Found 16 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24485
(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50184869
(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C26H23N3O4S/c1-31-23-15-20-21(16-24(23)32-2)27-13-12-22(20)33-19-10-8-18(9-11-19)28-26(34)29-25(30)14-17-6-4-3-5-7-17/h3-13,15-16H,14H2,1-2H3,(H2,28,29,30,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245264
(CHEMBL510112 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C25H22N4O4S/c1-31-21-13-18-19(14-22(21)32-2)26-11-10-20(18)33-24-9-8-17(15-27-24)28-25(34)29-23(30)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,28,29,30,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245431
(CHEMBL472552 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C24H20N4O5/c1-31-20-12-17-18(13-21(20)32-2)25-11-10-19(17)33-16-8-9-22(26-14-16)27-24(30)28-23(29)15-6-4-3-5-7-15/h3-14H,1-2H3,(H2,26,27,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245395
(CHEMBL461998 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4c(F)cccc4F)nc3)c2cc1OC Show InChI InChI=1S/C24H18F2N4O5/c1-33-19-10-14-17(11-20(19)34-2)27-9-8-18(14)35-13-6-7-21(28-12-13)29-24(32)30-23(31)22-15(25)4-3-5-16(22)26/h3-12H,1-2H3,(H2,28,29,30,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245311
(CHEMBL518511 | N-[5-(6,7-Dimethoxy-quinolin-4-ylox...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-13-18-19(14-22(21)30-2)25-11-10-20(18)31-17-8-9-23(26-15-17)27-24(28)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245394
(CHEMBL461120 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)CN4CCCCC4)nc3)c2cc1OC Show InChI InChI=1S/C24H27N5O5/c1-32-20-12-17-18(13-21(20)33-2)25-9-8-19(17)34-16-6-7-22(26-14-16)27-24(31)28-23(30)15-29-10-4-3-5-11-29/h6-9,12-14H,3-5,10-11,15H2,1-2H3,(H2,26,27,28,30,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245393
(CHEMBL461119 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)CN4CCCC4)nc3)c2cc1OC Show InChI InChI=1S/C23H25N5O5/c1-31-19-11-16-17(12-20(19)32-2)24-8-7-18(16)33-15-5-6-21(25-13-15)26-23(30)27-22(29)14-28-9-3-4-10-28/h5-8,11-13H,3-4,9-10,14H2,1-2H3,(H2,25,26,27,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245351
(CHEMBL461118 | N-{5-[(6,7-Dimethoxyquinolin-4-yl)a...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NCCc4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C25H24N4O4/c1-31-22-14-19-20(15-23(22)32-2)26-13-11-21(19)33-18-8-9-24(28-16-18)29-25(30)27-12-10-17-6-4-3-5-7-17/h3-9,11,13-16H,10,12H2,1-2H3,(H2,27,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245392
(CHEMBL459892 | N-Benzyl-N0-{5-[(6,7-dimethoxyquino...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NCc4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C24H22N4O4/c1-30-21-12-18-19(13-22(21)31-2)25-11-10-20(18)32-17-8-9-23(26-15-17)28-24(29)27-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H2,26,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245353
(CHEMBL518357 | N-Cyclohexyl-N0-{5-[(6,7-dimethoxyq...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NCC(=O)N4CCCCC4)nc3)c2cc1OC Show InChI InChI=1S/C24H27N5O5/c1-32-20-12-17-18(13-21(20)33-2)25-9-8-19(17)34-16-6-7-22(26-14-16)28-24(31)27-15-23(30)29-10-4-3-5-11-29/h6-9,12-14H,3-5,10-11,15H2,1-2H3,(H2,26,27,28,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245350
(CHEMBL460944 | N-Cyclohexyl-N0-{5-[(6,7-dimethoxyq...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC4CCCCC4)nc3)c2cc1OC Show InChI InChI=1S/C23H26N4O4/c1-29-20-12-17-18(13-21(20)30-2)24-11-10-19(17)31-16-8-9-22(25-14-16)27-23(28)26-15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H2,25,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245352
(1-[5-(6,7-Dimethoxy-quinolin-4-yloxy)-pyridin-2-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NCC(=O)N4CCCC4)nc3)c2cc1OC Show InChI InChI=1S/C23H25N5O5/c1-31-19-11-16-17(12-20(19)32-2)24-8-7-18(16)33-15-5-6-21(25-13-15)27-23(30)26-14-22(29)28-9-3-4-10-28/h5-8,11-13H,3-4,9-10,14H2,1-2H3,(H2,25,26,27,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245310
(CHEMBL462183 | N-{5-[(6,7-Dimethoxyquinolin-4-yl)o...)Show InChI InChI=1S/C18H17N3O4/c1-11(22)21-18-5-4-12(10-20-18)25-15-6-7-19-14-9-17(24-3)16(23-2)8-13(14)15/h4-10H,1-3H3,(H,20,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245312
(CHEMBL462357 | N-{5-[(6,7-Dimethoxyquinolin-4-yl)-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccccn4)nc3)c2cc1OC Show InChI InChI=1S/C23H20N4O4/c1-29-20-12-17-18(13-21(20)30-2)25-10-8-19(17)31-16-6-7-22(26-14-16)27-23(28)11-15-5-3-4-9-24-15/h3-10,12-14H,11H2,1-2H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245313
(CHEMBL462358 | N-{5-[(6,7-dimethoxyquinolin-4-yl)o...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCNCC4)nc3)c2cc1OC Show InChI InChI=1S/C21H23N5O4/c1-28-18-11-15-16(12-19(18)29-2)23-6-5-17(15)30-14-3-4-20(24-13-14)25-21(27)26-9-7-22-8-10-26/h3-6,11-13,22H,7-10H2,1-2H3,(H,24,25,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
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