Found 99 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calcium/calmodulin-dependent protein kinase kinase 2
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CAMKKbeta in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aurora kinase C
(Homo sapiens (Human)) | BDBM50307127
((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- | PDB
NCI pathway KEGG
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| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Aurora C in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50307127
((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- | PDB
Reactome pathway KEGG
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Aurora B in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)Show InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of RIP2 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50095227
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25) | PDB
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of RIP2 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM25116
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) | PDB
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| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of RIP2 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM50169959
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) | KEGG
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM3 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM27216
((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)Show SMILES CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 Show InChI InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CDK2-cyclinA in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50153835
(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1 Show InChI InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of c-Raf in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)Show InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM4811
((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...)Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccccc23)c(C)c1CCC(O)=O Show InChI InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9- | PDB
Reactome pathway KEGG
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Aurora B in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)Show InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) | PDB MMDB
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50169959
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of GSK3-beta in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM13534
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) | PDB
Reactome pathway KEGG
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Aurora B in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM25116
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)Show InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CK1delta in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM25116
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) | PDB MMDB
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Aurora kinase C
(Homo sapiens (Human)) | BDBM13534
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) | PDB
NCI pathway KEGG
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Aurora C in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50358043
(CHEMBL1794051 | GW-5074)Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H | PDB MMDB
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| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM2 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50169959
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) | PDB MMDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM1 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | KEGG
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| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM3 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase BRSK2
(Homo sapiens (Human)) | BDBM50307127
((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- | PDB
NCI pathway KEGG
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of BRSK2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50307127
((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- | PDB MMDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM50358043
(CHEMBL1794051 | GW-5074)Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H | KEGG
UniProtKB/SwissProt
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM3 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | PDB MMDB
KEGG
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM2 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase 3
(Homo sapiens (Human)) | BDBM50307127
((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of MST2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of MNK1 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of RIP2 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | PDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CAMKKalpha in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | PDB
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of RIP2 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PAK 4
(Homo sapiens (Human)) | BDBM27216
((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)Show SMILES CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 Show InChI InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PAK4 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM7533
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CDK2-cyclinA in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of JNK-M108G in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM50307127
((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cc4CCCCc4[nH]3)c2c1 Show InChI InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CK1delta in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50358043
(CHEMBL1794051 | GW-5074)Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H | PDB MMDB
KEGG
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| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM1 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM25116
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) | PDB
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| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CK1delta in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50358043
(CHEMBL1794051 | GW-5074)Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of c-Raf in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50095227
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25) | PDB MMDB
KEGG
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50358043
(CHEMBL1794051 | GW-5074)Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of B-Raf in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Aurora kinase C
(Homo sapiens (Human)) | BDBM4811
((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...)Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccccc23)c(C)c1CCC(O)=O Show InChI InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9- | PDB
NCI pathway KEGG
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| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Aurora C in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50153835
(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1 Show InChI InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of B-Raf in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PKD1 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of JNK-M108A in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM50130248
(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)Show InChI InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of IKK-beta in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of JNK-M108A in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50229971
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1 Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CK1delta in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human)) | BDBM50169959
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) | PDB MMDB
NCI pathway KEGG
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of DYRK2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM13534
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) | PDB MMDB
KEGG
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| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | PDB MMDB
KEGG
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| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of c-Raf in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Maternal embryonic leucine zipper kinase
(Homo sapiens (Human)) | BDBM13534
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) | PDB
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| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of MELK in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Homo sapiens (Human)) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PKA in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Yes
(Homo sapiens (Human)) | BDBM50248765
(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Yes in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Homo sapiens (Human)) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CSK in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB
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| Article PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CK1delta in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50248765
(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) | PDB MMDB
KEGG
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| Article PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM50153835
(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1 Show InChI InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50298225
(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)Show InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) | PDB MMDB
KEGG
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| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Src in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of JNK-M108G in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Homo sapiens (Human)) | BDBM25116
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CSK in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM50248765
(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50248765
(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Eph-A2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human)) | BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of DYRK3 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM12915
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM1 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of MNK1 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM50130248
(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)Show InChI InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23) | KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM3 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human)) | BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of DYRK2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PKD1 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50248765
(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12 Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of S6K1 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of DYRK2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50130248
(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)Show InChI InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM1 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase BRSK2
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of BRSK2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM15234
((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)Show SMILES [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3c2[C@]1(C)[C@@H](COC)OC3=O |r,c:15| Show InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PLK1 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM12915
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM3 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 | PDB
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CK1delta in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB MMDB
KEGG
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of MNK2 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Homo sapiens (Human)) | BDBM50229961
(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of CSK in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM12915
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PLK1 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM26098
(3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide |...)Show InChI InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of IKK-beta in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Lck in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of Aurora B in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human)) | BDBM25919
(BMS-345541 | BMS345541 | CHEMBL471496 | N-(2-amino...)Show InChI InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of IKK-beta in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50169959
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of JNK1 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of SGK1 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB
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Similars
| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of DYRK3 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
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| MMDB PDB Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of p38-alpha MAPK in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of RIP2 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 | KEGG
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Similars
| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PIM3 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50169959
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of JNK2 in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Myosin light chain kinase, smooth muscle
(Homo sapiens (Human)) | BDBM15234
((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)Show SMILES [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3c2[C@]1(C)[C@@H](COC)OC3=O |r,c:15| Show InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 | PDB MMDB
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of SmMLCK in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50229971
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1 Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of p38-alpha MAPK in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PAK 4
(Homo sapiens (Human)) | BDBM7533
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PAK4 in the presence of 5uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
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| DrugBank PDB Article PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of B-Raf in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50229971
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1 Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) | NCI pathway Reactome pathway KEGG
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of PKD1 in the presence of 50uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50153835
(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1 Show InChI InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of RIP2 in the presence of 100uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this Ligand-Target Pair | |