Affinity Data by PubMed id=18393409

PubMed code 18393409

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261157 (5-(2-Ethoxy-5-(N-acetic acid,N'-5-(2-ethoxy-5-sulf...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261649 (5-{2-Ethoxy-5-[(4-(4-nitrophenyl))piperazinylsulph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261602 (5-{2-Ethoxy-5-[(4-(2-fluorophenyl)piperazinylsulph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261603 (5-{2-Ethoxy-5-[(4-(4-fluorophenyl)piperazinylsulph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261652 (5-{2-Ethoxy-5-[(4-(1-(cyclohexyl))piperazinylsulph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261647 (5-{2-Ethoxy-5-[(4-(3-chlorophenyl))piperazinylsulp...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261648 (5-{2-Ethoxy-5-[(4-(4-chlorophenyl))piperazinylsulp...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261574 (5-{2-Ethoxy-5-[(4-(1-(2-methoxyphenyl))piperazinyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261154 (5-(2-Ethoxy-5-(N-phenyl-ethylenediamine-sulfonyl)p...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261158 (5-(2-Ethoxy-5-(N-ethanol,N'-5-(2-ethoxy-5-sulfonyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261651 (5-{2-Ethoxy-5-[(4-(1-piperonyl)piperazinylsulphony...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261650 (5-{2-Ethoxy-5-[4-(1-naphthyl)piperazinylsulphonyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261156 (5-(2-Ethoxy-5-(N-acetic acid ethylenediamine-sulfo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261155 (5-(2-Ethoxy-5-(N-naphthyl-ethylenediamine-sulfonyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50261653 (4-Nitrooxy-butyric acid 2-{4-[4-ethoxy-3-(1-methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
State University of Campinas Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis				J Med Chem 51: 2807-15 (2008) Article DOI: 10.1021/jm701400r BindingDB Entry DOI: 10.7270/Q2NC6100
State University of Campinas Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%