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PubMed code 17981461

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25987
PNG
(N-[(4-methanesulfonamidophenyl)methyl]-4-[2-methyl...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCc1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C25H24N4O4S/c1-16-4-7-21(25-28-27-17(2)33-25)14-23(16)19-8-10-20(11-9-19)24(30)26-15-18-5-12-22(13-6-18)29-34(3,31)32/h4-14,29H,15H2,1-3H3,(H,26,30)
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PubMed
40 -41.8 280n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25986
PNG
(D3RKN_63 | N-(4-methanesulfonamidophenyl)-4-[2-met...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C24H22N4O4S/c1-15-4-5-19(24-27-26-16(2)32-24)14-22(15)17-6-8-18(9-7-17)23(29)25-20-10-12-21(13-11-20)28-33(3,30)31/h4-14,28H,1-3H3,(H,25,29)
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40 -41.8 280n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25989
PNG
(N-[(3-methoxyphenyl)methyl]-4-[2-methyl-5-(5-methy...)
Show SMILES COc1cccc(CNC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)c1
Show InChI InChI=1S/C25H23N3O3/c1-16-7-8-21(25-28-27-17(2)31-25)14-23(16)19-9-11-20(12-10-19)24(29)26-15-18-5-4-6-22(13-18)30-3/h4-14H,15H2,1-3H3,(H,26,29)
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60 -40.8 370n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25990
PNG
(N-[(4-methoxyphenyl)methyl]-4-[2-methyl-5-(5-methy...)
Show SMILES COc1ccc(CNC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)cc1
Show InChI InChI=1S/C25H23N3O3/c1-16-4-7-21(25-28-27-17(2)31-25)14-23(16)19-8-10-20(11-9-19)24(29)26-15-18-5-12-22(30-3)13-6-18/h4-14H,15H2,1-3H3,(H,26,29)
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80 -40.1 520n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25985
PNG
(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Show SMILES CNC(=O)c1cccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)c1
Show InChI InChI=1S/C25H22N4O3/c1-15-7-8-20(25-29-28-16(2)32-25)14-22(15)17-9-11-18(12-10-17)24(31)27-21-6-4-5-19(13-21)23(30)26-3/h4-14H,1-3H3,(H,26,30)(H,27,31)
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100 -39.6 600n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25991
PNG
(N-[(4-chlorophenyl)methyl]-4-[2-methyl-5-(5-methyl...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C24H20ClN3O2/c1-15-3-6-20(24-28-27-16(2)30-24)13-22(15)18-7-9-19(10-8-18)23(29)26-14-17-4-11-21(25)12-5-17/h3-13H,14H2,1-2H3,(H,26,29)
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100 -39.6 600n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25988
PNG
(N-benzyl-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H21N3O2/c1-16-8-9-21(24-27-26-17(2)29-24)14-22(16)19-10-12-20(13-11-19)23(28)25-15-18-6-4-3-5-7-18/h3-14H,15H2,1-2H3,(H,25,28)
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100 -39.6 610n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25992
PNG
(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCc1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C29H30N4O3/c1-20-6-7-26(29-32-31-21(2)36-29)17-27(20)24-8-10-25(11-9-24)28(34)30-18-22-4-3-5-23(16-22)19-33-12-14-35-15-13-33/h3-11,16-17H,12-15,18-19H2,1-2H3,(H,30,34)
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140 -38.7 870n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25993
PNG
(N-[(4-chlorophenyl)methyl]-N-methyl-4-[2-methyl-5-...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)c1ccc(cc1)-c1cc(ccc1C)-c1nnc(C)o1
Show InChI InChI=1S/C25H22ClN3O2/c1-16-4-7-21(24-28-27-17(2)31-24)14-23(16)19-8-10-20(11-9-19)25(30)29(3)15-18-5-12-22(26)13-6-18/h4-14H,15H2,1-3H3
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140 -38.7 890n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26005
PNG
(N-(cyclopropylmethyl)-4-[2-methyl-5-(5-methyl-4H-1...)
Show SMILES Cc1nnc([nH]1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C21H22N4O/c1-13-3-6-18(20-23-14(2)24-25-20)11-19(13)16-7-9-17(10-8-16)21(26)22-12-15-4-5-15/h3,6-11,15H,4-5,12H2,1-2H3,(H,22,26)(H,23,24,25)
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220 -37.6 1.40E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25980
PNG
(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C24H18N4O2/c1-15-6-7-20(24-28-27-16(2)30-24)13-22(15)18-8-10-19(11-9-18)23(29)26-21-5-3-4-17(12-21)14-25/h3-13H,1-2H3,(H,26,29)
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240 -37.4 1.50E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25984
PNG
(N-(2-methoxyphenyl)-4-[2-methyl-5-(5-methyl-1,3,4-...)
Show SMILES COc1ccccc1NC(=O)c1ccc(cc1)-c1cc(ccc1C)-c1nnc(C)o1
Show InChI InChI=1S/C24H21N3O3/c1-15-8-9-19(24-27-26-16(2)30-24)14-20(15)17-10-12-18(13-11-17)23(28)25-21-6-4-5-7-22(21)29-3/h4-14H,1-3H3,(H,25,28)
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250 -37.3 1.60E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25983
PNG
(D3RKN_86 | N-(4-methoxyphenyl)-4-[2-methyl-5-(5-me...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)cc1
Show InChI InChI=1S/C24H21N3O3/c1-15-4-5-19(24-27-26-16(2)30-24)14-22(15)17-6-8-18(9-7-17)23(28)25-20-10-12-21(29-3)13-11-20/h4-14H,1-3H3,(H,25,28)
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360 -36.4 2.30E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25981
PNG
(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C21H21N3O2/c1-13-3-6-18(21-24-23-14(2)26-21)11-19(13)16-7-9-17(10-8-16)20(25)22-12-15-4-5-15/h3,6-11,15H,4-5,12H2,1-2H3,(H,22,25)
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480 -35.7 3.00E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25982
PNG
(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Show SMILES CN1CCN(CC1)c1cccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)c1
Show InChI InChI=1S/C28H29N5O2/c1-19-7-8-23(28-31-30-20(2)35-28)17-26(19)21-9-11-22(12-10-21)27(34)29-24-5-4-6-25(18-24)33-15-13-32(3)14-16-33/h4-12,17-18H,13-16H2,1-3H3,(H,29,34)
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490 -35.7 3.10E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25996
PNG
(N-(3-hydroxypropyl)-4-[2-methyl-5-(5-methyl-1,3,4-...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCCCO
Show InChI InChI=1S/C20H21N3O3/c1-13-4-5-17(20-23-22-14(2)26-20)12-18(13)15-6-8-16(9-7-15)19(25)21-10-3-11-24/h4-9,12,24H,3,10-11H2,1-2H3,(H,21,25)
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1.10E+3 -33.7 7.10E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26001
PNG
(N-(cyclopropylmethyl)-4-[2-methyl-5-(5-propyl-1,3,...)
Show SMILES CCCc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C23H25N3O2/c1-3-4-21-25-26-23(28-21)19-8-5-15(2)20(13-19)17-9-11-18(12-10-17)22(27)24-14-16-6-7-16/h5,8-13,16H,3-4,6-7,14H2,1-2H3,(H,24,27)
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1.50E+3 -32.9 9.70E+3n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25998
PNG
(2-methyl-5-{4-methyl-3-[4-(piperidin-1-ylcarbonyl)...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H23N3O2/c1-15-6-7-19(21-24-23-16(2)27-21)14-20(15)17-8-10-18(11-9-17)22(26)25-12-4-3-5-13-25/h6-11,14H,3-5,12-13H2,1-2H3
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1.60E+3 -32.7 1.00E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25979
PNG
(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)cc1N1CCN(C)CC1
Show InChI InChI=1S/C29H31N5O3/c1-19-5-6-23(29-32-31-20(2)37-29)17-25(19)21-7-9-22(10-8-21)28(35)30-24-11-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,30,35)
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1.60E+3 -32.7 1.00E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26000
PNG
(N-(cyclopropylmethyl)-4-[5-(5-ethyl-1,3,4-oxadiazo...)
Show SMILES CCc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C22H23N3O2/c1-3-20-24-25-22(27-20)18-7-4-14(2)19(12-18)16-8-10-17(11-9-16)21(26)23-13-15-5-6-15/h4,7-12,15H,3,5-6,13H2,1-2H3,(H,23,26)
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1.60E+3 -32.7 1.00E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26004
PNG
(N-(cyclopropylmethyl)-4-[5-(1H-imidazol-2-yl)-2-me...)
Show SMILES Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)-c1ncc[nH]1
Show InChI InChI=1S/C21H21N3O/c1-14-2-5-18(20-22-10-11-23-20)12-19(14)16-6-8-17(9-7-16)21(25)24-13-15-3-4-15/h2,5-12,15H,3-4,13H2,1H3,(H,22,23)(H,24,25)
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1.70E+3 -32.6 1.10E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25994
PNG
(N-(3-cyanophenyl)-N-methyl-4-[2-methyl-5-(5-methyl...)
Show SMILES CN(C(=O)c1ccc(cc1)-c1cc(ccc1C)-c1nnc(C)o1)c1cccc(c1)C#N
Show InChI InChI=1S/C25H20N4O2/c1-16-7-8-21(24-28-27-17(2)31-24)14-23(16)19-9-11-20(12-10-19)25(30)29(3)22-6-4-5-18(13-22)15-26/h4-14H,1-3H3
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1.90E+3 -32.3 1.20E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26003
PNG
(N-(cyclopropylmethyl)-4-[2-methyl-5-(5-methyl-1,2,...)
Show SMILES Cc1nc(no1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C21H21N3O2/c1-13-3-6-18(20-23-14(2)26-24-20)11-19(13)16-7-9-17(10-8-16)21(25)22-12-15-4-5-15/h3,6-11,15H,4-5,12H2,1-2H3,(H,22,25)
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PubMed
2.00E+3 -32.2 1.40E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25999
PNG
(N-(cyclopropylmethyl)-4-[2-methyl-5-(1,3,4-oxadiaz...)
Show SMILES Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)-c1nnco1
Show InChI InChI=1S/C20H19N3O2/c1-13-2-5-17(20-23-22-12-25-20)10-18(13)15-6-8-16(9-7-15)19(24)21-11-14-3-4-14/h2,5-10,12,14H,3-4,11H2,1H3,(H,21,24)
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>2.50E+3>-31.7>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26002
PNG
(4-[5-(5-butyl-1,3,4-oxadiazol-2-yl)-2-methylphenyl...)
Show SMILES CCCCc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C24H27N3O2/c1-3-4-5-22-26-27-24(29-22)20-9-6-16(2)21(14-20)18-10-12-19(13-11-18)23(28)25-15-17-7-8-17/h6,9-14,17H,3-5,7-8,15H2,1-2H3,(H,25,28)
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>2.50E+3>-31.7>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26006
PNG
(N-(cyclopropylmethyl)-4-[3-(5-methyl-1,3,4-oxadiaz...)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C20H19N3O2/c1-13-22-23-20(25-13)18-4-2-3-17(11-18)15-7-9-16(10-8-15)19(24)21-12-14-5-6-14/h2-4,7-11,14H,5-6,12H2,1H3,(H,21,24)
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>2.50E+3>-31.7>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM26007
PNG
(N-(cyclopropylmethyl)-3-methyl-4-[3-(5-methyl-1,3,...)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1ccc(cc1C)C(=O)NCC1CC1
Show InChI InChI=1S/C21H21N3O2/c1-13-10-17(20(25)22-12-15-6-7-15)8-9-19(13)16-4-3-5-18(11-16)21-24-23-14(2)26-21/h3-5,8-11,15H,6-7,12H2,1-2H3,(H,22,25)
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>2.50E+3>-31.7>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25995
PNG
(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C17H14N2O3/c1-10-3-4-14(16-19-18-11(2)22-16)9-15(10)12-5-7-13(8-6-12)17(20)21/h3-9H,1-2H3,(H,20,21)
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>2.50E+3>-31.7>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM25997
PNG
(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C23H26N4O3/c1-16-3-4-20(23-26-25-17(2)30-23)15-21(16)18-5-7-19(8-6-18)22(28)24-9-10-27-11-13-29-14-12-27/h3-8,15H,9-14H2,1-2H3,(H,24,28)
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>2.50E+3>-31.7>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 324-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2FX77RC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%