Found 64 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376815
(CHEMBL259563)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cccc2ccccc12 |w:16.24| Show InChI InChI=1S/C31H34N2O/c1-5-21-13-9-14-22(6-2)30(21)26-20-29(34-4)31-25(32-26)17-11-19-28(31)33(3)27-18-10-15-23-12-7-8-16-24(23)27/h7-10,12-16,18,20,28H,5-6,11,17,19H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376793
(CHEMBL259769)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C32H36N2O/c1-5-22-14-10-15-23(6-2)31(22)27-21-30(35-4)32-26(33-27)18-12-20-29(32)34(7-3)28-19-11-16-24-13-8-9-17-25(24)28/h8-11,13-17,19,21,29H,5-7,12,18,20H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376803
(CHEMBL262330)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2cccc(c2C1)C(F)(F)F |w:16.24| Show InChI InChI=1S/C30H33F3N2O/c1-4-19-9-6-10-20(5-2)28(19)25-17-27(36-3)29-24(34-25)13-8-14-26(29)35-16-15-21-11-7-12-23(22(21)18-35)30(31,32)33/h6-7,9-12,17,26H,4-5,8,13-16,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376802
(CHEMBL258658)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2ccccc2C1 |w:16.24| Show InChI InChI=1S/C29H34N2O/c1-4-20-12-8-13-21(5-2)28(20)25-18-27(32-3)29-24(30-25)14-9-15-26(29)31-17-16-22-10-6-7-11-23(22)19-31/h6-8,10-13,18,26H,4-5,9,14-17,19H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376817
(CHEMBL259643)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C30H32N2O/c1-4-21-12-6-8-15-23(21)26-20-29(33-3)30-25(31-26)17-11-19-28(30)32(5-2)27-18-10-14-22-13-7-9-16-24(22)27/h6-10,12-16,18,20,28H,4-5,11,17,19H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376831
(CHEMBL410032)Show SMILES CCN(C1CCCc2nc(cc(Cl)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C31H33ClN2/c1-4-21-13-9-14-22(5-2)30(21)27-20-25(32)31-26(33-27)17-11-19-29(31)34(6-3)28-18-10-15-23-12-7-8-16-24(23)28/h7-10,12-16,18,20,29H,4-6,11,17,19H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376795
(CHEMBL260176)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(CCO)c1cccc2ccccc12 |w:16.24| Show InChI InChI=1S/C32H36N2O2/c1-4-22-12-8-13-23(5-2)31(22)27-21-30(36-3)32-26(33-27)16-10-18-29(32)34(19-20-35)28-17-9-14-24-11-6-7-15-25(24)28/h6-9,11-15,17,21,29,35H,4-5,10,16,18-20H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376824
(CHEMBL408458)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1cccc2ccccc12)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C32H30N2O/c1-3-34(29-19-9-14-23-12-5-7-16-25(23)29)30-20-10-18-27-32(30)31(35-2)21-28(33-27)26-17-8-13-22-11-4-6-15-24(22)26/h4-9,11-17,19,21,30H,3,10,18,20H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50238586
((+/-)-2-(2,6-diethylphenyl)-4-methoxy-N-methyl-N-p...)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1ccccc1 Show InChI InChI=1S/C27H32N2O/c1-5-19-12-10-13-20(6-2)26(19)23-18-25(30-4)27-22(28-23)16-11-17-24(27)29(3)21-14-8-7-9-15-21/h7-10,12-15,18,24H,5-6,11,16-17H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376818
(CHEMBL259984)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(OC)cccc1OC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C30H32N2O3/c1-5-32(24-15-8-12-20-11-6-7-13-21(20)24)25-16-9-14-22-29(25)28(35-4)19-23(31-22)30-26(33-2)17-10-18-27(30)34-3/h6-8,10-13,15,17-19,25H,5,9,14,16H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376816
(CHEMBL260175)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1F)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C28H27FN2O/c1-3-31(25-16-8-11-19-10-4-5-12-20(19)25)26-17-9-15-23-28(26)27(32-2)18-24(30-23)21-13-6-7-14-22(21)29/h4-8,10-14,16,18,26H,3,9,15,17H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376797
(CHEMBL259639)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C28H28N2O/c1-3-30(25-17-9-14-20-11-7-8-15-22(20)25)26-18-10-16-23-28(26)27(31-2)19-24(29-23)21-12-5-4-6-13-21/h4-9,11-15,17,19,26H,3,10,16,18H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Displacement of [125I]C5a from human C5a receptor in U937 cells |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376833
(CHEMBL258797)Show SMILES CCN(C1CCCc2nc(cc(OC3CCCC3)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C36H42N2O/c1-4-25-15-11-16-26(5-2)35(25)31-24-34(39-28-18-8-9-19-28)36-30(37-31)21-13-23-33(36)38(6-3)32-22-12-17-27-14-7-10-20-29(27)32/h7,10-12,14-17,20,22,24,28,33H,4-6,8-9,13,18-19,21,23H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376835
(CHEMBL261276)Show SMILES CCOc1cc(nc2CCCC(N(CC)c3cccc4ccccc34)c12)-c1c(CC)cccc1CC |w:11.11| Show InChI InChI=1S/C33H38N2O/c1-5-23-15-11-16-24(6-2)32(23)28-22-31(36-8-4)33-27(34-28)19-13-21-30(33)35(7-3)29-20-12-17-25-14-9-10-18-26(25)29/h9-12,14-18,20,22,30H,5-8,13,19,21H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376832
(CHEMBL408432)Show SMILES CCN(C1CCCc2nc(cc(SC)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C32H36N2S/c1-5-22-14-10-15-23(6-2)31(22)27-21-30(35-4)32-26(33-27)18-12-20-29(32)34(7-3)28-19-11-16-24-13-8-9-17-25(24)28/h8-11,13-17,19,21,29H,5-7,12,18,20H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376793
(CHEMBL259769)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C32H36N2O/c1-5-22-14-10-15-23(6-2)31(22)27-21-30(35-4)32-26(33-27)18-12-20-29(32)34(7-3)28-19-11-16-24-13-8-9-17-25(24)28/h8-11,13-17,19,21,29H,5-7,12,18,20H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376793
(CHEMBL259769)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C32H36N2O/c1-5-22-14-10-15-23(6-2)31(22)27-21-30(35-4)32-26(33-27)18-12-20-29(32)34(7-3)28-19-11-16-24-13-8-9-17-25(24)28/h8-11,13-17,19,21,29H,5-7,12,18,20H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376827
(CHEMBL411265)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(Cl)cccc1OC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C29H29ClN2O2/c1-4-32(24-15-7-11-19-10-5-6-12-20(19)24)25-16-9-14-22-29(25)27(34-3)18-23(31-22)28-21(30)13-8-17-26(28)33-2/h5-8,10-13,15,17-18,25H,4,9,14,16H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376829
(CHEMBL260476)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(C)cccc1C)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C30H32N2O/c1-5-32(26-17-9-14-22-13-6-7-15-23(22)26)27-18-10-16-24-30(27)28(33-4)19-25(31-24)29-20(2)11-8-12-21(29)3/h6-9,11-15,17,19,27H,5,10,16,18H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376815
(CHEMBL259563)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cccc2ccccc12 |w:16.24| Show InChI InChI=1S/C31H34N2O/c1-5-21-13-9-14-22(6-2)30(21)26-20-29(34-4)31-25(32-26)17-11-19-28(31)33(3)27-18-10-15-23-12-7-8-16-24(23)27/h7-10,12-16,18,20,28H,5-6,11,17,19H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376828
(CHEMBL260188)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(C)cc(OC)cc1C)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C31H34N2O2/c1-6-33(27-15-9-12-22-11-7-8-13-24(22)27)28-16-10-14-25-31(28)29(35-5)19-26(32-25)30-20(2)17-23(34-4)18-21(30)3/h7-9,11-13,15,17-19,28H,6,10,14,16H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376794
(CHEMBL261278)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cccc2cc(OC)ccc12 |w:16.24| Show InChI InChI=1S/C32H36N2O2/c1-6-21-11-8-12-22(7-2)31(21)27-20-30(36-5)32-26(33-27)14-10-16-29(32)34(3)28-15-9-13-23-19-24(35-4)17-18-25(23)28/h8-9,11-13,15,17-20,29H,6-7,10,14,16H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376795
(CHEMBL260176)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(CCO)c1cccc2ccccc12 |w:16.24| Show InChI InChI=1S/C32H36N2O2/c1-4-22-12-8-13-23(5-2)31(22)27-21-30(36-3)32-26(33-27)16-10-18-29(32)34(19-20-35)28-17-9-14-24-11-6-7-15-25(24)28/h6-9,11-15,17,21,29,35H,4-5,10,16,18-20H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376811
(CHEMBL259021)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(CC)cccc1CC)c1cccc2CCCCc12 |w:3.2| Show InChI InChI=1S/C32H40N2O/c1-5-22-14-10-15-23(6-2)31(22)27-21-30(35-4)32-26(33-27)18-12-20-29(32)34(7-3)28-19-11-16-24-13-8-9-17-25(24)28/h10-11,14-16,19,21,29H,5-9,12-13,17-18,20H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376834
(CHEMBL259713)Show SMILES CCN(C1CCCc2nc(cc(OCc3ccccc3)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C38H40N2O/c1-4-28-18-12-19-29(5-2)37(28)33-25-36(41-26-27-15-8-7-9-16-27)38-32(39-33)22-14-24-35(38)40(6-3)34-23-13-20-30-17-10-11-21-31(30)34/h7-13,15-21,23,25,35H,4-6,14,22,24,26H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376803
(CHEMBL262330)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2cccc(c2C1)C(F)(F)F |w:16.24| Show InChI InChI=1S/C30H33F3N2O/c1-4-19-9-6-10-20(5-2)28(19)25-17-27(36-3)29-24(34-25)13-8-14-26(29)35-16-15-21-11-7-12-23(22(21)18-35)30(31,32)33/h6-7,9-12,17,26H,4-5,8,13-16,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376826
(CHEMBL408460)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1C)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C29H30N2O/c1-4-31(26-17-9-13-21-12-6-8-15-23(21)26)27-18-10-16-24-29(27)28(32-3)19-25(30-24)22-14-7-5-11-20(22)2/h5-9,11-15,17,19,27H,4,10,16,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376812
(CHEMBL261277)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1ccc(OC)c2ccccc12 |w:16.24| Show InChI InChI=1S/C32H36N2O2/c1-6-21-12-10-13-22(7-2)31(21)26-20-30(36-5)32-25(33-26)16-11-17-28(32)34(3)27-18-19-29(35-4)24-15-9-8-14-23(24)27/h8-10,12-15,18-20,28H,6-7,11,16-17H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376817
(CHEMBL259643)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C30H32N2O/c1-4-21-12-6-8-15-23(21)26-20-29(33-3)30-25(31-26)17-11-19-28(30)32(5-2)27-18-10-14-22-13-7-9-16-24(22)27/h6-10,12-16,18,20,28H,4-5,11,17,19H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376789
(CHEMBL257128)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N[C@H]1CCCc2ccccc12 |w:16.24| Show InChI InChI=1S/C30H36N2O/c1-4-20-12-8-13-21(5-2)29(20)27-19-28(33-3)30-25(17-10-18-26(30)32-27)31-24-16-9-14-22-11-6-7-15-23(22)24/h6-8,11-13,15,19,24-25,31H,4-5,9-10,14,16-18H2,1-3H3/t24-,25?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376789
(CHEMBL257128)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N[C@H]1CCCc2ccccc12 |w:16.24| Show InChI InChI=1S/C30H36N2O/c1-4-20-12-8-13-21(5-2)29(20)27-19-28(33-3)30-25(17-10-18-26(30)32-27)31-24-16-9-14-22-11-6-7-15-23(22)24/h6-8,11-13,15,19,24-25,31H,4-5,9-10,14,16-18H2,1-3H3/t24-,25?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376804
(CHEMBL261594)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2cccc(C(=O)OC)c2C1 |w:16.24| Show InChI InChI=1S/C31H36N2O3/c1-5-20-10-7-11-21(6-2)29(20)26-18-28(35-3)30-25(32-26)14-9-15-27(30)33-17-16-22-12-8-13-23(24(22)19-33)31(34)36-4/h7-8,10-13,18,27H,5-6,9,14-17,19H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376791
(CHEMBL259645)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2ccc(F)cc2C1 |w:16.24| Show InChI InChI=1S/C29H33FN2O/c1-4-19-8-6-9-20(5-2)28(19)25-17-27(33-3)29-24(31-25)10-7-11-26(29)32-15-14-21-12-13-23(30)16-22(21)18-32/h6,8-9,12-13,16-17,26H,4-5,7,10-11,14-15,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376802
(CHEMBL258658)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2ccccc2C1 |w:16.24| Show InChI InChI=1S/C29H34N2O/c1-4-20-12-8-13-21(5-2)28(20)25-18-27(32-3)29-24(30-25)14-9-15-26(29)31-17-16-22-10-6-7-11-23(22)19-31/h6-8,10-13,18,26H,4-5,9,14-17,19H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376805
(CHEMBL405887)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2ccc(Cl)cc2C1 |w:16.24| Show InChI InChI=1S/C29H33ClN2O/c1-4-19-8-6-9-20(5-2)28(19)25-17-27(33-3)29-24(31-25)10-7-11-26(29)32-15-14-21-12-13-23(30)16-22(21)18-32/h6,8-9,12-13,16-17,26H,4-5,7,10-11,14-15,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376813
(CHEMBL259971)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1c(C)ccc2ccccc12 |w:16.24| Show InChI InChI=1S/C32H36N2O/c1-6-22-13-10-14-23(7-2)30(22)27-20-29(35-5)31-26(33-27)16-11-17-28(31)34(4)32-21(3)18-19-24-12-8-9-15-25(24)32/h8-10,12-15,18-20,28H,6-7,11,16-17H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376825
(CHEMBL259642)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1C(C)C)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C31H34N2O/c1-5-33(28-18-10-13-22-12-6-7-15-24(22)28)29-19-11-17-26-31(29)30(34-4)20-27(32-26)25-16-9-8-14-23(25)21(2)3/h6-10,12-16,18,20-21,29H,5,11,17,19H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376806
(CHEMBL409128)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2c(Cl)cccc2C1 |w:16.24| Show InChI InChI=1S/C29H33ClN2O/c1-4-19-9-6-10-20(5-2)28(19)25-17-27(33-3)29-24(31-25)13-8-14-26(29)32-16-15-22-21(18-32)11-7-12-23(22)30/h6-7,9-12,17,26H,4-5,8,13-16,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376818
(CHEMBL259984)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(OC)cccc1OC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C30H32N2O3/c1-5-32(24-15-8-12-20-11-6-7-13-21(20)24)25-16-9-14-22-29(25)28(35-4)19-23(31-22)30-26(33-2)17-10-18-27(30)34-3/h6-8,10-13,15,17-19,25H,5,9,14,16H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376790
(CHEMBL257175)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N[C@@H]1CCCc2ccccc12 |w:16.24| Show InChI InChI=1S/C30H36N2O/c1-4-20-12-8-13-21(5-2)29(20)27-19-28(33-3)30-25(17-10-18-26(30)32-27)31-24-16-9-14-22-11-6-7-15-23(22)24/h6-8,11-13,15,19,24-25,31H,4-5,9-10,14,16-18H2,1-3H3/t24-,25?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376790
(CHEMBL257175)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N[C@@H]1CCCc2ccccc12 |w:16.24| Show InChI InChI=1S/C30H36N2O/c1-4-20-12-8-13-21(5-2)29(20)27-19-28(33-3)30-25(17-10-18-26(30)32-27)31-24-16-9-14-22-11-6-7-15-23(22)24/h6-8,11-13,15,19,24-25,31H,4-5,9-10,14,16-18H2,1-3H3/t24-,25?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376831
(CHEMBL410032)Show SMILES CCN(C1CCCc2nc(cc(Cl)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C31H33ClN2/c1-4-21-13-9-14-22(5-2)30(21)27-20-25(32)31-26(33-27)17-11-19-29(31)34(6-3)28-18-10-15-23-12-7-8-16-24(23)28/h7-10,12-16,18,20,29H,4-6,11,17,19H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376816
(CHEMBL260175)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1F)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C28H27FN2O/c1-3-31(25-16-8-11-19-10-4-5-12-20(19)25)26-17-9-15-23-28(26)27(32-2)18-24(30-23)21-13-6-7-14-22(21)29/h4-8,10-14,16,18,26H,3,9,15,17H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376824
(CHEMBL408458)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1cccc2ccccc12)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C32H30N2O/c1-3-34(29-19-9-14-23-12-5-7-16-25(23)29)30-20-10-18-27-32(30)31(35-2)21-28(33-27)26-17-8-13-22-11-4-6-15-24(22)26/h4-9,11-17,19,21,30H,3,10,18,20H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376814
(CHEMBL260472)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C(C)=O)c1cccc2ccccc12 |w:16.24| Show InChI InChI=1S/C32H34N2O2/c1-5-22-13-9-14-23(6-2)31(22)27-20-30(36-4)32-26(33-27)17-11-19-29(32)34(21(3)35)28-18-10-15-24-12-7-8-16-25(24)28/h7-10,12-16,18,20,29H,5-6,11,17,19H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50238586
((+/-)-2-(2,6-diethylphenyl)-4-methoxy-N-methyl-N-p...)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1ccccc1 Show InChI InChI=1S/C27H32N2O/c1-5-19-12-10-13-20(6-2)26(19)23-18-25(30-4)27-22(28-23)16-11-17-24(27)29(3)21-14-8-7-9-15-21/h7-10,12-15,18,24H,5-6,11,16-17H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376820
(CHEMBL259970)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1ccc2ccccc2c1 |w:16.24| Show InChI InChI=1S/C31H34N2O/c1-5-21-13-9-14-22(6-2)30(21)27-20-29(34-4)31-26(32-27)15-10-16-28(31)33(3)25-18-17-23-11-7-8-12-24(23)19-25/h7-9,11-14,17-20,28H,5-6,10,15-16H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376799
(CHEMBL259754)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1cccnc1)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C27H27N3O/c1-3-30(24-14-6-10-19-9-4-5-12-21(19)24)25-15-7-13-22-27(25)26(31-2)17-23(29-22)20-11-8-16-28-18-20/h4-6,8-12,14,16-18,25H,3,7,13,15H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376808
(CHEMBL408944)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2ccc(OC)cc2C1 |w:16.24| Show InChI InChI=1S/C30H36N2O2/c1-5-20-9-7-10-21(6-2)29(20)26-18-28(34-4)30-25(31-26)11-8-12-27(30)32-16-15-22-13-14-24(33-3)17-23(22)19-32/h7,9-10,13-14,17-18,27H,5-6,8,11-12,15-16,19H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376801
(CHEMBL259640)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccsc1)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C26H26N2OS/c1-3-28(23-12-6-9-18-8-4-5-10-20(18)23)24-13-7-11-21-26(24)25(29-2)16-22(27-21)19-14-15-30-17-19/h4-6,8-10,12,14-17,24H,3,7,11,13H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376798
(CHEMBL407004)Show SMILES CCN(C1CCCc2nc(Cl)cc(OC)c12)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C22H23ClN2O/c1-3-25(18-12-6-9-15-8-4-5-10-16(15)18)19-13-7-11-17-22(19)20(26-2)14-21(23)24-17/h4-6,8-10,12,14,19H,3,7,11,13H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376797
(CHEMBL259639)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C28H28N2O/c1-3-30(25-17-9-14-20-11-7-8-15-22(20)25)26-18-10-16-23-28(26)27(31-2)19-24(29-23)21-12-5-4-6-13-21/h4-9,11-15,17,19,26H,3,10,16,18H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376793
(CHEMBL259769)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C32H36N2O/c1-5-22-14-10-15-23(6-2)31(22)27-21-30(35-4)32-26(33-27)18-12-20-29(32)34(7-3)28-19-11-16-24-13-8-9-17-25(24)28/h8-11,13-17,19,21,29H,5-7,12,18,20H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376810
(CHEMBL260610)Show SMILES CCc1cccc(CC)c1-c1cc(CC)c2C(CCCc2n1)N(C)Cc1cccc2ccccc12 |w:16.24| Show InChI InChI=1S/C33H38N2/c1-5-23-14-10-15-24(6-2)32(23)30-21-25(7-3)33-29(34-30)19-12-20-31(33)35(4)22-27-17-11-16-26-13-8-9-18-28(26)27/h8-11,13-18,21,31H,5-7,12,19-20,22H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376792
(CHEMBL261593)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2ccc(cc2C1)C(F)(F)F |w:16.24| Show InChI InChI=1S/C30H33F3N2O/c1-4-19-8-6-9-20(5-2)28(19)25-17-27(36-3)29-24(34-25)10-7-11-26(29)35-15-14-21-12-13-23(30(31,32)33)16-22(21)18-35/h6,8-9,12-13,16-17,26H,4-5,7,10-11,14-15,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376819
(CHEMBL261499)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cccc2c(OC)cccc12 |w:16.24| Show InChI InChI=1S/C32H36N2O2/c1-6-21-12-8-13-22(7-2)31(21)26-20-30(36-5)32-25(33-26)16-11-18-28(32)34(3)27-17-9-15-24-23(27)14-10-19-29(24)35-4/h8-10,12-15,17,19-20,28H,6-7,11,16,18H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376809
(CHEMBL260825)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2cc(OC)c(OC)cc2C1 |w:16.24| Show InChI InChI=1S/C31H38N2O3/c1-6-20-10-8-11-21(7-2)30(20)25-18-29(36-5)31-24(32-25)12-9-13-26(31)33-15-14-22-16-27(34-3)28(35-4)17-23(22)19-33/h8,10-11,16-18,26H,6-7,9,12-15,19H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376807
(CHEMBL259022)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N1CCc2c(C1)cccc2C(F)(F)F |w:16.24| Show InChI InChI=1S/C30H33F3N2O/c1-4-19-9-6-10-20(5-2)28(19)25-17-27(36-3)29-24(34-25)13-8-14-26(29)35-16-15-22-21(18-35)11-7-12-23(22)30(31,32)33/h6-7,9-12,17,26H,4-5,8,13-16,18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376796
(CHEMBL260824)Show SMILES CCN(Cc1ccccc1)C1CCCc2nc(cc(CC)c12)-c1c(CC)cccc1CC |w:10.10| Show InChI InChI=1S/C30H38N2/c1-5-23-16-12-17-24(6-2)29(23)27-20-25(7-3)30-26(31-27)18-13-19-28(30)32(8-4)21-22-14-10-9-11-15-22/h9-12,14-17,20,28H,5-8,13,18-19,21H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376830
(CHEMBL258967)Show SMILES CCN(C1CCCc2nc(ccc12)-c1c(CC)cccc1CC)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C31H34N2/c1-4-22-13-9-14-23(5-2)31(22)28-21-20-26-27(32-28)17-11-19-30(26)33(6-3)29-18-10-15-24-12-7-8-16-25(24)29/h7-10,12-16,18,20-21,30H,4-6,11,17,19H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376822
(CHEMBL408459)Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1cccc2ccccc12 |w:16.24| Show InChI InChI=1S/C30H32N2O/c1-4-20-12-8-13-21(5-2)29(20)27-19-28(33-3)30-25(17-10-18-26(30)32-27)31-24-16-9-14-22-11-6-7-15-23(22)24/h6-9,11-16,19,25,31H,4-5,10,17-18H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376821
(CHEMBL259341)Show SMILES CCNC1CCCc2nc(cc(OC)c12)-c1c(CC)cccc1CC |w:3.2| Show InChI InChI=1S/C22H30N2O/c1-5-15-10-8-11-16(6-2)21(15)19-14-20(25-4)22-17(23-7-3)12-9-13-18(22)24-19/h8,10-11,14,17,23H,5-7,9,12-13H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376823
(CHEMBL260177)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccccc1-c1ccccc1)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C34H32N2O/c1-3-36(31-21-11-16-25-15-7-8-18-27(25)31)32-22-12-20-29-34(32)33(37-2)23-30(35-29)28-19-10-9-17-26(28)24-13-5-4-6-14-24/h4-11,13-19,21,23,32H,3,12,20,22H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50376800
(CHEMBL259743)Show SMILES CCN(C1CCCc2nc(cc(OC)c12)-c1ccc2OCOc2c1)c1cccc2ccccc12 |w:3.2| Show InChI InChI=1S/C29H28N2O3/c1-3-31(24-12-6-9-19-8-4-5-10-21(19)24)25-13-7-11-22-29(25)28(32-2)17-23(30-22)20-14-15-26-27(16-20)34-18-33-26/h4-6,8-10,12,14-17,25H,3,7,11,13,18H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson PRD
Curated by ChEMBL
| Assay Description
Antagonist activity at human C5a receptor in U937 cells assessed as inhibition of anaphylatoxin-induced intracellular calcium mobilization |
Bioorg Med Chem Lett 18: 2544-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.049
BindingDB Entry DOI: 10.7270/Q2JM2BHD |
More data for this
Ligand-Target Pair | |
Search and Browse
