-22(30)28-20-26-18-10-9-17(12-19(18)27-20)32-16-7-5-14(6-8-16)24-21(29)25-15-4-2-3-13(23)11-15/h2-12H,1H3,(H2,24,25,29)(H2,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.30n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17813
PNG
(benzthiazole-urea, 40 | methyl N-{6-[4-({[2-fluoro...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2s1
Show InChI InChI=1S/C23H16F4N4O4S/c1-34-22(33)31-21-30-17-9-7-15(11-19(17)36-21)35-14-5-3-13(4-6-14)28-20(32)29-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,29,32)(H,30,31,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 6.5n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17789
PNG
(benzimidazole-urea, 17 | methyl N-{6-[4-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O4/c1-35-22(34)32-20-29-17-9-7-15(11-19(17)30-20)36-14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.90n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17794
PNG
(benzimidazole-urea, 22 | methyl N-[6-(4-{[(2,5-dif...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H17F2N5O4/c1-32-22(31)29-20-26-17-9-7-15(11-19(17)27-20)33-14-5-3-13(4-6-14)25-21(30)28-18-10-12(23)2-8-16(18)24/h2-11H,1H3,(H2,25,28,30)(H2,26,27,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 7.60n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17814
PNG
(benzoxazole-urea, 41 | methyl N-{6-[4-({[2-fluoro-...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2o1
Show InChI InChI=1S/C23H16F4N4O5/c1-34-22(33)31-21-30-17-9-7-15(11-19(17)36-21)35-14-5-3-13(4-6-14)28-20(32)29-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,29,32)(H,30,31,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 8.90n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17807
PNG
(benzimidazole-urea, 34 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(Sc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O3S/c1-35-22(34)32-20-29-17-9-7-15(11-19(17)30-20)36-14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17795
PNG
(benzimidazole-urea, 23 | methyl N-(6-{4-[({3-[(tri...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(SC(F)(F)F)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C23H18F3N5O4S/c1-34-22(33)31-20-29-18-10-9-16(12-19(18)30-20)35-15-7-5-13(6-8-15)27-21(32)28-14-3-2-4-17(11-14)36-23(24,25)26/h2-12H,1H3,(H2,27,28,32)(H2,29,30,31,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 10n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17807
PNG
(benzimidazole-urea, 34 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(Sc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O3S/c1-35-22(34)32-20-29-17-9-7-15(11-19(17)30-20)36-14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17810
PNG
(benzimidazole-urea, 37 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C24H17F4N5O4/c1-37-23(36)33-21-30-17-9-4-13(10-19(17)31-21)20(34)12-2-6-15(7-3-12)29-22(35)32-18-11-14(24(26,27)28)5-8-16(18)25/h2-11H,1H3,(H2,29,32,35)(H2,30,31,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17792
PNG
(benzimidazole-urea, 20 | methyl N-[6-(4-{[(3-bromo...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C22H18BrN5O4/c1-31-22(30)28-20-26-18-10-9-17(12-19(18)27-20)32-16-7-5-14(6-8-16)24-21(29)25-15-4-2-3-13(23)11-15/h2-12H,1H3,(H2,24,25,29)(H2,26,27,28,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 13n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17819
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4ccccc4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C28H19F4N5O3/c29-21-12-6-17(28(30,31)32)14-23(21)36-27(39)33-18-7-9-19(10-8-18)40-20-11-13-22-24(15-20)35-26(34-22)37-25(38)16-4-2-1-3-5-16/h1-15H,(H2,33,36,39)(H2,34,35,37,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17818
PNG
(1-{4-[(2-amino-1H-1,3-benzodiazol-6-yl)oxy]phenyl}...)
Show SMILES Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C21H15F4N5O2/c22-15-7-1-11(21(23,24)25)9-17(15)30-20(31)27-12-2-4-13(5-3-12)32-14-6-8-16-18(10-14)29-19(26)28-16/h1-10H,(H3,26,28,29)(H2,27,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17803
PNG
(benzimidazole-urea, 31 | methyl N-(6-{[5-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cn3)cc2[nH]1
Show InChI InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-29-15-6-4-13(9-17(15)30-19)36-18-7-3-12(10-27-18)28-20(33)31-16-8-11(22(24,25)26)2-5-14(16)23/h2-10H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17822
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4cccnc4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C27H18F4N6O3/c28-20-9-3-16(27(29,30)31)12-22(20)36-26(39)33-17-4-6-18(7-5-17)40-19-8-10-21-23(13-19)35-25(34-21)37-24(38)15-2-1-11-32-14-15/h1-14H,(H2,33,36,39)(H2,34,35,37,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17801
PNG
(benzimidazole-acetamide, 29 | methyl N-{6-[4-({[2-...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(CC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C24H18F4N4O4/c1-35-23(34)32-22-30-18-9-7-16(12-20(18)31-22)36-15-5-2-13(3-6-15)10-21(33)29-19-11-14(24(26,27)28)4-8-17(19)25/h2-9,11-12H,10H2,1H3,(H,29,33)(H2,30,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17822
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4cccnc4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C27H18F4N6O3/c28-20-9-3-16(27(29,30)31)12-22(20)36-26(39)33-17-4-6-18(7-5-17)40-19-8-10-21-23(13-19)35-25(34-21)37-24(38)15-2-1-11-32-14-15/h1-14H,(H2,33,36,39)(H2,34,35,37,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 16.5n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17802
PNG
(benzimidazole-urea, 30 | methyl N-{6-[3-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3cccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O4/c1-35-22(34)32-20-29-17-8-6-15(11-19(17)30-20)36-14-4-2-3-13(10-14)28-21(33)31-18-9-12(23(25,26)27)5-7-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17791
PNG
(benzimidazole-urea, 19 | methyl N-[6-(4-{[(3-ethyl...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(Oc3ccc4nc(NC(=O)OC)[nH]c4c3)cc2)c1
Show InChI InChI=1S/C24H23N5O4/c1-3-15-5-4-6-17(13-15)26-23(30)25-16-7-9-18(10-8-16)33-19-11-12-20-21(14-19)28-22(27-20)29-24(31)32-2/h4-14H,3H2,1-2H3,(H2,25,26,30)(H2,27,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 18n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17803
PNG
(benzimidazole-urea, 31 | methyl N-(6-{[5-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cn3)cc2[nH]1
Show InChI InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-29-15-6-4-13(9-17(15)30-19)36-18-7-3-12(10-27-18)28-20(33)31-16-8-11(22(24,25)26)2-5-14(16)23/h2-10H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 20n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17810
PNG
(benzimidazole-urea, 37 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C24H17F4N5O4/c1-37-23(36)33-21-30-17-9-4-13(10-19(17)31-21)20(34)12-2-6-15(7-3-12)29-22(35)32-18-11-14(24(26,27)28)5-8-16(18)25/h2-11H,1H3,(H2,29,32,35)(H2,30,31,33,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17811
PNG
(benzimidazole-urea, 38 | methyl N-{6-[4-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2n1C
Show InChI InChI=1S/C24H19F4N5O4/c1-33-20-12-16(8-10-18(20)30-21(33)32-23(35)36-2)37-15-6-4-14(5-7-15)29-22(34)31-19-11-13(24(26,27)28)3-9-17(19)25/h3-12H,1-2H3,(H2,29,31,34)(H,30,32,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17802
PNG
(benzimidazole-urea, 30 | methyl N-{6-[3-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3cccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O4/c1-35-22(34)32-20-29-17-8-6-15(11-19(17)30-20)36-14-4-2-3-13(10-14)28-21(33)31-18-9-12(23(25,26)27)5-7-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 28n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17787
PNG
(benzimidazole-urea, 15 | methyl N-(6-{4-[(phenylca...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)cc2[nH]1
Show InChI InChI=1S/C22H19N5O4/c1-30-22(29)27-20-25-18-12-11-17(13-19(18)26-20)31-16-9-7-15(8-10-16)24-21(28)23-14-5-3-2-4-6-14/h2-13H,1H3,(H2,23,24,28)(H2,25,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17825
PNG
(3-[2-fluoro-5-(trifluoromethyl)phenyl]-1-{4-[(2-{[...)
Show SMILES CN1CCN(CCNc2nc3ccc(Oc4ccc(NC(=O)Nc5cc(ccc5F)C(F)(F)F)cc4)cc3[nH]2)CC1
Show InChI InChI=1S/C28H29F4N7O2/c1-38-12-14-39(15-13-38)11-10-33-26-35-23-9-7-21(17-25(23)36-26)41-20-5-3-19(4-6-20)34-27(40)37-24-16-18(28(30,31)32)2-8-22(24)29/h2-9,16-17H,10-15H2,1H3,(H2,33,35,36)(H2,34,37,40)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17793
PNG
(benzimidazole-urea, 21 | methyl N-[6-(4-{[(3-chlor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C22H18ClN5O4/c1-31-22(30)28-20-26-18-10-9-17(12-19(18)27-20)32-16-7-5-14(6-8-16)24-21(29)25-15-4-2-3-13(23)11-15/h2-12H,1H3,(H2,24,25,29)(H2,26,27,28,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 40n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17819
PNG
(N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carb...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4ccccc4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C28H19F4N5O3/c29-21-12-6-17(28(30,31)32)14-23(21)36-27(39)33-18-7-9-19(10-8-18)40-20-11-13-22-24(15-20)35-26(34-22)37-25(38)16-4-2-1-3-5-16/h1-15H,(H2,33,36,39)(H2,34,35,37,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17796
PNG
(benzimidazole-urea, 24 | methyl N-{6-[4-({[3-(meth...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(SC)c4)cc3)cc2[nH]1
Show InChI InChI=1S/C23H21N5O4S/c1-31-23(30)28-21-26-19-11-10-17(13-20(19)27-21)32-16-8-6-14(7-9-16)24-22(29)25-15-4-3-5-18(12-15)33-2/h3-13H,1-2H3,(H2,24,25,29)(H2,26,27,28,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 58n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17818
PNG
(1-{4-[(2-amino-1H-1,3-benzodiazol-6-yl)oxy]phenyl}...)
Show SMILES Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C21H15F4N5O2/c22-15-7-1-11(21(23,24)25)9-17(15)30-20(31)27-12-2-4-13(5-3-12)32-14-6-8-16-18(10-14)29-19(26)28-16/h1-10H,(H3,26,28,29)(H2,27,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17811
PNG
(benzimidazole-urea, 38 | methyl N-{6-[4-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2n1C
Show InChI InChI=1S/C24H19F4N5O4/c1-33-20-12-16(8-10-18(20)30-21(33)32-23(35)36-2)37-15-6-4-14(5-7-15)29-22(34)31-19-11-13(24(26,27)28)3-9-17(19)25/h3-12H,1-2H3,(H2,29,31,34)(H,30,32,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17808
PNG
(benzimidazole-urea, 35 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)S(=O)c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F4N5O4S/c1-36-22(34)32-20-29-17-9-7-15(11-19(17)30-20)37(35)14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 69n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17804
PNG
(5-({[2-fluoro-5-(trifluoromethyl)phenyl]carbamoyl}...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c[n+]3[O-])cc2[nH]1
Show InChI InChI=1S/C22H16F4N6O5/c1-36-21(34)31-19-28-15-6-4-13(9-17(15)29-19)37-18-7-3-12(10-32(18)35)27-20(33)30-16-8-11(22(24,25)26)2-5-14(16)23/h2-10H,1H3,(H2,27,30,33)(H2,28,29,31,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 71n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17799
PNG
(benzimidazole-thiourea, 27 | methyl N-{6-[4-({[3-(...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=S)Nc4cccc(c4)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H18F3N5O3S/c1-33-22(32)31-20-29-18-10-9-17(12-19(18)30-20)34-16-7-5-14(6-8-16)27-21(35)28-15-4-2-3-13(11-15)23(24,25)26/h2-12H,1H3,(H2,27,28,35)(H2,29,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 105n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17809
PNG
(benzimidazole-urea, 36 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)S(=O)(=O)c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F4N5O5S/c1-37-22(34)32-20-29-17-9-7-15(11-19(17)30-20)38(35,36)14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17817
PNG
(imidazopyridine-urea, 44 | methyl N-{6-[4-({[2-flu...)
Show SMILES COC(=O)Nc1nc2ncc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H16F4N6O4/c1-35-21(34)32-19-29-17-9-14(10-27-18(17)31-19)36-13-5-3-12(4-6-13)28-20(33)30-16-8-11(22(24,25)26)2-7-15(16)23/h2-10H,1H3,(H2,28,30,33)(H2,27,29,31,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17825
PNG
(3-[2-fluoro-5-(trifluoromethyl)phenyl]-1-{4-[(2-{[...)
Show SMILES CN1CCN(CCNc2nc3ccc(Oc4ccc(NC(=O)Nc5cc(ccc5F)C(F)(F)F)cc4)cc3[nH]2)CC1
Show InChI InChI=1S/C28H29F4N7O2/c1-38-12-14-39(15-13-38)11-10-33-26-35-23-9-7-21(17-25(23)36-26)41-20-5-3-19(4-6-20)34-27(40)37-24-16-18(28(30,31)32)2-8-22(24)29/h2-9,16-17H,10-15H2,1H3,(H2,33,35,36)(H2,34,37,40)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17797
PNG
(benzimidazole-urea, 25 | methyl N-[6-(4-{[(5-amino...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(N)ccc4F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H19FN6O4/c1-32-22(31)29-20-26-17-9-7-15(11-19(17)27-20)33-14-5-3-13(4-6-14)25-21(30)28-18-10-12(24)2-8-16(18)23/h2-11H,24H2,1H3,(H2,25,28,30)(H2,26,27,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17804
PNG
(5-({[2-fluoro-5-(trifluoromethyl)phenyl]carbamoyl}...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c[n+]3[O-])cc2[nH]1
Show InChI InChI=1S/C22H16F4N6O5/c1-36-21(34)31-19-28-15-6-4-13(9-17(15)29-19)37-18-7-3-12(10-32(18)35)27-20(33)30-16-8-11(22(24,25)26)2-5-14(16)23/h2-10H,1H3,(H2,27,30,33)(H2,28,29,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17794
PNG
(benzimidazole-urea, 22 | methyl N-[6-(4-{[(2,5-dif...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H17F2N5O4/c1-32-22(31)29-20-26-17-9-7-15(11-19(17)27-20)33-14-5-3-13(4-6-14)25-21(30)28-18-10-12(23)2-8-16(18)24/h2-11H,1H3,(H2,25,28,30)(H2,26,27,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 390n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17812
PNG
(benzimidazole-urea, 39 | methyl N-{5-[4-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2cc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2n1C
Show InChI InChI=1S/C24H19F4N5O4/c1-33-20-10-8-16(12-19(20)30-21(33)32-23(35)36-2)37-15-6-4-14(5-7-15)29-22(34)31-18-11-13(24(26,27)28)3-9-17(18)25/h3-12H,1-2H3,(H2,29,31,34)(H,30,32,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 420n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17820
PNG
(N-(6-(4-((2-Fluoro-5(trifluoromethyl)phenyl)aminoc...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4ccccc4-n4cccc4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C32H22F4N6O3/c33-24-13-7-19(32(34,35)36)17-26(24)40-31(44)37-20-8-10-21(11-9-20)45-22-12-14-25-27(18-22)39-30(38-25)41-29(43)23-5-1-2-6-28(23)42-15-3-4-16-42/h1-18H,(H2,37,40,44)(H2,38,39,41,43)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 510n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17798
PNG
(3-({[4-({2-[(methoxycarbonyl)amino]-1H-1,3-benzodi...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(c4)C(O)=O)cc3)cc2[nH]1
Show InChI InChI=1S/C23H19N5O6/c1-33-23(32)28-21-26-18-10-9-17(12-19(18)27-21)34-16-7-5-14(6-8-16)24-22(31)25-15-4-2-3-13(11-15)20(29)30/h2-12H,1H3,(H,29,30)(H2,24,25,31)(H2,26,27,28,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 603n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17820
PNG
(N-(6-(4-((2-Fluoro-5(trifluoromethyl)phenyl)aminoc...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccc3nc(NC(=O)c4ccccc4-n4cccc4)[nH]c3c2)cc1)C(F)(F)F
Show InChI InChI=1S/C32H22F4N6O3/c33-24-13-7-19(32(34,35)36)17-26(24)40-31(44)37-20-8-10-21(11-9-20)45-22-12-14-25-27(18-22)39-30(38-25)41-29(43)23-5-1-2-6-28(23)42-15-3-4-16-42/h1-18H,(H2,37,40,44)(H2,38,39,41,43)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17797
PNG
(benzimidazole-urea, 25 | methyl N-[6-(4-{[(5-amino...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(N)ccc4F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H19FN6O4/c1-32-22(31)29-20-26-17-9-7-15(11-19(17)27-20)33-14-5-3-13(4-6-14)25-21(30)28-18-10-12(24)2-8-16(18)23/h2-11H,24H2,1H3,(H2,25,28,30)(H2,26,27,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.19E+3n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17799
PNG
(benzimidazole-thiourea, 27 | methyl N-{6-[4-({[3-(...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=S)Nc4cccc(c4)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H18F3N5O3S/c1-33-22(32)31-20-29-18-10-9-17(12-19(18)30-20)34-16-7-5-14(6-8-16)27-21(35)28-15-4-2-3-13(11-15)23(24,25)26/h2-12H,1H3,(H2,27,28,35)(H2,29,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.20E+3n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17787
PNG
(benzimidazole-urea, 15 | methyl N-(6-{4-[(phenylca...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)cc2[nH]1
Show InChI InChI=1S/C22H19N5O4/c1-30-22(29)27-20-25-18-12-11-17(13-19(18)26-20)31-16-9-7-15(8-10-16)24-21(28)23-14-5-3-2-4-6-14/h2-13H,1H3,(H2,23,24,28)(H2,25,26,27,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.20E+3n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17800
PNG
(benzimidazole-acetamide, 28 | methyl N-[6-(4-{2-[3...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Cc4cccc(c4)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C24H19F3N4O4/c1-34-23(33)31-22-29-19-10-9-18(13-20(19)30-22)35-17-7-5-16(6-8-17)28-21(32)12-14-3-2-4-15(11-14)24(25,26)27/h2-11,13H,12H2,1H3,(H,28,32)(H2,29,30,31,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.20E+3n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17826
PNG
(3-[2-fluoro-5-(trifluoromethyl)phenyl]-1-{4-[(2-me...)
Show SMILES CS(=O)(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2s1
Show InChI InChI=1S/C22H16F4N4O4S2/c1-36(32,33)30-21-29-17-9-7-15(11-19(17)35-21)34-14-5-3-13(4-6-14)27-20(31)28-18-10-12(22(24,25)26)2-8-16(18)23/h2-11H,1H3,(H,29,30)(H2,27,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17826
PNG
(3-[2-fluoro-5-(trifluoromethyl)phenyl]-1-{4-[(2-me...)
Show SMILES CS(=O)(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2s1
Show InChI InChI=1S/C22H16F4N4O4S2/c1-36(32,33)30-21-29-17-9-7-15(11-19(17)35-21)34-14-5-3-13(4-6-14)27-20(31)28-18-10-12(22(24,25)26)2-8-16(18)23/h2-11H,1H3,(H,29,30)(H2,27,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17801
PNG
(benzimidazole-acetamide, 29 | methyl N-{6-[4-({[2-...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(CC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C24H18F4N4O4/c1-35-23(34)32-22-30-18-9-7-16(12-20(18)31-22)36-15-5-2-13(3-6-15)10-21(33)29-19-11-14(24(26,27)28)4-8-17(19)25/h2-9,11-12H,10H2,1H3,(H,29,33)(H2,30,31,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.40E+3n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17812
PNG
(benzimidazole-urea, 39 | methyl N-{5-[4-({[2-fluor...)
Show SMILES COC(=O)Nc1nc2cc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2n1C
Show InChI InChI=1S/C24H19F4N5O4/c1-33-20-10-8-16(12-19(20)30-21(33)32-23(35)36-2)37-15-6-4-14(5-7-15)29-22(34)31-18-11-13(24(26,27)28)3-9-17(18)25/h3-12H,1-2H3,(H2,29,31,34)(H,30,32,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.60E+3n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17808
PNG
(benzimidazole-urea, 35 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)S(=O)c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F4N5O4S/c1-36-22(34)32-20-29-17-9-7-15(11-19(17)30-20)37(35)14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 9.50E+3n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))		BDBM17798
PNG
(3-({[4-({2-[(methoxycarbonyl)amino]-1H-1,3-benzodi...)
Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cccc(c4)C(O)=O)cc3)cc2[nH]1
Show InChI InChI=1S/C23H19N5O6/c1-33-23(32)28-21-26-18-10-9-17(12-19(18)27-21)34-16-7-5-14(6-8-16)24-22(31)25-15-4-2-3-13(11-15)20(29)30/h2-12H,1H3,(H,29,30)(H2,24,25,31)(H2,26,27,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/a7.422



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM17809
PNG
(benzimidazole-urea, 36 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)S(=O)(=O)c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F4N5O5S/c1-37-22(34)32-20-29-17-9-7-15(11-19(17)30-20)38(35,36)14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



GSK



Assay Description
The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...

J Med Chem 50: 4453-70 (2007)


Article DOI: 10.1021/jm0611051
BindingDB Entry DOI: 10.7270/Q20V8B29
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%