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PubMed code 18558492

Compile data set for download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50178807
PNG
(3,4-dichloro-N-(3-(5-chloro-2-(phenylthio)phenylam...)
Show SMILES C[N+](C)(CCCNc1cc(Cl)ccc1Sc1ccccc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H24Cl3N2S/c1-28(2,18-10-11-20(25)21(26)16-18)14-6-13-27-22-15-17(24)9-12-23(22)29-19-7-4-3-5-8-19/h3-5,7-12,15-16,27H,6,13-14H2,1-2H3/q+1
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 1.70E+3n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Crithidia fasciculata)		BDBM50240622
PNG
(3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydr...)
Show SMILES Oc1ccc(CCC(=O)NCCCNCCCCNCCCNC(=O)CCc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C28H42N4O6/c33-23-9-5-21(19-25(23)35)7-11-27(37)31-17-3-15-29-13-1-2-14-30-16-4-18-32-28(38)12-8-22-6-10-24(34)26(36)20-22/h5-6,9-10,19-20,29-30,33-36H,1-4,7-8,11-18H2,(H,31,37)(H,32,38)
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 1.80E+3n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Crithidia fasciculata free trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50240625
PNG
(4-(2,3,4,9-Tetrahydro-1H-beta-carbolin-1-yl)-benzo...)
Show SMILES N#Cc1ccc(cc1)C1NCCc2c1[nH]c1ccccc21
Show InChI InChI=1S/C18H15N3/c19-11-12-5-7-13(8-6-12)17-18-15(9-10-20-17)14-3-1-2-4-16(14)21-18/h1-8,17,20-21H,9-10H2
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 2.00E+3n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 3.20E+3n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM77970
PNG
(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
Show InChI InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
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 7.00E+3n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50240624
PNG
(2-Methoxy-4-(2,3,4,9-tetrahydro-1H-beta-carbolin-1...)
Show SMILES COc1cc(CC2NCCc3c2[nH]c2ccccc32)ccc1O
Show InChI InChI=1S/C19H20N2O2/c1-23-18-11-12(6-7-17(18)22)10-16-19-14(8-9-20-16)13-4-2-3-5-15(13)21-19/h2-7,11,16,20-22H,8-10H2,1H3
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 7.00E+3n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50423643
PNG
(CEPHARANTHINE)
Show SMILES COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c6OCOc6cc6CCN(C)[C@@H](Cc7ccc(Oc1c2)cc7)c56)cc34 |r|
Show InChI InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
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 7.60E+3n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50242976
PNG
(4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10...)
Show SMILES COc1ccc2nc3cc(Cl)ccc3c(Cc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1
Show InChI InChI=1S/C30H33ClN4O2/c1-37-28-9-8-26-29(33-28)25(24-7-6-23(31)17-27(24)32-26)16-20-14-21(18-34-10-2-3-11-34)30(36)22(15-20)19-35-12-4-5-13-35/h6-9,14-15,17,36H,2-5,10-13,16,18-19H2,1H3
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 1.20E+4n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Crithidia fasciculata)		BDBM50240622
PNG
(3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydr...)
Show SMILES Oc1ccc(CCC(=O)NCCCNCCCCNCCCNC(=O)CCc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C28H42N4O6/c33-23-9-5-21(19-25(23)35)7-11-27(37)31-17-3-15-29-13-1-2-14-30-16-4-18-32-28(38)12-8-22-6-10-24(34)26(36)20-22/h5-6,9-10,19-20,29-30,33-36H,1-4,7-8,11-18H2,(H,31,37)(H,32,38)
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 1.30E+4n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Crithidia fasciculata trypanothione reductase-substrate complex

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50252053
PNG
(1,3-Bis[3-(dimethylamino)propyl]-1,5-dihydro-2Hpyr...)
Show SMILES CN(C)CCCn1c2Sc3ccccc3Nc2c(=O)n(CCCN(C)C)c1=O
Show InChI InChI=1S/C20H29N5O2S/c1-22(2)11-7-13-24-18(26)17-19(25(20(24)27)14-8-12-23(3)4)28-16-10-6-5-9-15(16)21-17/h5-6,9-10,21H,7-8,11-14H2,1-4H3
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 2.69E+4n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50252003
PNG
(CHEMBL481876 | N,N-dimethyl-N-[3-(7-methoxy-1-meth...)
Show SMILES COc1ccc2c3CCN=C(C)c3n(CCCN(C)C)c2c1 |t:9|
Show InChI InChI=1S/C18H25N3O/c1-13-18-16(8-9-19-13)15-7-6-14(22-4)12-17(15)21(18)11-5-10-20(2)3/h6-7,12H,5,8-11H2,1-4H3
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 3.51E+4n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50423643
PNG
(CEPHARANTHINE)
Show SMILES COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c6OCOc6cc6CCN(C)[C@@H](Cc7ccc(Oc1c2)cc7)c56)cc34 |r|
Show InChI InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
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 5.16E+4n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase-substrate complex

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50252054
PNG
(1-((3aR,5aR,10bR,12bR)-3a-Ethyl-7-methoxy-2,3,3a,5...)
Show SMILES CC[C@@]12CCCN3CC[C@@]4([C@@H](CC1)N(C(C)=O)c1c4cccc1OC)[C@@H]23 |r|
Show InChI InChI=1S/C22H30N2O2/c1-4-21-10-6-13-23-14-12-22(20(21)23)16-7-5-8-17(26-3)19(16)24(15(2)25)18(22)9-11-21/h5,7-8,18,20H,4,6,9-14H2,1-3H3/t18-,20-,21-,22-/m1/s1
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 6.46E+4n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50243034
PNG
(CHEMBL511447 | lunarine)
Show SMILES O=C1CCC23\C=C\C(=O)NCCCCNCCCNC(=O)\C=C\c4ccc(OC2C1)c3c4 |t:5,21|
Show InChI InChI=1S/C25H31N3O4/c29-19-8-10-25-11-9-24(31)27-14-2-1-12-26-13-3-15-28-23(30)7-5-18-4-6-21(20(25)16-18)32-22(25)17-19/h4-7,9,11,16,22,26H,1-3,8,10,12-15,17H2,(H,27,31)(H,28,30)/b7-5+,11-9+
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 1.44E+5n/an/an/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)		BDBM50252054
PNG
(1-((3aR,5aR,10bR,12bR)-3a-Ethyl-7-methoxy-2,3,3a,5...)
Show SMILES CC[C@@]12CCCN3CC[C@@]4([C@@H](CC1)N(C(C)=O)c1c4cccc1OC)[C@@H]23 |r|
Show InChI InChI=1S/C22H30N2O2/c1-4-21-10-6-13-23-14-12-22(20(21)23)16-7-5-8-17(26-3)19(16)24(15(2)25)18(22)9-11-21/h5,7-8,18,20H,4,6,9-14H2,1-3H3/t18-,20-,21-,22-/m1/s1
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n/an/a 9.04E+4n/an/an/an/an/an/a



Pontificia Universidad Catolica del Peru

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant trypanothione reductase

Bioorg Med Chem 16: 6689-95 (2008)


Article DOI: 10.1016/j.bmc.2008.05.074
BindingDB Entry DOI: 10.7270/Q2F18ZHB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%