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PubMed code 17855092

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.0540n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))		BDBM50222089
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5-et...)
Show SMILES CCC1=N[C@]2(CC[C@H]3[C@@H]4CCC5=CC(=O)CCC5=C4[C@H](C[C@]23C)c2ccc(cc2)C(C)=O)C(=C)O1 |c:18,t:2,11|
Show InChI InChI=1S/C31H35NO3/c1-5-28-32-31(19(3)35-28)15-14-27-25-12-10-22-16-23(34)11-13-24(22)29(25)26(17-30(27,31)4)21-8-6-20(7-9-21)18(2)33/h6-9,16,25-27H,3,5,10-15,17H2,1-2,4H3/t25-,26+,27-,30-,31+/m0/s1
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n/an/a 0.340n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50222091
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5,15...)
Show SMILES CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=C(C)OC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:19,29,36|
Show InChI InChI=1S/C30H33NO3/c1-17(32)20-5-7-21(8-6-20)26-16-29(4)27(13-14-30(29)18(2)34-19(3)31-30)25-11-9-22-15-23(33)10-12-24(22)28(25)26/h5-8,15,25-27H,2,9-14,16H2,1,3-4H3/t25-,26+,27-,29-,30+/m0/s1
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n/an/a 0.590n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50222086
PNG
((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=C(C)OC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:19,29,36|
Show InChI InChI=1S/C30H36N2O2/c1-18-30(31-19(2)34-18)15-14-27-25-12-8-21-16-23(33)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)32(4)5/h6-7,9-10,16,25-27H,1,8,11-15,17H2,2-5H3/t25-,26+,27-,29-,30+/m0/s1
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n/an/a 0.630n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50222092
PNG
((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Show SMILES CCC1=N[C@]2(CC[C@H]3[C@@H]4CCC5=CC(=O)CCC5=C4[C@H](C[C@]23C)c2ccc(cc2)N(C)C)C(=C)O1 |c:18,t:2,11|
Show InChI InChI=1S/C31H38N2O2/c1-6-28-32-31(19(2)35-28)16-15-27-25-13-9-21-17-23(34)12-14-24(21)29(25)26(18-30(27,31)3)20-7-10-22(11-8-20)33(4)5/h7-8,10-11,17,25-27H,2,6,9,12-16,18H2,1,3-5H3/t25-,26+,27-,30-,31+/m0/s1
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n/an/a 0.980n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50222088
PNG
((3S,10'S,11'S,15'S,17'R)-5-ethyl-17'-(3-fluoro-4-m...)
Show SMILES CCC1=N[C@]2(CC[C@H]3[C@@H]4CCC5=CC(=O)CCC5=C4[C@H](C[C@]23C)c2ccc(OC)c(F)c2)C(=C)O1 |c:18,t:2,11|
Show InChI InChI=1S/C30H34FNO3/c1-5-27-32-30(17(2)35-27)13-12-24-22-9-6-18-14-20(33)8-10-21(18)28(22)23(16-29(24,30)3)19-7-11-26(34-4)25(31)15-19/h7,11,14-15,22-24H,2,5-6,8-10,12-13,16H2,1,3-4H3/t22-,23+,24-,29-,30+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50222087
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(3-fluoro-4-methoxyph...)
Show SMILES COc1ccc(cc1F)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=C(C)OC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:19,29,36|
Show InChI InChI=1S/C29H32FNO3/c1-16-29(31-17(2)34-16)12-11-24-22-8-5-18-13-20(32)7-9-21(18)27(22)23(15-28(24,29)3)19-6-10-26(33-4)25(30)14-19/h6,10,13-14,22-24H,1,5,7-9,11-12,15H2,2-4H3/t22-,23+,24-,28-,29+/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))		BDBM50222085
PNG
((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=COC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |c:19,t:28,35|
Show InChI InChI=1S/C29H34N2O2/c1-18-29(30-17-33-18)14-13-26-24-11-7-20-15-22(32)10-12-23(20)27(24)25(16-28(26,29)2)19-5-8-21(9-6-19)31(3)4/h5-6,8-9,15,17,24-26H,1,7,10-14,16H2,2-4H3/t24-,25+,26-,28-,29+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222092
PNG
((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Show SMILES CCC1=N[C@]2(CC[C@H]3[C@@H]4CCC5=CC(=O)CCC5=C4[C@H](C[C@]23C)c2ccc(cc2)N(C)C)C(=C)O1 |c:18,t:2,11|
Show InChI InChI=1S/C31H38N2O2/c1-6-28-32-31(19(2)35-28)16-15-27-25-13-9-21-17-23(34)12-14-24(21)29(25)26(18-30(27,31)3)20-7-10-22(11-8-20)33(4)5/h7-8,10-11,17,25-27H,2,6,9,12-16,18H2,1,3-5H3/t25-,26+,27-,30-,31+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222086
PNG
((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=C(C)OC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:19,29,36|
Show InChI InChI=1S/C30H36N2O2/c1-18-30(31-19(2)34-18)15-14-27-25-12-8-21-16-23(33)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)32(4)5/h6-7,9-10,16,25-27H,1,8,11-15,17H2,2-5H3/t25-,26+,27-,29-,30+/m0/s1
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n/an/a 82n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50222090
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-15'-...)
Show SMILES CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=COC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |c:19,t:28,35|
Show InChI InChI=1S/C29H31NO3/c1-17(31)19-4-6-20(7-5-19)25-15-28(3)26(12-13-29(28)18(2)33-16-30-29)24-10-8-21-14-22(32)9-11-23(21)27(24)25/h4-7,14,16,24-26H,2,8-13,15H2,1,3H3/t24-,25+,26-,28-,29+/m0/s1
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n/an/a 82n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222089
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5-et...)
Show SMILES CCC1=N[C@]2(CC[C@H]3[C@@H]4CCC5=CC(=O)CCC5=C4[C@H](C[C@]23C)c2ccc(cc2)C(C)=O)C(=C)O1 |c:18,t:2,11|
Show InChI InChI=1S/C31H35NO3/c1-5-28-32-31(19(3)35-28)15-14-27-25-12-10-22-16-23(34)11-13-24(22)29(25)26(17-30(27,31)4)21-8-6-20(7-9-21)18(2)33/h6-9,16,25-27H,3,5,10-15,17H2,1-2,4H3/t25-,26+,27-,30-,31+/m0/s1
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n/an/a 210n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222091
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5,15...)
Show SMILES CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=C(C)OC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:19,29,36|
Show InChI InChI=1S/C30H33NO3/c1-17(32)20-5-7-21(8-6-20)26-16-29(4)27(13-14-30(29)18(2)34-19(3)31-30)25-11-9-22-15-23(33)10-12-24(22)28(25)26/h5-8,15,25-27H,2,9-14,16H2,1,3-4H3/t25-,26+,27-,29-,30+/m0/s1
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n/an/a 460n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222085
PNG
((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=COC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |c:19,t:28,35|
Show InChI InChI=1S/C29H34N2O2/c1-18-29(30-17-33-18)14-13-26-24-11-7-20-15-22(32)10-12-23(20)27(24)25(16-28(26,29)2)19-5-8-21(9-6-19)31(3)4/h5-6,8-9,15,17,24-26H,1,7,10-14,16H2,2-4H3/t24-,25+,26-,28-,29+/m0/s1
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n/an/a 540n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222087
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(3-fluoro-4-methoxyph...)
Show SMILES COc1ccc(cc1F)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=C(C)OC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:19,29,36|
Show InChI InChI=1S/C29H32FNO3/c1-16-29(31-17(2)34-16)12-11-24-22-8-5-18-13-20(32)7-9-21(18)27(22)23(15-28(24,29)3)19-6-10-26(33-4)25(30)14-19/h6,10,13-14,22-24H,1,5,7-9,11-12,15H2,2-4H3/t22-,23+,24-,28-,29+/m0/s1
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PC cid
PC sid
UniChem

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n/an/a 660n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222088
PNG
((3S,10'S,11'S,15'S,17'R)-5-ethyl-17'-(3-fluoro-4-m...)
Show SMILES CCC1=N[C@]2(CC[C@H]3[C@@H]4CCC5=CC(=O)CCC5=C4[C@H](C[C@]23C)c2ccc(OC)c(F)c2)C(=C)O1 |c:18,t:2,11|
Show InChI InChI=1S/C30H34FNO3/c1-5-27-32-30(17(2)35-27)13-12-24-22-9-6-18-14-20(33)8-10-21(18)28(22)23(16-29(24,30)3)19-7-11-26(34-4)25(31)15-19/h7,11,14-15,22-24H,2,5-6,8-10,12-13,16H2,1,3-4H3/t22-,23+,24-,29-,30+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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AffyNet 
CHEMBL
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UniChem

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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50222090
PNG
((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-15'-...)
Show SMILES CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=COC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |c:19,t:28,35|
Show InChI InChI=1S/C29H31NO3/c1-17(31)19-4-6-20(7-5-19)25-15-28(3)26(12-13-29(28)18(2)33-16-30-29)24-10-8-21-14-22(32)9-11-23(21)27(24)25/h4-7,14,16,24-26H,2,8-13,15H2,1,3H3/t24-,25+,26-,28-,29+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...

Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%