Found 71 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262214
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-methyl-...)Show SMILES Cc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C24H20N4O/c1-15-6-9-22-19(10-15)20(14-26-22)24(29)18-4-2-3-5-21(18)25-12-16-7-8-17-13-27-28-23(17)11-16/h2-11,13-14,25-26H,12H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261960
((2-((1H-indazol-6-yl)methylamino)phenyl)(1H-indazo...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-16-5-1-4-8-19(16)26-27-21)17-6-2-3-7-18(17)23-12-14-9-10-15-13-24-25-20(15)11-14/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262274
((2-((1H-indazol-6-yl)methylamino)phenyl)(6-methyl-...)Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C24H20N4O/c1-15-6-9-18-20(14-26-23(18)10-15)24(29)19-4-2-3-5-21(19)25-12-16-7-8-17-13-27-28-22(17)11-16/h2-11,13-14,25-26H,12H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM21
(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261959
((2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indazo...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-16-5-1-4-8-20(16)26-27-21)17-6-2-3-7-19(17)23-12-14-9-10-18-15(11-14)13-24-25-18/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261961
((1H-indazol-3-yl)(2-(quinolin-6-ylmethylamino)phen...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C24H18N4O/c29-24(23-18-7-1-4-10-22(18)27-28-23)19-8-2-3-9-21(19)26-15-16-11-12-20-17(14-16)6-5-13-25-20/h1-14,26H,15H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262057
((2-((1H-indazol-6-yl)methylamino)phenyl)(1H-indol-...)Show SMILES O=C(c1c[nH]c2ccccc12)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C23H18N4O/c28-23(19-14-25-20-7-3-1-5-17(19)20)18-6-2-4-8-21(18)24-12-15-9-10-16-13-26-27-22(16)11-15/h1-11,13-14,24-25H,12H2,(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262105
((5-methyl-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Cc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C26H21N3O/c1-17-8-10-25-21(13-17)22(16-29-25)26(30)20-6-2-3-7-24(20)28-15-18-9-11-23-19(14-18)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262057
((2-((1H-indazol-6-yl)methylamino)phenyl)(1H-indol-...)Show SMILES O=C(c1c[nH]c2ccccc12)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C23H18N4O/c28-23(19-14-25-20-7-3-1-5-17(19)20)18-6-2-4-8-21(18)24-12-15-9-10-16-13-26-27-22(16)11-15/h1-11,13-14,24-25H,12H2,(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262106
((1,5-dimethyl-1H-indol-3-yl)(2-(quinolin-6-ylmethy...)Show SMILES Cc1ccc2n(C)cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C27H23N3O/c1-18-9-12-26-22(14-18)23(17-30(26)2)27(31)21-7-3-4-8-25(21)29-16-19-10-11-24-20(15-19)6-5-13-28-24/h3-15,17,29H,16H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261961
((1H-indazol-3-yl)(2-(quinolin-6-ylmethylamino)phen...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C24H18N4O/c29-24(23-18-7-1-4-10-22(18)27-28-23)19-8-2-3-9-21(19)26-15-16-11-12-20-17(14-16)6-5-13-25-20/h1-14,26H,15H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262056
((2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indol-...)Show SMILES O=C(c1c[nH]c2ccccc12)c1ccccc1NCc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C23H18N4O/c28-23(19-14-25-21-7-3-1-5-17(19)21)18-6-2-4-8-22(18)24-12-15-9-10-20-16(11-15)13-26-27-20/h1-11,13-14,24-25H,12H2,(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262274
((2-((1H-indazol-6-yl)methylamino)phenyl)(6-methyl-...)Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C24H20N4O/c1-15-6-9-18-20(14-26-23(18)10-15)24(29)19-4-2-3-5-21(19)25-12-16-7-8-17-13-27-28-22(17)11-16/h2-11,13-14,25-26H,12H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262054
((2-((1H-indazol-6-yl)methylamino)phenyl)(1-methyl-...)Show SMILES Cn1nc(C(=O)c2ccccc2NCc2ccc3cn[nH]c3c2)c2ccccc12 Show InChI InChI=1S/C23H19N5O/c1-28-21-9-5-3-7-18(21)22(27-28)23(29)17-6-2-4-8-19(17)24-13-15-10-11-16-14-25-26-20(16)12-15/h2-12,14,24H,13H2,1H3,(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262278
((2-((1H-indazol-6-yl)methylamino)phenyl)(6-fluoro-...)Show SMILES Fc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C23H17FN4O/c24-16-7-8-17-19(13-26-22(17)10-16)23(29)18-3-1-2-4-20(18)25-11-14-5-6-15-12-27-28-21(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262277
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-fluoro-...)Show SMILES Fc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C23H17FN4O/c24-16-7-8-21-18(10-16)19(13-26-21)23(29)17-3-1-2-4-20(17)25-11-14-5-6-15-12-27-28-22(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50261960
((2-((1H-indazol-6-yl)methylamino)phenyl)(1H-indazo...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-16-5-1-4-8-19(16)26-27-21)17-6-2-3-7-18(17)23-12-14-9-10-15-13-24-25-20(15)11-14/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262054
((2-((1H-indazol-6-yl)methylamino)phenyl)(1-methyl-...)Show SMILES Cn1nc(C(=O)c2ccccc2NCc2ccc3cn[nH]c3c2)c2ccccc12 Show InChI InChI=1S/C23H19N5O/c1-28-21-9-5-3-7-18(21)22(27-28)23(29)17-6-2-4-8-19(17)24-13-15-10-11-16-14-25-26-20(16)12-15/h2-12,14,24H,13H2,1H3,(H,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50261961
((1H-indazol-3-yl)(2-(quinolin-6-ylmethylamino)phen...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C24H18N4O/c29-24(23-18-7-1-4-10-22(18)27-28-23)19-8-2-3-9-21(19)26-15-16-11-12-20-17(14-16)6-5-13-25-20/h1-14,26H,15H2,(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262007
((2-((1H-benzo[d]imidazol-5-yl)methylamino)phenyl)(...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2nc[nH]c2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-15-5-1-4-8-18(15)26-27-21)16-6-2-3-7-17(16)23-12-14-9-10-19-20(11-14)25-13-24-19/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262275
((2-((1H-indazol-6-yl)methylamino)phenyl)(7-methyl-...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C24H20N4O/c1-15-5-4-7-18-20(14-26-23(15)18)24(29)19-6-2-3-8-21(19)25-12-16-9-10-17-13-27-28-22(17)11-16/h2-11,13-14,25-26H,12H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 355 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262157
((5-methoxy-1H-indol-3-yl)(2-(quinolin-6-ylmethylam...)Show SMILES COc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C26H21N3O2/c1-31-19-9-11-25-21(14-19)22(16-29-25)26(30)20-6-2-3-7-24(20)28-15-17-8-10-23-18(13-17)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50261959
((2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indazo...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-16-5-1-4-8-20(16)26-27-21)17-6-2-3-7-19(17)23-12-14-9-10-18-15(11-14)13-24-25-18/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262106
((1,5-dimethyl-1H-indol-3-yl)(2-(quinolin-6-ylmethy...)Show SMILES Cc1ccc2n(C)cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C27H23N3O/c1-18-9-12-26-22(14-18)23(17-30(26)2)27(31)21-7-3-4-8-25(21)29-16-19-10-11-24-20(15-19)6-5-13-28-24/h3-15,17,29H,16H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262009
((2-((1H-indazol-6-yl)methylamino)phenyl)(1-(2-meth...)Show SMILES COCCn1nc(C(=O)c2ccccc2NCc2ccc3cn[nH]c3c2)c2ccccc12 Show InChI InChI=1S/C25H23N5O2/c1-32-13-12-30-23-9-5-3-7-20(23)24(29-30)25(31)19-6-2-4-8-21(19)26-15-17-10-11-18-16-27-28-22(18)14-17/h2-11,14,16,26H,12-13,15H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262213
((5-chloro-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Clc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C25H18ClN3O/c26-18-8-10-24-20(13-18)21(15-29-24)25(30)19-5-1-2-6-23(19)28-14-16-7-9-22-17(12-16)4-3-11-27-22/h1-13,15,28-29H,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262056
((2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indol-...)Show SMILES O=C(c1c[nH]c2ccccc12)c1ccccc1NCc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C23H18N4O/c28-23(19-14-25-21-7-3-1-5-17(19)21)18-6-2-4-8-22(18)24-12-15-9-10-20-16(11-15)13-26-27-20/h1-11,13-14,24-25H,12H2,(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262158
((6-methoxy-1H-indol-3-yl)(2-(quinolin-6-ylmethylam...)Show SMILES COc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C26H21N3O2/c1-31-19-9-10-20-22(16-29-25(20)14-19)26(30)21-6-2-3-7-24(21)28-15-17-8-11-23-18(13-17)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262108
((7-methyl-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C26H21N3O/c1-17-6-4-9-20-22(16-29-25(17)20)26(30)21-8-2-3-10-24(21)28-15-18-11-12-23-19(14-18)7-5-13-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262107
((6-methyl-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C26H21N3O/c1-17-8-10-20-22(16-29-25(20)13-17)26(30)21-6-2-3-7-24(21)28-15-18-9-11-23-19(14-18)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261960
((2-((1H-indazol-6-yl)methylamino)phenyl)(1H-indazo...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-16-5-1-4-8-19(16)26-27-21)17-6-2-3-7-18(17)23-12-14-9-10-15-13-24-25-20(15)11-14/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261959
((2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indazo...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2[nH]ncc2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-16-5-1-4-8-20(16)26-27-21)17-6-2-3-7-19(17)23-12-14-9-10-18-15(11-14)13-24-25-18/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262212
((6-fluoro-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Fc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C25H18FN3O/c26-18-8-9-19-21(15-29-24(19)13-18)25(30)20-5-1-2-6-23(20)28-14-16-7-10-22-17(12-16)4-3-11-27-22/h1-13,15,28-29H,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262331
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-chloro-...)Show SMILES Clc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C23H17ClN4O/c24-16-7-8-21-18(10-16)19(13-26-21)23(29)17-3-1-2-4-20(17)25-11-14-5-6-15-12-27-28-22(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261904
((1H-indazol-3-yl)(2-(pyridin-4-ylmethylamino)pheny...)Show InChI InChI=1S/C20H16N4O/c25-20(19-15-5-1-4-8-18(15)23-24-19)16-6-2-3-7-17(16)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262214
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-methyl-...)Show SMILES Cc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C24H20N4O/c1-15-6-9-22-19(10-15)20(14-26-22)24(29)18-4-2-3-5-21(18)25-12-16-7-8-17-13-27-28-23(17)11-16/h2-11,13-14,25-26H,12H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262107
((6-methyl-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Cc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C26H21N3O/c1-17-8-10-20-22(16-29-25(20)13-17)26(30)21-6-2-3-7-24(21)28-15-18-9-11-23-19(14-18)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262275
((2-((1H-indazol-6-yl)methylamino)phenyl)(7-methyl-...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C24H20N4O/c1-15-5-4-7-18-20(14-26-23(15)18)24(29)19-6-2-3-8-21(19)25-12-16-9-10-17-13-27-28-22(17)11-16/h2-11,13-14,25-26H,12H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262058
((1H-indol-3-yl)(2-(quinolin-6-ylmethylamino)phenyl...)Show SMILES O=C(c1c[nH]c2ccccc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C25H19N3O/c29-25(21-16-28-23-9-3-1-7-19(21)23)20-8-2-4-10-24(20)27-15-17-11-12-22-18(14-17)6-5-13-26-22/h1-14,16,27-28H,15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262211
((5-fluoro-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Fc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C25H18FN3O/c26-18-8-10-24-20(13-18)21(15-29-24)25(30)19-5-1-2-6-23(19)28-14-16-7-9-22-17(12-16)4-3-11-27-22/h1-13,15,28-29H,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262331
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-chloro-...)Show SMILES Clc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C23H17ClN4O/c24-16-7-8-21-18(10-16)19(13-26-21)23(29)17-3-1-2-4-20(17)25-11-14-5-6-15-12-27-28-22(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262278
((2-((1H-indazol-6-yl)methylamino)phenyl)(6-fluoro-...)Show SMILES Fc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C23H17FN4O/c24-16-7-8-17-19(13-26-22(17)10-16)23(29)18-3-1-2-4-20(18)25-11-14-5-6-15-12-27-28-21(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261904
((1H-indazol-3-yl)(2-(pyridin-4-ylmethylamino)pheny...)Show InChI InChI=1S/C20H16N4O/c25-20(19-15-5-1-4-8-18(15)23-24-19)16-6-2-3-7-17(16)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262277
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-fluoro-...)Show SMILES Fc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C23H17FN4O/c24-16-7-8-21-18(10-16)19(13-26-21)23(29)17-3-1-2-4-20(17)25-11-14-5-6-15-12-27-28-22(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262009
((2-((1H-indazol-6-yl)methylamino)phenyl)(1-(2-meth...)Show SMILES COCCn1nc(C(=O)c2ccccc2NCc2ccc3cn[nH]c3c2)c2ccccc12 Show InChI InChI=1S/C25H23N5O2/c1-32-13-12-30-23-9-5-3-7-20(23)24(29-30)25(31)19-6-2-4-8-21(19)26-15-17-10-11-18-16-27-28-22(18)14-17/h2-11,14,16,26H,12-13,15H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262157
((5-methoxy-1H-indol-3-yl)(2-(quinolin-6-ylmethylam...)Show SMILES COc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C26H21N3O2/c1-31-19-9-11-25-21(14-19)22(16-29-25)26(30)20-6-2-3-7-24(20)28-15-17-8-10-23-18(13-17)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262105
((5-methyl-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Cc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C26H21N3O/c1-17-8-10-25-21(13-17)22(16-29-25)26(30)20-6-2-3-7-24(20)28-15-18-9-11-23-19(14-18)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262212
((6-fluoro-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Fc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C25H18FN3O/c26-18-8-9-19-21(15-29-24(19)13-18)25(30)20-5-1-2-6-23(20)28-14-16-7-10-22-17(12-16)4-3-11-27-22/h1-13,15,28-29H,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50261904
((1H-indazol-3-yl)(2-(pyridin-4-ylmethylamino)pheny...)Show InChI InChI=1S/C20H16N4O/c25-20(19-15-5-1-4-8-18(15)23-24-19)16-6-2-3-7-17(16)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262158
((6-methoxy-1H-indol-3-yl)(2-(quinolin-6-ylmethylam...)Show SMILES COc1ccc2c(c[nH]c2c1)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C26H21N3O2/c1-31-19-9-10-20-22(16-29-25(20)14-19)26(30)21-6-2-3-7-24(21)28-15-17-8-11-23-18(13-17)5-4-12-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262058
((1H-indol-3-yl)(2-(quinolin-6-ylmethylamino)phenyl...)Show SMILES O=C(c1c[nH]c2ccccc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C25H19N3O/c29-25(21-16-28-23-9-3-1-7-19(21)23)20-8-2-4-10-24(20)27-15-17-11-12-22-18(14-17)6-5-13-26-22/h1-14,16,27-28H,15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262108
((7-methyl-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C26H21N3O/c1-17-6-4-9-20-22(16-29-25(17)20)26(30)21-8-2-3-10-24(21)28-15-18-11-12-23-19(14-18)7-5-13-27-23/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262055
((1H-indol-3-yl)(2-(pyridin-4-ylmethylamino)phenyl)...)Show InChI InChI=1S/C21H17N3O/c25-21(18-14-24-19-7-3-1-5-16(18)19)17-6-2-4-8-20(17)23-13-15-9-11-22-12-10-15/h1-12,14,23-24H,13H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262006
((2-(benzo[d][1,3]dioxol-5-ylmethylamino)phenyl)(1H...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2OCOc2c1 Show InChI InChI=1S/C22H17N3O3/c26-22(21-15-5-1-4-8-18(15)24-25-21)16-6-2-3-7-17(16)23-12-14-9-10-19-20(11-14)28-13-27-19/h1-11,23H,12-13H2,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262007
((2-((1H-benzo[d]imidazol-5-yl)methylamino)phenyl)(...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2nc[nH]c2c1 Show InChI InChI=1S/C22H17N5O/c28-22(21-15-5-1-4-8-18(15)26-27-21)16-6-2-3-7-17(16)23-12-14-9-10-19-20(11-14)25-13-24-19/h1-11,13,23H,12H2,(H,24,25)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262213
((5-chloro-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Clc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C25H18ClN3O/c26-18-8-10-24-20(13-18)21(15-29-24)25(30)19-5-1-2-6-23(19)28-14-16-7-9-22-17(12-16)4-3-11-27-22/h1-13,15,28-29H,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262211
((5-fluoro-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Fc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c2c1 Show InChI InChI=1S/C25H18FN3O/c26-18-8-10-24-20(13-18)21(15-29-24)25(30)19-5-1-2-6-23(19)28-14-16-7-9-22-17(12-16)4-3-11-27-22/h1-13,15,28-29H,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262334
((1H-pyrrolo[2,3-b]pyridin-3-yl)(2-(quinolin-6-ylme...)Show SMILES O=C(c1c[nH]c2ncccc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C24H18N4O/c29-23(20-15-28-24-18(20)7-4-12-26-24)19-6-1-2-8-22(19)27-14-16-9-10-21-17(13-16)5-3-11-25-21/h1-13,15,27H,14H2,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262008
((1-methyl-1H-indazol-3-yl)(2-(quinolin-6-ylmethyla...)Show SMILES Cn1nc(C(=O)c2ccccc2NCc2ccc3ncccc3c2)c2ccccc12 Show InChI InChI=1S/C25H20N4O/c1-29-23-11-5-3-9-20(23)24(28-29)25(30)19-8-2-4-10-22(19)27-16-17-12-13-21-18(15-17)7-6-14-26-21/h2-15,27H,16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262055
((1H-indol-3-yl)(2-(pyridin-4-ylmethylamino)phenyl)...)Show InChI InChI=1S/C21H17N3O/c25-21(18-14-24-19-7-3-1-5-16(18)19)17-6-2-4-8-20(17)23-13-15-9-11-22-12-10-15/h1-12,14,23-24H,13H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262156
((4-methoxy-1H-indol-3-yl)(2-(quinolin-6-ylmethylam...)Show SMILES COc1cccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4ncccc4c3)c12 Show InChI InChI=1S/C26H21N3O2/c1-31-24-10-4-9-23-25(24)20(16-29-23)26(30)19-7-2-3-8-22(19)28-15-17-11-12-21-18(14-17)6-5-13-27-21/h2-14,16,28-29H,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262155
((2-methyl-1H-indol-3-yl)(2-(quinolin-6-ylmethylami...)Show SMILES Cc1[nH]c2ccccc2c1C(=O)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C26H21N3O/c1-17-25(20-8-2-5-11-24(20)29-17)26(30)21-9-3-4-10-23(21)28-16-18-12-13-22-19(15-18)7-6-14-27-22/h2-15,28-29H,16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262276
((2-((1H-indazol-6-yl)methylamino)phenyl)(2-methyl-...)Show SMILES Cc1[nH]c2ccccc2c1C(=O)c1ccccc1NCc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C24H20N4O/c1-15-23(18-6-2-5-9-21(18)27-15)24(29)19-7-3-4-8-20(19)25-13-16-10-11-17-14-26-28-22(17)12-16/h2-12,14,25,27H,13H2,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262333
((1H-pyrrolo[3,2-c]pyridin-3-yl)(2-(quinolin-6-ylme...)Show SMILES O=C(c1c[nH]c2ccncc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C24H18N4O/c29-24(20-15-28-23-9-11-25-14-19(20)23)18-5-1-2-6-22(18)27-13-16-7-8-21-17(12-16)4-3-10-26-21/h1-12,14-15,27-28H,13H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262332
((1H-indol-3-yl)(2-(isoquinolin-6-ylmethylamino)phe...)Show SMILES O=C(c1c[nH]c2ccccc12)c1ccccc1NCc1ccc2cnccc2c1 Show InChI InChI=1S/C25H19N3O/c29-25(22-16-28-23-7-3-1-5-20(22)23)21-6-2-4-8-24(21)27-14-17-9-10-19-15-26-12-11-18(19)13-17/h1-13,15-16,27-28H,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262006
((2-(benzo[d][1,3]dioxol-5-ylmethylamino)phenyl)(1H...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2OCOc2c1 Show InChI InChI=1S/C22H17N3O3/c26-22(21-15-5-1-4-8-18(15)24-25-21)16-6-2-3-7-17(16)23-12-14-9-10-19-20(11-14)28-13-27-19/h1-11,23H,12-13H2,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262334
((1H-pyrrolo[2,3-b]pyridin-3-yl)(2-(quinolin-6-ylme...)Show SMILES O=C(c1c[nH]c2ncccc12)c1ccccc1NCc1ccc2ncccc2c1 Show InChI InChI=1S/C24H18N4O/c29-23(20-15-28-24-18(20)7-4-12-26-24)19-6-1-2-8-22(19)27-14-16-9-10-21-17(13-16)5-3-11-25-21/h1-13,15,27H,14H2,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261963
(CHEMBL467980 | N-(4-((2-(1H-indazole-3-carbonyl)ph...)Show SMILES CC(=O)Nc1ccc(CNc2ccccc2C(=O)c2n[nH]c3ccccc23)cc1 Show InChI InChI=1S/C23H20N4O2/c1-15(28)25-17-12-10-16(11-13-17)14-24-20-8-4-3-7-19(20)23(29)22-18-6-2-5-9-21(18)26-27-22/h2-13,24H,14H2,1H3,(H,25,28)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261905
((2-((1H-pyrazol-4-yl)methylamino)phenyl)(1H-indazo...)Show InChI InChI=1S/C18H15N5O/c24-18(17-13-5-1-4-8-16(13)22-23-17)14-6-2-3-7-15(14)19-9-12-10-20-21-11-12/h1-8,10-11,19H,9H2,(H,20,21)(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50261962
((1H-indazol-3-yl)(2-(isoquinolin-6-ylmethylamino)p...)Show SMILES O=C(c1n[nH]c2ccccc12)c1ccccc1NCc1ccc2cnccc2c1 Show InChI InChI=1S/C24H18N4O/c29-24(23-19-5-1-4-8-22(19)27-28-23)20-6-2-3-7-21(20)26-14-16-9-10-18-15-25-12-11-17(18)13-16/h1-13,15,26H,14H2,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) by HTRF assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262008
((1-methyl-1H-indazol-3-yl)(2-(quinolin-6-ylmethyla...)Show SMILES Cn1nc(C(=O)c2ccccc2NCc2ccc3ncccc3c2)c2ccccc12 Show InChI InChI=1S/C25H20N4O/c1-29-23-11-5-3-9-20(23)24(28-29)25(30)19-8-2-4-10-22(19)27-16-17-12-13-21-18(15-17)7-6-14-26-21/h2-15,27H,16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Inc
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay |
Bioorg Med Chem Lett 18: 4344-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0 |
More data for this
Ligand-Target Pair | |
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