Found 4 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calcium-activated potassium channel subunit alpha-1
(Rattus norvegicus) | BDBM50347497
(CHEMBL384903)Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F |(19.17,-33.76,;20.68,-34.08,;21.16,-35.54,;22.67,-35.85,;23.69,-34.69,;23.2,-33.23,;21.7,-32.94,;21.22,-31.47,;19.75,-31.01,;18.41,-31.79,;17.08,-31.01,;17.08,-29.47,;18.41,-28.7,;19.74,-29.46,;21.21,-28.98,;22.12,-30.22,;23.66,-30.22,;15.74,-28.7,;14.4,-27.93,;16.51,-27.37,;14.98,-30.04,;25.2,-35,;26.69,-35.39,;25.55,-33.5,;24.86,-36.5,)| Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction |
Eur J Med Chem 43: 2618-26 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.032
BindingDB Entry DOI: 10.7270/Q2WM1FMQ |
More data for this
Ligand-Target Pair | |
Calcium-activated potassium channel subunit alpha-1
(Rattus norvegicus) | BDBM50413656
(CHEMBL511502)Show InChI InChI=1S/C17H16N4O2/c1-12-16(17(23)18-14-8-3-2-4-9-14)19-20-21(12)11-13-7-5-6-10-15(13)22/h2-10,22H,11H2,1H3,(H,18,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.78E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction |
Eur J Med Chem 43: 2618-26 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.032
BindingDB Entry DOI: 10.7270/Q2WM1FMQ |
More data for this
Ligand-Target Pair | |
Calcium-activated potassium channel subunit alpha-1
(Rattus norvegicus) | BDBM50413657
(CHEMBL511864)Show InChI InChI=1S/C17H16N4O3/c1-11-16(17(24)18-13-7-3-5-9-15(13)23)19-20-21(11)10-12-6-2-4-8-14(12)22/h2-9,22-23H,10H2,1H3,(H,18,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction |
Eur J Med Chem 43: 2618-26 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.032
BindingDB Entry DOI: 10.7270/Q2WM1FMQ |
More data for this
Ligand-Target Pair | |
Calcium-activated potassium channel subunit alpha-1
(Rattus norvegicus) | BDBM50413658
(CHEMBL517023)Show InChI InChI=1S/C18H18N4O3/c1-12-17(18(25)19-10-13-6-2-4-8-15(13)23)20-21-22(12)11-14-7-3-5-9-16(14)24/h2-9,23-24H,10-11H2,1H3,(H,19,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction |
Eur J Med Chem 43: 2618-26 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.032
BindingDB Entry DOI: 10.7270/Q2WM1FMQ |
More data for this
Ligand-Target Pair | |
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