Found 24 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coagulation factor X
(Homo sapiens (Human)) | BDBM50231646
(3-(6-Chloro-naphthalene-2-sulfonyl)-1-[4-(2-hydrox...)Show SMILES OCc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C25H25ClN4O4S/c26-20-6-4-19-15-22(7-5-18(19)14-20)35(33,34)13-8-25(32)29-11-9-28(10-12-29)24-3-1-2-23-27-21(17-31)16-30(23)24/h1-7,14-16,31H,8-13,17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50231646
(3-(6-Chloro-naphthalene-2-sulfonyl)-1-[4-(2-hydrox...)Show SMILES OCc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C25H25ClN4O4S/c26-20-6-4-19-15-22(7-5-18(19)14-20)35(33,34)13-8-25(32)29-11-9-28(10-12-29)24-3-1-2-23-27-21(17-31)16-30(23)24/h1-7,14-16,31H,8-13,17H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human thrombin after 30 mins |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50231646
(3-(6-Chloro-naphthalene-2-sulfonyl)-1-[4-(2-hydrox...)Show SMILES OCc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C25H25ClN4O4S/c26-20-6-4-19-15-22(7-5-18(19)14-20)35(33,34)13-8-25(32)29-11-9-28(10-12-29)24-3-1-2-23-27-21(17-31)16-30(23)24/h1-7,14-16,31H,8-13,17H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human plasmin after 30 mins |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50231646
(3-(6-Chloro-naphthalene-2-sulfonyl)-1-[4-(2-hydrox...)Show SMILES OCc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C25H25ClN4O4S/c26-20-6-4-19-15-22(7-5-18(19)14-20)35(33,34)13-8-25(32)29-11-9-28(10-12-29)24-3-1-2-23-27-21(17-31)16-30(23)24/h1-7,14-16,31H,8-13,17H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human tPA after 30 mins |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50231646
(3-(6-Chloro-naphthalene-2-sulfonyl)-1-[4-(2-hydrox...)Show SMILES OCc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C25H25ClN4O4S/c26-20-6-4-19-15-22(7-5-18(19)14-20)35(33,34)13-8-25(32)29-11-9-28(10-12-29)24-3-1-2-23-27-21(17-31)16-30(23)24/h1-7,14-16,31H,8-13,17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375053
(CHEMBL405361)Show SMILES Cc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C25H25ClN4O3S/c1-18-17-30-23(27-18)3-2-4-24(30)28-10-12-29(13-11-28)25(31)9-14-34(32,33)22-8-6-19-15-21(26)7-5-20(19)16-22/h2-8,15-17H,9-14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375047
(CHEMBL409115)Show SMILES CC(O)Cc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 |w:1.0| Show InChI InChI=1S/C27H29ClN4O4S/c1-19(33)15-23-18-32-25(29-23)3-2-4-26(32)30-10-12-31(13-11-30)27(34)9-14-37(35,36)24-8-6-20-16-22(28)7-5-21(20)17-24/h2-8,16-19,33H,9-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375051
(CHEMBL260152)Show SMILES CC(C)(O)c1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C27H29ClN4O4S/c1-27(2,34)23-18-32-24(29-23)4-3-5-25(32)30-11-13-31(14-12-30)26(33)10-15-37(35,36)22-9-7-19-16-21(28)8-6-20(19)17-22/h3-9,16-18,34H,10-15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375039
(CHEMBL265456)Show SMILES CC(O)c1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 |w:1.0| Show InChI InChI=1S/C26H27ClN4O4S/c1-18(32)23-17-31-24(28-23)3-2-4-25(31)29-10-12-30(13-11-29)26(33)9-14-36(34,35)22-8-6-19-15-21(27)7-5-20(19)16-22/h2-8,15-18,32H,9-14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375040
(CHEMBL409851)Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)CCC(=O)N1CCN(CC1)c1cccc2nccn12 Show InChI InChI=1S/C24H23ClN4O3S/c25-20-6-4-19-17-21(7-5-18(19)16-20)33(31,32)15-8-24(30)28-13-11-27(12-14-28)23-3-1-2-22-26-9-10-29(22)23/h1-7,9-10,16-17H,8,11-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375038
(CHEMBL410528)Show SMILES CC(C)(O)Cc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C28H31ClN4O4S/c1-28(2,35)18-23-19-33-25(30-23)4-3-5-26(33)31-11-13-32(14-12-31)27(34)10-15-38(36,37)24-9-7-20-16-22(29)8-6-21(20)17-24/h3-9,16-17,19,35H,10-15,18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375041
(CHEMBL258716)Show SMILES CC(=O)Nc1cnc2cccc(N3CCN(CC3)C(=O)CCS(=O)(=O)c3ccc4cc(Cl)ccc4c3)n12 Show InChI InChI=1S/C26H26ClN5O4S/c1-18(33)29-24-17-28-23-3-2-4-25(32(23)24)30-10-12-31(13-11-30)26(34)9-14-37(35,36)22-8-6-19-15-21(27)7-5-20(19)16-22/h2-8,15-17H,9-14H2,1H3,(H,29,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375045
(CHEMBL261775)Show SMILES [O-][N+](=O)c1cnc2cccc(N3CCN(CC3)C(=O)CCS(=O)(=O)c3ccc4cc(Cl)ccc4c3)n12 Show InChI InChI=1S/C24H22ClN5O5S/c25-19-6-4-18-15-20(7-5-17(18)14-19)36(34,35)13-8-24(31)28-11-9-27(10-12-28)22-3-1-2-21-26-16-23(29(21)22)30(32)33/h1-7,14-16H,8-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375046
(CHEMBL261774)Show SMILES OCc1cnc2cccc(N3CCN(CC3)C(=O)CCS(=O)(=O)c3ccc4cc(Cl)ccc4c3)n12 Show InChI InChI=1S/C25H25ClN4O4S/c26-20-6-4-19-15-22(7-5-18(19)14-20)35(33,34)13-8-25(32)29-11-9-28(10-12-29)24-3-1-2-23-27-16-21(17-31)30(23)24/h1-7,14-16,31H,8-13,17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375037
(CHEMBL409850)Show SMILES Nc1cnc2cccc(N3CCN(CC3)C(=O)CCS(=O)(=O)c3ccc4cc(Cl)ccc4c3)n12 Show InChI InChI=1S/C24H24ClN5O3S/c25-19-6-4-18-15-20(7-5-17(18)14-19)34(32,33)13-8-24(31)29-11-9-28(10-12-29)23-3-1-2-22-27-16-21(26)30(22)23/h1-7,14-16H,8-13,26H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375048
(CHEMBL261323)Show SMILES CNC(=O)Cc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C27H28ClN5O4S/c1-29-25(34)17-22-18-33-24(30-22)3-2-4-26(33)31-10-12-32(13-11-31)27(35)9-14-38(36,37)23-8-6-19-15-21(28)7-5-20(19)16-23/h2-8,15-16,18H,9-14,17H2,1H3,(H,29,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375049
(CHEMBL261324)Show SMILES NC(=O)Cc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C26H26ClN5O4S/c27-20-6-4-19-15-22(7-5-18(19)14-20)37(35,36)13-8-26(34)31-11-9-30(10-12-31)25-3-1-2-24-29-21(16-23(28)33)17-32(24)25/h1-7,14-15,17H,8-13,16H2,(H2,28,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375050
(CHEMBL265455)Show SMILES CN(C)C(=O)Cc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C28H30ClN5O4S/c1-31(2)28(36)18-23-19-34-25(30-23)4-3-5-26(34)32-11-13-33(14-12-32)27(35)10-15-39(37,38)24-9-7-20-16-22(29)8-6-21(20)17-24/h3-9,16-17,19H,10-15,18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50372526
(CHEMBL261646)Show SMILES CN(C1CCN(CC1)c1ccnc(C)c1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C25H28ClN3O3S/c1-18-15-23(7-11-27-18)29-12-8-22(9-13-29)28(2)25(30)10-14-33(31,32)24-6-4-19-16-21(26)5-3-20(19)17-24/h3-7,11,15-17,22H,8-10,12-14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375043
(CHEMBL259663)Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)CCC(=O)N1CCN(CC1)c1ccn2ccnc2c1 Show InChI InChI=1S/C24H23ClN4O3S/c25-20-3-1-19-16-22(4-2-18(19)15-20)33(31,32)14-6-24(30)29-12-10-27(11-13-29)21-5-8-28-9-7-26-23(28)17-21/h1-5,7-9,15-17H,6,10-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375044
(CHEMBL261524)Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)CCC(=O)N1CCN(CC1)c1ccc2nccn2c1 Show InChI InChI=1S/C24H23ClN4O3S/c25-20-3-1-19-16-22(5-2-18(19)15-20)33(31,32)14-7-24(30)28-12-10-27(11-13-28)21-4-6-23-26-8-9-29(23)17-21/h1-6,8-9,15-17H,7,10-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375052
(CHEMBL260360)Show SMILES CCOC(=O)Cc1cn2c(cccc2n1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C28H29ClN4O5S/c1-2-38-28(35)18-23-19-33-25(30-23)4-3-5-26(33)31-11-13-32(14-12-31)27(34)10-15-39(36,37)24-9-7-20-16-22(29)8-6-21(20)17-24/h3-9,16-17,19H,2,10-15,18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM17283
((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)Show SMILES CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)[C@H](Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O |r| Show InChI InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50375042
(CHEMBL428081)Show SMILES CN(C1CCN(CC1)c1cccc2nccn12)C(=O)CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1 Show InChI InChI=1S/C26H27ClN4O3S/c1-29(22-9-13-30(14-10-22)25-4-2-3-24-28-12-15-31(24)25)26(32)11-16-35(33,34)23-8-6-19-17-21(27)7-5-20(19)18-23/h2-8,12,15,17-18,22H,9-11,13-14,16H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human factor 10a |
Bioorg Med Chem 16: 3125-40 (2008)
Article DOI: 10.1016/j.bmc.2007.12.024
BindingDB Entry DOI: 10.7270/Q2VQ33J5 |
More data for this
Ligand-Target Pair | |
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