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PubMed code 18554904

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50232355
PNG
((3aR,6aR)-2-(cyclopropylmethyl)-6-(4-(2-(pyrrolidi...)
Show SMILES C(Cc1ccc(cc1)C1=CC[C@H]2CN(CC3CC3)C[C@@H]12)N1CCCC1 |r,t:9|
Show InChI InChI=1S/C23H32N2/c1-2-13-24(12-1)14-11-18-5-7-20(8-6-18)22-10-9-21-16-25(17-23(21)22)15-19-3-4-19/h5-8,10,19,21,23H,1-4,9,11-17H2/t21-,23+/m0/s1
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 0.0700n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243638
PNG
(1-((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)...)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)Cc1ccccc1 |r,t:16|
Show InChI InChI=1S/C28H34N2O/c1-21-6-5-16-29(21)17-15-22-9-11-24(12-10-22)26-14-13-25-19-30(20-27(25)26)28(31)18-23-7-3-2-4-8-23/h2-4,7-12,14,21,25,27H,5-6,13,15-20H2,1H3/t21-,25+,27-/m1/s1
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PubMed
 0.300n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243123
PNG
(CHEMBL488464 | cyclopentyl((3aR,6aR)-6-(4-(2-((R)-...)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)C1CCCC1 |r,t:16|
Show InChI InChI=1S/C26H36N2O/c1-19-5-4-15-27(19)16-14-20-8-10-21(11-9-20)24-13-12-23-17-28(18-25(23)24)26(29)22-6-2-3-7-22/h8-11,13,19,22-23,25H,2-7,12,14-18H2,1H3/t19-,23+,25-/m1/s1
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 0.400n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243122
PNG
(2-methyl-1-((3aR,6aR)-6-(4-(2-((R)-2-methylpyrroli...)
Show SMILES CC(C)C(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCC[C@H]2C)cc1 |r,c:9|
Show InChI InChI=1S/C24H34N2O/c1-17(2)24(27)26-15-21-10-11-22(23(21)16-26)20-8-6-19(7-9-20)12-14-25-13-4-5-18(25)3/h6-9,11,17-18,21,23H,4-5,10,12-16H2,1-3H3/t18-,21+,23-/m1/s1
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 0.400n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243674
PNG
(((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)C1CCOCC1 |r,t:16|
Show InChI InChI=1S/C26H36N2O2/c1-19-3-2-13-27(19)14-10-20-4-6-21(7-5-20)24-9-8-23-17-28(18-25(23)24)26(29)22-11-15-30-16-12-22/h4-7,9,19,22-23,25H,2-3,8,10-18H2,1H3/t19-,23+,25-/m1/s1
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 0.700n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50232355
PNG
((3aR,6aR)-2-(cyclopropylmethyl)-6-(4-(2-(pyrrolidi...)
Show SMILES C(Cc1ccc(cc1)C1=CC[C@H]2CN(CC3CC3)C[C@@H]12)N1CCCC1 |r,t:9|
Show InChI InChI=1S/C23H32N2/c1-2-13-24(12-1)14-11-18-5-7-20(8-6-18)22-10-9-21-16-25(17-23(21)22)15-19-3-4-19/h5-8,10,19,21,23H,1-4,9,11-17H2/t21-,23+/m0/s1
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 0.900n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H3 receptor expressed in CHOK1 cells by [3H]R(-)-alpha-methylhistamine displacement assay

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50232355
PNG
((3aR,6aR)-2-(cyclopropylmethyl)-6-(4-(2-(pyrrolidi...)
Show SMILES C(Cc1ccc(cc1)C1=CC[C@H]2CN(CC3CC3)C[C@@H]12)N1CCCC1 |r,t:9|
Show InChI InChI=1S/C23H32N2/c1-2-13-24(12-1)14-11-18-5-7-20(8-6-18)22-10-9-21-16-25(17-23(21)22)15-19-3-4-19/h5-8,10,19,21,23H,1-4,9,11-17H2/t21-,23+/m0/s1
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 1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at human H3 receptor expressed in CHOK1 cells by GTPgammaS binding assay

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243639
PNG
(((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)c1cccnc1 |r,t:16|
Show InChI InChI=1S/C26H31N3O/c1-19-4-3-14-28(19)15-12-20-6-8-21(9-7-20)24-11-10-23-17-29(18-25(23)24)26(30)22-5-2-13-27-16-22/h2,5-9,11,13,16,19,23,25H,3-4,10,12,14-15,17-18H2,1H3/t19-,23+,25-/m1/s1
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 1n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50243674
PNG
(((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)C1CCOCC1 |r,t:16|
Show InChI InChI=1S/C26H36N2O2/c1-19-3-2-13-27(19)14-10-20-4-6-21(7-5-20)24-9-8-23-17-28(18-25(23)24)26(29)22-11-15-30-16-12-22/h4-7,9,19,22-23,25H,2-3,8,10-18H2,1H3/t19-,23+,25-/m1/s1
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 2n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H3 receptor expressed in CHOK1 cells by [3H]R(-)-alpha-methylhistamine displacement assay

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243175
PNG
(((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)c1ccccc1 |r,t:16|
Show InChI InChI=1S/C27H32N2O/c1-20-6-5-16-28(20)17-15-21-9-11-22(12-10-21)25-14-13-24-18-29(19-26(24)25)27(30)23-7-3-2-4-8-23/h2-4,7-12,14,20,24,26H,5-6,13,15-19H2,1H3/t20-,24+,26-/m1/s1
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 3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243120
PNG
(CHEMBL520719 | cyclopentyl((3aR,6aR)-6-(4-(2-(pyrr...)
Show SMILES O=C(C1CCCC1)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:12|
Show InChI InChI=1S/C25H34N2O/c28-25(21-5-1-2-6-21)27-17-22-11-12-23(24(22)18-27)20-9-7-19(8-10-20)13-16-26-14-3-4-15-26/h7-10,12,21-22,24H,1-6,11,13-18H2/t22-,24+/m0/s1
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 3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50243674
PNG
(((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)C1CCOCC1 |r,t:16|
Show InChI InChI=1S/C26H36N2O2/c1-19-3-2-13-27(19)14-10-20-4-6-21(7-5-20)24-9-8-23-17-28(18-25(23)24)26(29)22-11-15-30-16-12-22/h4-7,9,19,22-23,25H,2-3,8,10-18H2,1H3/t19-,23+,25-/m1/s1
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 4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at human H3 receptor expressed in CHOK1 cells by GTPgammaS binding assay

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243676
PNG
(((3aR,6aR)-6-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)-...)
Show SMILES O=C(C1CCOC1)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:12|
Show InChI InChI=1S/C24H32N2O2/c27-24(21-10-14-28-17-21)26-15-20-7-8-22(23(20)16-26)19-5-3-18(4-6-19)9-13-25-11-1-2-12-25/h3-6,8,20-21,23H,1-2,7,9-17H2/t20-,21?,23+/m0/s1
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 4n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243119
PNG
(2-methyl-1-((3aR,6aR)-6-(4-(2-(pyrrolidin-1-yl)eth...)
Show SMILES CC(C)C(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:9|
Show InChI InChI=1S/C23H32N2O/c1-17(2)23(26)25-15-20-9-10-21(22(20)16-25)19-7-5-18(6-8-19)11-14-24-12-3-4-13-24/h5-8,10,17,20,22H,3-4,9,11-16H2,1-2H3/t20-,22+/m0/s1
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 5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243121
PNG
(2-hydroxy-1-((3aR,6aR)-6-(4-(2-(pyrrolidin-1-yl)et...)
Show SMILES OCC(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:8|
Show InChI InChI=1S/C21H28N2O2/c24-15-21(25)23-13-18-7-8-19(20(18)14-23)17-5-3-16(4-6-17)9-12-22-10-1-2-11-22/h3-6,8,18,20,24H,1-2,7,9-15H2/t18-,20+/m0/s1
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 6n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243072
PNG
(CHEMBL470286 | pyridin-3-yl((3aR,6aR)-6-(4-(2-(pyr...)
Show SMILES O=C(N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1)c1cccnc1 |r,c:6|
Show InChI InChI=1S/C25H29N3O/c29-25(21-4-3-12-26-16-21)28-17-22-9-10-23(24(22)18-28)20-7-5-19(6-8-20)11-15-27-13-1-2-14-27/h3-8,10,12,16,22,24H,1-2,9,11,13-15,17-18H2/t22-,24+/m0/s1
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 6n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243073
PNG
(2-phenyl-1-((3aR,6aR)-6-(4-(2-(pyrrolidin-1-yl)eth...)
Show SMILES O=C(Cc1ccccc1)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:14|
Show InChI InChI=1S/C27H32N2O/c30-27(18-22-6-2-1-3-7-22)29-19-24-12-13-25(26(24)20-29)23-10-8-21(9-11-23)14-17-28-15-4-5-16-28/h1-3,6-11,13,24,26H,4-5,12,14-20H2/t24-,26+/m0/s1
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 7n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243070
PNG
((3aR,6aR)-2-(benzylsulfonyl)-6-(4-(2-(pyrrolidin-1...)
Show SMILES O=S(=O)(Cc1ccccc1)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:15|
Show InChI InChI=1S/C26H32N2O2S/c29-31(30,20-22-6-2-1-3-7-22)28-18-24-12-13-25(26(24)19-28)23-10-8-21(9-11-23)14-17-27-15-4-5-16-27/h1-3,6-11,13,24,26H,4-5,12,14-20H2/t24-,26+/m0/s1
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 12n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50242917
PNG
((3aR,6aR)-2-(isopropylsulfonyl)-6-(4-(2-(pyrrolidi...)
Show SMILES CC(C)S(=O)(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:10|
Show InChI InChI=1S/C22H32N2O2S/c1-17(2)27(25,26)24-15-20-9-10-21(22(20)16-24)19-7-5-18(6-8-19)11-14-23-12-3-4-13-23/h5-8,10,17,20,22H,3-4,9,11-16H2,1-2H3/t20-,22+/m0/s1
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 12n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50242845
PNG
(CHEMBL512484 | morpholino((3aR,6aR)-6-(4-(2-(pyrro...)
Show SMILES O=C(N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1)N1CCOCC1 |r,c:6|
Show InChI InChI=1S/C24H33N3O2/c28-24(26-13-15-29-16-14-26)27-17-21-7-8-22(23(21)18-27)20-5-3-19(4-6-20)9-12-25-10-1-2-11-25/h3-6,8,21,23H,1-2,7,9-18H2/t21-,23+/m0/s1
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 12n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50242844
PNG
((3aR,6aR)-N,N-dimethyl-6-(4-(2-(pyrrolidin-1-yl)et...)
Show SMILES CN(C)C(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:9|
Show InChI InChI=1S/C22H31N3O/c1-23(2)22(26)25-15-19-9-10-20(21(19)16-25)18-7-5-17(6-8-18)11-14-24-12-3-4-13-24/h5-8,10,19,21H,3-4,9,11-16H2,1-2H3/t19-,21+/m0/s1
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 13n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50242843
PNG
((3aR,6aR)-N-cyclopentyl-6-(4-(2-(pyrrolidin-1-yl)e...)
Show SMILES O=C(NC1CCCC1)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:13|
Show InChI InChI=1S/C25H35N3O/c29-25(26-22-5-1-2-6-22)28-17-21-11-12-23(24(21)18-28)20-9-7-19(8-10-20)13-16-27-14-3-4-15-27/h7-10,12,21-22,24H,1-6,11,13-18H2,(H,26,29)/t21-,24+/m0/s1
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 16n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243071
PNG
((3aR,6aR)-2-(phenylsulfonyl)-6-(4-(2-(pyrrolidin-1...)
Show SMILES O=S(=O)(N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1)c1ccccc1 |r,c:7|
Show InChI InChI=1S/C25H30N2O2S/c28-30(29,23-6-2-1-3-7-23)27-18-22-12-13-24(25(22)19-27)21-10-8-20(9-11-21)14-17-26-15-4-5-16-26/h1-3,6-11,13,22,25H,4-5,12,14-19H2/t22-,25+/m0/s1
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 17n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50242842
PNG
((3aR,6aR)-N-isopropyl-6-(4-(2-(pyrrolidin-1-yl)eth...)
Show SMILES CC(C)NC(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:10|
Show InChI InChI=1S/C23H33N3O/c1-17(2)24-23(27)26-15-20-9-10-21(22(20)16-26)19-7-5-18(6-8-19)11-14-25-12-3-4-13-25/h5-8,10,17,20,22H,3-4,9,11-16H2,1-2H3,(H,24,27)/t20-,22+/m0/s1
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 20n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50243675
PNG
(CHEMBL512707 | phenyl((3aR,6aR)-6-(4-(2-(pyrrolidi...)
Show SMILES O=C(N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1)c1ccccc1 |r,c:6|
Show InChI InChI=1S/C26H30N2O/c29-26(22-6-2-1-3-7-22)28-18-23-12-13-24(25(23)19-28)21-10-8-20(9-11-21)14-17-27-15-4-5-16-27/h1-3,6-11,13,23,25H,4-5,12,14-19H2/t23-,25+/m0/s1
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 21n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50242846
PNG
((3aR,6aR)-2-(methylsulfonyl)-6-(4-(2-(pyrrolidin-1...)
Show SMILES CS(=O)(=O)N1C[C@@H]2CC=C([C@@H]2C1)c1ccc(CCN2CCCC2)cc1 |r,c:8|
Show InChI InChI=1S/C20H28N2O2S/c1-25(23,24)22-14-18-8-9-19(20(18)15-22)17-6-4-16(5-7-17)10-13-21-11-2-3-12-21/h4-7,9,18,20H,2-3,8,10-15H2,1H3/t18-,20+/m0/s1
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 27n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane

Bioorg Med Chem Lett 18: 4133-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.086
BindingDB Entry DOI: 10.7270/Q2C82942
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%