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PubMed code 18831576

Compile data set for download or QSAR
Found 66 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274182
PNG
(CHEMBL484392 | N-Formyl-L-proline-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCCN1C=O |r|
Show InChI InChI=1S/C28H49NO5/c1-3-5-7-9-10-11-12-13-14-17-23(33-28(32)25-19-16-20-29(25)22-30)21-26-24(27(31)34-26)18-15-8-6-4-2/h22-26H,3-21H2,1-2H3/t23-,24-,25-,26-/m0/s1
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1.70E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274020
PNG
(CHEMBL514886 | N-Formyl-beta-alanine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CCNC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-3-5-7-9-10-11-12-13-14-16-22(31-25(29)18-19-27-21-28)20-24-23(26(30)32-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,27,28)/t22-,23-,24-/m0/s1
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1.90E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274779
PNG
(CHEMBL458828 | N-Acetyl-glycine-(1S)-1-[[(2S,3S)-3...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC(C)=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)20-27-21(3)28)19-24-23(26(30)32-24)18-16-9-7-5-2/h22-24H,4-20H2,1-3H3,(H,27,28)/t22-,23-,24-/m0/s1
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2.30E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r|
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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2.50E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274183
PNG
(5-oxo-L-Proline-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C27H47NO5/c1-3-5-7-9-10-11-12-13-14-16-21(32-27(31)23-18-19-25(29)28-23)20-24-22(26(30)33-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,28,29)/t21-,22-,23-,24-/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274019
PNG
(CHEMBL516323 | N-Formyl-L-alanine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](C)NC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)21(3)27-20-28)19-24-23(26(30)32-24)18-16-9-7-5-2/h20-24H,4-19H2,1-3H3,(H,27,28)/t21-,22-,23-,24-/m0/s1
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3.10E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274021
PNG
(CHEMBL457232 | N-Formyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)C |r|
Show InChI InChI=1S/C28H51NO5/c1-5-7-9-11-12-13-14-15-16-18-23(33-28(32)26(22(3)4)29-21-30)20-25-24(27(31)34-25)19-17-10-8-6-2/h21-26H,5-20H2,1-4H3,(H,29,30)/t23-,24-,25-,26-/m0/s1
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5.70E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274180
PNG
(CHEMBL521157 | N-Formyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)CC |r|
Show InChI InChI=1S/C29H53NO5/c1-5-8-10-12-13-14-15-16-17-19-24(34-29(33)27(30-22-31)23(4)7-3)21-26-25(28(32)35-26)20-18-11-9-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t23?,24-,25-,26-,27-/m0/s1
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6.00E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274020
PNG
(CHEMBL514886 | N-Formyl-beta-alanine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CCNC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-3-5-7-9-10-11-12-13-14-16-22(31-25(29)18-19-27-21-28)20-24-23(26(30)32-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,27,28)/t22-,23-,24-/m0/s1
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6.40E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274182
PNG
(CHEMBL484392 | N-Formyl-L-proline-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCCN1C=O |r|
Show InChI InChI=1S/C28H49NO5/c1-3-5-7-9-10-11-12-13-14-17-23(33-28(32)25-19-16-20-29(25)22-30)21-26-24(27(31)34-26)18-15-8-6-4-2/h22-26H,3-21H2,1-2H3/t23-,24-,25-,26-/m0/s1
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7.40E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274056
PNG
(CHEMBL521467 | N-Acetyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)C |r|
Show InChI InChI=1S/C29H53NO5/c1-6-8-10-12-13-14-15-16-17-19-24(34-29(33)27(22(3)4)30-23(5)31)21-26-25(28(32)35-26)20-18-11-9-7-2/h22,24-27H,6-21H2,1-5H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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8.40E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50274181
PNG
(CHEMBL484215 | N-Acetyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)CC |r|
Show InChI InChI=1S/C30H55NO5/c1-6-9-11-13-14-15-16-17-18-20-25(35-30(34)28(23(4)8-3)31-24(5)32)22-27-26(29(33)36-27)21-19-12-10-7-2/h23,25-28H,6-22H2,1-5H3,(H,31,32)/t23?,25-,26-,27-,28-/m0/s1
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8.60E+3n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274021
PNG
(CHEMBL457232 | N-Formyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)C |r|
Show InChI InChI=1S/C28H51NO5/c1-5-7-9-11-12-13-14-15-16-18-23(33-28(32)26(22(3)4)29-21-30)20-25-24(27(31)34-25)19-17-10-8-6-2/h21-26H,5-20H2,1-4H3,(H,29,30)/t23-,24-,25-,26-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r|
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274180
PNG
(CHEMBL521157 | N-Formyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)CC |r|
Show InChI InChI=1S/C29H53NO5/c1-5-8-10-12-13-14-15-16-17-19-24(34-29(33)27(30-22-31)23(4)7-3)21-26-25(28(32)35-26)20-18-11-9-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t23?,24-,25-,26-,27-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274019
PNG
(CHEMBL516323 | N-Formyl-L-alanine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](C)NC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)21(3)27-20-28)19-24-23(26(30)32-24)18-16-9-7-5-2/h20-24H,4-19H2,1-3H3,(H,27,28)/t21-,22-,23-,24-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274779
PNG
(CHEMBL458828 | N-Acetyl-glycine-(1S)-1-[[(2S,3S)-3...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC(C)=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)20-27-21(3)28)19-24-23(26(30)32-24)18-16-9-7-5-2/h22-24H,4-20H2,1-3H3,(H,27,28)/t22-,23-,24-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM24586
PNG
((1R)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}d...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC=O |r|
Show InChI InChI=1S/C25H45NO5/c1-3-5-7-9-10-11-12-13-14-16-21(30-24(28)19-26-20-27)18-23-22(25(29)31-23)17-15-8-6-4-2/h20-23H,3-19H2,1-2H3,(H,26,27)/t21-,22-,23-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274056
PNG
(CHEMBL521467 | N-Acetyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)C |r|
Show InChI InChI=1S/C29H53NO5/c1-6-8-10-12-13-14-15-16-17-19-24(34-29(33)27(22(3)4)30-23(5)31)21-26-25(28(32)35-26)20-18-11-9-7-2/h22,24-27H,6-21H2,1-5H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274181
PNG
(CHEMBL484215 | N-Acetyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)CC |r|
Show InChI InChI=1S/C30H55NO5/c1-6-9-11-13-14-15-16-17-18-20-25(35-30(34)28(23(4)8-3)31-24(5)32)22-27-26(29(33)36-27)21-19-12-10-7-2/h23,25-28H,6-22H2,1-5H3,(H,31,32)/t23?,25-,26-,27-,28-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50274183
PNG
(5-oxo-L-Proline-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C27H47NO5/c1-3-5-7-9-10-11-12-13-14-16-21(32-27(31)23-18-19-25(29)28-23)20-24-22(26(30)33-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,28,29)/t21-,22-,23-,24-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM24586
PNG
((1R)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}d...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC=O |r|
Show InChI InChI=1S/C25H45NO5/c1-3-5-7-9-10-11-12-13-14-16-21(30-24(28)19-26-20-27)18-23-22(25(29)31-23)17-15-8-6-4-2/h20-23H,3-19H2,1-2H3,(H,26,27)/t21-,22-,23-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells by scintillation counting


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274180
PNG
(CHEMBL521157 | N-Formyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)CC |r|
Show InChI InChI=1S/C29H53NO5/c1-5-8-10-12-13-14-15-16-17-19-24(34-29(33)27(30-22-31)23(4)7-3)21-26-25(28(32)35-26)20-18-11-9-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t23?,24-,25-,26-,27-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274021
PNG
(CHEMBL457232 | N-Formyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)C |r|
Show InChI InChI=1S/C28H51NO5/c1-5-7-9-11-12-13-14-15-16-18-23(33-28(32)26(22(3)4)29-21-30)20-25-24(27(31)34-25)19-17-10-8-6-2/h21-26H,5-20H2,1-4H3,(H,29,30)/t23-,24-,25-,26-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274019
PNG
(CHEMBL516323 | N-Formyl-L-alanine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](C)NC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)21(3)27-20-28)19-24-23(26(30)32-24)18-16-9-7-5-2/h20-24H,4-19H2,1-3H3,(H,27,28)/t21-,22-,23-,24-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274183
PNG
(5-oxo-L-Proline-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C27H47NO5/c1-3-5-7-9-10-11-12-13-14-16-21(32-27(31)23-18-19-25(29)28-23)20-24-22(26(30)33-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,28,29)/t21-,22-,23-,24-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274181
PNG
(CHEMBL484215 | N-Acetyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)CC |r|
Show InChI InChI=1S/C30H55NO5/c1-6-9-11-13-14-15-16-17-18-20-25(35-30(34)28(23(4)8-3)31-24(5)32)22-27-26(29(33)36-27)21-19-12-10-7-2/h23,25-28H,6-22H2,1-5H3,(H,31,32)/t23?,25-,26-,27-,28-/m0/s1
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n/an/a 430n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274056
PNG
(CHEMBL521467 | N-Acetyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)C |r|
Show InChI InChI=1S/C29H53NO5/c1-6-8-10-12-13-14-15-16-17-19-24(34-29(33)27(22(3)4)30-23(5)31)21-26-25(28(32)35-26)20-18-11-9-7-2/h22,24-27H,6-21H2,1-5H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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n/an/a 460n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274020
PNG
(CHEMBL514886 | N-Formyl-beta-alanine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CCNC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-3-5-7-9-10-11-12-13-14-16-22(31-25(29)18-19-27-21-28)20-24-23(26(30)32-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,27,28)/t22-,23-,24-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274779
PNG
(CHEMBL458828 | N-Acetyl-glycine-(1S)-1-[[(2S,3S)-3...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC(C)=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)20-27-21(3)28)19-24-23(26(30)32-24)18-16-9-7-5-2/h22-24H,4-20H2,1-3H3,(H,27,28)/t22-,23-,24-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r|
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274182
PNG
(CHEMBL484392 | N-Formyl-L-proline-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCCN1C=O |r|
Show InChI InChI=1S/C28H49NO5/c1-3-5-7-9-10-11-12-13-14-17-23(33-28(32)25-19-16-20-29(25)22-30)21-26-24(27(31)34-26)18-15-8-6-4-2/h22-26H,3-21H2,1-2H3/t23-,24-,25-,26-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM24586
PNG
((1R)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}d...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC=O |r|
Show InChI InChI=1S/C25H45NO5/c1-3-5-7-9-10-11-12-13-14-16-21(30-24(28)19-26-20-27)18-23-22(25(29)31-23)17-15-8-6-4-2/h20-23H,3-19H2,1-2H3,(H,26,27)/t21-,22-,23-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM24586
PNG
((1R)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}d...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC=O |r|
Show InChI InChI=1S/C25H45NO5/c1-3-5-7-9-10-11-12-13-14-16-21(30-24(28)19-26-20-27)18-23-22(25(29)31-23)17-15-8-6-4-2/h20-23H,3-19H2,1-2H3,(H,26,27)/t21-,22-,23-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274182
PNG
(CHEMBL484392 | N-Formyl-L-proline-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCCN1C=O |r|
Show InChI InChI=1S/C28H49NO5/c1-3-5-7-9-10-11-12-13-14-17-23(33-28(32)25-19-16-20-29(25)22-30)21-26-24(27(31)34-26)18-15-8-6-4-2/h22-26H,3-21H2,1-2H3/t23-,24-,25-,26-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274723
PNG
(CHEMBL458622 | N-Formyl-D-leucine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](CC(C)C)NC=O |r|
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26+,27-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274181
PNG
(CHEMBL484215 | N-Acetyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)CC |r|
Show InChI InChI=1S/C30H55NO5/c1-6-9-11-13-14-15-16-17-18-20-25(35-30(34)28(23(4)8-3)31-24(5)32)22-27-26(29(33)36-27)21-19-12-10-7-2/h23,25-28H,6-22H2,1-5H3,(H,31,32)/t23?,25-,26-,27-,28-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274778
PNG
(4-Methylpentanoic Acid (1S)-1-[[(2S,3S-3-Hexyl-4-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CCC(C)C |r|
Show InChI InChI=1S/C28H52O4/c1-5-7-9-11-12-13-14-15-16-18-24(31-27(29)21-20-23(3)4)22-26-25(28(30)32-26)19-17-10-8-6-2/h23-26H,5-22H2,1-4H3/t24-,25-,26-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274216
PNG
(CHEMBL443980 | N-[(Phenylmethoxy)carbonyl]-L-pheny...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C39H57NO6/c1-3-5-7-9-10-11-12-13-20-26-33(29-36-34(37(41)46-36)27-21-8-6-4-2)45-38(42)35(28-31-22-16-14-17-23-31)40-39(43)44-30-32-24-18-15-19-25-32/h14-19,22-25,33-36H,3-13,20-21,26-30H2,1-2H3,(H,40,43)/t33-,34-,35-,36-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274018
PNG
(CHEMBL458090 | N-[(Phenylmethoxy)carbonyl]-glycine...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C32H51NO6/c1-3-5-7-9-10-11-12-13-17-21-27(23-29-28(31(35)39-29)22-18-8-6-4-2)38-30(34)24-33-32(36)37-25-26-19-15-14-16-20-26/h14-16,19-20,27-29H,3-13,17-18,21-25H2,1-2H3,(H,33,36)/t27-,28-,29-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274777
PNG
(CHEMBL451312 | N-[(Phenylmethoxy)carbonyl]-D-Leuci...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](CC(C)C)NC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C36H59NO6/c1-5-7-9-11-12-13-14-15-19-23-30(26-33-31(34(38)43-33)24-20-10-8-6-2)42-35(39)32(25-28(3)4)37-36(40)41-27-29-21-17-16-18-22-29/h16-18,21-22,28,30-33H,5-15,19-20,23-27H2,1-4H3,(H,37,40)/t30-,31-,32+,33-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274722
PNG
((3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2...)
Show SMILES CCCCCCCCCCC[C@H](O)C[C@@H]1OC(=O)[C@H]1CCCCCC |r|
Show InChI InChI=1S/C22H42O3/c1-3-5-7-9-10-11-12-13-14-16-19(23)18-21-20(22(24)25-21)17-15-8-6-4-2/h19-21,23H,3-18H2,1-2H3/t19-,20-,21-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274776
PNG
(CHEMBL457736 | L-Leucine-(1S)-1-[[(2S,3S)-3-hexyl-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](N)CC(C)C |r|
Show InChI InChI=1S/C28H53NO4/c1-5-7-9-11-12-13-14-15-16-18-23(32-28(31)25(29)20-22(3)4)21-26-24(27(30)33-26)19-17-10-8-6-2/h22-26H,5-21,29H2,1-4H3/t23-,24-,25-,26-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274725
PNG
(CHEMBL453289 | N-[(Phenylmethoxy)carbonyl]-L-leuci...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C36H59NO6/c1-5-7-9-11-12-13-14-15-19-23-30(26-33-31(34(38)43-33)24-20-10-8-6-2)42-35(39)32(25-28(3)4)37-36(40)41-27-29-21-17-16-18-22-29/h16-18,21-22,28,30-33H,5-15,19-20,23-27H2,1-4H3,(H,37,40)/t30-,31-,32-,33-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274215
PNG
(CHEMBL520494 | N-Formyl-L-phenylalanine-(1S)-1-[[(...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](Cc1ccccc1)NC=O |r|
Show InChI InChI=1S/C32H51NO5/c1-3-5-7-9-10-11-12-13-17-21-27(24-30-28(31(35)38-30)22-18-8-6-4-2)37-32(36)29(33-25-34)23-26-19-15-14-16-20-26/h14-16,19-20,25,27-30H,3-13,17-18,21-24H2,1-2H3,(H,33,34)/t27-,28-,29-,30-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274724
PNG
(CHEMBL458623 | N-[(1,1-Dimethylethoxy)carbonyl]-L-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C33H61NO6/c1-8-10-12-14-15-16-17-18-19-21-26(24-29-27(30(35)39-29)22-20-13-11-9-2)38-31(36)28(23-25(3)4)34-32(37)40-33(5,6)7/h25-29H,8-24H2,1-7H3,(H,34,37)/t26-,27-,28-,29-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274778
PNG
(4-Methylpentanoic Acid (1S)-1-[[(2S,3S-3-Hexyl-4-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CCC(C)C |r|
Show InChI InChI=1S/C28H52O4/c1-5-7-9-11-12-13-14-15-16-18-24(31-27(29)21-20-23(3)4)22-26-25(28(30)32-26)19-17-10-8-6-2/h23-26H,5-22H2,1-4H3/t24-,25-,26-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50274680
PNG
(CHEMBL484371 | L-Phenylalanine-(1S)-1-[[(2S,3S)-3-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](N)Cc1ccccc1 |r|
Show InChI InChI=1S/C31H51NO4/c1-3-5-7-9-10-11-12-13-17-21-26(24-29-27(30(33)36-29)22-18-8-6-4-2)35-31(34)28(32)23-25-19-15-14-16-20-25/h14-16,19-20,26-29H,3-13,17-18,21-24,32H2,1-2H3/t26-,27-,28-,29-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAGLalpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey ...


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274722
PNG
((3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2...)
Show SMILES CCCCCCCCCCC[C@H](O)C[C@@H]1OC(=O)[C@H]1CCCCCC |r|
Show InChI InChI=1S/C22H42O3/c1-3-5-7-9-10-11-12-13-14-16-19(23)18-21-20(22(24)25-21)17-15-8-6-4-2/h19-21,23H,3-18H2,1-2H3/t19-,20-,21-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274723
PNG
(CHEMBL458622 | N-Formyl-D-leucine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](CC(C)C)NC=O |r|
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26+,27-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274056
PNG
(CHEMBL521467 | N-Acetyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC(C)=O)C(C)C |r|
Show InChI InChI=1S/C29H53NO5/c1-6-8-10-12-13-14-15-16-17-19-24(34-29(33)27(22(3)4)30-23(5)31)21-26-25(28(32)35-26)20-18-11-9-7-2/h22,24-27H,6-21H2,1-5H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274215
PNG
(CHEMBL520494 | N-Formyl-L-phenylalanine-(1S)-1-[[(...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](Cc1ccccc1)NC=O |r|
Show InChI InChI=1S/C32H51NO5/c1-3-5-7-9-10-11-12-13-17-21-27(24-30-28(31(35)38-30)22-18-8-6-4-2)37-32(36)29(33-25-34)23-26-19-15-14-16-20-26/h14-16,19-20,25,27-30H,3-13,17-18,21-24H2,1-2H3,(H,33,34)/t27-,28-,29-,30-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274680
PNG
(CHEMBL484371 | L-Phenylalanine-(1S)-1-[[(2S,3S)-3-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](N)Cc1ccccc1 |r|
Show InChI InChI=1S/C31H51NO4/c1-3-5-7-9-10-11-12-13-17-21-26(24-29-27(30(33)36-29)22-18-8-6-4-2)35-31(34)28(32)23-25-19-15-14-16-20-25/h14-16,19-20,26-29H,3-13,17-18,21-24,32H2,1-2H3/t26-,27-,28-,29-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274183
PNG
(5-oxo-L-Proline-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-o...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C27H47NO5/c1-3-5-7-9-10-11-12-13-14-16-21(32-27(31)23-18-19-25(29)28-23)20-24-22(26(30)33-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,28,29)/t21-,22-,23-,24-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274180
PNG
(CHEMBL521157 | N-Formyl-L-isoleucine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)CC |r|
Show InChI InChI=1S/C29H53NO5/c1-5-8-10-12-13-14-15-16-17-19-24(34-29(33)27(30-22-31)23(4)7-3)21-26-25(28(32)35-26)20-18-11-9-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t23?,24-,25-,26-,27-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274021
PNG
(CHEMBL457232 | N-Formyl-L-valine-(1S)-1-[[(2S,3S)-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](NC=O)C(C)C |r|
Show InChI InChI=1S/C28H51NO5/c1-5-7-9-11-12-13-14-15-16-18-23(33-28(32)26(22(3)4)29-21-30)20-25-24(27(31)34-25)19-17-10-8-6-2/h21-26H,5-20H2,1-4H3,(H,29,30)/t23-,24-,25-,26-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274776
PNG
(CHEMBL457736 | L-Leucine-(1S)-1-[[(2S,3S)-3-hexyl-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](N)CC(C)C |r|
Show InChI InChI=1S/C28H53NO4/c1-5-7-9-11-12-13-14-15-16-18-23(32-28(31)25(29)20-22(3)4)21-26-24(27(30)33-26)19-17-10-8-6-2/h22-26H,5-21,29H2,1-4H3/t23-,24-,25-,26-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274779
PNG
(CHEMBL458828 | N-Acetyl-glycine-(1S)-1-[[(2S,3S)-3...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC(C)=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)20-27-21(3)28)19-24-23(26(30)32-24)18-16-9-7-5-2/h22-24H,4-20H2,1-3H3,(H,27,28)/t22-,23-,24-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274019
PNG
(CHEMBL516323 | N-Formyl-L-alanine-(1S)-1-[[(2S,3S)...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](C)NC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-4-6-8-10-11-12-13-14-15-17-22(31-25(29)21(3)27-20-28)19-24-23(26(30)32-24)18-16-9-7-5-2/h20-24H,4-19H2,1-3H3,(H,27,28)/t21-,22-,23-,24-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274725
PNG
(CHEMBL453289 | N-[(Phenylmethoxy)carbonyl]-L-leuci...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C36H59NO6/c1-5-7-9-11-12-13-14-15-19-23-30(26-33-31(34(38)43-33)24-20-10-8-6-2)42-35(39)32(25-28(3)4)37-36(40)41-27-29-21-17-16-18-22-29/h16-18,21-22,28,30-33H,5-15,19-20,23-27H2,1-4H3,(H,37,40)/t30-,31-,32-,33-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM24567
PNG
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r|
Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274018
PNG
(CHEMBL458090 | N-[(Phenylmethoxy)carbonyl]-glycine...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C32H51NO6/c1-3-5-7-9-10-11-12-13-17-21-27(23-29-28(31(35)39-29)22-18-8-6-4-2)38-30(34)24-33-32(36)37-25-26-19-15-14-16-20-26/h14-16,19-20,27-29H,3-13,17-18,21-25H2,1-2H3,(H,33,36)/t27-,28-,29-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274777
PNG
(CHEMBL451312 | N-[(Phenylmethoxy)carbonyl]-D-Leuci...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](CC(C)C)NC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C36H59NO6/c1-5-7-9-11-12-13-14-15-19-23-30(26-33-31(34(38)43-33)24-20-10-8-6-2)42-35(39)32(25-28(3)4)37-36(40)41-27-29-21-17-16-18-22-29/h16-18,21-22,28,30-33H,5-15,19-20,23-27H2,1-4H3,(H,37,40)/t30-,31-,32+,33-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274216
PNG
(CHEMBL443980 | N-[(Phenylmethoxy)carbonyl]-L-pheny...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C39H57NO6/c1-3-5-7-9-10-11-12-13-20-26-33(29-36-34(37(41)46-36)27-21-8-6-4-2)45-38(42)35(28-31-22-16-14-17-23-31)40-39(43)44-30-32-24-18-15-19-25-32/h14-19,22-25,33-36H,3-13,20-21,26-30H2,1-2H3,(H,40,43)/t33-,34-,35-,36-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274020
PNG
(CHEMBL514886 | N-Formyl-beta-alanine-(1S)-1-[[(2S,...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CCNC=O |r|
Show InChI InChI=1S/C26H47NO5/c1-3-5-7-9-10-11-12-13-14-16-22(31-25(29)18-19-27-21-28)20-24-23(26(30)32-24)17-15-8-6-4-2/h21-24H,3-20H2,1-2H3,(H,27,28)/t22-,23-,24-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50274724
PNG
(CHEMBL458623 | N-[(1,1-Dimethylethoxy)carbonyl]-L-...)
Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C33H61NO6/c1-8-10-12-14-15-16-17-18-19-21-26(24-29-27(30(35)39-29)22-20-13-11-9-2)38-31(36)28(23-25(3)4)34-32(37)40-33(5,6)7/h25-29H,8-24H2,1-7H3,(H,34,37)/t26-,27-,28-,29-/m0/s1
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Sapienza Università di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [14C]anadamide hydrolysis in rat brain membrane


J Med Chem 51: 6970-9 (2008)


Article DOI: 10.1021/jm800978m
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%