BindingDB logo
myBDB logout

PubMed code 1848292

Compile data set for download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009002
PNG
(2-Methyl-1,2-dihydro-indazol-3-one | CHEMBL3144583)
Show SMILES Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C8H8N2O/c1-10-8(11)6-4-2-3-5-7(6)9-10/h2-5,9H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 200n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 (LT) production in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009008
PNG
(2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(Cc2ccco2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 270n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50406478
PNG
(CHEMBL274205 | CHEMBL3144721)
Show SMILES CCCCCNC(=O)c1cccc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C14H19N3O2/c1-3-4-5-9-15-13(18)10-7-6-8-11-12(10)14(19)17(2)16-11/h6-8,16H,3-5,9H2,1-2H3,(H,15,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 300n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 (LT) production in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50406485
PNG
(CHEMBL8429)
Show SMILES CCCCCNC(=O)c1cccc2[nH][nH]c(=O)c12
Show InChI InChI=1S/C13H17N3O2/c1-2-3-4-8-14-12(17)9-6-5-7-10-11(9)13(18)16-15-10/h5-7H,2-4,8H2,1H3,(H,14,17)(H2,15,16,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 300n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 (LT) production in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM46671
PNG
(2-Phenyl-1,2-dihydro-indazol-3-one | 2-phenyl-1H-i...)
Show SMILES O=c1n([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-13-11-8-4-5-9-12(11)14-15(13)10-6-2-1-3-7-10/h1-9,14H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 310n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009000
PNG
(2-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL1984519)
Show SMILES O=c1n(Cc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)15-16(14)10-11-6-2-1-3-7-11/h1-9,15H,10H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 360n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008989
PNG
(2-Thiophen-2-ylmethyl-1,2-dihydro-indazol-3-one | ...)
Show SMILES O=c1n(Cc2cccs2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2OS/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 400n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009009
PNG
(2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one | CH...)
Show SMILES O=c1n(CCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C16H16N2O/c19-16-14-10-4-5-11-15(14)17-18(16)12-6-9-13-7-2-1-3-8-13/h1-5,7-8,10-11,17H,6,9,12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 540n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009007
PNG
(2-Phenethyl-1,2-dihydro-indazol-3-one | CHEMBL3144...)
Show SMILES O=c1n(CCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C15H14N2O/c18-15-13-8-4-5-9-14(13)16-17(15)11-10-12-6-2-1-3-7-12/h1-9,16H,10-11H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 550n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008985
PNG
(2-Naphthalen-1-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2cccc3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-10-3-4-11-17(16)19-20(18)12-14-8-5-7-13-6-1-2-9-15(13)14/h1-11,19H,12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 610n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents
PubMed
n/an/a 700n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 (LT) production in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009016
PNG
(2-(4-Phenyl-butyl)-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(CCCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C17H18N2O/c20-17-15-11-4-5-12-16(15)18-19(17)13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12,18H,6-7,10,13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 780n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008992
PNG
(2-Pyridin-3-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cccnc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-5-1-2-6-12(11)15-16(13)9-10-4-3-7-14-8-10/h1-8,15H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 800n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 (LT) production in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009006
PNG
(2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2ccc3ccccc3c2)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-7-3-4-8-17(16)19-20(18)12-13-9-10-14-5-1-2-6-15(14)11-13/h1-11,19H,12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 970n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50229183
PNG
(CHEMBL3144587)
Show SMILES Clc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C13H10ClN3O/c14-12-6-5-9(7-15-12)8-17-13(18)10-3-1-2-4-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a<1.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008987
PNG
(2-(5-Bromo-pyridin-3-ylmethyl)-1,2-dihydro-indazol...)
Show SMILES Brc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C13H10BrN3O/c14-10-5-9(6-15-7-10)8-17-13(18)11-3-1-2-4-12(11)16-17/h1-7,16H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50229182
PNG
(CHEMBL3144723)
Show SMILES COc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O2/c1-19-13-7-6-10(8-15-13)9-17-14(18)11-4-2-3-5-12(11)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a<1.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009014
PNG
(2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2c[nH]c3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3O/c20-16-13-6-2-4-8-15(13)18-19(16)10-11-9-17-14-7-3-1-5-12(11)14/h1-9,17-18H,10H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009002
PNG
(2-Methyl-1,2-dihydro-indazol-3-one | CHEMBL3144583)
Show SMILES Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C8H8N2O/c1-10-8(11)6-4-2-3-5-7(6)9-10/h2-5,9H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009015
PNG
(2-(2-Chloro-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Clc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C13H10ClN3O/c14-12-9(4-3-7-15-12)8-17-13(18)10-5-1-2-6-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008986
PNG
(2-(1-Naphthalen-1-yl-ethyl)-1,2-dihydro-indazol-3-...)
Show SMILES C[C@H](c1cccc2ccccc12)n1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C19H16N2O/c1-13(15-11-6-8-14-7-2-3-9-16(14)15)21-19(22)17-10-4-5-12-18(17)20-21/h2-13,20H,1H3/t13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50406483
PNG
(CHEMBL3144585 | CHEMBL8567)
Show SMILES CCCCCNC(=O)c1cccc2[nH]n(Cc3cccnc3)c(=O)c12
Show InChI InChI=1S/C19H22N4O2/c1-2-3-4-11-21-18(24)15-8-5-9-16-17(15)19(25)23(22-16)13-14-7-6-10-20-12-14/h5-10,12,22H,2-4,11,13H2,1H3,(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 (LT) production in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008992
PNG
(2-Pyridin-3-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cccnc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-5-1-2-6-12(11)15-16(13)9-10-4-3-7-14-8-10/h1-8,15H,9H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008996
PNG
(2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cncs2)[nH]c2ccccc12
Show InChI InChI=1S/C11H9N3OS/c15-11-9-3-1-2-4-10(9)13-14(11)6-8-5-12-7-16-8/h1-5,7,13H,6H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009011
PNG
(2-(5-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C14H13N3O/c1-10-6-11(8-15-7-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008994
PNG
(2-Pyridin-4-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccncc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-3-1-2-4-12(11)15-16(13)9-10-5-7-14-8-6-10/h1-8,15H,9H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009019
PNG
(2-(6-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-11(8-15-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009003
PNG
(2-(2-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-11(5-4-8-15-10)9-17-14(18)12-6-2-3-7-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM46671
PNG
(2-Phenyl-1,2-dihydro-indazol-3-one | 2-phenyl-1H-i...)
Show SMILES O=c1n([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-13-11-8-4-5-9-12(11)14-15(13)10-6-2-1-3-7-10/h1-9,14H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008997
PNG
(1-Methyl-1,2-dihydro-indazol-3-one | CHEMBL412905)
Show SMILES Cn1[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C8H8N2O/c1-10-7-5-3-2-4-6(7)8(11)9-10/h2-5H,1H3,(H,9,11)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50229183
PNG
(CHEMBL3144587)
Show SMILES Clc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C13H10ClN3O/c14-12-6-5-9(7-15-12)8-17-13(18)10-3-1-2-4-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 (PG) production in rat blood; 3-30

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009017
PNG
(2-(4-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccncc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-15-8-11(10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50229182
PNG
(CHEMBL3144723)
Show SMILES COc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O2/c1-19-13-7-6-10(8-15-13)9-17-14(18)11-4-2-3-5-12(11)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 (PG) production in rat blood; 3-30

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50012434
PNG
((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009010
PNG
(2-Pyridin-2-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccccn2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-6-1-2-7-12(11)15-16(13)9-10-5-3-4-8-14-10/h1-8,15H,9H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008993
PNG
(1-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL8612)
Show SMILES O=c1[nH]n(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)16(15-14)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3.40E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009009
PNG
(2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one | CH...)
Show SMILES O=c1n(CCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C16H16N2O/c19-16-14-10-4-5-11-15(14)17-18(16)12-6-9-13-7-2-1-3-8-13/h1-5,7-8,10-11,17H,6,9,12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.80E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM22372
PNG
(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Show SMILES C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F |t:1|
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009001
PNG
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Show SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008988
PNG
(2-(1-Naphthalen-1-yl-ethyl)-1,2-dihydro-indazol-3-...)
Show SMILES C[C@@H](c1cccc2ccccc12)n1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C19H16N2O/c1-13(15-11-6-8-14-7-2-3-9-16(14)15)21-19(22)17-10-4-5-12-18(17)20-21/h2-13,20H,1H3/t13-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009015
PNG
(2-(2-Chloro-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Clc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C13H10ClN3O/c14-12-9(4-3-7-15-12)8-17-13(18)10-5-1-2-6-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009008
PNG
(2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(Cc2ccco2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009007
PNG
(2-Phenethyl-1,2-dihydro-indazol-3-one | CHEMBL3144...)
Show SMILES O=c1n(CCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C15H14N2O/c18-15-13-8-4-5-9-14(13)16-17(15)11-10-12-6-2-1-3-7-12/h1-9,16H,10-11H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009002
PNG
(2-Methyl-1,2-dihydro-indazol-3-one | CHEMBL3144583)
Show SMILES Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C8H8N2O/c1-10-8(11)6-4-2-3-5-7(6)9-10/h2-5,9H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009000
PNG
(2-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL1984519)
Show SMILES O=c1n(Cc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)15-16(14)10-11-6-2-1-3-7-11/h1-9,15H,10H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009006
PNG
(2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2ccc3ccccc3c2)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-7-3-4-8-17(16)19-20(18)12-13-9-10-14-5-1-2-6-15(14)11-13/h1-11,19H,12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F |t:1|
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008997
PNG
(1-Methyl-1,2-dihydro-indazol-3-one | CHEMBL412905)
Show SMILES Cn1[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C8H8N2O/c1-10-7-5-3-2-4-6(7)8(11)9-10/h2-5H,1H3,(H,9,11)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009019
PNG
(2-(6-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-11(8-15-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009016
PNG
(2-(4-Phenyl-butyl)-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(CCCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C17H18N2O/c20-17-15-11-4-5-12-16(15)18-19(17)13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12,18H,6-7,10,13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008989
PNG
(2-Thiophen-2-ylmethyl-1,2-dihydro-indazol-3-one | ...)
Show SMILES O=c1n(Cc2cccs2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2OS/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50406484
PNG
(CHEMBL268241)
Show SMILES C(Oc1[nH]nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-2-6-11(7-3-1)10-17-14-12-8-4-5-9-13(12)15-16-14/h1-9H,10H2,(H,15,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50406481
PNG
(CHEMBL8099)
Show SMILES COc1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C15H14N2O/c1-18-15-13-9-5-6-10-14(13)17(16-15)11-12-7-3-2-4-8-12/h2-10H,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM22372
PNG
(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Show SMILES C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009017
PNG
(2-(4-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccncc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-15-8-11(10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50406479
PNG
(CHEMBL274403)
Show SMILES O=c1[nH]n(-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C13H10N2O/c16-13-11-8-4-5-9-12(11)15(14-13)10-6-2-1-3-7-10/h1-9H,(H,14,16)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50406480
PNG
(CHEMBL276476)
Show SMILES Cn1n(Cc2ccccc2)c(=O)c2ccccc12
Show InChI InChI=1S/C15H14N2O/c1-16-14-10-6-5-9-13(14)15(18)17(16)11-12-7-3-2-4-8-12/h2-10H,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50406482
PNG
(CHEMBL8289)
Show SMILES Cn1n(Cc2ccccc2)c2ccccc2c1=O
Show InChI InChI=1S/C15H14N2O/c1-16-15(18)13-9-5-6-10-14(13)17(16)11-12-7-3-2-4-8-12/h2-10H,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008993
PNG
(1-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL8612)
Show SMILES O=c1[nH]n(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)16(15-14)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3.10E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008987
PNG
(2-(5-Bromo-pyridin-3-ylmethyl)-1,2-dihydro-indazol...)
Show SMILES Brc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C13H10BrN3O/c14-10-5-9(6-15-7-10)8-17-13(18)11-3-1-2-4-12(11)16-17/h1-7,16H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.90E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008988
PNG
(2-(1-Naphthalen-1-yl-ethyl)-1,2-dihydro-indazol-3-...)
Show SMILES C[C@@H](c1cccc2ccccc12)n1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C19H16N2O/c1-13(15-11-6-8-14-7-2-3-9-16(14)15)21-19(22)17-10-4-5-12-18(17)20-21/h2-13,20H,1H3/t13-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4.80E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009001
PNG
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Show SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50008999
PNG
(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Show SMILES Cc1cc(=O)n(CCOc2ccc3ccccc3c2)[nH]1
Show InChI InChI=1S/C16H16N2O2/c1-12-10-16(19)18(17-12)8-9-20-15-7-6-13-4-2-3-5-14(13)11-15/h2-7,10-11,17H,8-9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009003
PNG
(2-(2-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-11(5-4-8-15-10)9-17-14(18)12-6-2-3-7-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 5.80E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009010
PNG
(2-Pyridin-2-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccccn2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-6-1-2-7-12(11)15-16(13)9-10-5-3-4-8-14-10/h1-8,15H,9H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 6.70E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009011
PNG
(2-(5-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C14H13N3O/c1-10-6-11(8-15-7-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 8.10E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50009014
PNG
(2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2c[nH]c3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3O/c20-16-13-6-2-4-8-15(13)18-19(16)10-11-9-17-14-7-3-1-5-12(11)14/h1-9,17-18H,10H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 9.40E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008985
PNG
(2-Naphthalen-1-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2cccc3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-10-3-4-11-17(16)19-20(18)12-14-8-5-7-13-6-1-2-9-15(13)14/h1-11,19H,12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008999
PNG
(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Show SMILES Cc1cc(=O)n(CCOc2ccc3ccccc3c2)[nH]1
Show InChI InChI=1S/C16H16N2O2/c1-12-10-16(19)18(17-12)8-9-20-15-7-6-13-4-2-3-5-14(13)11-15/h2-7,10-11,17H,8-9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008996
PNG
(2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cncs2)[nH]c2ccccc12
Show InChI InChI=1S/C11H9N3OS/c15-11-9-3-1-2-4-10(9)13-14(11)6-8-5-12-7-16-8/h1-5,7,13H,6H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008994
PNG
(2-Pyridin-4-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccncc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-3-1-2-4-12(11)15-16(13)9-10-5-7-14-8-6-10/h1-8,15H,9H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.80E+5n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50012434
PNG
((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008992
PNG
(2-Pyridin-3-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cccnc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-5-1-2-6-12(11)15-16(13)9-10-4-3-7-14-8-10/h1-8,15H,9H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1/2


(RAT)		BDBM50008986
PNG
(2-(1-Naphthalen-1-yl-ethyl)-1,2-dihydro-indazol-3-...)
Show SMILES C[C@H](c1cccc2ccccc12)n1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C19H16N2O/c1-13(15-11-6-8-14-7-2-3-9-16(14)15)21-19(22)17-10-4-5-12-18(17)20-21/h2-13,20H,1H3/t13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4.00E+5n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008996
PNG
(2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cncs2)[nH]c2ccccc12
Show InChI InChI=1S/C11H9N3OS/c15-11-9-3-1-2-4-10(9)13-14(11)6-8-5-12-7-16-8/h1-5,7,13H,6H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 2.16E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009019
PNG
(2-(6-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-11(8-15-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 4.17E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008989
PNG
(2-Thiophen-2-ylmethyl-1,2-dihydro-indazol-3-one | ...)
Show SMILES O=c1n(Cc2cccs2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2OS/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 3.47E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PubMed
n/an/an/an/a>3.30E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008994
PNG
(2-Pyridin-4-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccncc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-3-1-2-4-12(11)15-16(13)9-10-5-7-14-8-6-10/h1-8,15H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 4.43E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009003
PNG
(2-(2-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-11(5-4-8-15-10)9-17-14(18)12-6-2-3-7-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 4.17E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009000
PNG
(2-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL1984519)
Show SMILES O=c1n(Cc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)15-16(14)10-11-6-2-1-3-7-11/h1-9,15H,10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a 8.91E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009008
PNG
(2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(Cc2ccco2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 7.00E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009007
PNG
(2-Phenethyl-1,2-dihydro-indazol-3-one | CHEMBL3144...)
Show SMILES O=c1n(CCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C15H14N2O/c18-15-13-8-4-5-9-14(13)16-17(15)11-10-12-6-2-1-3-7-12/h1-9,16H,10-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a>4.19E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents
PubMed
n/an/an/an/a>7.45E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM46671
PNG
(2-Phenyl-1,2-dihydro-indazol-3-one | 2-phenyl-1H-i...)
Show SMILES O=c1n([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-13-11-8-4-5-9-12(11)14-15(13)10-6-2-1-3-7-10/h1-9,14H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>4.75E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009015
PNG
(2-(2-Chloro-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Clc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C13H10ClN3O/c14-12-9(4-3-7-15-12)8-17-13(18)10-5-1-2-6-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 1.92E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009001
PNG
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Show SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
PubMed
n/an/an/an/a>3.70E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009011
PNG
(2-(5-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C14H13N3O/c1-10-6-11(8-15-7-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 6.26E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50229182
PNG
(CHEMBL3144723)
Show SMILES COc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O2/c1-19-13-7-6-10(8-15-13)9-17-14(18)11-4-2-3-5-12(11)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 3.91E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009017
PNG
(2-(4-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccncc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-15-8-11(10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 2.08E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009006
PNG
(2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2ccc3ccccc3c2)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-7-3-4-8-17(16)19-20(18)12-13-9-10-14-5-1-2-6-15(14)11-13/h1-11,19H,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a>3.64E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009009
PNG
(2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one | CH...)
Show SMILES O=c1n(CCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C16H16N2O/c19-16-14-10-4-5-11-15(14)17-18(16)12-6-9-13-7-2-1-3-8-13/h1-5,7-8,10-11,17H,6,9,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>3.96E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008993
PNG
(1-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL8612)
Show SMILES O=c1[nH]n(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)16(15-14)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,15,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a>4.45E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50406480
PNG
(CHEMBL276476)
Show SMILES Cn1n(Cc2ccccc2)c(=O)c2ccccc12
Show InChI InChI=1S/C15H14N2O/c1-16-14-10-6-5-9-13(14)15(18)17(16)11-12-7-3-2-4-8-12/h2-10H,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>4.19E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009010
PNG
(2-Pyridin-2-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccccn2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-6-1-2-7-12(11)15-16(13)9-10-5-3-4-8-14-10/h1-8,15H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 1.33E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50012434
PNG
((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a>2.98E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50229183
PNG
(CHEMBL3144587)
Show SMILES Clc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C13H10ClN3O/c14-12-6-5-9(7-15-12)8-17-13(18)10-3-1-2-4-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 5.77E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM22372
PNG
(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Show SMILES C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem

Patents

Similars
DrugBank
PubMed
n/an/an/an/a>3.30E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F |t:1|
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a 1.30E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009002
PNG
(2-Methyl-1,2-dihydro-indazol-3-one | CHEMBL3144583)
Show SMILES Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C8H8N2O/c1-10-8(11)6-4-2-3-5-7(6)9-10/h2-5,9H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a 6.74E+3n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008997
PNG
(1-Methyl-1,2-dihydro-indazol-3-one | CHEMBL412905)
Show SMILES Cn1[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C8H8N2O/c1-10-7-5-3-2-4-6(7)8(11)9-10/h2-5H,1H3,(H,9,11)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a>6.74E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008992
PNG
(2-Pyridin-3-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cccnc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-5-1-2-6-12(11)15-16(13)9-10-4-3-7-14-8-10/h1-8,15H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a 1.33E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008999
PNG
(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Show SMILES Cc1cc(=O)n(CCOc2ccc3ccccc3c2)[nH]1
Show InChI InChI=1S/C16H16N2O2/c1-12-10-16(19)18(17-12)8-9-20-15-7-6-13-4-2-3-5-14(13)11-15/h2-7,10-11,17H,8-9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a>3.72E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008986
PNG
(2-(1-Naphthalen-1-yl-ethyl)-1,2-dihydro-indazol-3-...)
Show SMILES C[C@H](c1cccc2ccccc12)n1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C19H16N2O/c1-13(15-11-6-8-14-7-2-3-9-16(14)15)21-19(22)17-10-4-5-12-18(17)20-21/h2-13,20H,1H3/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>3.46E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a 3.08E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009014
PNG
(2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2c[nH]c3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3O/c20-16-13-6-2-4-8-15(13)18-19(16)10-11-9-17-14-7-3-1-5-12(11)14/h1-9,17-18H,10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 1.13E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008987
PNG
(2-(5-Bromo-pyridin-3-ylmethyl)-1,2-dihydro-indazol...)
Show SMILES Brc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C13H10BrN3O/c14-10-5-9(6-15-7-10)8-17-13(18)11-3-1-2-4-12(11)16-17/h1-7,16H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 3.28E+4n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50008985
PNG
(2-Naphthalen-1-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2cccc3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-10-3-4-11-17(16)19-20(18)12-14-8-5-7-13-6-1-2-9-15(13)14/h1-11,19H,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/an/an/a>3.64E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009016
PNG
(2-(4-Phenyl-butyl)-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(CCCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C17H18N2O/c20-17-15-11-4-5-12-16(15)18-19(17)13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12,18H,6-7,10,13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>3.75E+5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood

J Med Chem 34: 1028-36 (1991)


BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%