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PubMed code 18342505

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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n/an/a 3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375139
PNG
(CHEMBL256459)
Show SMILES CN(C)CCc1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C27H28N6O2/c1-32(2)13-12-17-6-9-20(10-7-17)30-27-29-15-22-24(34)23(25(28)35)16-33(26(22)31-27)21-11-8-18-4-3-5-19(18)14-21/h6-11,14-16H,3-5,12-13H2,1-2H3,(H2,28,35)(H,29,30,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375138
PNG
(CHEMBL402852)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3cccc(c3)C(=O)N3CCCCC3)ncc2c1=O
Show InChI InChI=1S/C29H28N6O3/c30-26(37)24-17-35(22-11-10-18-6-4-7-19(18)15-22)27-23(25(24)36)16-31-29(33-27)32-21-9-5-8-20(14-21)28(38)34-12-2-1-3-13-34/h5,8-11,14-17H,1-4,6-7,12-13H2,(H2,30,37)(H,31,32,33)
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n/an/a 4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375145
PNG
(CHEMBL271461)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C27H27N7O2/c28-25(36)23-16-34(21-7-4-17-2-1-3-18(17)14-21)26-22(24(23)35)15-30-27(32-26)31-19-5-8-20(9-6-19)33-12-10-29-11-13-33/h4-9,14-16,29H,1-3,10-13H2,(H2,28,36)(H,30,31,32)
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n/an/a 5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375159
PNG
(CHEMBL255794)
Show SMILES CC1CN(CC(C)N1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 |w:1.0,5.5|
Show InChI InChI=1S/C29H31N7O2/c1-17-14-35(15-18(2)32-17)22-10-7-21(8-11-22)33-29-31-13-24-26(37)25(27(30)38)16-36(28(24)34-29)23-9-6-19-4-3-5-20(19)12-23/h6-13,16-18,32H,3-5,14-15H2,1-2H3,(H2,30,38)(H,31,33,34)
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n/an/a 7n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375142
PNG
(CHEMBL257528)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C28H28N6O2/c29-26(36)24-16-34(22-9-6-17-2-1-3-20(17)14-22)27-23(25(24)35)15-31-28(33-27)32-21-7-4-18(5-8-21)19-10-12-30-13-11-19/h4-9,14-16,19,30H,1-3,10-13H2,(H2,29,36)(H,31,32,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375158
PNG
(CHEMBL404188)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C29H30N6O3/c30-27(37)25-18-35(23-9-6-20-2-1-3-21(20)16-23)28-24(26(25)36)17-31-29(33-28)32-22-7-4-19(5-8-22)10-11-34-12-14-38-15-13-34/h4-9,16-18H,1-3,10-15H2,(H2,30,37)(H,31,32,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375144
PNG
(CHEMBL255584)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)c1
Show InChI InChI=1S/C28H29N7O2/c1-33-10-12-34(13-11-33)21-7-3-6-20(15-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-9-8-18-4-2-5-19(18)14-22/h3,6-9,14-17H,2,4-5,10-13H2,1H3,(H2,29,37)(H,30,31,32)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27890
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375157
PNG
(CHEMBL273193)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(C[C@H]4COC(=O)N4)cc3)ncc2c1=O
Show InChI InChI=1S/C27H24N6O4/c28-24(35)22-13-33(20-9-6-16-2-1-3-17(16)11-20)25-21(23(22)34)12-29-26(32-25)30-18-7-4-15(5-8-18)10-19-14-37-27(36)31-19/h4-9,11-13,19H,1-3,10,14H2,(H2,28,35)(H,31,36)(H,29,30,32)/t19-/m0/s1
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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n/an/a 13n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375140
PNG
(CHEMBL256405)
Show SMILES CN(C)Cc1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C26H26N6O2/c1-31(2)14-16-6-9-19(10-7-16)29-26-28-13-21-23(33)22(24(27)34)15-32(25(21)30-26)20-11-8-17-4-3-5-18(17)12-20/h6-13,15H,3-5,14H2,1-2H3,(H2,27,34)(H,28,29,30)
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n/an/a 21n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375141
PNG
(CHEMBL256406)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C28H28N6O3/c29-26(36)24-17-34(22-9-6-19-2-1-3-20(19)14-22)27-23(25(24)35)15-30-28(32-27)31-21-7-4-18(5-8-21)16-33-10-12-37-13-11-33/h4-9,14-15,17H,1-3,10-13,16H2,(H2,29,36)(H,30,31,32)
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n/an/a 22n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 28n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375152
PNG
(CHEMBL255182)
Show SMILES CNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C29H31N7O2/c1-30-28(38)25-18-36(23-9-6-19-4-3-5-20(19)16-23)27-24(26(25)37)17-31-29(33-27)32-21-7-10-22(11-8-21)35-14-12-34(2)13-15-35/h6-11,16-18H,3-5,12-15H2,1-2H3,(H,30,38)(H,31,32,33)
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n/an/a 31n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375150
PNG
(CHEMBL272332)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)C2CCCCC2)cc1
Show InChI InChI=1S/C25H31N7O2/c1-30-11-13-31(14-12-30)18-9-7-17(8-10-18)28-25-27-15-20-22(33)21(23(26)34)16-32(24(20)29-25)19-5-3-2-4-6-19/h7-10,15-16,19H,2-6,11-14H2,1H3,(H2,26,34)(H,27,28,29)
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n/an/a 35n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375153
PNG
(CHEMBL272738)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cc3n(cc(C(N)=O)c(=O)c3cn2)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-33-11-13-34(14-12-33)22-9-6-21(7-10-22)32-27-16-26-24(17-31-27)28(36)25(29(30)37)18-35(26)23-8-5-19-3-2-4-20(19)15-23/h5-10,15-18H,2-4,11-14H2,1H3,(H2,30,37)(H,31,32)
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n/an/a 56n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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n/an/a 56n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375149
PNG
(CHEMBL272117)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)C2CCCC2)cc1
Show InChI InChI=1S/C24H29N7O2/c1-29-10-12-30(13-11-29)17-8-6-16(7-9-17)27-24-26-14-19-21(32)20(22(25)33)15-31(23(19)28-24)18-4-2-3-5-18/h6-9,14-15,18H,2-5,10-13H2,1H3,(H2,25,33)(H,26,27,28)
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n/an/a 56n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375151
PNG
(CHEMBL255181)
Show SMILES CCNC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H33N7O2/c1-3-31-29(39)26-19-37(24-10-7-20-5-4-6-21(20)17-24)28-25(27(26)38)18-32-30(34-28)33-22-8-11-23(12-9-22)36-15-13-35(2)14-16-36/h7-12,17-19H,3-6,13-16H2,1-2H3,(H,31,39)(H,32,33,34)
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n/an/a 68n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375148
PNG
(CHEMBL257665)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)C2CC3CCC2C3)cc1 |w:31.33,28.31,26.28,TEB:18:26:29.30:32|
Show InChI InChI=1S/C26H31N7O2/c1-31-8-10-32(11-9-31)19-6-4-18(5-7-19)29-26-28-14-20-23(34)21(24(27)35)15-33(25(20)30-26)22-13-16-2-3-17(22)12-16/h4-7,14-17,22H,2-3,8-13H2,1H3,(H2,27,35)(H,28,29,30)
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n/an/a 81n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375143
PNG
(CHEMBL404909)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)c(O)c1
Show InChI InChI=1S/C28H29N7O3/c1-33-9-11-34(12-10-33)19-7-8-23(24(36)14-19)31-28-30-15-21-25(37)22(26(29)38)16-35(27(21)32-28)20-6-5-17-3-2-4-18(17)13-20/h5-8,13-16,36H,2-4,9-12H2,1H3,(H2,29,38)(H,30,31,32)
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n/an/a 93n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375134
PNG
(PTERIDINONE)
Show SMILES CCOC(=O)c1nc2cnc(Nc3ccccc3)nc2n(-c2ccccc2)c1=O
Show InChI InChI=1S/C21H17N5O3/c1-2-29-20(28)17-19(27)26(15-11-7-4-8-12-15)18-16(24-17)13-22-21(25-18)23-14-9-5-3-6-10-14/h3-13H,2H2,1H3,(H,22,23,25)
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n/an/a 180n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CSF1R


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of TrkA


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375156
PNG
(CHEMBL273194)
Show SMILES CCOC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-3-39-29(38)26-19-36(24-10-7-20-5-4-6-21(20)17-24)28-25(27(26)37)18-31-30(33-28)32-22-8-11-23(12-9-22)35-15-13-34(2)14-16-35/h7-12,17-19H,3-6,13-16H2,1-2H3,(H,31,32,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375146
PNG
(CHEMBL271460)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccccc3)ncc2c1=O
Show InChI InChI=1S/C23H19N5O2/c24-21(30)19-13-28(17-10-9-14-5-4-6-15(14)11-17)22-18(20(19)29)12-25-23(27-22)26-16-7-2-1-3-8-16/h1-3,7-13H,4-6H2,(H2,24,30)(H,25,26,27)
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n/an/a 280n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of Axl


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 310n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of TrkA


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375147
PNG
(CHEMBL257664)
Show SMILES CNC(=O)c1cn(Cc2ccccc2)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C27H29N7O2/c1-28-26(36)23-18-34(17-19-6-4-3-5-7-19)25-22(24(23)35)16-29-27(31-25)30-20-8-10-21(11-9-20)33-14-12-32(2)13-15-33/h3-11,16,18H,12-15,17H2,1-2H3,(H,28,36)(H,29,30,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of Axl


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375160
PNG
(CHEMBL257865)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccccc2)cc1
Show InChI InChI=1S/C25H25N7O2/c1-30-11-13-31(14-12-30)18-9-7-17(8-10-18)28-25-27-15-20-22(33)21(23(26)34)16-32(24(20)29-25)19-5-3-2-4-6-19/h2-10,15-16H,11-14H2,1H3,(H2,26,34)(H,27,28,29)
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n/an/a 730n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM27889
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375154
PNG
(CHEMBL257320)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(O)=O)c3=O)-c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C28H28N6O3/c1-32-11-13-33(14-12-32)21-9-6-20(7-10-21)30-28-29-16-23-25(35)24(27(36)37)17-34(26(23)31-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H,36,37)(H,29,30,31)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375136
PNG
(CHEMBL272560)
Show SMILES CN1CCN(CCCNc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)CC1
Show InChI InChI=1S/C25H31N7O2/c1-30-10-12-31(13-11-30)9-3-8-27-25-28-15-20-22(33)21(23(26)34)16-32(24(20)29-25)19-7-6-17-4-2-5-18(17)14-19/h6-7,14-16H,2-5,8-13H2,1H3,(H2,26,34)(H,27,28,29)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50375155
PNG
(CHEMBL256893)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375135
PNG
(CHEMBL257318)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(NCCCn3ccnc3)ncc2c1=O
Show InChI InChI=1S/C23H23N7O2/c24-21(32)19-13-30(17-6-5-15-3-1-4-16(15)11-17)22-18(20(19)31)12-27-23(28-22)26-7-2-9-29-10-8-25-14-29/h5-6,8,10-14H,1-4,7,9H2,(H2,24,32)(H,26,27,28)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50375137
PNG
(CHEMBL272773)
Show SMILES NC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(NCCN3CCOCC3)ncc2c1=O
Show InChI InChI=1S/C23H26N6O3/c24-21(31)19-14-29(17-5-4-15-2-1-3-16(15)12-17)22-18(20(19)30)13-26-23(27-22)25-6-7-28-8-10-32-11-9-28/h4-5,12-14H,1-3,6-11H2,(H2,24,31)(H,25,26,27)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of ATP-induced CSF1R autophosphorylation


Bioorg Med Chem Lett 18: 2355-61 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.070
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%