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PubMed code 18524592

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM20607
PNG
((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Show SMILES CC\C(=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
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n/an/an/an/a 5.65E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of P-glycoprotein-mediated [3H]vinblastine transport in human Caco2 cells

Bioorg Med Chem Lett 18: 3741-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.055
BindingDB Entry DOI: 10.7270/Q2MW2GXT
More data for this
Ligand-Target Pair
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM50338982
PNG
((R)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3...)
Show SMILES COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |r|
Show InChI InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3/t27-/m1/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of P-glycoprotein-mediated [3H]vinblastine transport in human Caco2 cells

Bioorg Med Chem Lett 18: 3741-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.055
BindingDB Entry DOI: 10.7270/Q2MW2GXT
More data for this
Ligand-Target Pair
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM50197200
PNG
(2-((2-(3-methoxyphenethyl)phenoxy)methyl)pyridine ...)
Show SMILES COc1cccc(CCc2ccccc2OCc2ccccn2)c1
Show InChI InChI=1S/C21H21NO2/c1-23-20-10-6-7-17(15-20)12-13-18-8-2-3-11-21(18)24-16-19-9-4-5-14-22-19/h2-11,14-15H,12-13,16H2,1H3
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n/an/an/an/a 2.76E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of P-glycoprotein-mediated [3H]vinblastine transport in human Caco2 cells

Bioorg Med Chem Lett 18: 3741-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.055
BindingDB Entry DOI: 10.7270/Q2MW2GXT
More data for this
Ligand-Target Pair
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM50022815
PNG
((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Show SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |r|
Show InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
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n/an/an/an/a 4.55E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of P-glycoprotein-mediated [3H]vinblastine transport in human Caco2 cells

Bioorg Med Chem Lett 18: 3741-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.055
BindingDB Entry DOI: 10.7270/Q2MW2GXT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%