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PubMed code 18420406

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50132151
PNG
(CHEMBL101683 | N-(4-Chloro-phenyl)-2-[(pyridin-4-y...)
Show SMILES Clc1ccc(NC(=O)c2ccccc2NCc2ccncc2)cc1
Show InChI InChI=1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)
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PubMed
n/an/a 20n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 23n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50377602
PNG
(CHEMBL256556)
Show SMILES Clc1ccc(NC(=O)c2cccnc2SCc2ccncc2)cc1
Show InChI InChI=1S/C18H14ClN3OS/c19-14-3-5-15(6-4-14)22-17(23)16-2-1-9-21-18(16)24-12-13-7-10-20-11-8-13/h1-11H,12H2,(H,22,23)
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n/an/a 26n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 37n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50377603
PNG
(CHEMBL402002)
Show SMILES Clc1ccc(NC(=O)c2ccccc2SCc2ccncc2)cc1
Show InChI InChI=1S/C19H15ClN2OS/c20-15-5-7-16(8-6-15)22-19(23)17-3-1-2-4-18(17)24-13-14-9-11-21-12-10-14/h1-12H,13H2,(H,22,23)
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n/an/a 46n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50377606
PNG
(CHEMBL427725)
Show SMILES CCCc1ccc(NC(=O)c2ccccc2CCc2ccncc2)cc1
Show InChI InChI=1S/C23H24N2O/c1-2-5-18-9-12-21(13-10-18)25-23(26)22-7-4-3-6-20(22)11-8-19-14-16-24-17-15-19/h3-4,6-7,9-10,12-17H,2,5,8,11H2,1H3,(H,25,26)
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n/an/a 200n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50377605
PNG
(CHEMBL404393)
Show SMILES Clc1ccc(NC(=S)c2ccccc2OCc2ccncc2)cc1
Show InChI InChI=1S/C19H15ClN2OS/c20-15-5-7-16(8-6-15)22-19(24)17-3-1-2-4-18(17)23-13-14-9-11-21-12-10-14/h1-12H,13H2,(H,22,24)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50377604
PNG
(CHEMBL256718)
Show SMILES Clc1ccc(NC(=O)c2ccccc2OCc2ccncc2)cc1
Show InChI InChI=1S/C19H15ClN2O2/c20-15-5-7-16(8-6-15)22-19(23)17-3-1-2-4-18(17)24-13-14-9-11-21-12-10-14/h1-12H,13H2,(H,22,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR by ELISA

Bioorg Med Chem Lett 18: 2939-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.068
BindingDB Entry DOI: 10.7270/Q2K938F8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%