Found 22 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251959
(2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...)Show SMILES CC(C)(C)c1ccc(CS(=O)(=O)CC(=O)N=c2scc(CC(O)=O)n2O)cc1 |w:15.14| Show InChI InChI=1S/C18H22N2O6S2/c1-18(2,3)13-6-4-12(5-7-13)10-28(25,26)11-15(21)19-17-20(24)14(9-27-17)8-16(22)23/h4-7,9,24H,8,10-11H2,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251958
(2-(2-(2-(benzylsulfonyl)acetamido)-3-hydroxy-2,3-d...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)Cc2ccccc2)n1O |w:8.8| Show InChI InChI=1S/C14H14N2O6S2/c17-12(9-24(21,22)8-10-4-2-1-3-5-10)15-14-16(20)11(7-23-14)6-13(18)19/h1-5,7,20H,6,8-9H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251957
(CHEMBL519615 | {2-[2-(Biphenyl-4-sulfonyl)-acetyli...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccc(cc2)-c2ccccc2)n1O |w:8.8| Show InChI InChI=1S/C19H16N2O6S2/c22-17(20-19-21(25)15(11-28-19)10-18(23)24)12-29(26,27)16-8-6-14(7-9-16)13-4-2-1-3-5-13/h1-9,11,25H,10,12H2,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50252002
(2-(2-(2-(4-tert-butylphenylsulfonyl)acetamido)-3-h...)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)CC(=O)N=c1scc(CC(O)=O)n1O |w:16.16| Show InChI InChI=1S/C17H20N2O6S2/c1-17(2,3)11-4-6-13(7-5-11)27(24,25)10-14(20)18-16-19(23)12(9-26-16)8-15(21)22/h4-7,9,23H,8,10H2,1-3H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251908
(2-(3-hydroxy-2-(2-(naphthalen-2-ylsulfonyl)acetami...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccc3ccccc3c2)n1O |w:8.8| Show InChI InChI=1S/C17H14N2O6S2/c20-15(18-17-19(23)13(9-26-17)8-16(21)22)10-27(24,25)14-6-5-11-3-1-2-4-12(11)7-14/h1-7,9,23H,8,10H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251907
(2-(2-(2-(4-chlorophenylsulfonyl)acetamido)-3-hydro...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccc(Cl)cc2)n1O |w:8.8| Show InChI InChI=1S/C13H11ClN2O6S2/c14-8-1-3-10(4-2-8)24(21,22)7-11(17)15-13-16(20)9(6-23-13)5-12(18)19/h1-4,6,20H,5,7H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50252001
(2-(3-hydroxy-2-(2-tosylacetamido)-2,3-dihydrothiaz...)Show SMILES Cc1ccc(cc1)S(=O)(=O)CC(=O)N=c1scc(CC(O)=O)n1O |w:13.13| Show InChI InChI=1S/C14H14N2O6S2/c1-9-2-4-11(5-3-9)24(21,22)8-12(17)15-14-16(20)10(7-23-14)6-13(18)19/h2-5,7,20H,6,8H2,1H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251900
(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccccc2)n1O |w:8.8| Show InChI InChI=1S/C13H12N2O6S2/c16-11(8-23(20,21)10-4-2-1-3-5-10)14-13-15(19)9(7-22-13)6-12(17)18/h1-5,7,19H,6,8H2,(H,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251905
(2-(2-(2-(2-chlorophenylsulfonyl)acetamido)-3-hydro...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccccc2Cl)n1O |w:8.8| Show InChI InChI=1S/C13H11ClN2O6S2/c14-9-3-1-2-4-10(9)24(21,22)7-11(17)15-13-16(20)8(6-23-13)5-12(18)19/h1-4,6,20H,5,7H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251906
(2-(2-(2-(3-chlorophenylsulfonyl)acetamido)-3-hydro...)Show SMILES OC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2cccc(Cl)c2)n1O |w:8.8| Show InChI InChI=1S/C13H11ClN2O6S2/c14-8-2-1-3-10(4-8)24(21,22)7-11(17)15-13-16(20)9(6-23-13)5-12(18)19/h1-4,6,20H,5,7H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251954
(2-(3-hydroxy-5-methyl-2-(2-(phenylsulfonyl)acetami...)Show SMILES Cc1sc(=NC(=O)CS(=O)(=O)c2ccccc2)n(O)c1CC(O)=O |w:4.4| Show InChI InChI=1S/C14H14N2O6S2/c1-9-11(7-13(18)19)16(20)14(23-9)15-12(17)8-24(21,22)10-5-3-2-4-6-10/h2-6,20H,7-8H2,1H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251955
(3-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)Show SMILES OC(=O)CCc1csc(=NC(=O)CS(=O)(=O)c2ccccc2)n1O |w:9.9| Show InChI InChI=1S/C14H14N2O6S2/c17-12(9-24(21,22)11-4-2-1-3-5-11)15-14-16(20)10(8-23-14)6-7-13(18)19/h1-5,8,20H,6-7,9H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50252000
(2-(3-hydroxy-2-(2-(methylsulfonyl)acetamido)-2,3-d...)Show SMILES CS(=O)(=O)CC(=O)N=c1scc(CC(O)=O)n1O |w:7.6| Show InChI InChI=1S/C8H10N2O6S2/c1-18(15,16)4-6(11)9-8-10(14)5(3-17-8)2-7(12)13/h3,14H,2,4H2,1H3,(H,12,13) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251904
(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)Show SMILES CC(C(O)=O)c1csc(=NC(=O)CS(=O)(=O)c2ccccc2)n1O |w:9.9| Show InChI InChI=1S/C14H14N2O6S2/c1-9(13(18)19)11-7-23-14(16(11)20)15-12(17)8-24(21,22)10-5-3-2-4-6-10/h2-7,9,20H,8H2,1H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251998
(2-(3-hydroxy-2-(2-(phenylamino)acetamido)-2,3-dihy...)Show InChI InChI=1S/C13H13N3O4S/c17-11(7-14-9-4-2-1-3-5-9)15-13-16(20)10(8-21-13)6-12(18)19/h1-5,8,14,20H,6-7H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251956
(2-(3-hydroxy-2-(2-(phenylthio)acetamido)-2,3-dihyd...)Show InChI InChI=1S/C13H12N2O4S2/c16-11(8-20-10-4-2-1-3-5-10)14-13-15(19)9(7-21-13)6-12(17)18/h1-5,7,19H,6,8H2,(H,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251997
(2-(3-hydroxy-2-(2-phenoxyacetamido)-2,3-dihydrothi...)Show InChI InChI=1S/C13H12N2O5S/c16-11(7-20-10-4-2-1-3-5-10)14-13-15(19)9(8-21-13)6-12(17)18/h1-5,8,19H,6-7H2,(H,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251902
(CHEMBL479405 | ethyl 2-(3-hydroxy-2-(2-(phenylsulf...)Show SMILES CCOC(=O)Cc1csc(=NC(=O)CS(=O)(=O)c2ccccc2)n1O |w:10.10| Show InChI InChI=1S/C15H16N2O6S2/c1-2-23-14(19)8-11-9-24-15(17(11)20)16-13(18)10-25(21,22)12-6-4-3-5-7-12/h3-7,9,20H,2,8,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251999
(2-(3-hydroxy-2-(3-phenylpropanamido)-2,3-dihydroth...)Show InChI InChI=1S/C14H14N2O4S/c17-12(7-6-10-4-2-1-3-5-10)15-14-16(20)11(9-21-14)8-13(18)19/h1-5,9,20H,6-8H2,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251901
(CHEMBL479404 | ethyl 2-(2-(2-(phenylsulfonyl)aceta...)Show InChI InChI=1S/C15H16N2O5S2/c1-2-22-14(19)8-11-9-23-15(16-11)17-13(18)10-24(20,21)12-6-4-3-5-7-12/h3-7,9H,2,8,10H2,1H3,(H,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251903
(2-(2-(2-(phenylsulfonyl)acetamido)thiazol-4-yl)ace...)Show InChI InChI=1S/C13H12N2O5S2/c16-11(8-22(19,20)10-4-2-1-3-5-10)15-13-14-9(7-21-13)6-12(17)18/h1-5,7H,6,8H2,(H,17,18)(H,14,15,16) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251953
(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)Show SMILES CC(C)(C(O)=O)c1csc(=NC(=O)CS(=O)(=O)c2ccccc2)n1O |w:10.10| Show InChI InChI=1S/C15H16N2O6S2/c1-15(2,13(19)20)11-8-24-14(17(11)21)16-12(18)9-25(22,23)10-6-4-3-5-7-10/h3-8,21H,9H2,1-2H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031
BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this
Ligand-Target Pair | |
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