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PubMed code 18502134

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271277
PNG
(1H-Indazole-7-carbonitrile | CHEMBL484298)
Show SMILES N#Cc1cccc2cn[nH]c12
Show InChI InChI=1S/C8H5N3/c9-4-6-2-1-3-7-5-10-11-8(6)7/h1-3,5H,(H,10,11)
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 1.30E+4n/an/an/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Activity of rat brain recombinant nNOS assessed as L-arginine oxidation in presence of 10 uM (6R)-5,6,7,8-tetrahydro-L-biopterin

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270528
PNG
(3-BROMO-7-NITROINDAZOLE | 3-bromo-7-nitro-1H-indaz...)
Show SMILES [O-][N+](=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270528
PNG
(3-BROMO-7-NITROINDAZOLE | 3-bromo-7-nitro-1H-indaz...)
Show SMILES [O-][N+](=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270528
PNG
(3-BROMO-7-NITROINDAZOLE | 3-bromo-7-nitro-1H-indaz...)
Show SMILES [O-][N+](=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270530
PNG
(3-Bromo-1H-indazole-7-carbonitrile | CHEMBL451541)
Show SMILES Brc1n[nH]c2c(cccc12)C#N
Show InChI InChI=1S/C8H4BrN3/c9-8-6-3-1-2-5(4-10)7(6)11-12-8/h1-3H,(H,11,12)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270530
PNG
(3-Bromo-1H-indazole-7-carbonitrile | CHEMBL451541)
Show SMILES Brc1n[nH]c2c(cccc12)C#N
Show InChI InChI=1S/C8H4BrN3/c9-8-6-3-1-2-5(4-10)7(6)11-12-8/h1-3H,(H,11,12)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270530
PNG
(3-Bromo-1H-indazole-7-carbonitrile | CHEMBL451541)
Show SMILES Brc1n[nH]c2c(cccc12)C#N
Show InChI InChI=1S/C8H4BrN3/c9-8-6-3-1-2-5(4-10)7(6)11-12-8/h1-3H,(H,11,12)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50209245
PNG
(CHEMBL247378)
Show SMILES [O-][N+](=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271277
PNG
(1H-Indazole-7-carbonitrile | CHEMBL484298)
Show SMILES N#Cc1cccc2cn[nH]c12
Show InChI InChI=1S/C8H5N3/c9-4-6-2-1-3-7-5-10-11-8(6)7/h1-3,5H,(H,10,11)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50271277
PNG
(1H-Indazole-7-carbonitrile | CHEMBL484298)
Show SMILES N#Cc1cccc2cn[nH]c12
Show InChI InChI=1S/C8H5N3/c9-4-6-2-1-3-7-5-10-11-8(6)7/h1-3,5H,(H,10,11)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50209245
PNG
(CHEMBL247378)
Show SMILES [O-][N+](=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50209245
PNG
(CHEMBL247378)
Show SMILES [O-][N+](=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271279
PNG
(1H-Indazole-7-carboxamide | CHEMBL451401)
Show SMILES NC(=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C8H7N3O/c9-8(12)6-3-1-2-5-4-10-11-7(5)6/h1-4H,(H2,9,12)(H,10,11)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50271277
PNG
(1H-Indazole-7-carbonitrile | CHEMBL484298)
Show SMILES N#Cc1cccc2cn[nH]c12
Show InChI InChI=1S/C8H5N3/c9-4-6-2-1-3-7-5-10-11-8(6)7/h1-3,5H,(H,10,11)
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n/an/a 1.10E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50271275
PNG
(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Show SMILES Nc1cccc2cn[nH]c12
Show InChI InChI=1S/C7H7N3/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,8H2,(H,9,10)
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n/an/a 1.10E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50271276
PNG
(7-Iodo-1H-indazole | CHEMBL510569)
Show SMILES Ic1cccc2cn[nH]c12
Show InChI InChI=1S/C7H5IN2/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)
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n/an/a 1.25E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271276
PNG
(7-Iodo-1H-indazole | CHEMBL510569)
Show SMILES Ic1cccc2cn[nH]c12
Show InChI InChI=1S/C7H5IN2/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)
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n/an/a 2.00E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270526
PNG
(7-Ethynyl-1H-indazole | CHEMBL452956)
Show SMILES C#Cc1cccc2cn[nH]c12
Show InChI InChI=1S/C9H6N2/c1-2-7-4-3-5-8-6-10-11-9(7)8/h1,3-6H,(H,10,11)
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n/an/a 2.25E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50240903
PNG
(1-methyl-7-nitro-1H-indazole | CHEMBL354723)
Show SMILES Cn1ncc2cccc([N+]([O-])=O)c12
Show InChI InChI=1S/C8H7N3O2/c1-10-8-6(5-9-10)3-2-4-7(8)11(12)13/h2-5H,1H3
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50271276
PNG
(7-Iodo-1H-indazole | CHEMBL510569)
Show SMILES Ic1cccc2cn[nH]c12
Show InChI InChI=1S/C7H5IN2/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)
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n/an/a 3.70E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50271275
PNG
(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Show SMILES Nc1cccc2cn[nH]c12
Show InChI InChI=1S/C7H7N3/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,8H2,(H,9,10)
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n/an/a 4.00E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270533
PNG
(3-Bromo-1-methyl-7-nitro-1H-indazole | CHEMBL50488...)
Show SMILES Cn1nc(Br)c2cccc([N+]([O-])=O)c12
Show InChI InChI=1S/C8H6BrN3O2/c1-11-7-5(8(9)10-11)3-2-4-6(7)12(13)14/h2-4H,1H3
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n/an/a>5.00E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270533
PNG
(3-Bromo-1-methyl-7-nitro-1H-indazole | CHEMBL50488...)
Show SMILES Cn1nc(Br)c2cccc([N+]([O-])=O)c12
Show InChI InChI=1S/C8H6BrN3O2/c1-11-7-5(8(9)10-11)3-2-4-6(7)12(13)14/h2-4H,1H3
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270529
PNG
(3-Bromo-7-iodo-1H-indazole | CHEMBL456579)
Show SMILES Brc1n[nH]c2c(I)cccc12
Show InChI InChI=1S/C7H4BrIN2/c8-7-4-2-1-3-5(9)6(4)10-11-7/h1-3H,(H,10,11)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50271279
PNG
(1H-Indazole-7-carboxamide | CHEMBL451401)
Show SMILES NC(=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C8H7N3O/c9-8(12)6-3-1-2-5-4-10-11-7(5)6/h1-4H,(H2,9,12)(H,10,11)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270533
PNG
(3-Bromo-1-methyl-7-nitro-1H-indazole | CHEMBL50488...)
Show SMILES Cn1nc(Br)c2cccc([N+]([O-])=O)c12
Show InChI InChI=1S/C8H6BrN3O2/c1-11-7-5(8(9)10-11)3-2-4-6(7)12(13)14/h2-4H,1H3
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50099397
PNG
(1H-indazol-7-ol | CHEMBL278175)
Show SMILES Oc1cccc2cn[nH]c12
Show InChI InChI=1S/C7H6N2O/c10-6-3-1-2-5-4-8-9-7(5)6/h1-4,10H,(H,8,9)
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n/an/a 6.50E+5n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270531
PNG
(3-Bromo-1H-indazole-7-carboxylic acid | CHEMBL5106...)
Show SMILES OC(=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C8H5BrN2O2/c9-7-4-2-1-3-5(8(12)13)6(4)10-11-7/h1-3H,(H,10,11)(H,12,13)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50099397
PNG
(1H-indazol-7-ol | CHEMBL278175)
Show SMILES Oc1cccc2cn[nH]c12
Show InChI InChI=1S/C7H6N2O/c10-6-3-1-2-5-4-8-9-7(5)6/h1-4,10H,(H,8,9)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50099397
PNG
(1H-indazol-7-ol | CHEMBL278175)
Show SMILES Oc1cccc2cn[nH]c12
Show InChI InChI=1S/C7H6N2O/c10-6-3-1-2-5-4-8-9-7(5)6/h1-4,10H,(H,8,9)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50240903
PNG
(1-methyl-7-nitro-1H-indazole | CHEMBL354723)
Show SMILES Cn1ncc2cccc([N+]([O-])=O)c12
Show InChI InChI=1S/C8H7N3O2/c1-10-8-6(5-9-10)3-2-4-7(8)11(12)13/h2-5H,1H3
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50240903
PNG
(1-methyl-7-nitro-1H-indazole | CHEMBL354723)
Show SMILES Cn1ncc2cccc([N+]([O-])=O)c12
Show InChI InChI=1S/C8H7N3O2/c1-10-8-6(5-9-10)3-2-4-7(8)11(12)13/h2-5H,1H3
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270529
PNG
(3-Bromo-7-iodo-1H-indazole | CHEMBL456579)
Show SMILES Brc1n[nH]c2c(I)cccc12
Show InChI InChI=1S/C7H4BrIN2/c8-7-4-2-1-3-5(9)6(4)10-11-7/h1-3H,(H,10,11)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50271279
PNG
(1H-Indazole-7-carboxamide | CHEMBL451401)
Show SMILES NC(=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C8H7N3O/c9-8(12)6-3-1-2-5-4-10-11-7(5)6/h1-4H,(H2,9,12)(H,10,11)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271275
PNG
(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Show SMILES Nc1cccc2cn[nH]c12
Show InChI InChI=1S/C7H7N3/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,8H2,(H,9,10)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270529
PNG
(3-Bromo-7-iodo-1H-indazole | CHEMBL456579)
Show SMILES Brc1n[nH]c2c(I)cccc12
Show InChI InChI=1S/C7H4BrIN2/c8-7-4-2-1-3-5(9)6(4)10-11-7/h1-3H,(H,10,11)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50271278
PNG
(1H-Indazole-7-carboxylic acid | CHEMBL473471)
Show SMILES OC(=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C8H6N2O2/c11-8(12)6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)(H,11,12)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270531
PNG
(3-Bromo-1H-indazole-7-carboxylic acid | CHEMBL5106...)
Show SMILES OC(=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C8H5BrN2O2/c9-7-4-2-1-3-5(8(12)13)6(4)10-11-7/h1-3H,(H,10,11)(H,12,13)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270526
PNG
(7-Ethynyl-1H-indazole | CHEMBL452956)
Show SMILES C#Cc1cccc2cn[nH]c12
Show InChI InChI=1S/C9H6N2/c1-2-7-4-3-5-8-6-10-11-9(7)8/h1,3-6H,(H,10,11)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50271278
PNG
(1H-Indazole-7-carboxylic acid | CHEMBL473471)
Show SMILES OC(=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C8H6N2O2/c11-8(12)6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)(H,11,12)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270531
PNG
(3-Bromo-1H-indazole-7-carboxylic acid | CHEMBL5106...)
Show SMILES OC(=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C8H5BrN2O2/c9-7-4-2-1-3-5(8(12)13)6(4)10-11-7/h1-3H,(H,10,11)(H,12,13)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50271274
PNG
(1H-Indazol-7-yl trifluoromethanesulfonate | CHEMBL...)
Show SMILES FC(F)(F)S(=O)(=O)Oc1cccc2cn[nH]c12
Show InChI InChI=1S/C8H5F3N2O3S/c9-8(10,11)17(14,15)16-6-3-1-2-5-4-12-13-7(5)6/h1-4H,(H,12,13)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50271280
PNG
(7-(1H-Tetrazol-5-yl)-1H-indazole | CHEMBL499583)
Show SMILES c1[nH]nc2c(cccc12)-c1nnn[nH]1
Show InChI InChI=1S/C8H6N6/c1-2-5-4-9-10-7(5)6(3-1)8-11-13-14-12-8/h1-4H,(H,9,10)(H,11,12,13,14)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270527
PNG
(7-(1H-[1,2,3]Triazol-5-yl)-1H-indazole | CHEMBL516...)
Show SMILES c1[nH]nnc1-c1cccc2c[nH]nc12
Show InChI InChI=1S/C9H7N5/c1-2-6-4-10-13-9(6)7(3-1)8-5-11-14-12-8/h1-5H,(H,10,13)(H,11,12,14)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271278
PNG
(1H-Indazole-7-carboxylic acid | CHEMBL473471)
Show SMILES OC(=O)c1cccc2cn[nH]c12
Show InChI InChI=1S/C8H6N2O2/c11-8(12)6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)(H,11,12)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270532
PNG
(3-Bromo-1H-indazole-7-carboxamide | CHEMBL516741)
Show SMILES NC(=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C8H6BrN3O/c9-7-4-2-1-3-5(8(10)13)6(4)11-12-7/h1-3H,(H2,10,13)(H,11,12)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50270527
PNG
(7-(1H-[1,2,3]Triazol-5-yl)-1H-indazole | CHEMBL516...)
Show SMILES c1[nH]nnc1-c1cccc2c[nH]nc12
Show InChI InChI=1S/C9H7N5/c1-2-6-4-10-13-9(6)7(3-1)8-5-11-14-12-8/h1-5H,(H,10,13)(H,11,12,14)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270532
PNG
(3-Bromo-1H-indazole-7-carboxamide | CHEMBL516741)
Show SMILES NC(=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C8H6BrN3O/c9-7-4-2-1-3-5(8(10)13)6(4)11-12-7/h1-3H,(H2,10,13)(H,11,12)
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n/an/a 1.00E+6n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270526
PNG
(7-Ethynyl-1H-indazole | CHEMBL452956)
Show SMILES C#Cc1cccc2cn[nH]c12
Show InChI InChI=1S/C9H6N2/c1-2-7-4-3-5-8-6-10-11-9(7)8/h1,3-6H,(H,10,11)
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n/an/a 1.00E+6n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50271280
PNG
(7-(1H-Tetrazol-5-yl)-1H-indazole | CHEMBL499583)
Show SMILES c1[nH]nc2c(cccc12)-c1nnn[nH]1
Show InChI InChI=1S/C8H6N6/c1-2-5-4-9-10-7(5)6(3-1)8-11-13-14-12-8/h1-4H,(H,9,10)(H,11,12,13,14)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271280
PNG
(7-(1H-Tetrazol-5-yl)-1H-indazole | CHEMBL499583)
Show SMILES c1[nH]nc2c(cccc12)-c1nnn[nH]1
Show InChI InChI=1S/C8H6N6/c1-2-5-4-9-10-7(5)6(3-1)8-11-13-14-12-8/h1-4H,(H,9,10)(H,11,12,13,14)
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Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50270532
PNG
(3-Bromo-1H-indazole-7-carboxamide | CHEMBL516741)
Show SMILES NC(=O)c1cccc2c(Br)n[nH]c12
Show InChI InChI=1S/C8H6BrN3O/c9-7-4-2-1-3-5(8(10)13)6(4)11-12-7/h1-3H,(H2,10,13)(H,11,12)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Bos taurus (bovine))		BDBM50271274
PNG
(1H-Indazol-7-yl trifluoromethanesulfonate | CHEMBL...)
Show SMILES FC(F)(F)S(=O)(=O)Oc1cccc2cn[nH]c12
Show InChI InChI=1S/C8H5F3N2O3S/c9-8(10,11)17(14,15)16-6-3-1-2-5-4-12-13-7(5)6/h1-4H,(H,12,13)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of bovine recombinant eNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Mus musculus (mouse))		BDBM50270527
PNG
(7-(1H-[1,2,3]Triazol-5-yl)-1H-indazole | CHEMBL516...)
Show SMILES c1[nH]nnc1-c1cccc2c[nH]nc12
Show InChI InChI=1S/C9H7N5/c1-2-6-4-10-13-9(6)7(3-1)8-5-11-14-12-8/h1-5H,(H,10,13)(H,11,12,14)
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n/an/a 1.00E+6n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant iNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Rattus norvegicus (rat))		BDBM50271274
PNG
(1H-Indazol-7-yl trifluoromethanesulfonate | CHEMBL...)
Show SMILES FC(F)(F)S(=O)(=O)Oc1cccc2cn[nH]c12
Show InChI InChI=1S/C8H5F3N2O3S/c9-8(10,11)17(14,15)16-6-3-1-2-5-4-12-13-7(5)6/h1-4H,(H,12,13)
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n/an/a 5.00E+8n/an/an/an/an/an/a



Université de Versailles

Curated by ChEMBL


Assay Description
Inhibition of rat brain recombinant nNOS

Bioorg Med Chem 16: 5962-73 (2008)


Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%