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PubMed code 18514530

Compile data set for download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271101
PNG
(CHEMBL488132 | [(2R,3S,4R,5R)-5-(5-amino-2,4-dioxo...)
Show SMILES Nc1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H15N3O12P2/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(23-8)2-22-26(20,21)24-25(17,18)19/h1,4-6,8,13-14H,2,10H2,(H,20,21)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 610n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270544
PNG
(CHEMBL500840 | Uridine-5'-fructose-6'-tetraphospha...)
Show SMILES CC[C@]1(O)O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C16H28N2O22P4/c1-2-16(25)13(23)11(21)8(37-16)6-35-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-5-7-10(20)12(22)14(36-7)18-4-3-9(19)17-15(18)24/h3-4,7-8,10-14,20-23,25H,2,5-6H2,1H3,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,17,19,24)/t7-,8+,10-,11+,12-,13-,14-,16+/m1/s1
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n/an/an/an/a 3.33E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50205405
PNG
(({[({[(2R,3S,4R,5R)-4-amino-5-(2,4-dioxo-1,2,3,4-t...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N3O14P3/c10-6-7(14)4(24-8(6)12-2-1-5(13)11-9(12)15)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,14H,3,10H2,(H,19,20)(H,21,22)(H,11,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 62n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270553
PNG
(CHEMBL507282 | INS-37217 | INS37217)
Show SMILES Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3ccc(=O)[nH]c3=O)O2)c(=O)n1 |r|
Show InChI InChI=1S/C18H27N5O21P4/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(40-13)6-38-45(30,31)42-47(34,35)44-48(36,37)43-46(32,33)39-7-10-14(26)15(27)16(41-10)23-4-2-12(25)21-18(23)29/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)(H2,19,20,28)(H,21,25,29)/t8-,9+,10+,13+,14+,15+,16+/m0/s1
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n/an/an/an/a 140n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270546
PNG
(CHEMBL444212 | Uridine-5'-galactose-1'-tetraphosph...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-3-5-8(20)10(22)12(24)14(36-5)37-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-4-6-9(21)11(23)13(35-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 1.77E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50205405
PNG
(({[({[(2R,3S,4R,5R)-4-amino-5-(2,4-dioxo-1,2,3,4-t...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N3O14P3/c10-6-7(14)4(24-8(6)12-2-1-5(13)11-9(12)15)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,14H,3,10H2,(H,19,20)(H,21,22)(H,11,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270554
PNG
(CHEMBL509434 | P1-(2-thiouridine 5'-)-P4-(2'-deoxy...)
Show SMILES Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3ccc(=O)[nH]c3=S)O2)c(=O)n1 |r|
Show InChI InChI=1S/C18H27N5O20P4S/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(39-13)6-37-44(29,30)41-46(33,34)43-47(35,36)42-45(31,32)38-7-10-14(26)15(27)16(40-10)23-4-2-12(25)21-18(23)48/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,19,20,28)(H,21,25,48)/t8-,9+,10+,13+,14+,15+,16+/m0/s1
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n/an/an/an/a 1.05E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270548
PNG
(CHEMBL454230 | Uridine-5'-(2'-deoxy-glucose)-6'-te...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)C[C@@H](O)[C@@H]2O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O22P4/c18-6-3-10(20)35-7(11(6)21)4-33-40(25,26)37-42(29,30)39-43(31,32)38-41(27,28)34-5-8-12(22)13(23)14(36-8)17-2-1-9(19)16-15(17)24/h1-2,6-8,10-14,18,20-23H,3-5H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)(H,16,19,24)/t6-,7-,8-,10?,11+,12-,13-,14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270542
PNG
(CHEMBL474887 | Uridine-5'-cyclohexane-tetraphospha...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC2CCCCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O18P4/c18-11-6-7-17(15(21)16-11)14-13(20)12(19)10(31-14)8-30-36(22,23)33-38(26,27)35-39(28,29)34-37(24,25)32-9-4-2-1-3-5-9/h6-7,9-10,12-14,19-20H,1-5,8H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)(H,16,18,21)/t10-,12-,13-,14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270545
PNG
(CHEMBL499138 | Uridine-5'-glucose-1'-tetraphosphat...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-3-5-8(20)10(22)12(24)14(36-5)37-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-4-6-9(21)11(23)13(35-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 7.83E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271290
PNG
(CHEMBL483913 | Uridine-5'-methyl(C-P)-tetraphospha...)
Show SMILES CP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H18N2O17P4/c1-30(17,18)27-32(21,22)29-33(23,24)28-31(19,20)25-4-5-7(14)8(15)9(26-5)12-3-2-6(13)11-10(12)16/h2-3,5,7-9,14-15H,4H2,1H3,(H,17,18)(H,19,20)(H,21,22)(H,23,24)(H,11,13,16)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 8.16E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271251
PNG
(CHEMBL483502 | {[({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N2O18P4/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(26-8)3-25-31(19,20)28-33(23,24)29-32(21,22)27-30(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,23,24)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 7.56E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271187
PNG
(CHEMBL519835 | [dichloro({[({[(2R,3S,4R,5R)-3,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C10H15Cl2N2O13P3S/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(16)7(17)8(26-4)14-2-1-5(15)13-9(14)31/h1-2,4,6-8,16-17H,3H2,(H,21,22)(H,23,24)(H,13,15,31)(H2,18,19,20)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271138
PNG
(CHEMBL527872 | [(2R,3S,4R,5R)-4-[(aminocarbonyl)am...)
Show SMILES NC(=O)N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H16N4O12P2/c11-9(17)13-6-7(16)4(3-24-28(22,23)26-27(19,20)21)25-8(6)14-2-1-5(15)12-10(14)18/h1-2,4,6-8,16H,3H2,(H,22,23)(H3,11,13,17)(H,12,15,18)(H2,19,20,21)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 4.70E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270554
PNG
(CHEMBL509434 | P1-(2-thiouridine 5'-)-P4-(2'-deoxy...)
Show SMILES Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3ccc(=O)[nH]c3=S)O2)c(=O)n1 |r|
Show InChI InChI=1S/C18H27N5O20P4S/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(39-13)6-37-44(29,30)41-46(33,34)43-47(35,36)42-45(31,32)38-7-10-14(26)15(27)16(40-10)23-4-2-12(25)21-18(23)48/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,19,20,28)(H,21,25,48)/t8-,9+,10+,13+,14+,15+,16+/m0/s1
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n/an/an/an/a 80n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270547
PNG
(CHEMBL508122 | Uridine-5'-mannose-6'-tetraphosphat...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)[C@@H](O)[C@@H](O)[C@@H]2O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-7-1-2-17(15(25)16-7)13-11(22)9(20)5(36-13)3-34-41(26,27)38-43(30,31)40-44(32,33)39-42(28,29)35-4-6-8(19)10(21)12(23)14(24)37-6/h1-2,5-6,8-14,19-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,18,25)/t5-,6-,8-,9-,10+,11-,12+,13-,14?/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270546
PNG
(CHEMBL444212 | Uridine-5'-galactose-1'-tetraphosph...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-3-5-8(20)10(22)12(24)14(36-5)37-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-4-6-9(21)11(23)13(35-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 4.85E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271289
PNG
(CHEMBL519991 | Uridine-5'-methyl-tetraphosphate)
Show SMILES COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H18N2O18P4/c1-25-31(17,18)28-33(21,22)30-34(23,24)29-32(19,20)26-4-5-7(14)8(15)9(27-5)12-3-2-6(13)11-10(12)16/h2-3,5,7-9,14-15H,4H2,1H3,(H,17,18)(H,19,20)(H,21,22)(H,23,24)(H,11,13,16)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 3.95E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271222
PNG
(({[({[(2R,3S,4R,5R)-4-(carbamoylamino)-5-(2,4-diox...)
Show SMILES NC(=O)N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H17N4O15P3/c11-9(17)13-6-7(16)4(27-8(6)14-2-1-5(15)12-10(14)18)3-26-31(22,23)29-32(24,25)28-30(19,20)21/h1-2,4,6-8,16H,3H2,(H,22,23)(H,24,25)(H3,11,13,17)(H,12,15,18)(H2,19,20,21)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 1.74E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50205406
PNG
(((2R,3S,4R,5R)-4-amino-3-hydroxy-5-(4-oxo-2-thioxo...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H16N3O13P3S/c10-6-7(14)4(23-8(6)12-2-1-5(13)11-9(12)29)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,14H,3,10H2,(H,18,19)(H,20,21)(H,11,13,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 8n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50205413
PNG
(CHEMBL221326 | P(1),P(4)-bis(uridin-5'-yl) tetraph...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C18H26N4O23P4/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 130n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270545
PNG
(CHEMBL499138 | Uridine-5'-glucose-1'-tetraphosphat...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-3-5-8(20)10(22)12(24)14(36-5)37-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-4-6-9(21)11(23)13(35-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 2.06E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270544
PNG
(CHEMBL500840 | Uridine-5'-fructose-6'-tetraphospha...)
Show SMILES CC[C@]1(O)O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C16H28N2O22P4/c1-2-16(25)13(23)11(21)8(37-16)6-35-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-5-7-10(20)12(22)14(36-7)18-4-3-9(19)17-15(18)24/h3-4,7-8,10-14,20-23,25H,2,5-6H2,1H3,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,17,19,24)/t7-,8+,10-,11+,12-,13-,14-,16+/m1/s1
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n/an/an/an/a 6.30E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270555
PNG
(CHEMBL505403 | {[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-d...)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O1 |r|
Show InChI InChI=1S/C19H27N7O21P4/c20-18-23-15-12(16(31)24-18)21-6-26(15)11-3-7(27)8(43-11)4-41-48(33,34)45-50(37,38)47-51(39,40)46-49(35,36)42-5-9-13(29)14(30)17(44-9)25-2-1-10(28)22-19(25)32/h1-2,6-9,11,13-14,17,27,29-30H,3-5H2,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,22,28,32)(H3,20,23,24,31)/t7-,8+,9+,11+,13+,14+,17+/m0/s1
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n/an/an/an/a 1.03E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270553
PNG
(CHEMBL507282 | INS-37217 | INS37217)
Show SMILES Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3ccc(=O)[nH]c3=O)O2)c(=O)n1 |r|
Show InChI InChI=1S/C18H27N5O21P4/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(40-13)6-38-45(30,31)42-47(34,35)44-48(36,37)43-46(32,33)39-7-10-14(26)15(27)16(41-10)23-4-2-12(25)21-18(23)29/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)(H2,19,20,28)(H,21,25,29)/t8-,9+,10+,13+,14+,15+,16+/m0/s1
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n/an/an/an/a 950n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270550
PNG
(CHEMBL503798 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=S)[nH]c1=O)n1ccc(=S)[nH]c1=O |r|
Show InChI InChI=1S/C18H26N4O21P4S2/c23-11-7(39-15(13(11)25)21-3-1-9(48)19-17(21)27)5-37-44(29,30)41-46(33,34)43-47(35,36)42-45(31,32)38-6-8-12(24)14(26)16(40-8)22-4-2-10(49)20-18(22)28/h1-4,7-8,11-16,23-26H,5-6H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H,19,27,48)(H,20,28,49)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 2.03E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271254
PNG
(2-Thio-uridine-5'-pentaphosphate | CHEMBL482683)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H17N2O20P5S/c12-5-1-2-11(9(37)10-5)8-7(14)6(13)4(27-8)3-26-33(18,19)29-35(22,23)31-36(24,25)30-34(20,21)28-32(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,10,12,37)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 5.27E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271188
PNG
(2-Thio-4-methylthio-uridine-5'-triphosphate | CHEM...)
Show SMILES CSc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=S)n1 |r|
Show InChI InChI=1S/C10H17N2O13P3S2/c1-30-6-2-3-12(10(29)11-6)9-8(14)7(13)5(23-9)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h2-3,5,7-9,13-14H,4H2,1H3,(H,18,19)(H,20,21)(H2,15,16,17)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 5.35E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271187
PNG
(CHEMBL519835 | [dichloro({[({[(2R,3S,4R,5R)-3,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C10H15Cl2N2O13P3S/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(16)7(17)8(26-4)14-2-1-5(15)13-9(14)31/h1-2,4,6-8,16-17H,3H2,(H,21,22)(H,23,24)(H,13,15,31)(H2,18,19,20)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 90n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270544
PNG
(CHEMBL500840 | Uridine-5'-fructose-6'-tetraphospha...)
Show SMILES CC[C@]1(O)O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C16H28N2O22P4/c1-2-16(25)13(23)11(21)8(37-16)6-35-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-5-7-10(20)12(22)14(36-7)18-4-3-9(19)17-15(18)24/h3-4,7-8,10-14,20-23,25H,2,5-6H2,1H3,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,17,19,24)/t7-,8+,10-,11+,12-,13-,14-,16+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271292
PNG
(CHEMBL482895 | Uridine-5'-alpha-glycerol-tetraphos...)
Show SMILES OCC(O)COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C12H22N2O20P4/c15-3-6(16)4-29-35(21,22)32-37(25,26)34-38(27,28)33-36(23,24)30-5-7-9(18)10(19)11(31-7)14-2-1-8(17)13-12(14)20/h1-2,6-7,9-11,15-16,18-19H,3-5H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)(H,13,17,20)/t6?,7-,9-,10-,11-/m1/s1
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n/an/an/an/a 8.19E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271253
PNG
(4-Thio-uridine-5'-tetraphosphate | CHEMBL521451)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=S)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N2O17P4S/c12-6-4(25-8(7(6)13)11-2-1-5(33)10-9(11)14)3-24-30(18,19)27-32(22,23)28-31(20,21)26-29(15,16)17/h1-2,4,6-8,12-13H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,10,14,33)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 6.46E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271222
PNG
(({[({[(2R,3S,4R,5R)-4-(carbamoylamino)-5-(2,4-diox...)
Show SMILES NC(=O)N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H17N4O15P3/c11-9(17)13-6-7(16)4(27-8(6)14-2-1-5(15)12-10(14)18)3-26-31(22,23)29-32(24,25)28-30(19,20)21/h1-2,4,6-8,16H,3H2,(H,22,23)(H,24,25)(H3,11,13,17)(H,12,15,18)(H2,19,20,21)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50118239
PNG
(CHEMBL130266 | UDP | Uridine diphosphate | uridine...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270552
PNG
(CHEMBL476021 | P1,P4-di(uridine 5'-)beta,gamma-dic...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C19H26Cl2N4O22P4/c20-19(21,48(34,35)46-50(38,39)42-5-7-11(28)13(30)15(44-7)24-3-1-9(26)22-17(24)32)49(36,37)47-51(40,41)43-6-8-12(29)14(31)16(45-8)25-4-2-10(27)23-18(25)33/h1-4,7-8,11-16,28-31H,5-6H2,(H,34,35)(H,36,37)(H,38,39)(H,40,41)(H,22,26,32)(H,23,27,33)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 7.77E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270550
PNG
(CHEMBL503798 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=S)[nH]c1=O)n1ccc(=S)[nH]c1=O |r|
Show InChI InChI=1S/C18H26N4O21P4S2/c23-11-7(39-15(13(11)25)21-3-1-9(48)19-17(21)27)5-37-44(29,30)41-46(33,34)43-47(35,36)42-45(31,32)38-6-8-12(24)14(26)16(40-8)22-4-2-10(49)20-18(22)28/h1-4,7-8,11-16,23-26H,5-6H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H,19,27,48)(H,20,28,49)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50205413
PNG
(CHEMBL221326 | P(1),P(4)-bis(uridin-5'-yl) tetraph...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C18H26N4O23P4/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 210n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270549
PNG
(CHEMBL503256 | P1-((2-benzyl-1,3-dioxolo-4-yl)urid...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@@H]2OC(Cc3ccccc3)O[C@H]12)n1ccc(=O)[nH]c1=O)n1cc(I)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C26H30IN4O20P3/c27-13-9-31(26(37)29-22(13)35)23-19(34)18(33)14(46-23)10-44-52(38,39)50-54(42,43)51-53(40,41)45-11-15-20-21(24(47-15)30-7-6-16(32)28-25(30)36)49-17(48-20)8-12-4-2-1-3-5-12/h1-7,9,14-15,17-21,23-24,33-34H,8,10-11H2,(H,38,39)(H,40,41)(H,42,43)(H,28,32,36)(H,29,35,37)/t14-,15-,17?,18-,19-,20-,21-,23-,24-/m1/s1
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n/an/an/an/a 9.97E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270545
PNG
(CHEMBL499138 | Uridine-5'-glucose-1'-tetraphosphat...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-3-5-8(20)10(22)12(24)14(36-5)37-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-4-6-9(21)11(23)13(35-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270541
PNG
(CHEMBL474886 | Uridine-5'-phenyl-tetraphosphate)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)Oc2ccccc2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H20N2O18P4/c18-11-6-7-17(15(21)16-11)14-13(20)12(19)10(31-14)8-30-36(22,23)33-38(26,27)35-39(28,29)34-37(24,25)32-9-4-2-1-3-5-9/h1-7,10,12-14,19-20H,8H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)(H,16,18,21)/t10-,12-,13-,14-/m1/s1
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n/an/an/an/a 1.89E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271292
PNG
(CHEMBL482895 | Uridine-5'-alpha-glycerol-tetraphos...)
Show SMILES OCC(O)COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C12H22N2O20P4/c15-3-6(16)4-29-35(21,22)32-37(25,26)34-38(27,28)33-36(23,24)30-5-7-9(18)10(19)11(31-7)14-2-1-8(17)13-12(14)20/h1-2,6-7,9-11,15-16,18-19H,3-5H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)(H,13,17,20)/t6?,7-,9-,10-,11-/m1/s1
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n/an/an/an/a 1.87E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271188
PNG
(2-Thio-4-methylthio-uridine-5'-triphosphate | CHEM...)
Show SMILES CSc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=S)n1 |r|
Show InChI InChI=1S/C10H17N2O13P3S2/c1-30-6-2-3-12(10(29)11-6)9-8(14)7(13)5(23-9)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h2-3,5,7-9,13-14H,4H2,1H3,(H,18,19)(H,20,21)(H2,15,16,17)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 910n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270555
PNG
(CHEMBL505403 | {[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-d...)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O1 |r|
Show InChI InChI=1S/C19H27N7O21P4/c20-18-23-15-12(16(31)24-18)21-6-26(15)11-3-7(27)8(43-11)4-41-48(33,34)45-50(37,38)47-51(39,40)46-49(35,36)42-5-9-13(29)14(30)17(44-9)25-2-1-10(28)22-19(25)32/h1-2,6-9,11,13-14,17,27,29-30H,3-5H2,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,22,28,32)(H3,20,23,24,31)/t7-,8+,9+,11+,13+,14+,17+/m0/s1
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n/an/an/an/a 540n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270543
PNG
(CHEMBL448985 | [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,...)
Show SMILES OC1O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H24N2O22P4/c17-7-1-2-16(14(23)15-7)12-10(20)8(18)5(34-12)3-32-39(24,25)36-41(28,29)38-42(30,31)37-40(26,27)33-4-6-9(19)11(21)13(22)35-6/h1-2,5-6,8-13,18-22H,3-4H2,(H,24,25)(H,26,27)(H,28,29)(H,30,31)(H,15,17,23)/t5-,6+,8-,9+,10-,11+,12-,13?/m1/s1
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n/an/an/an/a 4.78E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271292
PNG
(CHEMBL482895 | Uridine-5'-alpha-glycerol-tetraphos...)
Show SMILES OCC(O)COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C12H22N2O20P4/c15-3-6(16)4-29-35(21,22)32-37(25,26)34-38(27,28)33-36(23,24)30-5-7-9(18)10(19)11(31-7)14-2-1-8(17)13-12(14)20/h1-2,6-7,9-11,15-16,18-19H,3-5H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)(H,13,17,20)/t6?,7-,9-,10-,11-/m1/s1
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n/an/an/an/a 1.12E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271290
PNG
(CHEMBL483913 | Uridine-5'-methyl(C-P)-tetraphospha...)
Show SMILES CP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H18N2O17P4/c1-30(17,18)27-32(21,22)29-33(23,24)28-31(19,20)25-4-5-7(14)8(15)9(26-5)12-3-2-6(13)11-10(12)16/h2-3,5,7-9,14-15H,4H2,1H3,(H,17,18)(H,19,20)(H,21,22)(H,23,24)(H,11,13,16)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 2.53E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271186
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfa...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(F)(F)P(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C10H15F2N2O13P3S/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(16)7(17)8(26-4)14-2-1-5(15)13-9(14)31/h1-2,4,6-8,16-17H,3H2,(H,21,22)(H,23,24)(H,13,15,31)(H2,18,19,20)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 8.11E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270542
PNG
(CHEMBL474887 | Uridine-5'-cyclohexane-tetraphospha...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC2CCCCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O18P4/c18-11-6-7-17(15(21)16-11)14-13(20)12(19)10(31-14)8-30-36(22,23)33-38(26,27)35-39(28,29)34-37(24,25)32-9-4-2-1-3-5-9/h6-7,9-10,12-14,19-20H,1-5,8H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)(H,16,18,21)/t10-,12-,13-,14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271252
PNG
(2-Thio-uridine-5'-tetraphosphate | CHEMBL482485)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H16N2O17P4S/c12-5-1-2-11(9(33)10-5)8-7(14)6(13)4(25-8)3-24-30(18,19)27-32(22,23)28-31(20,21)26-29(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,10,12,33)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 6.83E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 1.50E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 90n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271254
PNG
(2-Thio-uridine-5'-pentaphosphate | CHEMBL482683)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H17N2O20P5S/c12-5-1-2-11(9(37)10-5)8-7(14)6(13)4(27-8)3-26-33(18,19)29-35(22,23)31-36(24,25)30-34(20,21)28-32(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,10,12,37)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 570n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271252
PNG
(2-Thio-uridine-5'-tetraphosphate | CHEMBL482485)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H16N2O17P4S/c12-5-1-2-11(9(33)10-5)8-7(14)6(13)4(25-8)3-24-30(18,19)27-32(22,23)28-31(20,21)26-29(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,10,12,33)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 600n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271251
PNG
(CHEMBL483502 | {[({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N2O18P4/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(26-8)3-25-31(19,20)28-33(23,24)29-32(21,22)27-30(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,23,24)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 2.61E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271224
PNG
(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)
Show SMILES C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H17N2O15P3/c1-10(16)7(14)5(25-8(10)12-3-2-6(13)11-9(12)15)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,14,16H,4H2,1H3,(H,20,21)(H,22,23)(H,11,13,15)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1
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n/an/an/an/a 1.45E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271223
PNG
(({[({[(2R,3S,4S,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfa...)
Show SMILES O[C@H]1[C@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7+,8-/m1/s1
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n/an/an/an/a 140n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50205406
PNG
(((2R,3S,4R,5R)-4-amino-3-hydroxy-5-(4-oxo-2-thioxo...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H16N3O13P3S/c10-6-7(14)4(23-8(6)12-2-1-5(13)11-9(12)29)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,14H,3,10H2,(H,18,19)(H,20,21)(H,11,13,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270551
PNG
(CHEMBL502712 | P1,P4-di(uridine 5'-)beta,gamma-dif...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(F)(F)P(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C19H26F2N4O22P4/c20-19(21,48(34,35)46-50(38,39)42-5-7-11(28)13(30)15(44-7)24-3-1-9(26)22-17(24)32)49(36,37)47-51(40,41)43-6-8-12(29)14(31)16(45-8)25-4-2-10(27)23-18(25)33/h1-4,7-8,11-16,28-31H,5-6H2,(H,34,35)(H,36,37)(H,38,39)(H,40,41)(H,22,26,32)(H,23,27,33)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270547
PNG
(CHEMBL508122 | Uridine-5'-mannose-6'-tetraphosphat...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)[C@@H](O)[C@@H](O)[C@@H]2O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-7-1-2-17(15(25)16-7)13-11(22)9(20)5(36-13)3-34-41(26,27)38-43(30,31)40-44(32,33)39-42(28,29)35-4-6-8(19)10(21)12(23)14(24)37-6/h1-2,5-6,8-14,19-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,18,25)/t5-,6-,8-,9-,10+,11-,12+,13-,14?/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271253
PNG
(4-Thio-uridine-5'-tetraphosphate | CHEMBL521451)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=S)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N2O17P4S/c12-6-4(25-8(7(6)13)11-2-1-5(33)10-9(11)14)3-24-30(18,19)27-32(22,23)28-31(20,21)26-29(15,16)17/h1-2,4,6-8,12-13H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,10,14,33)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 280n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271223
PNG
(({[({[(2R,3S,4S,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfa...)
Show SMILES O[C@H]1[C@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7+,8-/m1/s1
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n/an/an/an/a 7.93E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50241299
PNG
(CHEMBL239151 | {[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C18H25N4O20P3/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(39-15)5-37-43(31,32)41-45(35,36)42-44(33,34)38-6-8-12(26)14(28)16(40-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 1.31E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271291
PNG
(CHEMBL484105 | Uridine-5'-(2-cyanoethyl)-tetraphos...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCCC#N)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C12H19N3O18P4/c13-3-1-5-28-34(20,21)31-36(24,25)33-37(26,27)32-35(22,23)29-6-7-9(17)10(18)11(30-7)15-4-2-8(16)14-12(15)19/h2,4,7,9-11,17-18H,1,5-6H2,(H,20,21)(H,22,23)(H,24,25)(H,26,27)(H,14,16,19)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271253
PNG
(4-Thio-uridine-5'-tetraphosphate | CHEMBL521451)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=S)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N2O17P4S/c12-6-4(25-8(7(6)13)11-2-1-5(33)10-9(11)14)3-24-30(18,19)27-32(22,23)28-31(20,21)26-29(15,16)17/h1-2,4,6-8,12-13H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,10,14,33)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 70n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270551
PNG
(CHEMBL502712 | P1,P4-di(uridine 5'-)beta,gamma-dif...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(F)(F)P(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C19H26F2N4O22P4/c20-19(21,48(34,35)46-50(38,39)42-5-7-11(28)13(30)15(44-7)24-3-1-9(26)22-17(24)32)49(36,37)47-51(40,41)43-6-8-12(29)14(31)16(45-8)25-4-2-10(27)23-18(25)33/h1-4,7-8,11-16,28-31H,5-6H2,(H,34,35)(H,36,37)(H,38,39)(H,40,41)(H,22,26,32)(H,23,27,33)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270548
PNG
(CHEMBL454230 | Uridine-5'-(2'-deoxy-glucose)-6'-te...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)C[C@@H](O)[C@@H]2O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O22P4/c18-6-3-10(20)35-7(11(6)21)4-33-40(25,26)37-42(29,30)39-43(31,32)38-41(27,28)34-5-8-12(22)13(23)14(36-8)17-2-1-9(19)16-15(17)24/h1-2,6-8,10-14,18,20-23H,3-5H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)(H,16,19,24)/t6-,7-,8-,10?,11+,12-,13-,14-/m1/s1
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n/an/an/an/a 4.32E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50205413
PNG
(CHEMBL221326 | P(1),P(4)-bis(uridin-5'-yl) tetraph...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C18H26N4O23P4/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 1.16E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270546
PNG
(CHEMBL444212 | Uridine-5'-galactose-1'-tetraphosph...)
Show SMILES OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-3-5-8(20)10(22)12(24)14(36-5)37-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-4-6-9(21)11(23)13(35-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1
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n/an/an/an/a 8.19E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271224
PNG
(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)
Show SMILES C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H17N2O15P3/c1-10(16)7(14)5(25-8(10)12-3-2-6(13)11-9(12)15)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,14,16H,4H2,1H3,(H,20,21)(H,22,23)(H,11,13,15)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1
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n/an/an/an/a 1.26E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271222
PNG
(({[({[(2R,3S,4R,5R)-4-(carbamoylamino)-5-(2,4-diox...)
Show SMILES NC(=O)N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H17N4O15P3/c11-9(17)13-6-7(16)4(27-8(6)14-2-1-5(15)12-10(14)18)3-26-31(22,23)29-32(24,25)28-30(19,20)21/h1-2,4,6-8,16H,3H2,(H,22,23)(H,24,25)(H3,11,13,17)(H,12,15,18)(H2,19,20,21)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 4.64E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271254
PNG
(2-Thio-uridine-5'-pentaphosphate | CHEMBL482683)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H17N2O20P5S/c12-5-1-2-11(9(37)10-5)8-7(14)6(13)4(27-8)3-26-33(18,19)29-35(22,23)31-36(24,25)30-34(20,21)28-32(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,10,12,37)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 7.33E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271102
PNG
(((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)CP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H16N2O11P2/c13-6-1-2-12(10(16)11-6)9-8(15)7(14)5(23-9)3-22-25(20,21)4-24(17,18)19/h1-2,5,7-9,14-15H,3-4H2,(H,20,21)(H,11,13,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 660n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270555
PNG
(CHEMBL505403 | {[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-d...)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O1 |r|
Show InChI InChI=1S/C19H27N7O21P4/c20-18-23-15-12(16(31)24-18)21-6-26(15)11-3-7(27)8(43-11)4-41-48(33,34)45-50(37,38)47-51(39,40)46-49(35,36)42-5-9-13(29)14(30)17(44-9)25-2-1-10(28)22-19(25)32/h1-2,6-9,11,13-14,17,27,29-30H,3-5H2,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,22,28,32)(H3,20,23,24,31)/t7-,8+,9+,11+,13+,14+,17+/m0/s1
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n/an/an/an/a 140n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270548
PNG
(CHEMBL454230 | Uridine-5'-(2'-deoxy-glucose)-6'-te...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)C[C@@H](O)[C@@H]2O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O22P4/c18-6-3-10(20)35-7(11(6)21)4-33-40(25,26)37-42(29,30)39-43(31,32)38-41(27,28)34-5-8-12(22)13(23)14(36-8)17-2-1-9(19)16-15(17)24/h1-2,6-8,10-14,18,20-23H,3-5H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)(H,16,19,24)/t6-,7-,8-,10?,11+,12-,13-,14-/m1/s1
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n/an/an/an/a 3.54E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270542
PNG
(CHEMBL474887 | Uridine-5'-cyclohexane-tetraphospha...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC2CCCCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O18P4/c18-11-6-7-17(15(21)16-11)14-13(20)12(19)10(31-14)8-30-36(22,23)33-38(26,27)35-39(28,29)34-37(24,25)32-9-4-2-1-3-5-9/h6-7,9-10,12-14,19-20H,1-5,8H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)(H,16,18,21)/t10-,12-,13-,14-/m1/s1
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n/an/an/an/a 5.86E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271290
PNG
(CHEMBL483913 | Uridine-5'-methyl(C-P)-tetraphospha...)
Show SMILES CP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H18N2O17P4/c1-30(17,18)27-32(21,22)29-33(23,24)28-31(19,20)25-4-5-7(14)8(15)9(26-5)12-3-2-6(13)11-10(12)16/h2-3,5,7-9,14-15H,4H2,1H3,(H,17,18)(H,19,20)(H,21,22)(H,23,24)(H,11,13,16)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 4.18E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271187
PNG
(CHEMBL519835 | [dichloro({[({[(2R,3S,4R,5R)-3,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C10H15Cl2N2O13P3S/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(16)7(17)8(26-4)14-2-1-5(15)13-9(14)31/h1-2,4,6-8,16-17H,3H2,(H,21,22)(H,23,24)(H,13,15,31)(H2,18,19,20)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 2.51E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50271186
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfa...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(F)(F)P(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C10H15F2N2O13P3S/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(16)7(17)8(26-4)14-2-1-5(15)13-9(14)31/h1-2,4,6-8,16-17H,3H2,(H,21,22)(H,23,24)(H,13,15,31)(H2,18,19,20)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 1.63E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270554
PNG
(CHEMBL509434 | P1-(2-thiouridine 5'-)-P4-(2'-deoxy...)
Show SMILES Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3ccc(=O)[nH]c3=S)O2)c(=O)n1 |r|
Show InChI InChI=1S/C18H27N5O20P4S/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(39-13)6-37-44(29,30)41-46(33,34)43-47(35,36)42-45(31,32)38-7-10-14(26)15(27)16(40-10)23-4-2-12(25)21-18(23)48/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,19,20,28)(H,21,25,48)/t8-,9+,10+,13+,14+,15+,16+/m0/s1
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n/an/an/an/a 710n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270550
PNG
(CHEMBL503798 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=S)[nH]c1=O)n1ccc(=S)[nH]c1=O |r|
Show InChI InChI=1S/C18H26N4O21P4S2/c23-11-7(39-15(13(11)25)21-3-1-9(48)19-17(21)27)5-37-44(29,30)41-46(33,34)43-47(35,36)42-45(31,32)38-6-8-12(24)14(26)16(40-8)22-4-2-10(49)20-18(22)28/h1-4,7-8,11-16,23-26H,5-6H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H,19,27,48)(H,20,28,49)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 80n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271188
PNG
(2-Thio-4-methylthio-uridine-5'-triphosphate | CHEM...)
Show SMILES CSc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=S)n1 |r|
Show InChI InChI=1S/C10H17N2O13P3S2/c1-30-6-2-3-12(10(29)11-6)9-8(14)7(13)5(23-9)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h2-3,5,7-9,13-14H,4H2,1H3,(H,18,19)(H,20,21)(H2,15,16,17)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271186
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfa...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(F)(F)P(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C10H15F2N2O13P3S/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(16)7(17)8(26-4)14-2-1-5(15)13-9(14)31/h1-2,4,6-8,16-17H,3H2,(H,21,22)(H,23,24)(H,13,15,31)(H2,18,19,20)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 5.15E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270551
PNG
(CHEMBL502712 | P1,P4-di(uridine 5'-)beta,gamma-dif...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(F)(F)P(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C19H26F2N4O22P4/c20-19(21,48(34,35)46-50(38,39)42-5-7-11(28)13(30)15(44-7)24-3-1-9(26)22-17(24)32)49(36,37)47-51(40,41)43-6-8-12(29)14(31)16(45-8)25-4-2-10(27)23-18(25)33/h1-4,7-8,11-16,28-31H,5-6H2,(H,34,35)(H,36,37)(H,38,39)(H,40,41)(H,22,26,32)(H,23,27,33)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 2.27E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270543
PNG
(CHEMBL448985 | [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,...)
Show SMILES OC1O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H24N2O22P4/c17-7-1-2-16(14(23)15-7)12-10(20)8(18)5(34-12)3-32-39(24,25)36-41(28,29)38-42(30,31)37-40(26,27)33-4-6-9(19)11(21)13(22)35-6/h1-2,5-6,8-13,18-22H,3-4H2,(H,24,25)(H,26,27)(H,28,29)(H,30,31)(H,15,17,23)/t5-,6+,8-,9+,10-,11+,12-,13?/m1/s1
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n/an/an/an/a 1.88E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50241299
PNG
(CHEMBL239151 | {[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C18H25N4O20P3/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(39-15)5-37-43(31,32)41-45(35,36)42-44(33,34)38-6-8-12(26)14(28)16(40-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 870n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50270547
PNG
(CHEMBL508122 | Uridine-5'-mannose-6'-tetraphosphat...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC(O)[C@@H](O)[C@@H](O)[C@@H]2O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C15H26N2O23P4/c18-7-1-2-17(15(25)16-7)13-11(22)9(20)5(36-13)3-34-41(26,27)38-43(30,31)40-44(32,33)39-42(28,29)35-4-6-8(19)10(21)12(23)14(24)37-6/h1-2,5-6,8-14,19-24H,3-4H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,16,18,25)/t5-,6-,8-,9-,10+,11-,12+,13-,14?/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50241299
PNG
(CHEMBL239151 | {[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C18H25N4O20P3/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(39-15)5-37-43(31,32)41-45(35,36)42-44(33,34)38-6-8-12(26)14(28)16(40-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,19,23,29)(H,20,24,30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 270n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271289
PNG
(CHEMBL519991 | Uridine-5'-methyl-tetraphosphate)
Show SMILES COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H18N2O18P4/c1-25-31(17,18)28-33(21,22)30-34(23,24)29-32(19,20)26-4-5-7(14)8(15)9(27-5)12-3-2-6(13)11-10(12)16/h2-3,5,7-9,14-15H,4H2,1H3,(H,17,18)(H,19,20)(H,21,22)(H,23,24)(H,11,13,16)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50270553
PNG
(CHEMBL507282 | INS-37217 | INS37217)
Show SMILES Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3ccc(=O)[nH]c3=O)O2)c(=O)n1 |r|
Show InChI InChI=1S/C18H27N5O21P4/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(40-13)6-38-45(30,31)42-47(34,35)44-48(36,37)43-46(32,33)39-7-10-14(26)15(27)16(41-10)23-4-2-12(25)21-18(23)29/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)(H2,19,20,28)(H,21,25,29)/t8-,9+,10+,13+,14+,15+,16+/m0/s1
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n/an/an/an/a 140n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 350n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270549
PNG
(CHEMBL503256 | P1-((2-benzyl-1,3-dioxolo-4-yl)urid...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@@H]2OC(Cc3ccccc3)O[C@H]12)n1ccc(=O)[nH]c1=O)n1cc(I)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C26H30IN4O20P3/c27-13-9-31(26(37)29-22(13)35)23-19(34)18(33)14(46-23)10-44-52(38,39)50-54(42,43)51-53(40,41)45-11-15-20-21(24(47-15)30-7-6-16(32)28-25(30)36)49-17(48-20)8-12-4-2-1-3-5-12/h1-7,9,14-15,17-21,23-24,33-34H,8,10-11H2,(H,38,39)(H,40,41)(H,42,43)(H,28,32,36)(H,29,35,37)/t14-,15-,17?,18-,19-,20-,21-,23-,24-/m1/s1
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n/an/an/an/a 5.49E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271291
PNG
(CHEMBL484105 | Uridine-5'-(2-cyanoethyl)-tetraphos...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCCC#N)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C12H19N3O18P4/c13-3-1-5-28-34(20,21)31-36(24,25)33-37(26,27)32-35(22,23)29-6-7-9(17)10(18)11(30-7)15-4-2-8(16)14-12(15)19/h2,4,7,9-11,17-18H,1,5-6H2,(H,20,21)(H,22,23)(H,24,25)(H,26,27)(H,14,16,19)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a 1.96E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271289
PNG
(CHEMBL519991 | Uridine-5'-methyl-tetraphosphate)
Show SMILES COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H18N2O18P4/c1-25-31(17,18)28-33(21,22)30-34(23,24)29-32(19,20)26-4-5-7(14)8(15)9(27-5)12-3-2-6(13)11-10(12)16/h2-3,5,7-9,14-15H,4H2,1H3,(H,17,18)(H,19,20)(H,21,22)(H,23,24)(H,11,13,16)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271252
PNG
(2-Thio-uridine-5'-tetraphosphate | CHEMBL482485)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H16N2O17P4S/c12-5-1-2-11(9(33)10-5)8-7(14)6(13)4(25-8)3-24-30(18,19)27-32(22,23)28-31(20,21)26-29(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,22,23)(H,10,12,33)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 5.52E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50271251
PNG
(CHEMBL483502 | {[({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H16N2O18P4/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(26-8)3-25-31(19,20)28-33(23,24)29-32(21,22)27-30(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,23,24)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 4.64E+3n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50270543
PNG
(CHEMBL448985 | [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,...)
Show SMILES OC1O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H24N2O22P4/c17-7-1-2-16(14(23)15-7)12-10(20)8(18)5(34-12)3-32-39(24,25)36-41(28,29)38-42(30,31)37-40(26,27)33-4-6-9(19)11(21)13(22)35-6/h1-2,5-6,8-13,18-22H,3-4H2,(H,24,25)(H,26,27)(H,28,29)(H,30,31)(H,15,17,23)/t5-,6+,8-,9+,10-,11+,12-,13?/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50271291
PNG
(CHEMBL484105 | Uridine-5'-(2-cyanoethyl)-tetraphos...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCCC#N)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C12H19N3O18P4/c13-3-1-5-28-34(20,21)31-36(24,25)33-37(26,27)32-35(22,23)29-6-7-9(17)10(18)11(30-7)15-4-2-8(16)14-12(15)19/h2,4,7,9-11,17-18H,1,5-6H2,(H,20,21)(H,22,23)(H,24,25)(H,26,27)(H,14,16,19)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 60n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...

Bioorg Med Chem 16: 6319-32 (2008)


Article DOI: 10.1016/j.bmc.2008.05.013
BindingDB Entry DOI: 10.7270/Q2K07569
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%