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PubMed code 18571404

Compile data set for download or QSAR
Found 132 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252172
PNG
(5-(3,4-dichlorophenyl)-8-(methylamino)-5,6,7,8-tet...)
Show SMILES CNC1CCC(c2ccc(Cl)c(Cl)c2)c2ccc(cc12)S(N)(=O)=O
Show InChI InChI=1S/C17H18Cl2N2O2S/c1-21-17-7-5-12(10-2-6-15(18)16(19)8-10)13-4-3-11(9-14(13)17)24(20,22)23/h2-4,6,8-9,12,17,21H,5,7H2,1H3,(H2,20,22,23)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252020
PNG
((5-bromo-2-(4-(methylthio)phenoxy)phenyl)-N,N-dime...)
Show SMILES CSc1ccc(Oc2ccc(Br)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18BrNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252168
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethoxy)p...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)C(N)=O
Show InChI InChI=1S/C17H17F3N2O3/c1-22(2)10-12-9-11(16(21)23)3-8-15(12)24-13-4-6-14(7-5-13)25-17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252119
PNG
(CHEMBL449015 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CSc1ccc(Sc2ccc(NS(C)(=O)=O)cc2CN(C)C)cc1
Show InChI InChI=1S/C17H22N2O2S3/c1-19(2)12-13-11-14(18-24(4,20)21)5-10-17(13)23-16-8-6-15(22-3)7-9-16/h5-11,18H,12H2,1-4H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252022
PNG
(4-(3,4-dichlorobenzyl)-3-((dimethylamino)methyl)be...)
Show SMILES CN(C)Cc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)C(N)=O
Show InChI InChI=1S/C17H18Cl2N2O/c1-21(2)10-14-9-13(17(20)22)5-4-12(14)7-11-3-6-15(18)16(19)8-11/h3-6,8-9H,7,10H2,1-2H3,(H2,20,22)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252074
PNG
(CHEMBL482295 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(NS(C)(=O)=O)ccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N2O2S2/c1-22(2)11-12-10-14(21-26(3,23)24)6-9-16(12)25-15-7-4-13(5-8-15)17(18,19)20/h4-10,21H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50251869
PNG
((5-bromo-2-(4-(trifluoromethyl)phenoxy)phenyl)-N,N...)
Show SMILES CN(C)Cc1cc(Br)ccc1Oc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H15BrF3NO/c1-21(2)10-11-9-13(17)5-8-15(11)22-14-6-3-12(4-7-14)16(18,19)20/h3-9H,10H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252021
PNG
(4-(3,4-dichlorobenzyl)-3-((methylamino)methyl)benz...)
Show SMILES CNCc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)C(N)=O
Show InChI InChI=1S/C16H16Cl2N2O/c1-20-9-13-8-12(16(19)21)4-3-11(13)6-10-2-5-14(17)15(18)7-10/h2-5,7-8,20H,6,9H2,1H3,(H2,19,21)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252581
PNG
((2-(4-(methylthio)benzyl)phenyl)-N-methylmethanami...)
Show SMILES CNCc1ccccc1Cc1ccc(SC)cc1
Show InChI InChI=1S/C16H19NS/c1-17-12-15-6-4-3-5-14(15)11-13-7-9-16(18-2)10-8-13/h3-10,17H,11-12H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252019
PNG
((5-chloro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...)
Show SMILES CSc1ccc(Oc2ccc(Cl)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18ClNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252528
PNG
((2-(3,4-dichlorobenzyl)phenyl)-N,N-dimethylmethana...)
Show SMILES CN(C)Cc1ccccc1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2N/c1-19(2)11-14-6-4-3-5-13(14)9-12-7-8-15(17)16(18)10-12/h3-8,10H,9,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252582
PNG
((2-(4-(methylthio)benzyl)phenyl)-N,N-dimethylmetha...)
Show SMILES CSc1ccc(Cc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C17H21NS/c1-18(2)13-16-7-5-4-6-15(16)12-14-8-10-17(19-3)11-9-14/h4-11H,12-13H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252122
PNG
(CHEMBL479410 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(NS(C)(=O)=O)ccc1Oc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N2O3S/c1-22(2)11-12-10-14(21-26(3,23)24)6-9-16(12)25-15-7-4-13(5-8-15)17(18,19)20/h4-10,21H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252120
PNG
(CHEMBL479783 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CSc1ccc(Sc2ccc(cc2CN(C)C)N(C)S(C)(=O)=O)cc1
Show InChI InChI=1S/C18H24N2O2S3/c1-19(2)13-14-12-15(20(3)25(5,21)22)6-11-18(14)24-17-9-7-16(23-4)8-10-17/h6-12H,13H2,1-5H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252069
PNG
(4-(3,4-dichlorobenzyl)-3-((methylamino)methyl)benz...)
Show SMILES CNCc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)S(N)(=O)=O
Show InChI InChI=1S/C15H16Cl2N2O2S/c1-19-9-12-8-13(22(18,20)21)4-3-11(12)6-10-2-5-14(16)15(17)7-10/h2-5,7-8,19H,6,9H2,1H3,(H2,18,20,21)
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n/an/a 6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50251870
PNG
(CHEMBL481353 | N,N-dimethyl(2-(4-(trifluoromethoxy...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C16H16F3NO2/c1-20(2)11-12-5-3-4-6-15(12)21-13-7-9-14(10-8-13)22-16(17,18)19/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252121
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethoxy)p...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O4S/c1-21(2)10-11-9-14(26(20,22)23)7-8-15(11)24-12-3-5-13(6-4-12)25-16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252018
PNG
((5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...)
Show SMILES CSc1ccc(Oc2ccc(F)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18FNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252169
PNG
(3-((dimethylamino)methyl)-N-methyl-4-(4-(trifluoro...)
Show SMILES CNC(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)c(CN(C)C)c1
Show InChI InChI=1S/C18H19F3N2O3/c1-22-17(24)12-4-9-16(13(10-12)11-23(2)3)25-14-5-7-15(8-6-14)26-18(19,20)21/h4-10H,11H2,1-3H3,(H,22,24)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252118
PNG
(CHEMBL479411 | N-(3-((methylamino)methyl)-4-(4-(me...)
Show SMILES CNCc1cc(NS(C)(=O)=O)ccc1Sc1ccc(SC)cc1
Show InChI InChI=1S/C16H20N2O2S3/c1-17-11-12-10-13(18-23(3,19)20)4-9-16(12)22-15-7-5-14(21-2)6-8-15/h4-10,17-18H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252171
PNG
(CHEMBL481697 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(CNS(C)(=O)=O)ccc1Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H21F3N2O4S/c1-23(2)12-14-10-13(11-22-28(3,24)25)4-9-17(14)26-15-5-7-16(8-6-15)27-18(19,20)21/h4-10,22H,11-12H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50246181
PNG
((2-(3,4-dichlorophenoxy)phenyl)-N,N-dimethylmethan...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2NO/c1-18(2)10-11-5-3-4-6-15(11)19-12-7-8-13(16)14(17)9-12/h3-9H,10H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50251873
PNG
((2-(4-bromophenoxy)phenyl)-N,N-dimethylmethanamine...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Br)cc1
Show InChI InChI=1S/C15H16BrNO/c1-17(2)11-12-5-3-4-6-15(12)18-14-9-7-13(16)8-10-14/h3-10H,11H2,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252638
PNG
((2-(3-chlorophenylthio)phenyl)-N,N-dimethylmethana...)
Show SMILES CN(C)Cc1ccccc1Sc1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNS/c1-17(2)11-12-6-3-4-9-15(12)18-14-8-5-7-13(16)10-14/h3-10H,11H2,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252016
PNG
((2-(4-cyclopropylphenoxy)phenyl)-N,N-dimethylmetha...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(cc1)C1CC1
Show InChI InChI=1S/C18H21NO/c1-19(2)13-16-5-3-4-6-18(16)20-17-11-9-15(10-12-17)14-7-8-14/h3-6,9-12,14H,7-8,13H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252637
PNG
((2-(4-chlorophenylthio)phenyl)-N,N-dimethylmethana...)
Show SMILES CN(C)Cc1ccccc1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClNS/c1-17(2)11-12-5-3-4-6-15(12)18-14-9-7-13(16)8-10-14/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252117
PNG
(3-((dimethylamino)methyl)-4-(4-(methylthio)phenylt...)
Show SMILES CSc1ccc(Sc2ccc(cc2CN(C)C)S(N)(=O)=O)cc1
Show InChI InChI=1S/C16H20N2O2S3/c1-18(2)11-12-10-15(23(17,19)20)8-9-16(12)22-14-6-4-13(21-3)5-7-14/h4-10H,11H2,1-3H3,(H2,17,19,20)
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n/an/a 20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50233471
PNG
((2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClNO/c1-17(2)11-12-5-3-4-6-15(12)18-14-9-7-13(16)8-10-14/h3-10H,11H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252639
PNG
(CHEMBL493264 | N,N-dimethyl(2-(4-(methylthio)pheny...)
Show SMILES CSc1ccc(Sc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C16H19NS2/c1-17(2)12-13-6-4-5-7-16(13)19-15-10-8-14(18-3)9-11-15/h4-11H,12H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50251871
PNG
((2-(4-methoxyphenoxy)phenyl)-N,N-dimethylmethanami...)
Show SMILES COc1ccc(Oc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C16H19NO2/c1-17(2)12-13-6-4-5-7-16(13)19-15-10-8-14(18-3)9-11-15/h4-11H,12H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252071
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethyl)ph...)
Show SMILES CN(C)Cc1cc(ccc1Sc1ccc(cc1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O2S2/c1-21(2)10-11-9-14(25(20,22)23)7-8-15(11)24-13-5-3-12(4-6-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252635
PNG
(CHEMBL493027 | N,N-dimethyl(2-(4-(trifluoromethyl)...)
Show SMILES CN(C)Cc1ccccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H16F3NS/c1-20(2)11-12-5-3-4-6-15(12)21-14-9-7-13(8-10-14)16(17,18)19/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252527
PNG
((2-(3,4-dichlorobenzyl)phenyl)-N-methylmethanamine...)
Show SMILES CNCc1ccccc1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2N/c1-18-10-13-5-3-2-4-12(13)8-11-6-7-14(16)15(17)9-11/h2-7,9,18H,8,10H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50251872
PNG
((2-(4-ethoxyphenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CCOc1ccc(Oc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C17H21NO2/c1-4-19-15-9-11-16(12-10-15)20-17-8-6-5-7-14(17)13-18(2)3/h5-12H,4,13H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252072
PNG
(3-((dimethylamino)methyl)-4-(3-(trifluoromethyl)ph...)
Show SMILES CN(C)Cc1cc(ccc1Sc1cccc(c1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O2S2/c1-21(2)10-11-8-14(25(20,22)23)6-7-15(11)24-13-5-3-4-12(9-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252638
PNG
((2-(3-chlorophenylthio)phenyl)-N,N-dimethylmethana...)
Show SMILES CN(C)Cc1ccccc1Sc1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNS/c1-17(2)11-12-6-3-4-9-15(12)18-14-8-5-7-13(16)10-14/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252576
PNG
((+/-)-(2-(1-(3,4-dichlorophenyl)ethyl)phenyl)-N,N-...)
Show SMILES CC(c1ccc(Cl)c(Cl)c1)c1ccccc1CN(C)C
Show InChI InChI=1S/C17H19Cl2N/c1-12(13-8-9-16(18)17(19)10-13)15-7-5-4-6-14(15)11-20(2)3/h4-10,12H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252636
PNG
(CHEMBL493057 | N,N-dimethyl(2-(3-(trifluoromethyl)...)
Show SMILES CN(C)Cc1ccccc1Sc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H16F3NS/c1-20(2)11-12-6-3-4-9-15(12)21-14-8-5-7-13(10-14)16(17,18)19/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252580
PNG
((2-(4-(trifluoromethoxy)benzyl)phenyl)-N,N-dimethy...)
Show SMILES CN(C)Cc1ccccc1Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C17H18F3NO/c1-21(2)12-15-6-4-3-5-14(15)11-13-7-9-16(10-8-13)22-17(18,19)20/h3-10H,11-12H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252638
PNG
((2-(3-chlorophenylthio)phenyl)-N,N-dimethylmethana...)
Show SMILES CN(C)Cc1ccccc1Sc1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNS/c1-17(2)11-12-6-3-4-9-15(12)18-14-8-5-7-13(16)10-14/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252579
PNG
((3,4-dichlorophenyl)(2-((dimethylamino)methyl)phen...)
Show SMILES CN(C)Cc1ccccc1C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2NO/c1-19(2)10-12-5-3-4-6-13(12)16(20)11-7-8-14(17)15(18)9-11/h3-9H,10H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252021
PNG
(4-(3,4-dichlorobenzyl)-3-((methylamino)methyl)benz...)
Show SMILES CNCc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)C(N)=O
Show InChI InChI=1S/C16H16Cl2N2O/c1-20-9-13-8-12(16(19)21)4-3-11(13)6-10-2-5-14(17)15(18)7-10/h2-5,7-8,20H,6,9H2,1H3,(H2,19,21)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50233472
PNG
((2-(3-chlorophenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CN(C)Cc1ccccc1Oc1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNO/c1-17(2)11-12-6-3-4-9-15(12)18-14-8-5-7-13(16)10-14/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50251917
PNG
(4-(2-((dimethylamino)methyl)phenoxy)benzonitrile |...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(cc1)C#N
Show InChI InChI=1S/C16H16N2O/c1-18(2)12-14-5-3-4-6-16(14)19-15-9-7-13(11-17)8-10-15/h3-10H,12H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252070
PNG
(4-(3,4-dichlorobenzyl)-3-((dimethylamino)methyl)be...)
Show SMILES CN(C)Cc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)S(N)(=O)=O
Show InChI InChI=1S/C16H18Cl2N2O2S/c1-20(2)10-13-9-14(23(19,21)22)5-4-12(13)7-11-3-6-15(17)16(18)8-11/h3-6,8-9H,7,10H2,1-2H3,(H2,19,21,22)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252634
PNG
(CHEMBL493056 | N-methyl(2-(4-(trifluoromethyl)phen...)
Show SMILES CNCc1ccccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H14F3NS/c1-19-10-11-4-2-3-5-14(11)20-13-8-6-12(7-9-13)15(16,17)18/h2-9,19H,10H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252120
PNG
(CHEMBL479783 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CSc1ccc(Sc2ccc(cc2CN(C)C)N(C)S(C)(=O)=O)cc1
Show InChI InChI=1S/C18H24N2O2S3/c1-19(2)13-14-12-15(20(3)25(5,21)22)6-11-18(14)24-17-9-7-16(23-4)8-10-17/h6-12H,13H2,1-5H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252069
PNG
(4-(3,4-dichlorobenzyl)-3-((methylamino)methyl)benz...)
Show SMILES CNCc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)S(N)(=O)=O
Show InChI InChI=1S/C15H16Cl2N2O2S/c1-19-9-12-8-13(22(18,20)21)4-3-11(12)6-10-2-5-14(16)15(17)7-10/h2-5,7-8,19H,6,9H2,1H3,(H2,18,20,21)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252172
PNG
(5-(3,4-dichlorophenyl)-8-(methylamino)-5,6,7,8-tet...)
Show SMILES CNC1CCC(c2ccc(Cl)c(Cl)c2)c2ccc(cc12)S(N)(=O)=O
Show InChI InChI=1S/C17H18Cl2N2O2S/c1-21-17-7-5-12(10-2-6-15(18)16(19)8-10)13-4-3-11(9-14(13)17)24(20,22)23/h2-4,6,8-9,12,17,21H,5,7H2,1H3,(H2,20,22,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252170
PNG
(3-((dimethylamino)methyl)-N,N-dimethyl-4-(4-(trifl...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)C(=O)N(C)C
Show InChI InChI=1S/C19H21F3N2O3/c1-23(2)12-14-11-13(18(25)24(3)4)5-10-17(14)26-15-6-8-16(9-7-15)27-19(20,21)22/h5-11H,12H2,1-4H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50233471
PNG
((2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClNO/c1-17(2)11-12-5-3-4-6-15(12)18-14-9-7-13(16)8-10-14/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252021
PNG
(4-(3,4-dichlorobenzyl)-3-((methylamino)methyl)benz...)
Show SMILES CNCc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)C(N)=O
Show InChI InChI=1S/C16H16Cl2N2O/c1-20-9-13-8-12(16(19)21)4-3-11(13)6-10-2-5-14(17)15(18)7-10/h2-5,7-8,20H,6,9H2,1H3,(H2,19,21)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252069
PNG
(4-(3,4-dichlorobenzyl)-3-((methylamino)methyl)benz...)
Show SMILES CNCc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)S(N)(=O)=O
Show InChI InChI=1S/C15H16Cl2N2O2S/c1-19-9-12-8-13(22(18,20)21)4-3-11(12)6-10-2-5-14(16)15(17)7-10/h2-5,7-8,19H,6,9H2,1H3,(H2,18,20,21)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50246181
PNG
((2-(3,4-dichlorophenoxy)phenyl)-N,N-dimethylmethan...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2NO/c1-18(2)10-11-5-3-4-6-15(11)19-12-7-8-13(16)14(17)9-12/h3-9H,10H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50233471
PNG
((2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClNO/c1-17(2)11-12-5-3-4-6-15(12)18-14-9-7-13(16)8-10-14/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50233472
PNG
((2-(3-chlorophenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CN(C)Cc1ccccc1Oc1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNO/c1-17(2)11-12-6-3-4-9-15(12)18-14-8-5-7-13(16)10-14/h3-10H,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252070
PNG
(4-(3,4-dichlorobenzyl)-3-((dimethylamino)methyl)be...)
Show SMILES CN(C)Cc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)S(N)(=O)=O
Show InChI InChI=1S/C16H18Cl2N2O2S/c1-20(2)10-13-9-14(23(19,21)22)5-4-12(13)7-11-3-6-15(17)16(18)8-11/h3-6,8-9H,7,10H2,1-2H3,(H2,19,21,22)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252527
PNG
((2-(3,4-dichlorobenzyl)phenyl)-N-methylmethanamine...)
Show SMILES CNCc1ccccc1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2N/c1-18-10-13-5-3-2-4-12(13)8-11-6-7-14(16)15(17)9-11/h2-7,9,18H,8,10H2,1H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252577
PNG
((+/-)-(3,4-dichlorophenyl)(2-((dimethylamino)methy...)
Show SMILES CN(C)Cc1ccccc1C(O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2NO/c1-19(2)10-12-5-3-4-6-13(12)16(20)11-7-8-14(17)15(18)9-11/h3-9,16,20H,10H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252022
PNG
(4-(3,4-dichlorobenzyl)-3-((dimethylamino)methyl)be...)
Show SMILES CN(C)Cc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)C(N)=O
Show InChI InChI=1S/C17H18Cl2N2O/c1-21(2)10-14-9-13(17(20)22)5-4-12(14)7-11-3-6-15(18)16(19)8-11/h3-6,8-9H,7,10H2,1-2H3,(H2,20,22)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50246181
PNG
((2-(3,4-dichlorophenoxy)phenyl)-N,N-dimethylmethan...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2NO/c1-18(2)10-11-5-3-4-6-15(11)19-12-7-8-13(16)14(17)9-12/h3-9H,10H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252528
PNG
((2-(3,4-dichlorobenzyl)phenyl)-N,N-dimethylmethana...)
Show SMILES CN(C)Cc1ccccc1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2N/c1-19(2)11-14-6-4-3-5-13(14)9-12-7-8-15(17)16(18)10-12/h3-8,10H,9,11H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252022
PNG
(4-(3,4-dichlorobenzyl)-3-((dimethylamino)methyl)be...)
Show SMILES CN(C)Cc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)C(N)=O
Show InChI InChI=1S/C17H18Cl2N2O/c1-21(2)10-14-9-13(17(20)22)5-4-12(14)7-11-3-6-15(18)16(19)8-11/h3-6,8-9H,7,10H2,1-2H3,(H2,20,22)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252170
PNG
(3-((dimethylamino)methyl)-N,N-dimethyl-4-(4-(trifl...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)C(=O)N(C)C
Show InChI InChI=1S/C19H21F3N2O3/c1-23(2)12-14-11-13(18(25)24(3)4)5-10-17(14)26-15-6-8-16(9-7-15)27-19(20,21)22/h5-11H,12H2,1-4H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252119
PNG
(CHEMBL449015 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CSc1ccc(Sc2ccc(NS(C)(=O)=O)cc2CN(C)C)cc1
Show InChI InChI=1S/C17H22N2O2S3/c1-19(2)12-13-11-14(18-24(4,20)21)5-10-17(13)23-16-8-6-15(22-3)7-9-16/h5-11,18H,12H2,1-4H3
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n/an/a 530n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252018
PNG
((5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...)
Show SMILES CSc1ccc(Oc2ccc(F)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18FNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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n/an/a 630n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50251873
PNG
((2-(4-bromophenoxy)phenyl)-N,N-dimethylmethanamine...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Br)cc1
Show InChI InChI=1S/C15H16BrNO/c1-17(2)11-12-5-3-4-6-15(12)18-14-9-7-13(16)8-10-14/h3-10H,11H2,1-2H3
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n/an/a 640n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252639
PNG
(CHEMBL493264 | N,N-dimethyl(2-(4-(methylthio)pheny...)
Show SMILES CSc1ccc(Sc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C16H19NS2/c1-17(2)12-13-6-4-5-7-16(13)19-15-10-8-14(18-3)9-11-15/h4-11H,12H2,1-3H3
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n/an/a 640n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252017
PNG
((2-(4-(cyclopropylmethyl)phenoxy)phenyl)-N,N-dimet...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(CC2CC2)cc1
Show InChI InChI=1S/C19H23NO/c1-20(2)14-17-5-3-4-6-19(17)21-18-11-9-16(10-12-18)13-15-7-8-15/h3-6,9-12,15H,7-8,13-14H2,1-2H3
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n/an/a 660n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50251871
PNG
((2-(4-methoxyphenoxy)phenyl)-N,N-dimethylmethanami...)
Show SMILES COc1ccc(Oc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C16H19NO2/c1-17(2)12-13-6-4-5-7-16(13)19-15-10-8-14(18-3)9-11-15/h4-11H,12H2,1-3H3
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n/an/a 680n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252122
PNG
(CHEMBL479410 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(NS(C)(=O)=O)ccc1Oc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N2O3S/c1-22(2)11-12-10-14(21-26(3,23)24)6-9-16(12)25-15-7-4-13(5-8-15)17(18,19)20/h4-10,21H,11H2,1-3H3
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n/an/a 700n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50251873
PNG
((2-(4-bromophenoxy)phenyl)-N,N-dimethylmethanamine...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(Br)cc1
Show InChI InChI=1S/C15H16BrNO/c1-17(2)11-12-5-3-4-6-15(12)18-14-9-7-13(16)8-10-14/h3-10H,11H2,1-2H3
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n/an/a 760n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252172
PNG
(5-(3,4-dichlorophenyl)-8-(methylamino)-5,6,7,8-tet...)
Show SMILES CNC1CCC(c2ccc(Cl)c(Cl)c2)c2ccc(cc12)S(N)(=O)=O
Show InChI InChI=1S/C17H18Cl2N2O2S/c1-21-17-7-5-12(10-2-6-15(18)16(19)8-10)13-4-3-11(9-14(13)17)24(20,22)23/h2-4,6,8-9,12,17,21H,5,7H2,1H3,(H2,20,22,23)
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n/an/a 770n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50233472
PNG
((2-(3-chlorophenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CN(C)Cc1ccccc1Oc1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNO/c1-17(2)11-12-6-3-4-9-15(12)18-14-8-5-7-13(16)10-14/h3-10H,11H2,1-2H3
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n/an/a 910n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252578
PNG
((+/-)-(2-((3,4-dichlorophenyl)(methoxy)methyl)phen...)
Show SMILES COC(c1ccc(Cl)c(Cl)c1)c1ccccc1CN(C)C
Show InChI InChI=1S/C17H19Cl2NO/c1-20(2)11-13-6-4-5-7-14(13)17(21-3)12-8-9-15(18)16(19)10-12/h4-10,17H,11H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252070
PNG
(4-(3,4-dichlorobenzyl)-3-((dimethylamino)methyl)be...)
Show SMILES CN(C)Cc1cc(ccc1Cc1ccc(Cl)c(Cl)c1)S(N)(=O)=O
Show InChI InChI=1S/C16H18Cl2N2O2S/c1-20(2)10-13-9-14(23(19,21)22)5-4-12(13)7-11-3-6-15(17)16(18)8-11/h3-6,8-9H,7,10H2,1-2H3,(H2,19,21,22)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252582
PNG
((2-(4-(methylthio)benzyl)phenyl)-N,N-dimethylmetha...)
Show SMILES CSc1ccc(Cc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C17H21NS/c1-18(2)13-16-7-5-4-6-15(16)12-14-8-10-17(19-3)11-9-14/h4-11H,12-13H2,1-3H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252528
PNG
((2-(3,4-dichlorobenzyl)phenyl)-N,N-dimethylmethana...)
Show SMILES CN(C)Cc1ccccc1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2N/c1-19(2)11-14-6-4-3-5-13(14)9-12-7-8-15(17)16(18)10-12/h3-8,10H,9,11H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252016
PNG
((2-(4-cyclopropylphenoxy)phenyl)-N,N-dimethylmetha...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(cc1)C1CC1
Show InChI InChI=1S/C18H21NO/c1-19(2)13-16-5-3-4-6-18(16)20-17-11-9-15(10-12-17)14-7-8-14/h3-6,9-12,14H,7-8,13H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252119
PNG
(CHEMBL449015 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CSc1ccc(Sc2ccc(NS(C)(=O)=O)cc2CN(C)C)cc1
Show InChI InChI=1S/C17H22N2O2S3/c1-19(2)12-13-11-14(18-24(4,20)21)5-10-17(13)23-16-8-6-15(22-3)7-9-16/h5-11,18H,12H2,1-4H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50251872
PNG
((2-(4-ethoxyphenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CCOc1ccc(Oc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C17H21NO2/c1-4-19-15-9-11-16(12-10-15)20-17-8-6-5-7-14(17)13-18(2)3/h5-12H,4,13H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252020
PNG
((5-bromo-2-(4-(methylthio)phenoxy)phenyl)-N,N-dime...)
Show SMILES CSc1ccc(Oc2ccc(Br)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18BrNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252577
PNG
((+/-)-(3,4-dichlorophenyl)(2-((dimethylamino)methy...)
Show SMILES CN(C)Cc1ccccc1C(O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2NO/c1-19(2)10-12-5-3-4-6-13(12)16(20)11-7-8-14(17)15(18)9-11/h3-9,16,20H,10H2,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50252073
PNG
((+/-)-3-((dimethylamino)methyl)-4-(4-(trifluoromet...)
Show SMILES CN(C)Cc1cc(ccc1S(=O)c1ccc(cc1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O3S2/c1-21(2)10-11-9-14(26(20,23)24)7-8-15(11)25(22)13-5-3-12(4-6-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,23,24)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252636
PNG
(CHEMBL493057 | N,N-dimethyl(2-(3-(trifluoromethyl)...)
Show SMILES CN(C)Cc1ccccc1Sc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H16F3NS/c1-20(2)11-12-6-3-4-9-15(12)21-14-8-5-7-13(10-14)16(17,18)19/h3-10H,11H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252527
PNG
((2-(3,4-dichlorobenzyl)phenyl)-N-methylmethanamine...)
Show SMILES CNCc1ccccc1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2N/c1-18-10-13-5-3-2-4-12(13)8-11-6-7-14(16)15(17)9-11/h2-7,9,18H,8,10H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252118
PNG
(CHEMBL479411 | N-(3-((methylamino)methyl)-4-(4-(me...)
Show SMILES CNCc1cc(NS(C)(=O)=O)ccc1Sc1ccc(SC)cc1
Show InChI InChI=1S/C16H20N2O2S3/c1-17-11-12-10-13(18-23(3,19)20)4-9-16(12)22-15-7-5-14(21-2)6-8-15/h4-10,17-18H,11H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252579
PNG
((3,4-dichlorophenyl)(2-((dimethylamino)methyl)phen...)
Show SMILES CN(C)Cc1ccccc1C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2NO/c1-19(2)10-12-5-3-4-6-13(12)16(20)11-7-8-14(17)15(18)9-11/h3-9H,10H2,1-2H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252017
PNG
((2-(4-(cyclopropylmethyl)phenoxy)phenyl)-N,N-dimet...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(CC2CC2)cc1
Show InChI InChI=1S/C19H23NO/c1-20(2)14-17-5-3-4-6-19(17)21-18-11-9-16(10-12-18)13-15-7-8-15/h3-6,9-12,15H,7-8,13-14H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252634
PNG
(CHEMBL493056 | N-methyl(2-(4-(trifluoromethyl)phen...)
Show SMILES CNCc1ccccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H14F3NS/c1-19-10-11-4-2-3-5-14(11)20-13-8-6-12(7-9-13)15(16,17)18/h2-9,19H,10H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252169
PNG
(3-((dimethylamino)methyl)-N-methyl-4-(4-(trifluoro...)
Show SMILES CNC(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)c(CN(C)C)c1
Show InChI InChI=1S/C18H19F3N2O3/c1-22-17(24)12-4-9-16(13(10-12)11-23(2)3)25-14-5-7-15(8-6-14)26-18(19,20)21/h4-10H,11H2,1-3H3,(H,22,24)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252072
PNG
(3-((dimethylamino)methyl)-4-(3-(trifluoromethyl)ph...)
Show SMILES CN(C)Cc1cc(ccc1Sc1cccc(c1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O2S2/c1-21(2)10-11-8-14(25(20,22)23)6-7-15(11)24-13-5-3-4-12(9-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252577
PNG
((+/-)-(3,4-dichlorophenyl)(2-((dimethylamino)methy...)
Show SMILES CN(C)Cc1ccccc1C(O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2NO/c1-19(2)10-12-5-3-4-6-13(12)16(20)11-7-8-14(17)15(18)9-11/h3-9,16,20H,10H2,1-2H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252120
PNG
(CHEMBL479783 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CSc1ccc(Sc2ccc(cc2CN(C)C)N(C)S(C)(=O)=O)cc1
Show InChI InChI=1S/C18H24N2O2S3/c1-19(2)13-14-12-15(20(3)25(5,21)22)6-11-18(14)24-17-9-7-16(23-4)8-10-17/h6-12H,13H2,1-5H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252118
PNG
(CHEMBL479411 | N-(3-((methylamino)methyl)-4-(4-(me...)
Show SMILES CNCc1cc(NS(C)(=O)=O)ccc1Sc1ccc(SC)cc1
Show InChI InChI=1S/C16H20N2O2S3/c1-17-11-12-10-13(18-23(3,19)20)4-9-16(12)22-15-7-5-14(21-2)6-8-15/h4-10,17-18H,11H2,1-3H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252016
PNG
((2-(4-cyclopropylphenoxy)phenyl)-N,N-dimethylmetha...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(cc1)C1CC1
Show InChI InChI=1S/C18H21NO/c1-19(2)13-16-5-3-4-6-18(16)20-17-11-9-15(10-12-17)14-7-8-14/h3-6,9-12,14H,7-8,13H2,1-2H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252168
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethoxy)p...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)C(N)=O
Show InChI InChI=1S/C17H17F3N2O3/c1-22(2)10-12-9-11(16(21)23)3-8-15(12)24-13-4-6-14(7-5-13)25-17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,23)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252019
PNG
((5-chloro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...)
Show SMILES CSc1ccc(Oc2ccc(Cl)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18ClNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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n/an/a 4.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252639
PNG
(CHEMBL493264 | N,N-dimethyl(2-(4-(methylthio)pheny...)
Show SMILES CSc1ccc(Sc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C16H19NS2/c1-17(2)12-13-6-4-5-7-16(13)19-15-10-8-14(18-3)9-11-15/h4-11H,12H2,1-3H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252171
PNG
(CHEMBL481697 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(CNS(C)(=O)=O)ccc1Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H21F3N2O4S/c1-23(2)12-14-10-13(11-22-28(3,24)25)4-9-17(14)26-15-5-7-16(8-6-15)27-18(19,20)21/h4-10,22H,11-12H2,1-3H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252171
PNG
(CHEMBL481697 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(CNS(C)(=O)=O)ccc1Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H21F3N2O4S/c1-23(2)12-14-10-13(11-22-28(3,24)25)4-9-17(14)26-15-5-7-16(8-6-15)27-18(19,20)21/h4-10,22H,11-12H2,1-3H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50251870
PNG
(CHEMBL481353 | N,N-dimethyl(2-(4-(trifluoromethoxy...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C16H16F3NO2/c1-20(2)11-12-5-3-4-6-15(12)21-13-7-9-14(10-8-13)22-16(17,18)19/h3-10H,11H2,1-2H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252581
PNG
((2-(4-(methylthio)benzyl)phenyl)-N-methylmethanami...)
Show SMILES CNCc1ccccc1Cc1ccc(SC)cc1
Show InChI InChI=1S/C16H19NS/c1-17-12-15-6-4-3-5-14(15)11-13-7-9-16(18-2)10-8-13/h3-10,17H,11-12H2,1-2H3
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n/an/a 5.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252634
PNG
(CHEMBL493056 | N-methyl(2-(4-(trifluoromethyl)phen...)
Show SMILES CNCc1ccccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H14F3NS/c1-19-10-11-4-2-3-5-14(11)20-13-8-6-12(7-9-13)15(16,17)18/h2-9,19H,10H2,1H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252019
PNG
((5-chloro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...)
Show SMILES CSc1ccc(Oc2ccc(Cl)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18ClNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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n/an/a 6.10E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50251872
PNG
((2-(4-ethoxyphenoxy)phenyl)-N,N-dimethylmethanamin...)
Show SMILES CCOc1ccc(Oc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C17H21NO2/c1-4-19-15-9-11-16(12-10-15)20-17-8-6-5-7-14(17)13-18(2)3/h5-12H,4,13H2,1-3H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252074
PNG
(CHEMBL482295 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(NS(C)(=O)=O)ccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N2O2S2/c1-22(2)11-12-10-14(21-26(3,23)24)6-9-16(12)25-15-7-4-13(5-8-15)17(18,19)20/h4-10,21H,11H2,1-3H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50251871
PNG
((2-(4-methoxyphenoxy)phenyl)-N,N-dimethylmethanami...)
Show SMILES COc1ccc(Oc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C16H19NO2/c1-17(2)12-13-6-4-5-7-16(13)19-15-10-8-14(18-3)9-11-15/h4-11H,12H2,1-3H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50251870
PNG
(CHEMBL481353 | N,N-dimethyl(2-(4-(trifluoromethoxy...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C16H16F3NO2/c1-20(2)11-12-5-3-4-6-15(12)21-13-7-9-14(10-8-13)22-16(17,18)19/h3-10H,11H2,1-2H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252074
PNG
(CHEMBL482295 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(NS(C)(=O)=O)ccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N2O2S2/c1-22(2)11-12-10-14(21-26(3,23)24)6-9-16(12)25-15-7-4-13(5-8-15)17(18,19)20/h4-10,21H,11H2,1-3H3
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n/an/a 6.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252018
PNG
((5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dim...)
Show SMILES CSc1ccc(Oc2ccc(F)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18FNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252581
PNG
((2-(4-(methylthio)benzyl)phenyl)-N-methylmethanami...)
Show SMILES CNCc1ccccc1Cc1ccc(SC)cc1
Show InChI InChI=1S/C16H19NS/c1-17-12-15-6-4-3-5-14(15)11-13-7-9-16(18-2)10-8-13/h3-10,17H,11-12H2,1-2H3
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n/an/a 7.30E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252020
PNG
((5-bromo-2-(4-(methylthio)phenoxy)phenyl)-N,N-dime...)
Show SMILES CSc1ccc(Oc2ccc(Br)cc2CN(C)C)cc1
Show InChI InChI=1S/C16H18BrNOS/c1-18(2)11-12-10-13(17)4-9-16(12)19-14-5-7-15(20-3)8-6-14/h4-10H,11H2,1-3H3
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n/an/a 7.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252121
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethoxy)p...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O4S/c1-21(2)10-11-9-14(26(20,22)23)7-8-15(11)24-12-3-5-13(6-4-12)25-16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252579
PNG
((3,4-dichlorophenyl)(2-((dimethylamino)methyl)phen...)
Show SMILES CN(C)Cc1ccccc1C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2NO/c1-19(2)10-12-5-3-4-6-13(12)16(20)11-7-8-14(17)15(18)9-11/h3-9H,10H2,1-2H3
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n/an/a 8.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252635
PNG
(CHEMBL493027 | N,N-dimethyl(2-(4-(trifluoromethyl)...)
Show SMILES CN(C)Cc1ccccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H16F3NS/c1-20(2)11-12-5-3-4-6-15(12)21-14-9-7-13(8-10-14)16(17,18)19/h3-10H,11H2,1-2H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252636
PNG
(CHEMBL493057 | N,N-dimethyl(2-(3-(trifluoromethyl)...)
Show SMILES CN(C)Cc1ccccc1Sc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H16F3NS/c1-20(2)11-12-6-3-4-9-15(12)21-14-8-5-7-13(10-14)16(17,18)19/h3-10H,11H2,1-2H3
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n/an/a 9.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252635
PNG
(CHEMBL493027 | N,N-dimethyl(2-(4-(trifluoromethyl)...)
Show SMILES CN(C)Cc1ccccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H16F3NS/c1-20(2)11-12-5-3-4-6-15(12)21-14-9-7-13(8-10-14)16(17,18)19/h3-10H,11H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50251869
PNG
((5-bromo-2-(4-(trifluoromethyl)phenoxy)phenyl)-N,N...)
Show SMILES CN(C)Cc1cc(Br)ccc1Oc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H15BrF3NO/c1-21(2)10-11-9-13(17)5-8-15(11)22-14-6-3-12(4-7-14)16(18,19)20/h3-9H,10H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252071
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethyl)ph...)
Show SMILES CN(C)Cc1cc(ccc1Sc1ccc(cc1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O2S2/c1-21(2)10-11-9-14(25(20,22)23)7-8-15(11)24-13-5-3-12(4-6-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252073
PNG
((+/-)-3-((dimethylamino)methyl)-4-(4-(trifluoromet...)
Show SMILES CN(C)Cc1cc(ccc1S(=O)c1ccc(cc1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O3S2/c1-21(2)10-11-9-14(26(20,23)24)7-8-15(11)25(22)13-5-3-12(4-6-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50251869
PNG
((5-bromo-2-(4-(trifluoromethyl)phenoxy)phenyl)-N,N...)
Show SMILES CN(C)Cc1cc(Br)ccc1Oc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H15BrF3NO/c1-21(2)10-11-9-13(17)5-8-15(11)22-14-6-3-12(4-7-14)16(18,19)20/h3-9H,10H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252169
PNG
(3-((dimethylamino)methyl)-N-methyl-4-(4-(trifluoro...)
Show SMILES CNC(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)c(CN(C)C)c1
Show InChI InChI=1S/C18H19F3N2O3/c1-22-17(24)12-4-9-16(13(10-12)11-23(2)3)25-14-5-7-15(8-6-14)26-18(19,20)21/h4-10H,11H2,1-3H3,(H,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252122
PNG
(CHEMBL479410 | N-(3-((dimethylamino)methyl)-4-(4-(...)
Show SMILES CN(C)Cc1cc(NS(C)(=O)=O)ccc1Oc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N2O3S/c1-22(2)11-12-10-14(21-26(3,23)24)6-9-16(12)25-15-7-4-13(5-8-15)17(18,19)20/h4-10,21H,11H2,1-3H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252073
PNG
((+/-)-3-((dimethylamino)methyl)-4-(4-(trifluoromet...)
Show SMILES CN(C)Cc1cc(ccc1S(=O)c1ccc(cc1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O3S2/c1-21(2)10-11-9-14(26(20,23)24)7-8-15(11)25(22)13-5-3-12(4-6-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,23,24)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252168
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethoxy)p...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)C(N)=O
Show InChI InChI=1S/C17H17F3N2O3/c1-22(2)10-12-9-11(16(21)23)3-8-15(12)24-13-4-6-14(7-5-13)25-17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252071
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethyl)ph...)
Show SMILES CN(C)Cc1cc(ccc1Sc1ccc(cc1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O2S2/c1-21(2)10-11-9-14(25(20,22)23)7-8-15(11)24-13-5-3-12(4-6-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252121
PNG
(3-((dimethylamino)methyl)-4-(4-(trifluoromethoxy)p...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O4S/c1-21(2)10-11-9-14(26(20,22)23)7-8-15(11)24-12-3-5-13(6-4-12)25-16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252072
PNG
(3-((dimethylamino)methyl)-4-(3-(trifluoromethyl)ph...)
Show SMILES CN(C)Cc1cc(ccc1Sc1cccc(c1)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C16H17F3N2O2S2/c1-21(2)10-11-8-14(25(20,22)23)6-7-15(11)24-13-5-3-4-12(9-13)16(17,18)19/h3-9H,10H2,1-2H3,(H2,20,22,23)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252170
PNG
(3-((dimethylamino)methyl)-N,N-dimethyl-4-(4-(trifl...)
Show SMILES CN(C)Cc1cc(ccc1Oc1ccc(OC(F)(F)F)cc1)C(=O)N(C)C
Show InChI InChI=1S/C19H21F3N2O3/c1-23(2)12-14-11-13(18(25)24(3)4)5-10-17(14)26-15-6-8-16(9-7-15)27-19(20,21)22/h5-11H,12H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252582
PNG
((2-(4-(methylthio)benzyl)phenyl)-N,N-dimethylmetha...)
Show SMILES CSc1ccc(Cc2ccccc2CN(C)C)cc1
Show InChI InChI=1S/C17H21NS/c1-18(2)13-16-7-5-4-6-15(16)12-14-8-10-17(19-3)11-9-14/h4-11H,12-13H2,1-3H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252017
PNG
((2-(4-(cyclopropylmethyl)phenoxy)phenyl)-N,N-dimet...)
Show SMILES CN(C)Cc1ccccc1Oc1ccc(CC2CC2)cc1
Show InChI InChI=1S/C19H23NO/c1-20(2)14-17-5-3-4-6-19(17)21-18-11-9-16(10-12-18)13-15-7-8-15/h3-6,9-12,15H,7-8,13-14H2,1-2H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells

Bioorg Med Chem Lett 18: 4018-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.001
BindingDB Entry DOI: 10.7270/Q2W37W4X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%