Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23865 (3-[(2S)-2-[1-(9H-fluoren-9-yl)acetamido]-4-methylp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8 | -45.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23866 (MDL28170 | Z-Val-Phe-CHO | benzyl N-[(1S)-2-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 10 | -45.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23859 (3-[(2S)-2-[1-(adamantan-1-yl)acetamido]-4-methylpe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 41 | -41.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23857 (3-[(2S)-2-(3-cyclohexylpropanamido)-4-methylpentan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 50 | -41.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23863 (3-[(2S)-2-(3,3-diphenylpropanamido)-4-methylpentan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 63 | -40.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23861 (3-[(2S)-2-(1,1-diphenylacetamido)-4-methylpentanam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 108 | -39.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23858 (Peptidyl alpha-Ketoester, 1b | methyl 3-[(2S)-2-[1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 450 | -35.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23860 (Peptidyl alpha-Ketoester, 1c | methyl 3-[(2S)-2-(1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 944 | -34.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23855 (Peptidyl alpha-Ketoester, 1a | methyl 3-[(2S)-2-(3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.05E+3 | -33.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23864 (Peptidyl alpha-Ketoester, 1e | methyl 3-[(2S)-2-[1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.20E+3 | -33.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM23862 (Peptidyl alpha-Ketoester, 1d | methyl 3-[(2S)-2-(3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.15E+3 | -32.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Tennessee Health Science Center | Assay Description Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO... | J Med Chem 51: 4346-50 (2008) Article DOI: 10.1021/jm800182c BindingDB Entry DOI: 10.7270/Q2542KW0 | |||||||||||
More data for this Ligand-Target Pair |