Affinity Data by PubMed id=18624395

PubMed code 18624395

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50262295 (4-[(4R,7S,10S,13R)-10-(3-{[amino(iminiumyl)methyl]...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Binding affinity to human NOP receptor				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262291 (4-[(3S,6S,9S,17S)-6-(3-{[amino(iminiumyl)methyl]am...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262290 (4-[(3S,6S,9S,12S,20S)-6-(3-{[amino(iminiumyl)methy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Binding affinity to human NOP receptor				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262292 (CHEMBL507269 \| [Asp6,Lys10]N/OFQ(1-13)NH2) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106469 (CHEMBL269029 \| FGGFTCARKCARK \| cyclo[Cys6,Cys10]N/...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.830	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Binding affinity to human NOP receptor				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262293 (CHEMBL507653 \| [D-Asp7,Lys10]N/OFQ(1-13)NH2) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262291 (4-[(3S,6S,9S,17S)-6-(3-{[amino(iminiumyl)methyl]am...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106469 (CHEMBL269029 \| FGGFTCARKCARK \| cyclo[Cys6,Cys10]N/...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor by [35S]GTPgammaS binding assay				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.780	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor by [35S]GTPgammaS binding assay				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262290 (4-[(3S,6S,9S,12S,20S)-6-(3-{[amino(iminiumyl)methy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.12	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262295 (4-[(4R,7S,10S,13R)-10-(3-{[amino(iminiumyl)methyl]...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.690	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor by [35S]GTPgammaS binding assay				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262292 (CHEMBL507269 \| [Asp6,Lys10]N/OFQ(1-13)NH2) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22.3	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50262293 (CHEMBL507653 \| [D-Asp7,Lys10]N/OFQ(1-13)NH2) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	106	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.82	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%