Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25400 ((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 9 | -45.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM25392 (4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 136 | -38.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM25398 (Bivalent derivative, 12e | N-[5-(2-{[6-({9-[(2R,3R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 311 | -36.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25398 (Bivalent derivative, 12e | N-[5-(2-{[6-({9-[(2R,3R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 436 | -35.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM25396 (Bivalent derivative, 12c | N-[5-(2-{[4-({9-[(2R,3R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 863 | -34.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25397 ((2R,3R,4S,5R)-2-{6-[(4-{[2-(3-amino-4-hydroxypheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.01E+3 | -33.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25399 (Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.91E+3 | -32.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25396 (Bivalent derivative, 12c | N-[5-(2-{[4-({9-[(2R,3R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.91E+3 | -32.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25394 (Bivalent derivative, 12a | N-[5-(2-{[2-({9-[(2R,3R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.98E+3 | -32.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM25399 (Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.30E+3 | -31.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25395 ((2R,3R,4S,5R)-2-{6-[(2-{[2-(3-amino-4-hydroxypheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.75E+3 | -31.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM25397 ((2R,3R,4S,5R)-2-{6-[(4-{[2-(3-amino-4-hydroxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.31E+3 | -30.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM25395 ((2R,3R,4S,5R)-2-{6-[(2-{[2-(3-amino-4-hydroxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | >-28.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM25394 (Bivalent derivative, 12a | N-[5-(2-{[2-({9-[(2R,3R...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | >-28.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair |