BindingDB logo
myBDB logout

PubMed code 18271518

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 3


(Mus musculus)		BDBM50374115
PNG
(CHEMBL270691)
Show SMILES Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1ccccc1)NC2=O |w:21.24|
Show InChI InChI=1S/C27H21ClN2O2/c28-22-12-13-23-25(16-22)30(17-19-10-11-20-8-4-5-9-21(20)14-19)27(32)24(29-26(23)31)15-18-6-2-1-3-7-18/h1-14,16,24H,15,17H2,(H,29,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.33E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374119
PNG
(CHEMBL410435)
Show SMILES Cc1cccc2c1N(Cc1ccccc1)C(=O)C(Cc1cn(Cc3ccccc3)c3ccccc13)NC2=O |w:17.19|
Show InChI InChI=1S/C33H29N3O2/c1-23-11-10-17-28-31(23)36(21-25-14-6-3-7-15-25)33(38)29(34-32(28)37)19-26-22-35(20-24-12-4-2-5-13-24)30-18-9-8-16-27(26)30/h2-18,22,29H,19-21H2,1H3,(H,34,37)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374120
PNG
(CHEMBL272843)
Show SMILES O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N(Cc2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C25H21N3O2/c29-24-20-11-5-7-13-23(20)28(16-17-8-2-1-3-9-17)25(30)22(27-24)14-18-15-26-21-12-6-4-10-19(18)21/h1-13,15,22,26H,14,16H2,(H,27,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374116
PNG
(CHEMBL270270)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O |w:5.4|
Show InChI InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 48n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.29E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374123
PNG
(CHEMBL273044)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C29H24N2O2/c32-28-25-17-9-10-18-27(25)31(29(33)26(30-28)19-21-11-3-1-4-12-21)20-23-15-7-8-16-24(23)22-13-5-2-6-14-22/h1-18,26H,19-20H2,(H,30,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.16E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374124
PNG
(CHEMBL272439)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-c2ccc(Cl)cc2-[#7](-[#6]-c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C20H22ClN5O2/c21-14-8-9-15-17(11-14)26(12-13-5-2-1-3-6-13)19(28)16(25-18(15)27)7-4-10-24-20(22)23/h1-3,5-6,8-9,11,16H,4,7,10,12H2,(H,25,27)(H4,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.07E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50029747
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.14n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374116
PNG
(CHEMBL270270)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O |w:5.4|
Show InChI InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 320n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374122
PNG
(CHEMBL269837)
Show SMILES CCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O |w:13.14|
Show InChI InChI=1S/C19H20N2O2/c1-2-12-21-17-11-7-6-10-15(17)18(22)20-16(19(21)23)13-14-8-4-3-5-9-14/h3-11,16H,2,12-13H2,1H3,(H,20,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.90E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374121
PNG
(CHEMBL272662)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-c2ccccc2-[#7](-[#6]-c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374124
PNG
(CHEMBL272439)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-c2ccc(Cl)cc2-[#7](-[#6]-c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C20H22ClN5O2/c21-14-8-9-15-17(11-14)26(12-13-5-2-1-3-6-13)19(28)16(25-18(15)27)7-4-10-24-20(22)23/h1-3,5-6,8-9,11,16H,4,7,10,12H2,(H,25,27)(H4,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.80E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374122
PNG
(CHEMBL269837)
Show SMILES CCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O |w:13.14|
Show InChI InChI=1S/C19H20N2O2/c1-2-12-21-17-11-7-6-10-15(17)18(22)20-16(19(21)23)13-14-8-4-3-5-9-14/h3-11,16H,2,12-13H2,1H3,(H,20,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.50E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374118
PNG
(CHEMBL270689)
Show SMILES CCCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O |w:14.15|
Show InChI InChI=1S/C20H22N2O2/c1-2-3-13-22-18-12-8-7-11-16(18)19(23)21-17(20(22)24)14-15-9-5-4-6-10-15/h4-12,17H,2-3,13-14H2,1H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374115
PNG
(CHEMBL270691)
Show SMILES Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1ccccc1)NC2=O |w:21.24|
Show InChI InChI=1S/C27H21ClN2O2/c28-22-12-13-23-25(16-22)30(17-19-10-11-20-8-4-5-9-21(20)14-19)27(32)24(29-26(23)31)15-18-6-2-1-3-7-18/h1-14,16,24H,15,17H2,(H,29,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.35E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374116
PNG
(CHEMBL270270)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O |w:5.4|
Show InChI InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 240n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374114
PNG
(CHEMBL272437)
Show SMILES Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1c[nH]c3ccccc13)NC2=O |w:21.24|
Show InChI InChI=1S/C29H22ClN3O2/c30-22-11-12-24-27(15-22)33(17-18-9-10-19-5-1-2-6-20(19)13-18)29(35)26(32-28(24)34)14-21-16-31-25-8-4-3-7-23(21)25/h1-13,15-16,26,31H,14,17H2,(H,32,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50029747
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374125
PNG
(CHEMBL409222)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccc3ccccc3c2)C1=O |w:5.4|
Show InChI InChI=1S/C24H24ClN3O2/c25-19-10-11-20-22(14-19)28(24(30)21(27-23(20)29)7-3-4-12-26)15-16-8-9-17-5-1-2-6-18(17)13-16/h1-2,5-6,8-11,13-14,21H,3-4,7,12,15,26H2,(H,27,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.40E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374119
PNG
(CHEMBL410435)
Show SMILES Cc1cccc2c1N(Cc1ccccc1)C(=O)C(Cc1cn(Cc3ccccc3)c3ccccc13)NC2=O |w:17.19|
Show InChI InChI=1S/C33H29N3O2/c1-23-11-10-17-28-31(23)36(21-25-14-6-3-7-15-25)33(38)29(34-32(28)37)19-26-22-35(20-24-12-4-2-5-13-24)30-18-9-8-16-27(26)30/h2-18,22,29H,19-21H2,1H3,(H,34,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374114
PNG
(CHEMBL272437)
Show SMILES Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1c[nH]c3ccccc13)NC2=O |w:21.24|
Show InChI InChI=1S/C29H22ClN3O2/c30-22-11-12-24-27(15-22)33(17-18-9-10-19-5-1-2-6-20(19)13-18)29(35)26(32-28(24)34)14-21-16-31-25-8-4-3-7-23(21)25/h1-13,15-16,26,31H,14,17H2,(H,32,34)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374119
PNG
(CHEMBL410435)
Show SMILES Cc1cccc2c1N(Cc1ccccc1)C(=O)C(Cc1cn(Cc3ccccc3)c3ccccc13)NC2=O |w:17.19|
Show InChI InChI=1S/C33H29N3O2/c1-23-11-10-17-28-31(23)36(21-25-14-6-3-7-15-25)33(38)29(34-32(28)37)19-26-22-35(20-24-12-4-2-5-13-24)30-18-9-8-16-27(26)30/h2-18,22,29H,19-21H2,1H3,(H,34,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.16E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374120
PNG
(CHEMBL272843)
Show SMILES O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N(Cc2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C25H21N3O2/c29-24-20-11-5-7-13-23(20)28(16-17-8-2-1-3-9-17)25(30)22(27-24)14-18-15-26-21-12-6-4-10-19(18)21/h1-13,15,22,26H,14,16H2,(H,27,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374123
PNG
(CHEMBL273044)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C29H24N2O2/c32-28-25-17-9-10-18-27(25)31(29(33)26(30-28)19-21-11-3-1-4-12-21)20-23-15-7-8-16-24(23)22-13-5-2-6-14-22/h1-18,26H,19-20H2,(H,30,32)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.97E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374124
PNG
(CHEMBL272439)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-c2ccc(Cl)cc2-[#7](-[#6]-c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C20H22ClN5O2/c21-14-8-9-15-17(11-14)26(12-13-5-2-1-3-6-13)19(28)16(25-18(15)27)7-4-10-24-20(22)23/h1-3,5-6,8-9,11,16H,4,7,10,12H2,(H,25,27)(H4,22,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.70E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374122
PNG
(CHEMBL269837)
Show SMILES CCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O |w:13.14|
Show InChI InChI=1S/C19H20N2O2/c1-2-12-21-17-11-7-6-10-15(17)18(22)20-16(19(21)23)13-14-8-4-3-5-9-14/h3-11,16H,2,12-13H2,1H3,(H,20,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.27E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374121
PNG
(CHEMBL272662)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-c2ccccc2-[#7](-[#6]-c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374115
PNG
(CHEMBL270691)
Show SMILES Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1ccccc1)NC2=O |w:21.24|
Show InChI InChI=1S/C27H21ClN2O2/c28-22-12-13-23-25(16-22)30(17-19-10-11-20-8-4-5-9-21(20)14-19)27(32)24(29-26(23)31)15-18-6-2-1-3-7-18/h1-14,16,24H,15,17H2,(H,29,31)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.70E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374121
PNG
(CHEMBL272662)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-c2ccccc2-[#7](-[#6]-c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.65E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50029747
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.56n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374120
PNG
(CHEMBL272843)
Show SMILES O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N(Cc2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C25H21N3O2/c29-24-20-11-5-7-13-23(20)28(16-17-8-2-1-3-9-17)25(30)22(27-24)14-18-15-26-21-12-6-4-10-19(18)21/h1-13,15,22,26H,14,16H2,(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50029747
PNG
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.700n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374114
PNG
(CHEMBL272437)
Show SMILES Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1c[nH]c3ccccc13)NC2=O |w:21.24|
Show InChI InChI=1S/C29H22ClN3O2/c30-22-11-12-24-27(15-22)33(17-18-9-10-19-5-1-2-6-20(19)13-18)29(35)26(32-28(24)34)14-21-16-31-25-8-4-3-7-23(21)25/h1-13,15-16,26,31H,14,17H2,(H,32,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374116
PNG
(CHEMBL270270)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O |w:5.4|
Show InChI InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 87n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)		BDBM50374114
PNG
(CHEMBL272437)
Show SMILES Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1c[nH]c3ccccc13)NC2=O |w:21.24|
Show InChI InChI=1S/C29H22ClN3O2/c30-22-11-12-24-27(15-22)33(17-18-9-10-19-5-1-2-6-20(19)13-18)29(35)26(32-28(24)34)14-21-16-31-25-8-4-3-7-23(21)25/h1-13,15-16,26,31H,14,17H2,(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374119
PNG
(CHEMBL410435)
Show SMILES Cc1cccc2c1N(Cc1ccccc1)C(=O)C(Cc1cn(Cc3ccccc3)c3ccccc13)NC2=O |w:17.19|
Show InChI InChI=1S/C33H29N3O2/c1-23-11-10-17-28-31(23)36(21-25-14-6-3-7-15-25)33(38)29(34-32(28)37)19-26-22-35(20-24-12-4-2-5-13-24)30-18-9-8-16-27(26)30/h2-18,22,29H,19-21H2,1H3,(H,34,37)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Mus musculus)		BDBM50374123
PNG
(CHEMBL273044)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc12 |w:3.3|
Show InChI InChI=1S/C29H24N2O2/c32-28-25-17-9-10-18-27(25)31(29(33)26(30-28)19-21-11-3-1-4-12-21)20-23-15-7-8-16-24(23)22-13-5-2-6-14-22/h1-18,26H,19-20H2,(H,30,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 230n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374118
PNG
(CHEMBL270689)
Show SMILES CCCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O |w:14.15|
Show InChI InChI=1S/C20H22N2O2/c1-2-3-13-22-18-12-8-7-11-16(18)19(23)21-17(20(22)24)14-15-9-5-4-6-10-15/h4-12,17H,2-3,13-14H2,1H3,(H,21,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)		BDBM50374121
PNG
(CHEMBL272662)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-c2ccccc2-[#7](-[#6]-c2ccccc2)-[#6]-1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Mus musculus (Mouse))		BDBM50374118
PNG
(CHEMBL270689)
Show SMILES CCCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O |w:14.15|
Show InChI InChI=1S/C20H22N2O2/c1-2-3-13-22-18-12-8-7-11-16(18)19(23)21-17(20(22)24)14-15-9-5-4-6-10-15/h4-12,17H,2-3,13-14H2,1H3,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay

J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%