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PubMed code 17686765

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50242614
PNG
((S)-1-((S)-2-((S)-2,5-diamino-5-oxopentanamido)-3-...)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(O)=O |r|
Show InChI InChI=1S/C13H22N4O6/c14-7(3-4-10(15)19)11(20)16-8(6-18)12(21)17-5-1-2-9(17)13(22)23/h7-9,18H,1-6,14H2,(H2,15,19)(H,16,20)(H,22,23)/t7-,8-,9-/m0/s1
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PubMed
n/an/a 0.160n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs

J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50242617
PNG
(CHEMBL521026 | QSPac)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O |r|
Show InChI InChI=1S/C15H24N4O7/c1-8(21)19-6-2-3-11(19)14(24)18-10(7-20)13(23)17-9(15(25)26)4-5-12(16)22/h9-11,20H,2-7H2,1H3,(H2,16,22)(H,17,23)(H,18,24)(H,25,26)/t9-,10-,11-/m0/s1
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KEGG
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PubMed
n/an/a 0.170n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs

J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50242615
PNG
(CHEMBL486028 | QCPac)
Show SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CS)C(O)=O |r|
Show InChI InChI=1S/C13H21N3O5S/c1-7(11(18)15-9(6-22)13(20)21)14-12(19)10-4-3-5-16(10)8(2)17/h7,9-10,22H,3-6H2,1-2H3,(H,14,19)(H,15,18)(H,20,21)/t7-,9-,10-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs

J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50242616
PNG
(CHEMBL485831 | QCP)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(O)=O |r|
Show InChI InChI=1S/C13H22N4O5S/c14-7(3-4-10(15)18)11(19)16-8(6-23)12(20)17-5-1-2-9(17)13(21)22/h7-9,23H,1-6,14H2,(H2,15,18)(H,16,19)(H,21,22)/t7-,8-,9-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



University Würzburg

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrs

J Biol Chem 282: 28501-13 (2007)


Article DOI: 10.1074/jbc.M705416200
BindingDB Entry DOI: 10.7270/Q2SJ1KCM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%