Affinity Data by PubMed id=18257543

PubMed code 18257543

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP9				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP3				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP8				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP13				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP1				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP3				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP8				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP13				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant TACE				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP12				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP9				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant TACE				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50234465 (CHEMBL270083 \| cis-2-aminocyclohexylcarbamoylphosp...) Show SMILES N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP1				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50372742 (CHEMBL270296) Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP12				J Med Chem 51: 1406-14 (2008) Article DOI: 10.1021/jm701087n BindingDB Entry DOI: 10.7270/Q2H70GN0
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%