Found 12 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50227129
(CHEMBL241329 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)ccc1Cl Show InChI InChI=1S/C21H26ClN3O2/c1-3-27-20-11-16(4-5-19(20)22)14-25-8-6-18(7-9-25)24-21(26)17-10-15(2)12-23-13-17/h4-5,10-13,18H,3,6-9,14H2,1-2H3,(H,24,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST5R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50227132
(4-tert-butyl-N-(1-((1,4-dimethoxynaphthalen-2-yl)m...)Show SMILES COc1cc(CN2CCC(CC2)NC(=O)c2ccc(cc2)C(C)(C)C)c(OC)c2ccccc12 Show InChI InChI=1S/C29H36N2O3/c1-29(2,3)22-12-10-20(11-13-22)28(32)30-23-14-16-31(17-15-23)19-21-18-26(33-4)24-8-6-7-9-25(24)27(21)34-5/h6-13,18,23H,14-17,19H2,1-5H3,(H,30,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST5R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50227130
(CHEMBL241328 | N-(1-((1,4-dimethoxynaphthalen-2-yl...)Show SMILES COc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)c(OC)c2ccccc12 Show InChI InChI=1S/C25H29N3O3/c1-17-12-18(15-26-14-17)25(29)27-20-8-10-28(11-9-20)16-19-13-23(30-2)21-6-4-5-7-22(21)24(19)31-3/h4-7,12-15,20H,8-11,16H2,1-3H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST5R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50227131
(CHEMBL241330 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cccc(c2)S(C)(=O)=O)ccc1Cl Show InChI InChI=1S/C22H27ClN2O4S/c1-3-29-21-13-16(7-8-20(21)23)15-25-11-9-18(10-12-25)24-22(26)17-5-4-6-19(14-17)30(2,27)28/h4-8,13-14,18H,3,9-12,15H2,1-2H3,(H,24,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST5R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50227128
(CHEMBL268075 | N-(1-((1,4-dimethoxynaphthalen-2-yl...)Show SMILES COc1cc(CN2CCC(CC2)NC(=O)c2ccccc2)c(OC)c2ccccc12 Show InChI InChI=1S/C25H28N2O3/c1-29-23-16-19(24(30-2)22-11-7-6-10-21(22)23)17-27-14-12-20(13-15-27)26-25(28)18-8-4-3-5-9-18/h3-11,16,20H,12-15,17H2,1-2H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST5R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM50227129
(CHEMBL241329 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)ccc1Cl Show InChI InChI=1S/C21H26ClN3O2/c1-3-27-20-11-16(4-5-19(20)22)14-25-8-6-18(7-9-25)24-21(26)17-10-15(2)12-23-13-17/h4-5,10-13,18H,3,6-9,14H2,1-2H3,(H,24,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human histamine H1 receptor |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50227133
(1'-[(1,4-dimethoxynaphthalen-2-yl)methyl]-3H-spiro...)Show SMILES COc1cc(CN2CCC3(CC2)OC(=O)c2ccccc32)c(OC)c2ccccc12 Show InChI InChI=1S/C25H25NO4/c1-28-22-15-17(23(29-2)19-8-4-3-7-18(19)22)16-26-13-11-25(12-14-26)21-10-6-5-9-20(21)24(27)30-25/h3-10,15H,11-14,16H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST5R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM50227131
(CHEMBL241330 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cccc(c2)S(C)(=O)=O)ccc1Cl Show InChI InChI=1S/C22H27ClN2O4S/c1-3-29-21-13-16(7-8-20(21)23)15-25-11-9-18(10-12-25)24-22(26)17-5-4-6-19(14-17)30(2,27)28/h4-8,13-14,18H,3,9-12,15H2,1-2H3,(H,24,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human histamine H1 receptor |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 1
(Homo sapiens (Human)) | BDBM50227129
(CHEMBL241329 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)ccc1Cl Show InChI InChI=1S/C21H26ClN3O2/c1-3-27-20-11-16(4-5-19(20)22)14-25-8-6-18(7-9-25)24-21(26)17-10-15(2)12-23-13-17/h4-5,10-13,18H,3,6-9,14H2,1-2H3,(H,24,26) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST1R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 3
(Homo sapiens (Human)) | BDBM50227129
(CHEMBL241329 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)ccc1Cl Show InChI InChI=1S/C21H26ClN3O2/c1-3-27-20-11-16(4-5-19(20)22)14-25-8-6-18(7-9-25)24-21(26)17-10-15(2)12-23-13-17/h4-5,10-13,18H,3,6-9,14H2,1-2H3,(H,24,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST3R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50227129
(CHEMBL241329 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)ccc1Cl Show InChI InChI=1S/C21H26ClN3O2/c1-3-27-20-11-16(4-5-19(20)22)14-25-8-6-18(7-9-25)24-21(26)17-10-15(2)12-23-13-17/h4-5,10-13,18H,3,6-9,14H2,1-2H3,(H,24,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human SST2R |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50227131
(CHEMBL241330 | N-(1-(4-chloro-3-ethoxybenzyl)piper...)Show SMILES CCOc1cc(CN2CCC(CC2)NC(=O)c2cccc(c2)S(C)(=O)=O)ccc1Cl Show InChI InChI=1S/C22H27ClN2O4S/c1-3-29-21-13-16(7-8-20(21)23)15-25-11-9-18(10-12-25)24-22(26)17-5-4-6-19(14-17)30(2,27)28/h4-8,13-14,18H,3,9-12,15H2,1-2H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to human ERG channel |
J Med Chem 50: 6295-8 (2007)
Article DOI: 10.1021/jm701144e
BindingDB Entry DOI: 10.7270/Q2S18273 |
More data for this
Ligand-Target Pair | |
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