Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19152 ((1S,7R,10S,16E,21R)-21-methyl-7-(propan-2-yl)-2-ox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19153 ((1S,7R,10S,16E,21R)-7,21-bis(propan-2-yl)-2-oxa-12...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19151 ((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.97 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19154 ((6R,9R,12R,16R)-9,12-dimethyl-6-(propan-2-yl)-16-[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17.5 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19155 ((6R,9S,12R,16R)-16-[(1E)-4-(acetylsulfanyl)but-1-e...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >100 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19149 (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 196 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19149 (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 775 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19151 ((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 787 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19152 ((1S,7R,10S,16E,21R)-21-methyl-7-(propan-2-yl)-2-ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 881 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19153 ((1S,7R,10S,16E,21R)-7,21-bis(propan-2-yl)-2-oxa-12...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 897 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19154 ((6R,9R,12R,16R)-9,12-dimethyl-6-(propan-2-yl)-16-[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.92E+3 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Mus musculus) | BDBM19155 ((6R,9S,12R,16R)-16-[(1E)-4-(acetylsulfanyl)but-1-e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Southampton | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | J Med Chem 50: 5720-5726 (2007) Article DOI: 10.1021/jm0703800 BindingDB Entry DOI: 10.7270/Q2ST7N4B | |||||||||||
More data for this Ligand-Target Pair |